Chlorogenic acid inhibits human platelet activation and thrombus formation

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Fuentes, Eduardo ^a,b   Caballero, Julio ^a   Alarcón, Marcelo ^a,b   Rojas, Armando ^c   Palomo, Iván ^a,b  

^a UNIVERSIDAD DE TALCA   (Chile)

^b Centro de Estudios en Alimentos Procesados (CEAP)   (Chile)

^c UNIVERSIDAD CATÓLICA DEL MAULE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 9 (TETRAHYDRO 2 FURYL)ADENINE; ACETYLSALICYLIC ACID; ADENOSINE A2A RECEPTOR; ADENOSINE DIPHOSPHATE; ADENYLATE CYCLASE; ARACHIDONIC ACID; CD40 LIGAND; CHLOROGENIC ACID; COLLAGEN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; INTERLEUKIN 1BETA; PADGEM PROTEIN; RANTES; THROMBIN RECEPTOR ACTIVATING PEPTIDE 6;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; BLEEDING TIME; CELL INTERACTION; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VIVO STUDY; INHIBITION KINETICS; LEUKOCYTE; LEUKOCYTE ROLLING; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE RELEASE REACTION;

ADENINE; ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING SITES; BLEEDING TIME; CELL COMMUNICATION; CELL LINE; CELL SURVIVAL; CHLOROGENIC ACID; COLLAGEN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; HEMORHEOLOGY; HUMANS; INFLAMMATION MEDIATORS; LEUKOCYTES; MICE; MODELS, MOLECULAR; P-SELECTIN; PLATELET ACTIVATION; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; RECEPTOR, ADENOSINE A2A; THROMBOSIS; TRIAZINES; TRIAZOLES;

EID: 84897136409     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090699     Document Type: Article

References (49)

1. World Health Organization (2004) WHO publishes definitive atlas on global heart disease and stroke epidemic (The atlas of heart disease and stroke). GENEVA.
2. AHA Statistical Fact Sheet (2003) International Cardiovascular Disease Statistics. American Heart Association.
3. Badimon L, Padro T, Vilahur G (2012) Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease. Eur Heart J Acute Cardiovasc Care 1: 60-74.
4. da Costa Martins PA, van Gils JM, Mol A, Hordijk PL, Zwaginga JJ (2006) Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of beta1 and beta2 integrins. J Leukoc Biol 79: 499-507. (Pubitemid 44831227)
5. da Costa Martins P, van den Berk N, Ulfman LH, Koenderman L, Hordijk PL, et al. (2004) Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation. Arterioscler Thromb Vasc Biol 24: 193-199. (Pubitemid 38082433)
6. Massberg S, Schulz C, Gawaz M (2003) Role of platelets in the pathophysiology of acute coronary syndrome. Semin Vasc Med 3: 147-162.
7. Aukrust P, Muller F, Ueland T, Berget T, Aaser E, et al. (1999) Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina. Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes. Circulation 100: 614-620. (Pubitemid 29379750)
8. Nurden AT (2011) Platelets, inflammation and tissue regeneration. Thromb Haemost 105 Suppl 1: S13-33.
9. Barrett NE, Holbrook L, Jones S, Kaiser WJ, Moraes LA, et al. (2008) Future innovations in anti-platelet therapies. Br J Pharmacol 154: 918-939. (Pubitemid 351915054)
10. Raju NC, Eikelboom JW (2012) The aspirin controversy in primary prevention. Curr Opin Cardiol 27: 499-507.
11. Plaza M, Cifuentes A, Ibañez E (2008) In the search of new functional food ingredients from algae. Trends in Food Science and Technology 19: 31-39. (Pubitemid 350151710)
12. Wang Y, Wang J, Guo L, Gao X (2012) Antiplatelet effects of qishen yiqi dropping pill in platelets aggregation in hyperlipidemic rabbits. Evid Based Complement Alternat Med 2012: 1-5.
13. Fuentes E, Forero-Doria O, Carrasco G, Marican A, Santos LS, et al. (2013) Effect of tomato industrial processing on phenolic profile and antiplatelet activity. Molecules 18: 11526-11536.
14. Fuentes E, Palomo I (2013) Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression: Antiplatelet Activity of Natural Products. Evid Based Complement Alternat Med 2013: 1-10.
15. Karunanidhi A, Thomas R, van Belkum A, Neela V (2013) In vitro antibacterial and antibiofilm activities of chlorogenic acid against clinical isolates of Stenotrophomonas maltophilia including the trimethoprim/ sulfamethoxazole resistant strain. Biomed Res Int 2013: 1-7.
16. Meng S, Cao J, Feng Q, Peng J, Hu Y (2013) Roles of Chlorogenic Acid on Regulating Glucose and Lipids Metabolism: A Review. Evid Based Complement Alternat Med 2013: 1-11.
17. Hwang SJ, Kim YW, Park Y, Lee HJ, Kim KW (2013) Anti-inflammatory effects of chlorogenic acid in lipopolysaccharide-stimulated RAW 264.7 cells. Inflamm Res 2013: 1-10.
18. Amin RP, Kunaparaju N, Kumar S, Taldone T, Barletta MA, et al. (2013) Structure elucidation and inhibitory effects on human platelet aggregation of chlorogenic acid from Wrightia tinctoria. J Complement Integr Med 10: 1-8.
19. Bijak M, Saluk J, Ponczek MB, Nowak P (2013) Antithrombin effect of polyphenol-rich extracts from black chokeberry and grape seeds. Phytother Res 27: 71-76.
20. Frojmovic M, Wong T, van de Ven T (1991) Dynamic measurements of the platelet membrane glycoprotein IIb-IIIa receptor for fibrinogen by flow cytometry. I. Methodology, theory and results for two distinct activators. Biophys J 59: 815-827.
21. Conant CG, Schwartz MA, Nevill T, Ionescu-Zanetti C (2009) Platelet adhesion and aggregation under flow using microfluidic flow cells. J Vis Exp 32: 1-3.
22. Appeldoorn CC, Bonnefoy A, Lutters BC, Daenens K, van Berkel TJ, et al. (2005) Gallic acid antagonizes P-selectin-mediated platelet-leukocyte interactions: implications for the French paradox. Circulation 111: 106-112. (Pubitemid 40070851)
23. Marks DC, Belov L, Davey MW, Davey RA, Kidman AD (1992) The MTT cell viability assay for cytotoxicity testing in multidrug-resistant human leukemic cells. Leuk Res 16: 1165-1173. (Pubitemid 23028819)
24. Przyklenk K, Whittaker P (2007) Adaptation of a photochemical method to initiate recurrent platelet-mediated thrombosis in small animals. Lasers Med Sci 22: 42-45. (Pubitemid 46354778)
25. De Clerck F, Goossens J, Reneman R (1976) Effects of anti-inflammatory, anticoagulant and vasoactive compounds on tail bleeding time, whole blood coagulation time and platelet retention by glass beads in rats. Thromb Res 8: 179-193.
26. Friesner R, Banks J, Murphy R, Halgren T, Klicic J, et al. (2004) Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. Journal of Medicinal Chemistry 47: 1739-1749. (Pubitemid 38380917)
27. Munoz C, Adasme F, Alzate-Morales JH, Vergara-Jaque A, Kniess T, et al. (2012) Study of differences in the VEGFR2 inhibitory activities between semaxanib and SU5205 using 3D-QSAR, docking, and molecular dynamics simulations. J Mol Graph Model 32: 39-48.
28. Onate B, Vilahur G, Ferrer-Lorente R, Ybarra J, Diez-Caballero A, et al. (2012) The subcutaneous adipose tissue reservoir of functionally active stem cells is reduced in obese patients. FASEB J 26: 4327-4336.
29. Jorgensen W, Maxwell D, Tirado-Rives J (1996) Development and testing of the OPLS all-atom force field on conformational energetics and properties of organic liquids. Journal of the American Chemical Society 118: 11225-11236. (Pubitemid 26399746)
30. Eldridge MD, Murray CW, Auton TR, Paolini GV, Mee RP (1997) Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes. J Comput Aided Mol Des 11: 425-445. (Pubitemid 127505895)
31. Merten M, Thiagarajan P (2000) P-selectin expression on platelets determines size and stability of platelet aggregates. Circulation 102: 1931-1936.
32. Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, et al. (2011) Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation. Nature 474: 521-525.
33. Ji X, Hou M (2011) Novel agents for anti-platelet therapy. J Hematol Oncol 4: 1-7.
34. Albers GW, Amarenco P, Easton JD, Sacco RL, Teal P (2001) Antithrombotic and thrombolytic therapy for ischemic stroke. Chest 119: 300S-320S. (Pubitemid 32154207)
35. Albers GW, Amarenco P (2001) Combination therapy with clopidogrel and aspirin: can the CURE results be extrapolated to cerebrovascula patients? Stroke 32: 2948-2949. (Pubitemid 33134497)
36. Offermanns S (2006) Activation of platelet function through G protein-coupled receptors. Circ Res 99: 1293-1304.
37. Walter U, Eigenthaler M, Geiger J, Reinhard M (1993) Role of cyclic nucleotide-dependent protein kinases and their common substrate VASP in the regulation of human platelets. Adv Exp Med Biol 344: 237-249.
38. Jensen BO, Selheim F, Doskeland SO, Gear AR, Holmsen H (2004) Protein kinase A mediates inhibition of the thrombin-induced platelet shape change by nitric oxide. Blood 104: 2775-2782. (Pubitemid 39434961)
39. Libersan D, Rousseau G, Merhi Y (2003) Differential regulation of P-selectin expression by protein kinase A and protein kinase G in thrombin-stimulated human platelets. Thromb Haemost 89: 310-317. (Pubitemid 36227284)
40. Yang D, Chen H, Koupenova M, Carroll SH, Eliades A, et al. (2010) A new role for the A2b adenosine receptor in regulating platelet function. J Thromb Haemost 8: 817-827.
41. Loyau S, Dumont B, Ollivier V, Boulaftali Y, Feldman L, et al. (2012) Platelet glycoprotein VI dimerization, an active process inducing receptor competence, is an indicator of platelet reactivity. Arterioscler Thromb Vasc Biol 32: 778-785.
42. Enomoto Y, Adachi S, Doi T, Natsume H, Kato K, et al. (2011) cAMP regulates ADP-induced HSP27 phosphorylation in human platelets. Int J Mol Med 27: 695-700.
43. Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, et al. (2008) The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 322: 1211-1217.
44. Serebruany VL, Malinin AI, Eisert RM, Sane DC (2004) Risk of bleeding complications with antiplatelet agents: meta-analysis of 338,191 patients enrolled in 50 randomized controlled trials. Am J Hematol 75: 40-47. (Pubitemid 38040166)
45. Olthof MR, Hollman PC, Zock PL, Katan MB (2001) Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. Am J Clin Nutr 73: 532-538. (Pubitemid 32176503)
46. Laranjinha JA, Almeida LM, Madeira VM (1994) Reactivity of dietary phenolic acids with peroxyl radicals: antioxidant activity upon low density lipoprotein peroxidation. Biochem Pharmacol 48: 487-494. (Pubitemid 24257011)
47. Nardini M, D'Aquino M, Tomassi G, Gentili V, Di Felice M, et al. (1995) Inhibition of human low-density lipoprotein oxidation by caffeic acid and other hydroxycinnamic acid derivatives. Free Radic Biol Med 19: 541-552.
48. Watanabe T, Arai Y, Mitsui Y, Kusaura T, Okawa W, et al. (2006) The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp Hypertens 28: 439-449. (Pubitemid 44034669)
49. Bassoli BK, Cassolla P, Borba-Murad GR, Constantin J, Salgueiro-Pagadigorria CL, et al. (2008) Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia. Cell Biochem Funct 26: 320-328. (Pubitemid 351613172)