Early motor deficits in mouse disease models are reliably uncovered using an automated home-cage wheel-running system: A cross-laboratory validation

DMM Disease Models and Mechanisms

Volumn 7, Issue 3, 2014, Pages 397-407

  Mandillo, Silvia ^a   Heise, Ines ^b   Garbugino, Luciana ^a   Tocchini Valentini, Glauco P ^a   Giuliani, Alessandro ^c   Wells, Sara ^b   Nolan, Patrick M ^b  

^a CNR   (Italy)

^b MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Complex wheel; Motor function; Neurodegenerative disease

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOMATED HOME CAGE WHEEL RUNNING SYSTEM; CONTROLLED STUDY; EXPERIMENTAL LOCOMOTOR ACTIVITY TEST; GRIP STRENGTH; HOME-CAGE ACTIVITY TEST; IN VIVO STUDY; LONGITUDINAL STUDY; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPRODUCIBILITY; ROTAROD TEST; SENSITIVITY ANALYSIS; VALIDATION STUDY; ANIMAL; ANIMAL BEHAVIOR; AUTOMATION; C57BL MOUSE; DISEASE MODEL; HUMAN; HUNTINGTON CHOREA; LABORATORY; MALE; METABOLISM; MOTOR ACTIVITY; MOUSE MUTANT; PATHOPHYSIOLOGY; PRINCIPAL COMPONENT ANALYSIS; RUNNING; STANDARD; TRANSGENIC MOUSE;

SUPEROXIDE DISMUTASE;

ANIMALS; AUTOMATION; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; HUMANS; HUNTINGTON DISEASE; LABORATORIES; MALE; MICE, INBRED C57BL; MICE, NEUROLOGIC MUTANTS; MICE, TRANSGENIC; MOTOR ACTIVITY; PHYSICAL CONDITIONING, ANIMAL; PRINCIPAL COMPONENT ANALYSIS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; ROTAROD PERFORMANCE TEST; RUNNING; SUPEROXIDE DISMUTASE;

EID: 84897145300     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.013946     Document Type: Article

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