Jagged1 immobilization to an osteoconductive polymer activates the Notch signaling pathway and induces osteogenesis

Journal of Biomedical Materials Research - Part A

Volumn 102, Issue 5, 2014, Pages 1558-1567

  Dishowitz, Michael I ^a   Zhu, Fengchang ^b   Sundararaghavan, Harini G ^a   Ifkovits, Jamie L ^a   Burdick, Jason A ^a   Hankenson, Kurt D ^b,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Jagged1; Notch signaling; osteoblast differentiation; osteoinduction; translational medicine

Indexed keywords

BIOLOGICAL MATERIALS; BONE; FRACTURE; GENE EXPRESSION; LIGANDS; REPAIR; STEM CELLS;

JAGGED1; NOTCH SIGNALING; OSTEOBLAST DIFFERENTIATION; OSTEOINDUCTION; TRANSLATIONAL MEDICINE;

SCAFFOLDS (BIOLOGY);

ANTIBODY; BONE SIALOPROTEIN; JAGGED1; NOTCH RECEPTOR; POLYMER; TISSUE SCAFFOLD; TRANSCIPTION FACTOR HEY1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ALKALINE PHOSPHATASE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BIOMATERIAL; CALCIUM BINDING PROTEIN; CELL CYCLE PROTEIN; HEY1 PROTEIN, HUMAN; IMMOBILIZED PROTEIN; MEMBRANE PROTEIN; SERRATE PROTEINS; SIGNAL PEPTIDE;

ANTIBODY BLOOD LEVEL; ARTICLE; BONE DEVELOPMENT; BONE REGENERATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN MESENCHYMAL STEM CELL; IN VITRO STUDY; MESENCHYMAL STEM CELL; OSTEOBLAST; PROTEIN IMMOBILIZATION; SIGNAL TRANSDUCTION; SURFACE PROPERTY; UPREGULATION; ANIMAL; BONE MINERALIZATION; CELL COUNT; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; MESENCHYMAL STROMA CELL; METABOLISM; PHENOTYPE; RAT; TISSUE SCAFFOLD;

ALKALINE PHOSPHATASE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOCOMPATIBLE MATERIALS; CALCIFICATION, PHYSIOLOGIC; CALCIUM-BINDING PROTEINS; CELL COUNT; CELL CYCLE PROTEINS; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; IMMOBILIZED PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MESENCHYMAL STROMAL CELLS; OSSEOINTEGRATION; OSTEOGENESIS; PHENOTYPE; POLYMERS; RATS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TISSUE SCAFFOLDS;

EID: 84897114734     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.34825     Document Type: Article

References (34)

1. Braithwaite RS, Col NF, Wong JB,. Estimating hip fracture morbidity, mortality and costs. J Am Geriatr Soc 2003; 51: 364-370. (Pubitemid 36348898)
2. Audige L, Griffin D, Bhandari M, Kellam J, Ruedi TP,. Path analysis of factors for delayed healing and nonunion in 416 operatively treated tibial shaft fractures. Clin Orthop Relat Res 2005; 438: 221-232. (Pubitemid 41254341)
3. Dimitriou R, Jones E, McGonagle D, Giannoudis PV,. Bone regeneration: Current concepts and future directions. BMC Med 2011; 9: 66.
4. Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF, Zych GA, Calhoun JH, LaForte AJ, Yin S,. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am A 2001; 83 (Part 2): S151-S158.
5. Govender S, Csimma C, Genant HK, Valentin-Opran A, Amit Y, Arbel R, Aro H, Atar D, Bishay M, Borner MG, et al. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: A prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am A 2002; 84: 2123-2134. (Pubitemid 35417689)
6. Carragee EJ, Hurwitz EL, Weiner BK, Bono CM, Rothman DJ,. Future directions for The spine journal: managing and reporting conflict of interest issues. Spine J 2011; 11: 695-697.
7. Hilton MJ, Tu X, Wu X, Bai S, Zhao H, Kobayashi T, Kronenberg HM, Teitelbaum SL, Ross FP, Kopan R, Long F,. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med 2008; 14: 306-314. (Pubitemid 351347911)
8. Engin F, Yao Z, Yang T, Zhou G, Bertin T, Jiang MM, Chen Y, Wang L, Zheng H, Sutton RE, Boyce BF, Lee B,. Dimorphic effects of Notch signaling in bone homeostasis. Nat Med 2008; 14: 299-305. (Pubitemid 351347909)
9. Zanotti S, Smerdel-Ramoya A, Stadmeyer L, Durant D, Radtke F, Canalis E,. Notch inhibits osteoblast differentiation and causes osteopenia. Endocrinology 2008; 149: 3890-3899.
10. Mead TJ, Yutzey KE,. Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development. Proc Natl Acad Sci USA 2009; 106: 14420-14425.
11. Dong Y, Jesse AM, Kohn A, Gunnell LM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ,. RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development 2010; 137: 1461-1471.
12. Tao J, Chen S, Yang T, Dawson B, Munivez E, Bertin T, Lee B,. Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent. J Bone Miner Res 2010; 25: 2175-2183.
13. Kohn A, Dong Y, Mirando AJ, Jesse AM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ,. Cartilage-specific RBPjkappa-dependent and -independent Notch signals regulate cartilage and bone development. Development 2012; 139: 1198-1212.
14. Salie R, Kneissel M, Vukevic M, Zamurovic N, Kramer I, Evans G, Gerwin N, Mueller M, Kinzel B, Susa M,. Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in bone. Bone 2010; 46: 680-694.
15. Dishowitz MI, Terkhorn SP, Bostic SA, Hankenson KD,. Notch signaling components are upregulated during both endochondral and intramembranous bone regeneration. J Orthop Res 2012; 30: 296-303.
16. Li L, Krantz ID, Deng Y, Genin A, Banta AB, Collins CC, Qi M, Trask BJ, Kuo WL, Cochran J, et al. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet 1997; 16: 243-251.
17. Oda T, Elkahloun AG, Pike BL, Okajima K, Krantz ID, Genin A, Piccoli DA, Meltzer PS, Spinner NB, Collins FS, et al. Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet 1997; 16: 235-242.
18. Olsen IE, Ittenbach RF, Rovner AJ, Leonard MB, Mulberg AE, Stallings VA, Piccoli DA, Zemel BS,. Deficits in size-adjusted bone mass in children with Alagille syndrome. J Pediatr Gastroenterol Nutr 2005; 40: 76-82. (Pubitemid 40180062)
19. Bales CB, Kamath BM, Munoz PS, Nguyen A, Piccoli DA, Spinner NB, Horn D, Shults J, Leonard MB, Grimberg A, et al. Pathologic lower extremity fractures in children with Alagille syndrome. J Pediatr Gastroenterol Nutr 2010; 51: 66-70.
20. Zhu F, Sweetwyne MT, Hankenson KD,. PKCdelta is required for jagged-1 induction of Human Mesenchymal Stem Cell osteogenic differentiation. Stem Cells 2013; 31: 1181-1192.
21. Osathanon T, Ritprajak P, Nowwarote N, Manokawinchoke J, Giachelli C, Pavasant P,. Surface-bound orientated Jagged-1 enhances osteogenic differentiation of human periodontal ligament-derived mesenchymal stem cells. J Biomed Mater Res A 2013; 101: 358-367.
22. Vas V, Szilagyi L, Paloczi K, Uher F,. Soluble Jagged-1 is able to inhibit the function of its multivalent form to induce hematopoietic stem cell self-renewal in a surrogate in vitro assay. J Leukoc Biol 2004; 75: 714-720. (Pubitemid 38405664)
23. Beckstead BL, Santosa DM, Giachelli CM,. Mimicking cell-cell interactions at the biomaterial-cell interface for control of stem cell differentiation. J Biomed Mater Res A 2006; 79: 94-103. (Pubitemid 44452859)
24. Goncalves RM, Martins MC, Almeida-Porada G, Barbosa MA,. Induction of notch signaling by immobilization of jagged-1 on self-assembled monolayers. Biomaterials 2009; 30: 6879-6887.
25. Kramer H,. RIPping notch apart: A new role for endocytosis in signal transduction? Sci STKE 2000; 2000: pe1.
26. Beckstead BL, Tung JC, Liang KJ, Tavakkol Z, Usui ML, Olerud JE, Giachelli CM,. Methods to promote Notch signaling at the biomaterial interface and evaluation in a rafted organ culture model. J Biomed Mater Res A 2009; 91: 436-446.
27. Anderson DG, Tweedie CA, Hossain N, Navarro SM, Brey DM, Van Vliet KJ, Langer R, Burdick JA,. A combinatorial library of photocrosslinkable and degradable materials. Adv Mater 2006; 18: 2614-2618. (Pubitemid 44563486)
28. Brey DM, Chung C, Hankenson KD, Garino JP, Burdick JA,. Identification of osteoconductive and biodegradable polymers from a combinatorial polymer library. J Biomed Mater Res A 2010; 93: 807-816.
29. Kwon SM, Eguchi M, Wada M, Iwami Y, Hozumi K, Iwaguro H, Masuda H, Kawamoto A, Asahara T,. Specific Jagged-1 signal from bone marrow microenvironment is required for endothelial progenitor cell development for neovascularization. Circulation 2008; 118: 157-165.
30. Benedito R, Roca C, Sorensen I, Adams S, Gossler A, Fruttiger M, Adams RH,. The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell 2009; 137: 1124-1135.
31. Nobta M, Tsukazaki T, Shibata Y, Xin C, Moriishi T, Sakano S, Shindo H, Yamaguchi A,. Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling. J Biol Chem 2005; 280: 15842-15848. (Pubitemid 40616705)
32. Tezuka K, Yasuda M, Watanabe N, Morimura N, Kuroda K, Miyatani S, Hozumi N,. Stimulation of osteoblastic cell differentiation by Notch. J Bone Miner Res 2002; 17: 231-239. (Pubitemid 34087655)
33. Oldershaw RA, Tew SR, Russell AM, Meade K, Hawkins R, McKay TR, Brennan KR, Hardingham TE,. Notch signaling through Jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis. Stem Cells 2008; 26: 666-674.
34. Sekine C, Koyanagi A, Koyama N, Hozumi K, Chiba S, Yagita H,. Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes. Arthritis Res Ther 2012; 14: R45.