Efficacy of omega-3 for vasomotor symptoms treatment: A randomized controlled trial

Menopause

Volumn 21, Issue 4, 2014, Pages 347-354

  Cohen, Lee S ^a   Joffe, Hadine ^a   Guthrie, Katherine A ^b   Ensrud, Kristine E ^c   Freeman, Marlene ^a   Carpenter, Janet S ^d   Learman, Lee A ^e   Newton, Katherine M ^f   Reed, Susan D ^g   Manson, Joann E ^h   Sternfeld, Barbara ⁱ   Caan, Bette ⁱ   Freeman, Ellen W ^j   Lacroix, Andrea Z ^b   Tinker, Lesley F ^b   Booth Laforce, Cathryn ^k   Larson, Joseph C ^b   Anderson, Garnet L ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d INDIANA UNIVERSITY   (United States)

^e INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f CENTER FOR HEALTH STUDIES   (United States)

^g UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^h BRIGHAM AND WOMEN S HOSPITAL   (United States)

ⁱ DIVISION OF RESEARCH   (United States)

^j UNIVERSITY OF PENNSYLVANIA   (United States)

^k UNIVERSITY OF WASHINGTON   (United States)

more..

Author keywords

Clinical Trials Network; Fish oils; Hot flashes; Menopause; Omega 3; Vasomotor symptoms

Indexed keywords

DOCOSAHEXAENOIC ACID; ETHYL EICOSAPENTAENOIC ACID; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; PLACEBO; UNCLASSIFIED DRUG;

ADULT; AEROBIC EXERCISE; ARTICLE; BACKACHE; BLEEDING; CLIMACTERIUM; CONSTIPATION; CONTROLLED STUDY; DEPRESSION; DIARRHEA; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; ERUCTATION; FAINTNESS; FEMALE; FLU LIKE SYNDROME; FOLLOW UP; GENERALIZED ANXIETY DISORDER 7; HALITOSIS; HEART PALPITATION; HEARTBURN; HOT FLUSH; HUMAN; INSOMNIA SEVERITY INDEX; MAJOR CLINICAL STUDY; MIDDLE AGED; MULTICENTER STUDY; NAUSEA; OUTCOME ASSESSMENT; PHYSICAL ACTIVITY; PHYSICIAN HEALTH QUESTIONNAIRE 8; PITTSBURGH SLEEP QUALITY INDEX; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; RASH; SCORING SYSTEM; SELF REPORT; SKIN BRUISING; SLEEP QUALITY; TREATMENT DURATION; VASOMOTOR DISORDER; VASOMOTOR SYMPTOM; VOMITING; YOGA; AFFECT; ANALOGS AND DERIVATIVES; ANXIETY; DRUG THERAPY; EXERCISE; HOT FLASHES; MENOPAUSE; SLEEP; SLEEP INITIATION AND MAINTENANCE DISORDERS; TREATMENT OUTCOME;

ADULT; AFFECT; ANXIETY; DEPRESSION; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; EICOSAPENTAENOIC ACID; EXERCISE; FATTY ACIDS, OMEGA-3; FEMALE; HOT FLASHES; HUMANS; MENOPAUSE; MIDDLE AGED; PERIMENOPAUSE; PLACEBOS; POSTMENOPAUSE; SLEEP; SLEEP INITIATION AND MAINTENANCE DISORDERS; TREATMENT OUTCOME; YOGA;

EID: 84897413811     PISSN: 10723714     EISSN: 15300374     Source Type: Journal    
DOI: 10.1097/GME.0b013e31829e40b8     Document Type: Article

References (26)

1. Freeman EW, Sammel MD, Lin H, et al. Symptoms associated with menopausal transition and reproductive hormones in midlife women. Obstet Gynecol 2007;110(pt 1):230-240.
2. Hirschfeld RM. Long-term side effects of SSRIs: sexual dysfunction and weight gain. J Clin Psychiatry 2003;64(suppl 18):20-24.
3. Barnes PM, Bloom B, Nahin R. Complementary and Alternative Medicine Use Among Adults and Children: United States, 2007. CDC National Health Statistics Report No. 12. Hyattsville, MD: National Center for Health Statistics, 2008.
4. Eisenberg DM, Davis RB, Ettner SL, et al. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA 1998;280:1569-1575.
5. Hooper L, Thompson RL, Harrison RA, et al. Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. BMJ 2006;332:752-760.
6. Hibbeln JR, Linnoila M, Umhau JC, Rawlings R, George DT, Salem N Jr. Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early-and lateonset alcoholics. Biol Psychiatry 1998;44:235-242.
7. Chalon S. Omega-3 fatty acids and monoamine neurotransmission. Prostaglandins Leukot Essent Fatty Acids 2006;75:259-269.
8. Carlezon WA Jr, Mague SD, Parow AM, Stoll AL, Cohen BM, Renshaw PF. Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats. Biol Psychiatry 2005;57:343-350.
9. Lucas M, Asselin G, Merette C, Poulin MJ, Dodin S. Effects of ethyleicosapentaenoic acid omega-3 fatty acid supplementation on hot flashes and quality of life among middle-aged women: a double-blind, placebocontrolled, randomized clinical trial. Menopause 2009;16:357-366.
10. Campagnoli C, Abba C, Ambroggio S, Peris C, Perona M, Sanseverino P. Polyunsaturated fatty acids (PUFAs) might reduce hot flushes: an indication from two controlled trials on soy isoflavones alone and with a PUFA supplement. Maturitas 2005;51:127-134.
11. Freeman EW, Guthrie KA, Caan B, et al. Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial. JAMA 2011; 305:267-274.
12. Carpenter JS, AndrykowskiMA. Psychometric evaluation of the Pittsburgh Sleep Quality Index. J Psychosom Res 1998;45:5-13.
13. Bastien CH, Vallieres A, Morin CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med 2001;2: 297-307.
14. Kroenke K, Strine TW, Spitzer RL, Williams JB, Berry JT, Mokdad AH. The PHQ-8 as a measure of current depression in the general population. J Affect Disord 2009;114:163-173.
15. Spitzer RL, Kroenke K, Williams JB, Lowe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med 2006;166:1092-1097.
16. Dietary supplementation with n j 3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet 1999;354:447-455.
17. Yokoyama M, Origasa H, Matsuzaki M, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 2007;369: 1090-1098.
18. Peet M, Horrobin DF. A dose-ranging study of the effects of ethyleicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs. Arch Gen Psychiatry 2002;59: 913-919.
19. Nemets B, Stahl Z, Belmaker RH. Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry 2002;159:477-479.
20. Su KP, Huang SY, Chiu CC, Shen WW. Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial. Eur Neuropsychopharmacol 2003;13:267-271.
21. Marangell LB, Martinez JM, Zboyan HA, Kertz B, Kim HF, Puryear LJ. A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. Am J Psychiatry 2003;160:996-998.
22. Silvers KM, Woolley CC, Hamilton FC, Watts PM, Watson RA. Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression. Prostaglandins Leukot Essent Fatty Acids 2005;72: 211-218.
23. Bromberger JT, Schott LL, Kravitz HM, et al. Longitudinal change in reproductive hormones and depressive symptoms across the menopausal transition: results from the Study of Women's Health Across the Nation (SWAN). Arch Gen Psychiatry 2010;67:598-607.
24. Freeman EW, Sammel MD, Lin H. Temporal associations of hot flashes and depression in the transition to menopause. Menopause 2009;16:728-734.
25. Freeman EW, Sammel MD, Lin H, Nelson DB. Associations of hormones and menopausal status with depressed mood in women with no history of depression. Arch Gen Psychiatry 2006;63:375-382.
26. Cohen LS, Soares CN, Vitonis AF, Otto MW, Harlow BL. Risk for new onset of depression during the menopausal transition: the Harvard Study of Moods and Cycles. Arch Gen Psychiatry 2006;63:385-390.