Effects of SNP variants in the 17β-HSD2 and 17β-HSD7 genes and 17β-HSD7 copy number on gene transcript and estradiol levels in breast cancer tissue

Journal of Steroid Biochemistry and Molecular Biology

Volumn 143, Issue , 2014, Pages 192-198

  Straume, Anne Hege ^a,b   Knappskog, Stian ^a,b   Lønning, Per Eystein ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

17 HSD2; 17 HSD7; Breast cancer; Gene expression; Postmenopausal oestrogen synthesis; Single nucleotide polymorphisms

Indexed keywords

17BETA DEHYDROGENASE2; 17BETA DEHYDROGENASE7; ESTRADIOL; MESSENGER RNA; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG; 3 (OR 17)-BETA-HYDROXYSTEROID DEHYDROGENASE; ESTRADIOL 17BETA DEHYDROGENASE; HSD17B2 PROTEIN, HUMAN; HYDROXYSTEROID DEHYDROGENASE;

ALLELE; ARTICLE; BINDING SITE; BREAST CANCER; CANCER TISSUE; CLINICAL ARTICLE; CODING; COMPUTER MODEL; CONTROLLED STUDY; FEMALE; GENE DOSAGE; GENE EXPRESSION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; IN VITRO GENE TRANSFER; PROMOTER REGION; PSEUDOGENE; REGULATORY MECHANISM; SINGLE NUCLEOTIDE POLYMORPHISM; TISSUE LEVEL; TRANSCRIPTION INITIATION SITE; BREAST TUMOR; CELL CULTURE; GENETICS; METABOLISM; MUTATION; RADIOIMMUNOASSAY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

17-HYDROXYSTEROID DEHYDROGENASES; BREAST NEOPLASMS; CELLS, CULTURED; ESTRADIOL; ESTRADIOL DEHYDROGENASES; FEMALE; GENE DOSAGE; HUMANS; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RADIOIMMUNOASSAY; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84897432017     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2014.02.003     Document Type: Article

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