Urine proteomics for acute kidney injury prognosis: Another player and the long road ahead

Kidney International

Volumn 85, Issue 4, 2014, Pages 735-738

  Konvalinka, Ana ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; ALPHA 1 MICROGLOBULIN; APOLIPOPROTEIN D; CALRETICULIN; CATHEPSIN D; CD59 ANTIGEN; CREATININE; INSULIN LIKE GROWTH FACTOR BINDING PROTEIN 7; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; SOMATOMEDIN BINDING PROTEIN; UNCLASSIFIED DRUG; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED PROTEIN 1; BIOLOGICAL MARKER;

ACUTE KIDNEY FAILURE; AREA UNDER THE CURVE; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE URINE LEVEL; CRITICALLY ILL PATIENT; ENZYME LINKED IMMUNOSORBENT ASSAY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; INTENSIVE CARE UNIT; MASS SPECTROMETRY; MORTALITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN URINE LEVEL; PROTEOMICS; REVIEW; TURBIDIMETRY; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS; URINALYSIS; URINARY EXCRETION; FEMALE; MALE; URINE; CHRONIC KIDNEY DISEASE; CIRCADIAN RHYTHM; NONHUMAN; PROTEIN ANALYSIS; SYSTEMS BIOLOGY;

ACUTE KIDNEY INJURY; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; MALE;

EID: 84897410004     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2013.421     Document Type: Note

References (11)

1. Konvalinka A, Scholey JW, Diamandis EP. Searching for new biomarkers of renal diseases through proteomics. Clin Chem 2012; 58: 353-365.
2. Waikar SS, Sabbisetti VS, Bonventre JV. Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate. Kidney Int 2010; 78: 486-494.
3. Aregger F, Uehlinger DE, Witowski J et al. Identification of IGFBP-7 by urinary proteomics as a novel prognostic marker in early acute kidney injury. Kidney Int 2014; 85: 909-919.
4. Oh Y, Nagalla SR, Yamanaka Y et al. Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and-II. J Biol Chem 1996; 271: 30322-30325.
5. Yang QH, Liu DW, Long Y et al. Acute renal failure during sepsis: Potential role of cell cycle regulation. J Infect 2009; 58: 459-464.
6. Witzgall R, Brown D, Schwarz C et al. Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells. J Clin Invest 1994; 93: 2175-2188.
7. Kashani K, Al-Khafaji A, Ardiles T et al. Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care [online] 2013; 17: R25.
8. Haase M, Bellomo R, Devarajan P et al. Accuracy of neutrophil gelatinase-Associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: A systematic review and meta-Analysis. Am J Kidney Dis 2009; 54: 1012-1024.
9. Srisawat N, Wen X, Lee M et al. Urinary biomarkers and renal recovery in critically ill patients with renal support. Clin J Am Soc Nephrol 2011; 6: 1815-1823.
10. Parikh CR, Abraham E, Ancukiewicz M et al. Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit. J Am Soc Nephrol 2005; 16: 3046-3052.
11. Ho J, Lucy M, Krokhin O et al. Mass spectrometry-based proteomic analysis of urine in acute kidney injury following cardiopulmonary bypass: A nested case-control study. Am J Kidney Dis 2009; 53: 584-595.