Wound healing efficacy of a chitosan-based film-forming gel containing tyrothricin in various rat wound models

Archives of Pharmacal Research

Volumn 38, Issue 2, 2015, Pages 229-238

  Kim, Ju Young ^a,b   Jun, Joon Ho ^a,c   Kim, Sang Joon ^a   Hwang, Kyu Mok ^a   Choi, Sung Rak ^c   Han, Sang Duk ^c   Son, Mi Won ^c   Park, Eun Seok ^a  

^a Sungkyunkwan University   (South Korea)

^b Woosuk University   (South Korea)

^c Dong A Pharmaceutical Company   (South Korea)

Author keywords

Chitosan; Film forming gel; Tyrothricin; Wound healing

Indexed keywords

ANTIINFECTIVE AGENT; CHITOSAN; DRUG CARRIER; GEL; TYROTHRICIN;

ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; FEMALE; GEL; SPRAGUE DAWLEY RAT; WOUND HEALING; WOUNDS AND INJURIES;

ANIMALS; ANTI-BACTERIAL AGENTS; CHITOSAN; DISEASE MODELS, ANIMAL; DRUG CARRIERS; FEMALE; GELS; MOLECULAR STRUCTURE; RATS, SPRAGUE-DAWLEY; TYROTHRICIN; WOUND HEALING; WOUNDS AND INJURIES;

EID: 84897363153     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-014-0368-7     Document Type: Article

References (37)

1. Abdel-Hamid, S.M., S.E. Abdel-Hady, A.-H.A. El-Shamy, and H.F. El-Dessouky. 2007. A novel formulation for mebeverine hydrochloride. Drug Development and Industrial Pharmacy 33: 1078-1089.
2. Alberti, I., A. Grenier, H. Kraus, and D.N. Carrara. 2005. Pharmaceutical development and clinical effectiveness of a novel gel technology for transdermal drug delivery. Expert Opinion on Drug Delivery 2: 935-950.
3. Boateng, J.S., K.H. Matthews, H.N. Stevens, and G.M. Eccleston. 2008. Wound healing dressings and drug delivery systems: A review. Journal of Pharmaceutical Sciences 97: 2892-2923.
4. Branski, L.K., R. Mittermayr, D.N. Herndon, M.G. Jeschke, M. Hofmann, O.E. Masters, W.B. Norbury, D.L. Traber, S. Tangl, and H. Redl. 2011. Fibrin sealant improves graft adherence in a porcine full-thickness burn wound model. Burns 37: 1360-1366.
5. Butler, B., P. Vergano, R. Testin, J. Bunn, and J. Wiles. 1996. Mechanical and barrier properties of edible chitosan films as affected by composition and storage. Journal of Food Science 61: 953-956.
6. Chithra, P., G. Sajithlal, and G. Chandrakasan. 1998. Influence of Aloe vera on the healing of dermal wounds in diabetic rats. Journal of Ethnopharmacology 59: 195-201.
7. Dai, T., M. Tanaka, Y.-Y. Huang, and M.R. Hamblin. 2011. Chitosan preparations for wounds and burns: Antimicrobial and wound-healing effects. Expert Review of Anti-infective Therapy 9: 857-879.
8. De Oliveira, M.L.M., D.C.S. Nunes-Pinheiro, A.R. Tomé, F. Mota, I.A. Lima-Verde, F.G.D.M. Pinheiro, C.C. Campello, and S.M. De Morais. 2010. In vivo topical anti-inflammatory and wound healing activities of the fixed oil of Caryocar coriaceum Wittm. seeds. Journal of Ethnopharmacology 129: 214-219.
9. Deʇim, Z., N. Celebi, H. Sayan, A. Babül, D. Erdoʇan, and G. Take. 2002. An investigation on skin wound healing in mice with a taurine-chitosan gel formulation. Amino Acids 22: 187-198.
10. Dorsett-Martin, W.A. 2004. Rat models of skin wound healing: A review. Wound Repair and Regeneration 12: 591-599.
11. Falanga, V. 2005. Wound healing and its impairment in the diabetic foot. The Lancet 366: 1736-1743.
12. Guo, R., X. Du, R. Zhang, L. Deng, A. Dong, and J. Zhang. 2011. Bioadhesive film formed from a novel organic-inorganic hybrid gel for transdermal drug delivery system. European Journal of Pharmaceutics and Biopharmaceutics 79: 574-583.
13. Ilium, L. 1998. Chitosan and its use as a pharmaceutical excipient. Pharmaceutical Research 15: 1326-1331.
14. Ishihara, M., K. Ono, M. Sato, K. Nakanishi, Y. Saito, H. Yura, T. Matsui, H. Hattori, M. Fujita, and M. Kikuchi. 2001. Acceleration of wound contraction and healing with a photocrosslinkable chitosan hydrogel. Wound Repair and Regeneration 9: 513-521.
15. Kretschmar, M., T. Nichterlein, C. Nebe, H. Hof, and K. Burger. 1996. Fungicidal effect of tyrothricin on Candida albicans. Mycoses 39: 45-50.
16. Lateef, H., O.I. Abatan, M.N. Aslam, M.J. Stevens, and J. Varani. 2005. Topical pretreatment of diabetic rats with all-trans retinoic acid improves healing of subsequently induced abrasion wounds. Diabetes 54: 855-861.
17. Lazarus, G.S., D.M. Cooper, D.R. Knighton, D.J. Margolis, R.E. Percoraro, G. Rodeheaver, and M.C. Robson. 1994. Definitions and guidelines for assessment of wounds and evaluation of healing. Wound Repair and Regeneration 2: 165-170.
18. Lee, A.-R.C., and H.K. Moon. 2003. Effect of topically applied silver sulfadiazine on fibroblast cell proliferation and biomechanical properties of the wound. Archives of Pharmacal Research 26: 855-860.
19. Li, X., R. Zhang, R. Liang, W. Liu, C. Wang, Z. Su, F. Sun, and Y. Li. 2014. Preparation and characterization of sustained-release rotigotine film-forming gel. International Journal of Pharmaceutics 460: 273-279.
20. Like, A.A., and A.A. Rossini. 1976. Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus. Science 193: 415-417.
21. Lodhi, S., R.S. Pawar, A.P. Jain, and A. Singhai. 2006. Wound healing potential of Tephrosia purpurea (Linn.) Pers. in rats. Journal of Ethnopharmacology 108: 204-210.
22. Madden, J.W., and E.E. Peacock Jr. 1968. Studies on the biology of collagen during wound healing. I. Rate of collagen synthesis and deposition in cutaneous wounds of the rat. Surgery 64: 288.
23. Murakami, K., H. Aoki, S. Nakamura, S.-I. Nakamura, M. Takikawa, M. Hanzawa, S. Kishimoto, H. Hattori, Y. Tanaka, and T. Kiyosawa. 2010. Hydrogel blends of chitin/chitosan, fucoidan and alginate as healing-impaired wound dressings. Biomaterials 31: 83-90.
24. Penhallow, K. 2005. A review of studies that examine the impact of infection on the normal wound-healing process. Journal of Wound Care 14: 123-126.
25. Prasad, V., and A.K. Dorle. 2006. Evaluation of ghee based formulation for wound healing activity. Journal of Ethnopharmacology 107: 38-47.
26. Rabea, E.I., M.E.-T. Badawy, C.V. Stevens, G. Smagghe, and W. Steurbaut. 2003. Chitosan as antimicrobial agent: Applications and mode of action. Biomacromolecules 4: 1457-1465.
27. Rhett, J.M., G.S. Ghatnekar, J.A. Palatinus, M. O'quinn, M.J. Yost, and R.G. Gourdie. 2008. Novel therapies for scar reduction and regenerative healing of skin wounds. Trends in Biotechnology 26: 173-180.
28. Robson, M., B. Stenberg, and J. Heggers. 1990. Wound healing alterations caused by infection. Clinics in Plastic Surgery 17: 485-492.
29. Schuren, J., A. Becker, and R. Gary Sibbald. 2005. A liquid film-forming acrylate for peri-wound protection: A systematic review and meta-analysis (3M™ Cavilon™ no-sting barrier film). International Wound Journal 2: 230-238.
30. Sezer, A.D., F. Hatipoglu, E. Cevher, Z. Oʇurtan, A.L. Bas, and J. Akbuʇa. 2007. Chitosan film containing fucoidan as a wound dressing for dermal burn healing: Preparation and in vitro/in vivo evaluation. The American Association of Pharmaceutical Scientists 8: E94-E101.
31. Sung, J.H., M.-R. Hwang, J.O. Kim, J.H. Lee, Y.I. Kim, J.H. Kim, S.W. Chang, S.G. Jin, J. Kim, and W.S. Lyoo. 2010. Gel characterisation and in vivo evaluation of minocycline-loaded wound dressing with enhanced wound healing using polyvinyl alcohol and chitosan. International Journal of Pharmaceutics 392: 232-240.
32. Tapolsky, G.H., and D.W. Osborne. 2000. Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues.US Patent 6,103,266.
33. Ueno, H., T. Mori, and T. Fujinaga. 2001. Topical formulations and wound healing applications of chitosan. Advanced Drug Delivery Reviews 52: 105-115.
34. Ward, R.S., and J.R. Saffle. 1995. Topical agents in burn and wound care. Physical Therapy 75: 526-538.
35. Warner, R.L., N. Bhagavathula, K. Nerusu, A. Hanosh, S.D. Mcclintock, M.K. Naik, K.J. Johnson, I. Ginsburg, and J. Varani. 2008. MDI 301, a nonirritating retinoid, improves abrasion wound healing in damaged/atrophic skin. Wound Repair and Regeneration 16: 117-124.
36. Wigger-Alberti, W., M. Stauss-Grabo, K. Grigo, S. Atiye, R. Williams, and H. Korting. 2012. Efficacy of a tyrothricin-containing wound gel in an abrasive wound model for superficial wounds. Skin Pharmacology and Physiology 26: 52-56.
37. Yusof, N.L.B.M., A. Wee, L.Y. Lim, and E. Khor. 2003. Flexible chitin films as potential wound-dressing materials: Wound model studies. Journal of Biomedical Materials Research, Part A 66: 224-232.