메뉴 건너뛰기




Volumn 462, Issue 1, 2013, Pages 65-72

Aberrations of MET are associated with copy number gain of EGFR and loss of PTEN and predict poor outcome in patients with salivary gland cancer

Author keywords

EGFR; MET; Prognosis; PTEN; Salivary gland cancer

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SCATTER FACTOR RECEPTOR;

EID: 84872298896     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-012-1358-0     Document Type: Article
Times cited : (27)

References (43)
  • 1
    • 0036739548 scopus 로고    scopus 로고
    • Salivary gland tumours
    • 12363107 10.1034/j.1601-0825.2002.02870.x 1:STN:280: DC%2BD38ngvV2ktA%3D%3D
    • Speight PM, Barrett AW (2002) Salivary gland tumours. Oral Dis 8:229-240
    • (2002) Oral Dis , vol.8 , pp. 229-240
    • Speight, P.M.1    Barrett, A.W.2
  • 2
    • 0031657056 scopus 로고    scopus 로고
    • Amplification of c-myc, K-sam, and c-met in gastric cancers: Detection by fluorescence in situ hybridization
    • 9759658 1:STN:280:DyaK1cvjtVCmug%3D%3D
    • Hara T, Ooi A, Kobayashi M et al (1998) Amplification of c-myc, K-sam, and c-met in gastric cancers: detection by fluorescence in situ hybridization. Lab Invest 78:1143-1153
    • (1998) Lab Invest , vol.78 , pp. 1143-1153
    • Hara, T.1    Ooi, A.2    Kobayashi, M.3
  • 3
    • 2442513981 scopus 로고    scopus 로고
    • The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients
    • 15083185 10.1038/sj.bjc.6601718 1:CAS:528:DC%2BD2cXjtVWktr0%3D
    • Masuya D, Huang C, Liu D et al (2004) The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients. Br J Cancer 90:1555-1562
    • (2004) Br J Cancer , vol.90 , pp. 1555-1562
    • Masuya, D.1    Huang, C.2    Liu, D.3
  • 4
    • 30944452172 scopus 로고    scopus 로고
    • Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma
    • 16186806 1:CAS:528:DC%2BD28Xlt1ehuw%3D%3D
    • Miller CT, Lin L, Casper AM et al (2006) Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma. Oncogene 25:409-418
    • (2006) Oncogene , vol.25 , pp. 409-418
    • Miller, C.T.1    Lin, L.2    Casper, A.M.3
  • 5
    • 0345601083 scopus 로고    scopus 로고
    • Met, metastasis, motility and more
    • 14685170 10.1038/nrm1261 1:CAS:528:DC%2BD3sXpvFeju7s%3D
    • Birchmeier C, Birchmeier W, Gherardi E et al (2003) Met, metastasis, motility and more. Nat Rev Mol Cell Biol 4:915-925
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 915-925
    • Birchmeier, C.1    Birchmeier, W.2    Gherardi, E.3
  • 6
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • 17463250 10.1126/science.1141478 1:CAS:528:DC%2BD2sXltlOjt7g%3D
    • Engelman JA, Zejnullahu K, Mitsudomi T et al (2007) MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316:1039-1043
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3
  • 8
    • 72449131507 scopus 로고    scopus 로고
    • Prognostic value of a three-grade classification in primary epithelial parotid carcinoma: Result of a histological review from a 20-year experience of total parotidectomy with neck dissection in a single institution
    • 19931448 10.1016/j.ejca.2009.10.012
    • Jouzdani E, Yachouh J, Costes V et al (2010) Prognostic value of a three-grade classification in primary epithelial parotid carcinoma: result of a histological review from a 20-year experience of total parotidectomy with neck dissection in a single institution. Eur J Cancer 46:323-331
    • (2010) Eur J Cancer , vol.46 , pp. 323-331
    • Jouzdani, E.1    Yachouh, J.2    Costes, V.3
  • 9
    • 0032411496 scopus 로고    scopus 로고
    • Salivary gland carcinomas - Prognostic factors
    • 10050991 10.1080/028418698430089 1:STN:280:DyaK1M7lvVakug%3D%3D
    • Therkildsen MH, Christensen M, Andersen LJ et al (1998) Salivary gland carcinomas - prognostic factors. Acta Oncol 37:701-713
    • (1998) Acta Oncol , vol.37 , pp. 701-713
    • Therkildsen, M.H.1    Christensen, M.2    Andersen, L.J.3
  • 10
    • 0026072872 scopus 로고
    • Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up
    • 1757079 10.1111/j.1365-2559.1991.tb00229.x 1:STN:280: DyaK38%2FpvVSltw%3D%3D
    • Elston CW, Ellis IO (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19:403-410
    • (1991) Histopathology , vol.19 , pp. 403-410
    • Elston, C.W.1    Ellis, I.O.2
  • 11
    • 79952713252 scopus 로고    scopus 로고
    • Salivary gland mucoepidermoid carcinoma is a clinically, morphologically and genetically heterogeneous entity: A clinicopathological study of 40 cases with emphasis on grading, histological variants and presence of the t(11;19) translocation
    • 21371076 10.1111/j.1365-2559.2011.03777.x
    • Schwarz S, Stiegler C, Muller M et al (2011) Salivary gland mucoepidermoid carcinoma is a clinically, morphologically and genetically heterogeneous entity: a clinicopathological study of 40 cases with emphasis on grading, histological variants and presence of the t(11;19) translocation. Histopathology 58:557-570
    • (2011) Histopathology , vol.58 , pp. 557-570
    • Schwarz, S.1    Stiegler, C.2    Muller, M.3
  • 12
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
    • 15870435 10.1093/jnci/dji112 1:CAS:528:DC%2BD2MXjvFymt70%3D
    • Cappuzzo F, Hirsch FR, Rossi E et al (2005) Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 97:643-655
    • (2005) J Natl Cancer Inst , vol.97 , pp. 643-655
    • Cappuzzo, F.1    Hirsch, F.R.2    Rossi, E.3
  • 13
    • 60549110433 scopus 로고    scopus 로고
    • MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients
    • 18836087 10.1093/annonc/mdn635 1:STN:280:DC%2BD1M7jtlWlsg%3D%3D
    • Cappuzzo F, Janne PA, Skokan M et al (2009) MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients. Ann Oncol 20:298-304
    • (2009) Ann Oncol , vol.20 , pp. 298-304
    • Cappuzzo, F.1    Janne, P.A.2    Skokan, M.3
  • 14
    • 84861200509 scopus 로고    scopus 로고
    • EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis
    • 22154363 10.1016/j.humpath.2011.08.006 1:CAS:528:DC%2BC38Xnt1KqsLw%3D
    • Ettl T, Stiegler C, Zeitler K et al (2012) EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis. Hum Pathol 43:921-931
    • (2012) Hum Pathol , vol.43 , pp. 921-931
    • Ettl, T.1    Stiegler, C.2    Zeitler, K.3
  • 15
    • 84863418632 scopus 로고    scopus 로고
    • Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer
    • 22240798 10.1038/bjc.2011.605 1:CAS:528:DC%2BC38XisVGqt7c%3D
    • Ettl T, Baader K, Stiegler C et al (2012) Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer. Br J Cancer 106:719-726
    • (2012) Br J Cancer , vol.106 , pp. 719-726
    • Ettl, T.1    Baader, K.2    Stiegler, C.3
  • 16
    • 0021241398 scopus 로고
    • Molecular cloning of a new transforming gene from a chemically transformed human cell line
    • 6590967 10.1038/311029a0 1:CAS:528:DyaL2cXmt1ersbk%3D
    • Cooper CS, Park M, Blair DG et al (1984) Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 311:29-33
    • (1984) Nature , vol.311 , pp. 29-33
    • Cooper, C.S.1    Park, M.2    Blair, D.G.3
  • 17
    • 84555202728 scopus 로고    scopus 로고
    • MET signaling pathway: A rational target for cancer therapy
    • 22042966 10.1200/JCO.2011.37.7929 1:CAS:528:DC%2BC38Xhslygs7Y%3D
    • Appleman LJ (2011) MET signaling pathway: a rational target for cancer therapy. J Clin Oncol 29:4837-4838
    • (2011) J Clin Oncol , vol.29 , pp. 4837-4838
    • Appleman, L.J.1
  • 18
    • 67651174457 scopus 로고    scopus 로고
    • EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts
    • 19584231 10.1158/1535-7163.MCT-09-0188 1:CAS:528:DC%2BD1MXosVynurc%3D
    • Lal B, Goodwin CR, Sang Y et al (2009) EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts. Mol Cancer Ther 8:1751-1760
    • (2009) Mol Cancer Ther , vol.8 , pp. 1751-1760
    • Lal, B.1    Goodwin, C.R.2    Sang, Y.3
  • 19
    • 84867397439 scopus 로고    scopus 로고
    • EGFR and HER2-Akt-mTOR signaling pathways are activated in subgroups of salivary gland carcinomas
    • 22828828 10.1007/s00428-012-1282-3 1:CAS:528:DC%2BC38Xht12qsbjO
    • Suzuki S, Dobashi Y, Minato H et al (2012) EGFR and HER2-Akt-mTOR signaling pathways are activated in subgroups of salivary gland carcinomas. Virchows Arch 461:271-282
    • (2012) Virchows Arch , vol.461 , pp. 271-282
    • Suzuki, S.1    Dobashi, Y.2    Minato, H.3
  • 20
    • 77951004343 scopus 로고    scopus 로고
    • Genetic and expression analysis of HER-2 and EGFR genes in salivary duct carcinoma: Empirical and therapeutic significance
    • 20371674 10.1158/1078-0432.CCR-09-0238 1:CAS:528:DC%2BC3cXkslSmur0%3D
    • Williams MD, Roberts DB, Kies MS et al (2010) Genetic and expression analysis of HER-2 and EGFR genes in salivary duct carcinoma: empirical and therapeutic significance. Clin Cancer Res 16:2266-2274
    • (2010) Clin Cancer Res , vol.16 , pp. 2266-2274
    • Williams, M.D.1    Roberts, D.B.2    Kies, M.S.3
  • 21
    • 35448964238 scopus 로고    scopus 로고
    • Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis
    • 17942915 10.1158/0008-5472.CAN-07-1905 1:CAS:528:DC%2BD2sXhtFOnsbrK
    • Takami T, Kaposi-Novak P, Uchida K et al (2007) Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N- nitrosodiethylamine induced hepatocarcinogenesis. Cancer Res 67:9844-9851
    • (2007) Cancer Res , vol.67 , pp. 9844-9851
    • Takami, T.1    Kaposi-Novak, P.2    Uchida, K.3
  • 22
    • 84862777005 scopus 로고    scopus 로고
    • Correlation between MET gene copy number by silver in situ hybridization and protein expression by immunohistochemistry in non-small cell lung cancer
    • 22237262 10.1097/JTO.0b013e318240ca0d
    • Dziadziuszko R, Wynes MW, Singh S et al (2012) Correlation between MET gene copy number by silver in situ hybridization and protein expression by immunohistochemistry in non-small cell lung cancer. J Thorac Oncol 7:340-347
    • (2012) J Thorac Oncol , vol.7 , pp. 340-347
    • Dziadziuszko, R.1    Wynes, M.W.2    Singh, S.3
  • 23
    • 16544371848 scopus 로고    scopus 로고
    • Hepatocyte growth factor and c-Met immunoreactivity are associated with metastasis in high grade salivary gland carcinoma
    • 15492787 1:CAS:528:DC%2BD2cXhtVWksLvM
    • Tsukinoki K, Yasuda M, Mori Y et al (2004) Hepatocyte growth factor and c-Met immunoreactivity are associated with metastasis in high grade salivary gland carcinoma. Oncol Rep 12:1017-1021
    • (2004) Oncol Rep , vol.12 , pp. 1017-1021
    • Tsukinoki, K.1    Yasuda, M.2    Mori, Y.3
  • 24
    • 0037609677 scopus 로고    scopus 로고
    • Hepatocyte growth factor and c-Met (HGF/c-Met) in adenoid cystic carcinoma of the human salivary gland
    • 12542830 10.1034/j.1600-0714.2003.00018.x 1:CAS:528:DC%2BD3sXhsFOjtbo%3D
    • Suzuki K, Cheng J, Watanabe Y (2003) Hepatocyte growth factor and c-Met (HGF/c-Met) in adenoid cystic carcinoma of the human salivary gland. J Oral Pathol Med 32:84-89
    • (2003) J Oral Pathol Med , vol.32 , pp. 84-89
    • Suzuki, K.1    Cheng, J.2    Watanabe, Y.3
  • 25
    • 24644472051 scopus 로고    scopus 로고
    • CD151 forms a functional complex with c-Met in human salivary gland cancer cells
    • 16139245 10.1016/j.bbrc.2005.08.106 1:CAS:528:DC%2BD2MXhtVWns7nK
    • Klosek SK, Nakashiro K, Hara S, Shintani S, Hasegawa H, Hamakawa H (2005) CD151 forms a functional complex with c-Met in human salivary gland cancer cells. Biochem Biophys Res Commun 336:408-416
    • (2005) Biochem Biophys Res Commun , vol.336 , pp. 408-416
    • Klosek, S.K.1    Nakashiro, K.2    Hara, S.3    Shintani, S.4    Hasegawa, H.5    Hamakawa, H.6
  • 26
    • 84555190809 scopus 로고    scopus 로고
    • MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib
    • 22042947 10.1200/JCO.2011.35.4928 1:CAS:528:DC%2BC38Xhslygs7w%3D
    • Lennerz JK, Kwak EL, Ackerman A et al (2011) MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. J Clin Oncol 29:4803-4810
    • (2011) J Clin Oncol , vol.29 , pp. 4803-4810
    • Lennerz, J.K.1    Kwak, E.L.2    Ackerman, A.3
  • 27
    • 80052969848 scopus 로고    scopus 로고
    • MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations
    • 21716144 10.1097/JTO.0b013e31822591e9
    • Tanizaki J, Okamoto I, Okamoto K et al (2011) MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations. J Thorac Oncol 6:1624-1631
    • (2011) J Thorac Oncol , vol.6 , pp. 1624-1631
    • Tanizaki, J.1    Okamoto, I.2    Okamoto, K.3
  • 28
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • 18093943 10.1073/pnas.0710370104 1:CAS:528:DC%2BD1cXktlyhsg%3D%3D
    • Bean J, Brennan C, Shih JY et al (2007) MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 104:20932-20937
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3
  • 29
    • 77954586493 scopus 로고    scopus 로고
    • Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis
    • 20489150 10.2353/ajpath.2010.090863 1:CAS:528:DC%2BC3cXpslCrsLs%3D
    • Benedettini E, Sholl LM, Peyton M et al (2010) Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis. Am J Pathol 177:415-423
    • (2010) Am J Pathol , vol.177 , pp. 415-423
    • Benedettini, E.1    Sholl, L.M.2    Peyton, M.3
  • 30
    • 34249984736 scopus 로고    scopus 로고
    • HER3 and mutant EGFR meet MET
    • 17554333 10.1038/nm0607-675 1:CAS:528:DC%2BD2sXmtFeksr8%3D
    • Arteaga CL (2007) HER3 and mutant EGFR meet MET. Nat Med 13:675-677
    • (2007) Nat Med , vol.13 , pp. 675-677
    • Arteaga, C.L.1
  • 31
    • 77957328515 scopus 로고    scopus 로고
    • MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors
    • 20841479 10.1158/0008-5472.CAN-10-0436 1:CAS:528:DC%2BC3cXht1akt7bP
    • Cepero V, Sierra JR, Corso S et al (2010) MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors. Cancer Res 70:7580-7590
    • (2010) Cancer Res , vol.70 , pp. 7580-7590
    • Cepero, V.1    Sierra, J.R.2    Corso, S.3
  • 32
    • 0036221263 scopus 로고    scopus 로고
    • Dysregulation of Met receptor tyrosine kinase activity in invasive tumors
    • 11927612 1:CAS:528:DC%2BD38Xis1Kju74%3D
    • Danilkovitch-Miagkova A, Zbar B (2002) Dysregulation of Met receptor tyrosine kinase activity in invasive tumors. J Clin Invest 109:863-867
    • (2002) J Clin Invest , vol.109 , pp. 863-867
    • Danilkovitch-Miagkova, A.1    Zbar, B.2
  • 33
    • 79551559942 scopus 로고    scopus 로고
    • Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors
    • 21266357 10.1158/0008-5472.CAN-10-1623 1:CAS:528:DC%2BC3MXhsVCisr0%3D
    • Qi J, McTigue MA, Rogers A et al (2011) Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors. Cancer Res 71:1081-1091
    • (2011) Cancer Res , vol.71 , pp. 1081-1091
    • Qi, J.1    McTigue, M.A.2    Rogers, A.3
  • 34
    • 60849115563 scopus 로고    scopus 로고
    • Interactions between PTEN and the c-Met pathway in glioblastoma and implications for therapy
    • 19190120 10.1158/1535-7163.MCT-08-0627 1:CAS:528:DC%2BD1MXhvFamsLc%3D
    • Li Y, Guessous F, DiPierro C et al (2009) Interactions between PTEN and the c-Met pathway in glioblastoma and implications for therapy. Mol Cancer Ther 8:376-385
    • (2009) Mol Cancer Ther , vol.8 , pp. 376-385
    • Li, Y.1    Guessous, F.2    Dipierro, C.3
  • 35
    • 35348908314 scopus 로고    scopus 로고
    • PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients
    • 17940504 10.1038/sj.bjc.6604009 1:CAS:528:DC%2BD2sXhtFKktb7P
    • Frattini M, Saletti P, Romagnani E et al (2007) PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer 97:1139-1145
    • (2007) Br J Cancer , vol.97 , pp. 1139-1145
    • Frattini, M.1    Saletti, P.2    Romagnani, E.3
  • 36
    • 27744606737 scopus 로고    scopus 로고
    • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
    • 16282176 10.1056/NEJMoa051918 1:CAS:528:DC%2BD2MXht1SrtrrE
    • Mellinghoff IK, Wang MY, Vivanco I et al (2005) Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med 353:2012-2024
    • (2005) N Engl J Med , vol.353 , pp. 2012-2024
    • Mellinghoff, I.K.1    Wang, M.Y.2    Vivanco, I.3
  • 37
    • 9244219598 scopus 로고    scopus 로고
    • Breast cancer - Loss of PTEN predicts resistance to treatment
    • 15564551 10.1056/NEJMcibr043143 1:CAS:528:DC%2BD2cXhtValtrrN
    • Pandolfi PP (2004) Breast cancer - loss of PTEN predicts resistance to treatment. N Engl J Med 351:2337-2338
    • (2004) N Engl J Med , vol.351 , pp. 2337-2338
    • Pandolfi, P.P.1
  • 38
    • 34548533134 scopus 로고    scopus 로고
    • Phase II study of lapatinib in recurrent or metastatic epidermal growth factor receptor and/or erbB2 expressing adenoid cystic carcinoma and non adenoid cystic carcinoma malignant tumors of the salivary glands
    • 17761983 10.1200/JCO.2007.11.8612 1:CAS:528:DC%2BD2sXhtFanu73E
    • Agulnik M, Cohen EW, Cohen RB et al (2007) Phase II study of lapatinib in recurrent or metastatic epidermal growth factor receptor and/or erbB2 expressing adenoid cystic carcinoma and non adenoid cystic carcinoma malignant tumors of the salivary glands. J Clin Oncol 25:3978-3984
    • (2007) J Clin Oncol , vol.25 , pp. 3978-3984
    • Agulnik, M.1    Cohen, E.W.2    Cohen, R.B.3
  • 39
    • 33646704640 scopus 로고    scopus 로고
    • Phase II trial on gefitinib in patients with incurable salivary gland cancer [abstract]
    • Glisson BS, Blumenschein G, Francisco M et al (2005) Phase II trial on gefitinib in patients with incurable salivary gland cancer [abstract]. J Clin Oncol 23:5532
    • (2005) J Clin Oncol , vol.23 , pp. 5532
    • Glisson, B.S.1    Blumenschein, G.2    Francisco, M.3
  • 40
    • 0042703590 scopus 로고    scopus 로고
    • Herceptin in patients with advanced or metastatic salivary gland carcinomas. A phase II study
    • 12907212 10.1016/S1368-8375(03)00097-6 1:CAS:528:DC%2BD3sXlvFymt74%3D
    • Haddad R, Colevas AD, Krane JF et al (2003) Herceptin in patients with advanced or metastatic salivary gland carcinomas. A phase II study. Oral Oncol 39:724-727
    • (2003) Oral Oncol , vol.39 , pp. 724-727
    • Haddad, R.1    Colevas, A.D.2    Krane, J.F.3
  • 41
    • 67449087686 scopus 로고    scopus 로고
    • Cetuximab in recurrent and/or metastatic salivary gland carcinomas: A phase II study
    • 18804410 10.1016/j.oraloncology.2008.07.010
    • Locati LD, Bossi P, Perrone F et al (2008) Cetuximab in recurrent and/or metastatic salivary gland carcinomas: a phase II study. Oral Oncol 45:574-578
    • (2008) Oral Oncol , vol.45 , pp. 574-578
    • Locati, L.D.1    Bossi, P.2    Perrone, F.3
  • 42
    • 67650410074 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization gene amplification analysis of EGFR and HER2 in patients with malignant salivary gland tumors treated with lapatinib
    • 19309723 10.1002/hed.21052
    • Vidal L, Tsao MS, Pond GR et al (2009) Fluorescence in situ hybridization gene amplification analysis of EGFR and HER2 in patients with malignant salivary gland tumors treated with lapatinib. Head Neck 31:1006-1012
    • (2009) Head Neck , vol.31 , pp. 1006-1012
    • Vidal, L.1    Tsao, M.S.2    Pond, G.R.3
  • 43
    • 80053047138 scopus 로고    scopus 로고
    • Salivary duct carcinoma: Targeting the phosphatidylinositol 3-kinase pathway by blocking mammalian target of rapamycin with temsirolimus
    • 21844496 10.1200/JCO.2011.36.2095
    • Piha-Paul SA, Cohen PR, Kurzrock R (2011) Salivary duct carcinoma: targeting the phosphatidylinositol 3-kinase pathway by blocking mammalian target of rapamycin with temsirolimus. J Clin Oncol 29:e727-e730
    • (2011) J Clin Oncol , vol.29
    • Piha-Paul, S.A.1    Cohen, P.R.2    Kurzrock, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.