Overexpression of CMET is associated with signal transducer and activator of transcription 3 activation and diminished prognosis in oesophageal adenocarcinoma but not in squamous cell carcinoma

European Journal of Cancer

Volumn 50, Issue 7, 2014, Pages 1354-1360

  Mesteri, Ildiko ^a   Schoppmann, Sebastian F ^a   Preusser, Matthias ^a   Birner, Peter ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

C Met; cMet; MET; Oesophageal cancer; Prognosis; Survival

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SCATTER FACTOR RECEPTOR; STAT3 PROTEIN;

ARTICLE; CANCER PROGNOSIS; DISTANT METASTASIS; EPITHELIAL MESENCHYMAL TRANSITION; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGUS CARCINOMA; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPH VESSEL METASTASIS; METASTASIS; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; SURVIVAL; TUMOR CELL;

C-MET; CMET; MET; OESOPHAGEAL CANCER; PROGNOSIS; SURVIVAL;

ADENOCARCINOMA; AGED; CARCINOMA, SQUAMOUS CELL; EPITHELIAL-MESENCHYMAL TRANSITION; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-MET; PTEN PHOSPHOHYDROLASE; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; STAT3 TRANSCRIPTION FACTOR; SURVIVAL ANALYSIS; TRANSCRIPTIONAL ACTIVATION;

EID: 84897434022     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2014.01.022     Document Type: Article

References (35)

1. S. Giordano, C. Ponzetto, M.F. Di Renzo, C.S. Cooper, and P.M. Comoglio Tyrosine kinase receptor indistinguishable from the c-met protein Nature 339 6220 1989 155 156
2. G.A. Watson, X. Zhang, and M.T. Stang et al. Inhibition of c-Met as a therapeutic strategy for esophageal adenocarcinoma Neoplasia 8 11 2006 949 955
3. L.J. Herrera, T. El-Hefnawy, and P.E. Queiroz de Oliveira et al. The HGF receptor c-Met is overexpressed in esophageal adenocarcinoma Neoplasia 7 1 2005 75 84
4. J.K. Lennerz, E.L. Kwak, and A. Ackerman et al. MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib J Clin Oncol 29 36 2011 4803 4810
5. J.B. Tuynman, S.M. Lagarde, F.J. Ten Kate, D.J. Richel, and J.J. van Lanschot Met expression is an independent prognostic risk factor in patients with oesophageal adenocarcinoma Br J Cancer 98 6 2008 1102 1108
6. H. Kato, T. Arao, and K. Matsumoto et al. Gene amplification of EGFR, HER2, FGFR2 and MET in esophageal squamous cell carcinoma Int J Oncol 42 4 2013 1151 1158
7. Y.C. Hu, K.Y. Lam, S. Law, J. Wong, and G. Srivastava Profiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESCC) using human cancer cDNA arrays: overexpression of oncogene MET correlates with tumor differentiation in ESCC Clin Cancer Res 7 11 2001 3519 3525
8. A.S. Berghoff, M. Magerle, and A. Ilhan-Mutlu et al. Frequent overexpression of ErbB - receptor family members in brain metastases of non-small cell lung cancer patients APMIS 121 12 2013 1144 1152
9. S.F. Schoppmann, B. Jesch, J. Friedrich, G. Jomrich, F. Maroske, and P. Birner Phosphorylation of signal transducer and activator of transcription 3 (STAT3) correlates with Her-2 status, carbonic anhydrase 9 expression and prognosis in esophageal cancer Clin Exp Metastasis 29 6 2012 615 624
10. S.F. Schoppmann, B. Jesch, J. Zacherl, M.F. Riegler, J. Friedrich, and P. Birner Lymphangiogenesis and lymphovascular invasion diminishes prognosis in esophageal cancer Surgery 153 4 2013 526 534
11. S.F. Schoppmann, B. Jesch, and J. Friedrich et al. Expression of Her-2 in carcinomas of the esophagus Am J Surg Pathol 34 12 2010 1868 1873
12. Y. Benjamini, and Y. Hochberg Controlling the false discovery rate: a practical and powerful approach to multiple testing J R Stat Soc 57 1995 289 300
13. Y. Uehara, O. Minowa, and C. Mori et al. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor Nature 373 6516 1995 702 705
14. C.G. Huh, V.M. Factor, A. Sanchez, K. Uchida, E.A. Conner, and S.S. Thorgeirsson Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair Proc Natl Acad Sci U S A 101 13 2004 4477 4482
15. T. Nakamura, S. Mizuno, K. Matsumoto, Y. Sawa, H. Matsuda, and T. Nakamura Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF J Clin Invest 106 12 2000 1511 1519
16. J. Chmielowiec, M. Borowiak, and M. Morkel et al. C-Met is essential for wound healing in the skin J Cell Biol 177 1 2007 151 162
17. N.K. Venepalli, and L. Goff Targeting the HGF-cMET Axis in Hepatocellular Carcinoma Int J Hepatol 2013 2013 341636
18. Y.W. Zhang, L.M. Wang, R. Jove, and G.F. Vande Woude Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis Oncogene 21 2 2002 217 226
19. T. Ach, K. Zeitler, and S. Schwarz-Furlan et al. Aberrations of MET are associated with copy number gain of EGFR and loss of PTEN and predict poor outcome in patients with salivary gland cancer Virchows Arch 462 1 2013 65 72
20. Y. Li, F. Guessous, and C. DiPierro et al. Interactions between PTEN and the c-Met pathway in glioblastoma and implications for therapy Mol Cancer Ther 8 2 2009 376 385
21. J. Tanizaki, I. Okamoto, K. Sakai, and K. Nakagawa Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification Br J Cancer 105 6 2011 807 813
22. M. Jo, D.B. Stolz, J.E. Esplen, K. Dorko, G.K. Michalopoulos, and S.C. Strom Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells J Biol Chem 275 12 2000 8806 8811
23. J.D. Bergstrom, B. Westermark, and N.E. Heldin Epidermal growth factor receptor signaling activates met in human anaplastic thyroid carcinoma cells Exp Cell Res 259 1 2000 293 299
24. M. Gotte, C. Kersting, I. Radke, L. Kiesel, and P. Wulfing An expression signature of syndecan-1 (CD138), E-cadherin and c-met is associated with factors of angiogenesis and lymphangiogenesis in ductal breast carcinoma in situ Breast Cancer Res 9 1 2007 R8
25. D. Zhao, S.H. Wang, Y. Feng, C.G. Hua, J. Zhao, and X.F. Tang Intratumoral c-Met expression is associated with vascular endothelial growth factor C expression, lymphangiogenesis, and lymph node metastasis in oral squamous cell carcinoma: implications for use as a prognostic marker Hum Pathol 42 10 2011 1514 1523
26. M. Nakajima, H. Sawada, and Y. Yamada et al. The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas Cancer 85 9 1999 1894 1902
27. J. Ma, J. Ma, Q. Meng, Z.S. Zhao, and W.J. Xu Prognostic value and clinical pathology of MACC-1 and c-MET expression in gastric carcinoma Pathol Oncol Res 19 4 2013 821 832
28. T.J. Huang, J.Y. Wang, S.R. Lin, S.T. Lian, and J.S. Hsieh Overexpression of the c-met protooncogene in human gastric carcinoma - correlation to clinical features Acta Oncol 40 5 2001 638 643
29. T.A. Yap, S.K. Sandhu, S.M. Alam, and J.S. de Bono HGF/c-MET targeted therapeutics: novel strategies for cancer medicine Curr Drug Targets 12 14 2011 2045 2058
30. G.V. Scagliotti, S. Novello, and J. von Pawel The emerging role of MET/HGF inhibitors in oncology Cancer Treat Rev 39 7 2013 793 801
31. A. Avan, M. Maftouh, and N. Funel et al. MET as a potential target for the treatment of upper gastrointestinal cancers: characterization of novel C-Met inhibitors from bench to bedside Curr Med Chem 21 8 2014 975 989
32. H. Kawakami, I. Okamoto, and T. Arao et al. MET amplification as a potential therapeutic target in gastric cancer Oncotarget 4 1 2013 9 17
33. Y.L. Sun, W.D. Liu, and G.Y. Ma et al. Expression of HGF and Met in human tissues of colorectal cancers: biological and clinical implications for synchronous liver metastasis Int J Med Sci 10 5 2013 548 559
34. M. Isaksson-Mettavainio, B. Van Guelpen, A. Oberg, R. Stenling, R. Palmqvist, and M.L. Henriksson C-Met expression in primary tumors and their corresponding distant metastases Mol Med Rep 1 6 2008 787 790
35. M.F. Di Renzo, M. Olivero, and A. Giacomini et al. Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer Clin Cancer Res 1 2 1995 147 154