Continuous positive airway pressure increases pulsatile growth hormone secretion and circulating insulin-like growth factor-1 in a time-dependent manner in men with obstructive sleep apnea: A randomized sham-controlled study

Sleep

Volumn 37, Issue 4, 2014, Pages 733-741

  Hoyos, Camilla M ^a   Killick, Roo ^a   Keenan, Daniel M ^b   Baxter, Robert C ^c   Veldhuis, Johannes D ^d   Liu, Peter Y ^a,e  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

^d MAYO CLINIC   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Continuous positive airway pressure; Growth hormone; IGF binding protein; Insulin like growth factor 1; Obstructive sleep apnea; Pulsatility

Indexed keywords

GROWTH HORMONE; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C; HUMAN GROWTH HORMONE; IGFBP1 PROTEIN, HUMAN; IGFBP3 PROTEIN, HUMAN; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 3;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; HORMONE RELEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; POLYSOMNOGRAPHY; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SLEEP DISORDERED BREATHING; AGED; AUSTRALIA; BLOOD; METABOLISM; SECRETION (PROCESS); TIME;

AGED; AUSTRALIA; CONTINUOUS POSITIVE AIRWAY PRESSURE; DOUBLE-BLIND METHOD; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; SLEEP APNEA, OBSTRUCTIVE; SOMATOMEDINS; TIME FACTORS;

EID: 84897402649     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.5665/sleep.3580     Document Type: Article

References (43)

1. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993; 328: 1230-5.
2. Van Cauter E, Kerkhofs M, Caufriez A, Van Onderbergen A, Thorner MO, Copinschi G. A quantitative estimation of growth hormone secretion in normal man: reproducibility and relation to sleep and time of day. J Clin Endocrinol Metab 1992; 74: 1441-50.
3. Vgontzas AN, Mastorakos G, Bixler EO, Kales A, Gold PW, Chrousos GP. Sleep deprivation effects on the activity of the hypothalamic-pituitary-adrenal and growth axes: potential clinical implications. Clin. Endocrinol (Oxf) 1999; 51: 205-15.
4. Gronfer C, Luthringer R, Follenius M, et al. A quantitative evaluation of the relationships between growth hormone secretion and delta wave electroencephalographic activity during normal sleep and after enrichment in delta waves. Sleep 1996; 19: 817-24.
5. Liu PY, Yee BJ, Phillips CL, Grunstein RR. Sleep apnea and neuroendocrine function. Sleep Med Clin 2007; 2: 225-36.
6. Kaplan SA, Cohen P. The somatomedin hypothesis 2007: 50 years later. J Clin Endocrinol Metab 2007; 92: 4529-35.
7. Le Roith D, Bondy C, Yakar S, Liu JL, Butler A. The somatomedin hypothesis: 2001. Endocr Rev 2001; 22: 53-74.
8. Ohlsson C, Mohan S, Sjogren K, et al. The role of liver-derived insulinlike growth factor-I. Endocr Rev 2009; 30: 494-535.
9. Molitch ME, Clemmons DR, Malozowski S, Merriam GR, Vance ML. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96: 1587-609.
10. Veldhuis JD, Roemmich JN, Richmond EJ, Bowers C Y. Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition. Endocr Rev 2006; 27: 101-40.
11. Firth SM, Baxter RC. Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev 2002; 23: 824-54.
12. Jansson JO, Eden S, Isaksson O. Sexual dimorphism in the control of growth hormone secretion. Endocr Rev 1985; 6: 128-50.
13. Isgaard J, Carlsson L, Isaksson OG, Jansson JO. Pulsatile intravenous growth hormone (GH) infusion to hypophysectomized rats increases insulin-like growth factor I messenger ribonucleic acid in skeletal tissues more effectively than continuous GH infusion. Endocrinology 1988; 123: 2605-10.
14. Sotiropoulos A, Ohanna M, Kedzia C, et al. Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation. Proc Natl Acad Sci U S A 2006; 103: 7315-20.
15. Karimi M, Koranyi J, Franco C, et al. Increased neck soft tissue mass and worsening of obstructive sleep apnea after growth hormone treatment in men with abdominal obesity. J Clin Sleep Med 2010; 6: 256-63.
16. Peker Y, Svensson J, Hedner J, Grote L, Johannsson G. Sleep apnoea and quality of life in growth hormone (GH)-deficient adults before and after 6 months of GH replacement therapy. Clin Endocrinol (Oxf) 2006; 65: 98-105.
17. Liu PY, Yee BJ, Wishart SM, et al. The short-term effects of high dose testosterone on sleep, breathing and function in older men. J Clin Endocrinol Metab 2003; 88: 3605-13.
18. Hoyos CM, Killick R, Yee BJ, Grunstein RR, Liu P Y. Effects of testosterone therapy on sleep and breathing in obese men with severe obstructive sleep apnea: a randomised placebo-controlled trial. Clin Endocrinol (Oxf) 2012; 77: 599-607.
19. Grunstein RR, Handelsman DJ, Lawrence SJ, Blackwell C, Caterson ID, Sullivan CE. Neuroendocrine dysfunction in sleep apnea: reversal by continuous positive airways pressure therapy. J Clin Endocrinol Metab 1989; 68: 352-8.
20. Lindberg E, Berne C, Elmasry A, Hedner J, Janson C. CPAP treatment of a population-based sample-what are the benefits and the treatment compliance? Sleep Med 2006; 7: 553-60.
21. Munzer T, Hegglin A, Stannek T, et al. Effects of long-term continuous positive airway pressure on body composition and IGF1. Eur J Endocrinol 2010; 162: 695-704.
22. Meston N, Davies RJ, Mullins R, Jenkinson C, Wass JA, Stradling JR. Endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea. J Intern Med 2003; 254: 447-54.
23. Saini J, Krieger J, Brandenberger G, Wittersheim G, Simon C, Follenius M. Continuous positive airway pressure treatment. Effects on growth hormone, insulin and glucose profiles in obstructive sleep apnea patients. Horm Metab Res 1993; 25: 375-81.
24. Cooper BG, White JE, Ashworth LA, Alberti KG, Gibson GJ. Hormonal and metabolic profiles in subjects with obstructive sleep apnea syndrome and the acute effects of nasal continuous positive airway pressure (CPAP) treatment. Sleep 1995; 18: 172-9.
25. Veldhuis JD, Keenan DM, Pincus SM. Motivations and methods for analyzing pulsatile hormone secretion. Endocr Rev 2008; 29: 823-64.
26. Hoyos C, Sullivan D, Liu P. Effect of CPAP on the metabolic syndrome: a randomised sham-controlled study. Thorax 2013; 68: 588-9.
27. Hoyos CM, Killick R, Yee BJ, Phillips CL, Grunstein RR, Liu PY. Cardiometabolic changes after continuous positive airway pressure for obstructive sleep apnoea: a randomised sham-controlled study. Thorax 2012; 67: 1081-9.
28. Phillips CL, Yee BJ, Marshall NS, Liu PY, Sullivan DR, Grunstein RR. Continuous positive airway pressure reduces postprandial lipidemia in obstructive sleep apnea: a randomized, placebo-controlled crossover trial. Am J Respir Crit Care Med 2011; 184: 355-61.
29. Kushida CA, Nichols DA, Homes TH, et al. Effects of Continous Positive Airway Pressure on neurocognitive performance in obstructive sleep apnea patients-the Apnea Positive Pressure Long-term Efficacy Study (APPLES). Sleep 2012; 35: 1593-602.
30. Rechtschaffen A, Kales A. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Bethesda, MD: National Institute for Neurological Disease and Blindess, 1968. Report No.: NIH 204.
31. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep 1999; 22: 667-89.
32. Baxter RC, Martin JL. Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma. J Clin Invest 1986; 78: 1504-12.
33. Baxter RC, Cowell CT. Diurnal rhythm of growth hormone-independent binding protein for insulin-like growth factors in human plasma. J Clin Endocrinol Metab 1987; 65: 432-40.
34. Liu PY, Keenan DM, Kok P, Padmanabhan V, O'Byrne KT, Veldhuis JD. Sensitivity and specificity of pulse detection using a new deconvolution method. Am J Physiol Endocrinol Metab 2009; 297: E538-44.
35. Chattopadhyay S, Keenan DM, Veldhuis JD. Probabilistic recovery of neuroendocrine pulsatile, secretory and kinetic structure: an alternating discrete and continuous scheme. Q Appl Math 2008; 66: 401-21.
36. Faria AC, Veldhuis JD, Thorner MO, Vance ML. Half-time of endogenous growth hormone (GH) disappearance in normal man after stimulation of GH secretion by GH-releasing hormone and suppression with somatostatin. J Clin Endocrinol Metab 1989; 68: 535-41.
37. Veldhuis JD, Keenan DM, Bailey JN, et al. Testosterone supplementation in older men restrains insulin-like growth factor's dose-dependent feedback inhibition of pulsatile growth hormone secretion. J Clin Endocrinol Metab 2009; 94: 246-54.
38. Pincus S, Singer BH. Randomness and degrees of irregularity. Proc Natl Acad Sci U S A 1996; 93: 2083-8.
39. Pincus SM, Hartman ML, Roelfsema F, Thorner MO, Veldhuis JD. Hormone pulsatility discrimination via coarse and short time sampling. Am J Physiol 1999; 277: E948-57.
40. Veldhuis JD, Liem AY, South S, et al. Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay. J Clin Endocrinol Metab 1995; 80: 3209-22.
41. Ursavas A, Karadag M, Ilcol YO, et al. Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome. Lung 2007; 185: 309-14.
42. Zhang YS, Du JZ. The response of growth hormone and prolactin of rats to hypoxia. Neurosci Lett 2000; 279: 137-40.
43. Gianotti L, Pivetti S, Lanfranco F, et al. Concomitant impairment of growth hormone secretion and peripheral sensitivity in obese patients with obstructive sleep apnea syndrome. J Clin Endocrinol Metab 2002; 87: 5052-7.