Can local administration of tranexamic acid during total knee arthroplasty reduce blood loss and transfusion requirements in the absence of surgical drains?

European Journal of Orthopaedic Surgery and Traumatology

Volumn 24, Issue 3, 2014, Pages 379-384

  Craik, Johnathan D ^a   Ei Shafie, Sherif A ^b   Kidd, Alexander G ^b   Twyman, Roy S ^a  

^a EPSOM GENERAL HOSPITAL   (United Kingdom)

^b Elective Orthopaedic Centre   (United Kingdom)

Author keywords

Arthroplasty; Knee; Tranexamic acid; Transfusion

Indexed keywords

DALTEPARIN; ROPIVACAINE; TRANEXAMIC ACID;

AGED; ARTICLE; BLEEDING; BLOOD TRANSFUSION; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FIBRINOLYSIS; HUMAN; JOINT PROSTHESIS; MAJOR CLINICAL STUDY; MALE; PREOPERATIVE CARE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SURGICAL DRAINAGE; THROMBOEMBOLISM; TOTAL KNEE REPLACEMENT; TOURNIQUET; WOUND DRESSING; WOUND IRRIGATION;

ADMINISTRATION, TOPICAL; AGED; AGED, 80 AND OVER; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD TRANSFUSION; BLOOD VOLUME; DRAINAGE; FEMALE; HUMANS; INJECTIONS, INTRA-ARTICULAR; MALE; MIDDLE AGED; POSTOPERATIVE HEMORRHAGE; RETROSPECTIVE STUDIES; TRANEXAMIC ACID;

EID: 84897392625     PISSN: 16338065     EISSN: 14321068     Source Type: Journal    
DOI: 10.1007/s00590-013-1206-1     Document Type: Article

References (25)

1. Wong J, Abrishami A, El Beheiry H, Mahomed NN, Roderick Davey J, Gandhi R et al (2010) Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg [Am] 92A(15):2503-2513
2. Hiippala ST, Strid LJ, Wennerstrand MI, Arvela JVV, Niemelä HM, Mäntylä SK et al (1997) Tranexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty. Anaesth Analg 84:839-844 (Pubitemid 27147712)
3. Fahmy NR, Patel DG (1981) Hemostatic changes and postoperative deep-vein thrombosis associated with use of a pneumatic tourniquet. J Bone Joint Surg [Am] 63A(3):461-465 (Pubitemid 11154154)
4. Nakahara M, Sakahashi H (1967) Effect of application of a tourniquet on bleeding factors in dogs. J Bone Joint Surg [Am] 49A(7):1345-1351
5. Spahn DR, Casutt M (2000) Eliminating blood transfusions: new aspects and perspectives. Anesthesiology 93(1):242-255 (Pubitemid 30436699)
6. Etchason J, Petz L, Keeler E, Calhoun L, Kleinman S, Snider C, Fink A, Brook R (1995) The cost effectiveness of preoperative autologous blood donations. N Engl J Med 332(11):719-724
7. Yang ZG, Chen WP, Wu LD (2012) Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis. J Bone Joint Surg [Am] 94A(13):1-7
8. Alshryda S, Sarda P, Sukeik M, Nargol A, Blenkinsopp J, Mason JM (2011) Tranexamic acid in total knee replacement: a systematic review and meta-analysis. J Bone Joint Surg [Br] 93B(12):1577-1585
9. Zufferey P, Merquiol F, Laporte S, Decousus H, Mismetti P, Auboyer C et al (2006) Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery? Anesthesiology 105(5):1034-1046 (Pubitemid 44655516)
10. Camarasa MA, Ollé G, Serra-Prat M, Martín A, Sánchez M, Ricós P et al (2006) Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. Br J Anaesth 96(5):576-582
11. Good L, Peterson E, Lisander B (2003) Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement. Br J Anaesth 90(5):596-599 (Pubitemid 36592332)
12. Tanaka N, Sakahashi H, Sato E, Hirose K, Ishima T, Ishii S (2001) Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. J Bone Joint Surg [Br] 83B(5):702-705 (Pubitemid 32700674)
13. Jansen A, Andreica S, Claeys M, D'Haese J, Camu F, Jochmans K (1999) Use of tranexamic acid for an effective blood conservation strategy after total knee arthroplasty. Br J Anaesth 83(4):596-601 (Pubitemid 29458825)
14. Zohar E, Ellis M, Ifrach N, Stern A, Sapir O, Fredman B (2004) The postoperative blood-sparing efficacy of oral versus intravenous tranexamic acid after total knee replacement. Anaesth Analg 99:1679-1683 (Pubitemid 39551902)
15. Roy SP, Tanki UF, Dutta A, Jain SK, Nagi ON (2012) Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. doi:10.1007/s00167-012-1942-5
16. Ishida K, Tsumura N, Kitagawa A, Hamamura S, Fukuda K, Dogaki Y et al (2011) Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty. Int Orthop (SICOT) 35:1639-1645
17. Maniar RN, Kumar G, Singhi T, Nayak RM, Maniar PR (2012) Most effective regimen of tranexamic acid in knee arthroplasty: a prospective randomized controlled study in 240 patients. Clin Orthop Relat Res 470(9):2605-2612
18. Parker MJ, Roberts CP, Hay D (2004) Closed suction drainage for hip and knee arthroplasty. A meta-analysis. J Bone Joint Surg [Am] 86(6):1146-1152 (Pubitemid 38724876)
19. Parker MJ, Livingstone V, Clifton R, McKee A. (2007) Closed suction surgical wound drainage after orthopaedic surgery. Cochrane Database Syst Rev 18(3):CD001825
20. Nadler SB, Hidalgo JH (1962) Prediction of blood volume in normal human adults. Surgery 51(2):224-232
21. Kosmirak L. (2012) NHSBT Portfolio of blood components and guidance for their clinical use. 1-91. www.hospital.blood.co.uk
22. Benoni G, Carlsson A, Petersson C, Fredin H (1995) Does tranexamic acid reduce blood loss in knee arthroplasty? Am J Knee Surg 8(3):88-92
23. Sasanuma H, Sekiya H, Takatoku K, Takada H, Sugimoto N, Hoshino Y (2011) Efficient strategy for controlling postoperative hemorrhage in total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 19(6):921-925
24. Ralley FE, Berta D, Binns V, Howard J, Naudie DD (2010) One intraoperative dose of tranexamic acid for patients having primary hip or knee arthroplasty. Clin Orthop Relat Res 468(7):1905-1911
25. Lozano M, Basora M, Peidro L, Merino I, Segur JM, Pereira A et al (2008) Effectiveness and safety of tranexamic acid administration during total knee arthroplasty. Vox Sang 95(1):39-44 (Pubitemid 351799410)