5-Aza-2′-deoxycytidine potentiates antitumour immune response induced by photodynamic therapy

European Journal of Cancer

Volumn 50, Issue 7, 2014, Pages 1370-1381

  Wachowska, Malgorzata ^a   Gabrysiak, Magdalena ^a   Muchowicz, Angelika ^a   Bednarek, Weronika ^a   Barankiewicz, Joanna ^a   Rygiel, Tomasz ^a   Boon, Louis ^b   Mroz, Pawel ^c,d,e   Hamblin, Michael R ^c,d,f   Golab, Jakub ^a,g  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b BIOCEROS   (Netherlands)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

^f HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^g POLISH ACADEMY OF SCIENCES   (Poland)

Author keywords

5 Aza 2 deoxycitidine; Cancer; Photodynamic therapy; Specific antitumour immunity; Tumour associated antigens

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; P1A ANTIGEN; PHOTOFRIN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER INHIBITION; CD8+ T LYMPHOCYTE; COLON CARCINOMA; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG EFFICACY; DRUG POTENTIATION; FEMALE; IMMUNE RESPONSE; LEWIS CARCINOMA; LONG TERM SURVIVAL; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; TREATMENT RESPONSE; TUMOR CELL;

5-AZA-2′-DEOXYCITIDINE; CANCER; PHOTODYNAMIC THERAPY; SPECIFIC ANTITUMOUR IMMUNITY; TUMOUR ASSOCIATED ANTIGENS;

ANIMALS; ANTIGENS, NEOPLASM; ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; CARCINOMA, LEWIS LUNG; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; FEMALE; FLOW CYTOMETRY; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PHOTOCHEMOTHERAPY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84897382769     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2014.01.017     Document Type: Article

References (29)

1. P. Agostinis, K. Berg, K.A. Cengel, T.H. Foster, A.W. Girotti, and S.O. Gollnick et al. Photodynamic therapy of cancer: an update CA Cancer J Clin 61 4 2011 250 281
2. D. Nowis, M. Makowski, T. Stoklosa, M. Legat, T. Issat, and J. Golab Direct tumor damage mechanisms of photodynamic therapy Acta Biochim Pol 52 2 2005 339 352
3. A.P. Castano, P. Mroz, and M.R. Hamblin Photodynamic therapy and anti-tumour immunity Nat Rev Cancer 6 7 2006 535 545
4. P. Mroz, A. Szokalska, M.X. Wu, and M.R. Hamblin Photodynamic therapy of tumors can lead to development of systemic antigen-specific immune response PLoS One 5 12 2010 e15194
5. M. Korbelik PDT-associated host response and its role in the therapy outcome Lasers Surg Med 38 5 2006 500 508
6. A.D. Garg, D.V. Krysko, T. Verfaillie, A. Kaczmarek, G.B. Ferreira, and T. Marysael et al. A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death EMBO J 31 5 2012 1062 1079
7. D. Nowis, T. Stokłosa, M. Legat, T. Issat, M. Jakobisiak, and J. Gołab The influence of photodynamic therapy on the immune response Photodiagn Photodyn Ther 2 2005 283 298
8. M. Korbelik, G. Krosl, J. Krosl, and G.J. Dougherty The role of host lymphoid populations in the response of mouse EMT6 tumor to photodynamic therapy Cancer Res 56 24 1996 5647 5652
9. A.P. Castano, Q. Liu, and M.R. Hamblin A green fluorescent protein-expressing murine tumour but not its wild-type counterpart is cured by photodynamic therapy Br J Cancer 94 3 2006 391 397
10. P. Mroz, F. Vatansever, A. Muchowicz, and M.R. Hamblin Photodynamic therapy of murine mastocytoma induces specific immune responses against the cancer/testis antigen P1A Cancer Res 73 21 2013 6462 6470
11. Z.S. Guo, J.A. Hong, K.R. Irvine, G.A. Chen, P.J. Spiess, and Y. Liu et al. De novo induction of a cancer/testis antigen by 5-aza-2′-deoxycytidine augments adoptive immunotherapy in a murine tumor model Cancer Res 66 2 2006 1105 1113
12. S.B. Baylin, and J.E. Ohm Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer 6 2 2006 107 116
13. T.B. Tomasi, W.J. Magner, and A.N. Khan Epigenetic regulation of immune escape genes in cancer Cancer Immunol Immunother 55 10 2006 1159 1184
14. M.J. Scanlan, A.O. Gure, A.A. Jungbluth, L.J. Old, and Y.T. Chen Cancer/testis antigens: an expanding family of targets for cancer immunotherapy Immunol Rev 188 2002 22 32
15. A. Pandey, A. Kurup, A. Shrivastava, S. Radhi, D.D. Nguyen, and C. Arentz et al. Cancer testes antigens in breast cancer: biological role, regulation, and therapeutic applicability Int Rev Immunol 31 5 2012 302 320
16. A. Szokalska, M. Makowski, D. Nowis, G.M. Wilczynski, M. Kujawa, and C. Wojcik et al. Proteasome inhibition potentiates antitumor effects of photodynamic therapy in mice through induction of endoplasmic reticulum stress and unfolded protein response Cancer Res 69 10 2009 4235 4243
17. A. Jalili, M. Makowski, T. Switaj, D. Nowis, G.M. Wilczynski, and E. Wilczek et al. Effective photoimmunotherapy of murine colon carcinoma induced by the combination of photodynamic therapy and dendritic cells Clin Cancer Res 10 13 2004 4498 4508
18. K. Kozar, R. Kaminski, T. Switaj, T. Oldak, E. Machaj, and P.J. Wysocki et al. Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-Aza-2′-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice Clin Cancer Res 9 8 2003 3124 3133
19. A.A. Lettini, M. Guidoboni, E. Fonsatti, L. Anzalone, E. Cortini, and M. Maio Epigenetic remodelling of DNA in cancer Histol Histopathol 22 12 2007 1413 1424
20. B. Van den Eynde, B. Lethe, A. Van Pel, E. De Plaen, and T. Boon The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice J Exp Med 173 6 1991 1373 1384
21. L. Ramarathinam, S. Sarma, M. Maric, M. Zhao, G. Yang, and L. Chen et al. Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected J Immunol 155 11 1995 5323 5329
22. E.C. Bellavance, F.J. Kohlhapp, A. Zloza, J.A. O'Sullivan, J. McCracken, and M.C. Jagoda et al. Development of tumor-infiltrating CD8+ T cell memory precursor effector cells and antimelanoma memory responses are the result of vaccination and TGF-beta blockade during the perioperative period of tumor resection J Immunol 186 6 2011 3309 3316
23. J.A. Hendrzak-Henion et al. Role of the immune system in mediating the antitumor effect of benzophenothiazine photodynamic therapy Photochem Photobiol 69 5 1999 575 581
24. M. Korbelik, and G.J. Dougherty Photodynamic therapy-mediated immune response against subcutaneous mouse tumors Cancer Res 59 8 1999 1941 1946
25. E. Kabingu, A.R. Oseroff, G.E. Wilding, and S.O. Gollnick Enhanced systemic immune reactivity to a Basal cell carcinoma associated antigen following photodynamic therapy Clin Cancer Res 15 13 2009 4460 4466
26. P. Mroz, J.T. Hashmi, Y.Y. Huang, N. Lange, and M.R. Hamblin Stimulation of anti-tumor immunity by photodynamic therapy Expert Rev Clin Immunol 7 1 2011 75 91
27. M. Ankathatti Munegowda, Y. Deng, S.J. Mulligan, and J. Xiang Th17 and Th17-stimulated CD8(+) T cells play a distinct role in Th17-induced preventive and therapeutic antitumor immunity Cancer Immunol Immunother 60 10 2011 1473 1484
28. C.M. Brackett, J.B. Muhitch, S.S. Evans, and S.O. Gollnick IL-17 promotes neutrophil entry into tumor-draining lymph nodes following induction of sterile inflammation J Immunol 191 8 2013 4348 4357
29. M. Sideridou, R. Zakopoulou, K. Evangelou, M. Liontos, A. Kotsinas, and E. Rampakakis et al. Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins J Cell Biol 195 7 2011 1123 1140