Development of a luciferase-based system for the detection of ZnT8 autoantibodies

Journal of Immunological Methods

Volumn 405, Issue , 2014, Pages 67-73

  Ustinova, Julia ^a   Zusinaite, Eva ^a   Utt, Meeme ^a   Metsküla, Kaja ^a   Reimand, Koit ^a   Huchaiah, Vimala ^a   Merits, Andres ^a   Uibo, Raivo ^a,b  

^a UNIVERSITY OF TARTU   (Estonia)

^b Institute of Technology Faculty of Science and Technology University of Tartu ^*  (Estonia)

Author keywords

Autoantibodies; Luciferase immunoprecipitation system (LIPS); Type 1 diabetes; Zinc transporter 8 (ZnT8)

Indexed keywords

AUTOANTIBODY; DIMER; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; ZINC TRANSPORTER; ZINC TRANSPORTER 8;

ADULT; ANTIBODY DETECTION; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; CHILD; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOPRECIPITATION; INSECT CELL; INSULIN DEPENDENT DIABETES MELLITUS; LUCIFERASE ASSAY; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL;

GAUSSIA PRINCEPS (T. SCOTT, 1894); HEXAPODA;

AUTOANTIBODIES; LUCIFERASE IMMUNOPRECIPITATION SYSTEM (LIPS); TYPE 1 DIABETES; ZINC TRANSPORTER 8 (ZNT8);

ADULT; ANIMALS; AUTOANTIBODIES; CATION TRANSPORT PROTEINS; CHILD; DIABETES MELLITUS, TYPE 1; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOPRECIPITATION; LUCIFERASES; MALE; PROTEIN MULTIMERIZATION; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SF9 CELLS; SPODOPTERA;

EID: 84897407835     PISSN: 00221759     EISSN: 18727905     Source Type: Journal    
DOI: 10.1016/j.jim.2014.01.009     Document Type: Article

References (24)

1. Achenbach P., Bonifacio E., Ziegler A.G. Predicting type 1 diabetes. Curr. Diab. Rep. 2005, 5(2):98. (Apr).
2. Anderson M.S., Bluestone J.A. The NOD mouse: a model of immune dysregulation. Annu. Rev. Immunol. 2005, 23:447.
3. Burbelo P.D., Ramanathan R., Klion A.D., Iadarola M.J., Nutman T.B. Rapid, novel, specific, high-throughput assay for diagnosis of Loa loa infection. J. Clin. Microbiol. 2008, 46(7):2298.
4. Burbelo P.D., Hirai H., Leahy H., Lernmark A., Ivarsson S.A., Iadarola M.J., Notkins A.L. A new luminescence assay for autoantibodies to mammalian cell prepared insulinoma-associated protein 2. Diabetes Care 2008, 31(9):1824.
5. Burbelo P.D., Leahy H.P., Iadarola M.J., Nutman T.B. A four-antigen mixture for rapid assessment of Onchocerca volvulus infection. PLoS Negl. Trop. Dis. 2009, 3(5):e438.
6. Burbelo P.D., Ching K.H., Bush E.R., Han B.L., Iadarola M.J. Antibody-profiling technologies for studying humoral responses to infectious agents. Expert Rev. Vaccines 2010, 9(6):567.
7. Burbelo P.D., Hirai H., Issa A.T., Kingman A., Lernmark A., Ivarsson S.A., Notkins A.L., Iadarola M.J. Comparison of radioimmunoprecipitation with luciferase immunoprecipitation for autoantibodies to GAD65 and IA-2b. Diabetes Care 2010, 33(4):754.
8. Burbelo P.D., Ching K.H., Bren K.E., Iadarola M.J. Searching for biomarkers: humoral response profiling with luciferase immunoprecipitation systems. Expert Rev. Proteomics 2011, 8(3):309.
9. Chen X., Hu J., Jehle J.A., Zhang Y., Vlak J.M. Analysis of the ecdysteroid UDP-glucosyltransferase gene of Heliothis armigera single-nucleocapsid baculovirus. Virus Genes 1997, 15(3):219.
10. Chimienti F., Devergnas S., Favier A., Seve M. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 2004, 53(9):2330. (Sep).
11. Kawasaki E., Nakamura K., Kurija G., Satoh T., Kobayashi M., Kuwahara H., Abiru N., Yamasaki H., Matsuura N., Miura J., Uchigata Y., Eguchi K. Differences in the humoral autoreactivity to zinc transporter 8 between childhood- and adult-onset type 1 diabetes in Japanese patients. Clin. Immunol. 2011, 138:146.
12. Knip M., Siljander H. Autoimmune mechanisms in type 1 diabetes. Autoimmun. Rev. 2008, 7(7):550.
13. Liu E., Eisenbarth G.S. Accepting clocks that tell time poorly: fluid-phase versus standard ELISA autoantibody assays. Clin. Immunol. 2007, 125(2):120.
14. Mandrekar J.N. Receiver operating characteristic curve in diagnostic test assessment. J. Thorac. Oncol. 2010, 5:1315.
15. Mellitus ECotDaCoD: report of the expert committee on the diagnosis and classification of diabetes mellitus Diabetes Care 2003, 26(Suppl. 1):S5.
16. Pihoker C., Gilliam L.K., Hampe C.S., Lernmark A. Autoantibodies in diabetes. Diabetes 2005, 54(Suppl. 2):S52.
17. Riley W.J., Maclaren N.K., Krischer J., Spillar R.P., Silverstein J.H., Schatz D.A., Schwartz S., Malone J., Shah S., Vadheim C., Rotter J.I. A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes. N. Engl. J. Med. 1990, 323:1167.
18. Tannous B.A., Kim D.E., Fernandez J.L., Weissleder R., Breakefield X.O. Codon-optimized Gaussia luciferase cDNA for mammalian gene expression in culture and in vivo. Mol. Ther. 2005, 11(3):435.
19. Vaziri-Sani F., Delli A.J., Elding-Larsson H., Lindblad B., Carlsson A., Forsander G., Ivarsson S.A., Ludvigsson J., Marcus C., Lernmark Å. A novel triple mix radiobinding assay for the three ZnT8 (ZnT8-RWQ) autoantibody variants in children with newly diagnosed diabetes. J. Immunol. Methods 2011, 371:25.
20. Wenzlau J.M., Juhl K., Yu L., Moua O., Sarkar S.A., Gottlieb P., Rewers M., Eisenbarth G.S., Jensen J., Davidson H.W., Hutton J.C. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:17040.
21. Wenzlau J.M., Liu Y., Yu L., Moua O., Fowler K.T., Rangasamy S., Walters J., Eisenbarth G.S., Davidson H.W., Hutton J.C. A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes. Diabetes 2008, 57(10):2693. (Oct).
22. Wenzlau J.M., Ong M., Yu L., Eisenbarth G.S., Hutton J.C., Davidson H.W. Identification of a major humoral epitope in Slc30A8 (ZnT8). Ann. N. Y. Acad. Sci. 2008, 1150:252.
23. Wenzlau J.M., Frisch L.M., Gardner T.J., Sarkar S., Hutton J.C., Davidson H.W. Novel antigens in type 1 diabetes: the importance of ZnT8. Curr. Diab. Rep. 2009, 9:105.
24. Yu L., Liu Y., Miao D., Wenzlau J., Davidson H., Hutton J., Eisenbarth G.S. Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determination. J. Immunol. Methods 2010, 353:20.