Backbone 1H, 13C and 15N resonance assignment of the C-terminal EGF-cbEGF pair of LTBP1 and flanking residues

Biomolecular NMR Assignments

Volumn 8, Issue 1, 2014, Pages 159-163

  Robertson, Ian B ^a   Handford, Penny A ^a   Redfield, Christina ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Calcium binding; EGF; Epidermal growth factor like domain; Latent transforming growth factor beta binding protein; LTBP; NMR assignment

Indexed keywords

AMINO ACID; CALCIUM; CARBON; EPIDERMAL GROWTH FACTOR; HYDROGEN; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN; NITROGEN;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; AMINO ACIDS; CALCIUM; CARBON ISOTOPES; EPIDERMAL GROWTH FACTOR; HUMANS; HYDROGEN; LATENT TGF-BETA BINDING PROTEINS; MOLECULAR SEQUENCE DATA; NITROGEN ISOTOPES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, TERTIARY;

EID: 84897114487     PISSN: 18742718     EISSN: 1874270X     Source Type: Journal    
DOI: 10.1007/s12104-013-9474-6     Document Type: Article

References (20)

1. Chen Y, Ali T, Todorovic V, O'Leary JM, Downing AK, Rifkin DB (2005) Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes. J Mol Biol 345:175-186
2. Cohn RD, van Erp C, Habashi JP, Soleimani AA, Klein EC, Lisi MT, Gamradt M, Ap Rhys CM, Holm TM, Loeys BL, Ramirez F, Judge DP, Ward CW, Dietz HC (2007) Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states. Nat Med 13:204-210
3. Delaglio F, Grzesiek S, Vuister GW, Zhu G, Pfeifer J, Bax A (1995) NMRPipe: A multidimensional spectral processing system based on UNIX pipes. J Biomol NMR 6:277-293
4. Eswar N, Webb B, Marti-Renom MA, Madhusudhan MS, Eramian D, Shen MY, Pieper U, Sali A (2006) Comparative protein structure modeling using Modeller. Curr Protoc Bioinformatics, Chapter 5, Unit 5.6
5. Habashi JP, Judge DP, Holm TM, Cohn RD, Loeys BL, Cooper TK, Myers L, Klein EC, Liu G, Calvi C, Podowski M, Neptune ER, Halushka MK, Bedja D, Gabrielson K, Rifkin DB, Carta L, Ramirez F, Huso DL, Dietz HC (2006) Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 312:117-121
6. Habashi JP, Doyle JJ, Holm TM, Aziz H, Schoenhoff F, Bedja D, Chen Y, Modiri AN, Judge DP, Dietz HC (2011) Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism. Science 332:361-365
7. Hirani R, Hanssen E, Gibson MA (2007) LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein. Matrix Biol 26:213-223
8. Isogai Z, Ono RN, Ushiro S, Keene DR, Chen Y, Mazzieri R, Charbonneau NL, Reinhardt DP, Rifkin DB, Sakai LY (2003) Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein. J Biol Chem 278:2750-2757
9. Jensen SA, Robertson IB, Handford PA (2012) Dissecting the fibrillin microfibril: Structural insights into organization and function. Structure 20:215-225
10. Knott V, Downing AK, Cardy CM, Handford P (1996) Calcium binding properties of an epidermal growth factor-like domain pair from human fibrillin-1. J Mol Biol 255:22-27
11. Massam-Wu T, Chiu M, Choudhury R, Chaudhry SS, Baldwin AK, McGovern A, Baldock C, Shuttleworth CA, Kielty CM (2010) Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta. J Cell Sci 123:3006-3018
12. Miyazono K, Olofsson A, Colosetti P, Heldin CH (1991) A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1. EMBO J 10:1091-1101
13. Neptune ER, Frischmeyer PA, Arking DE, Myers L, Bunton TE, Gayraud B, Ramirez F, Sakai LY, Dietz HC (2003) Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome. Nat Genet 33:407-411
14. Ng CM, Cheng A, Myers LA, Martinez-Murillo F, Jie C, Bedja D, Gabrielson KL, Hausladen JM, Mecham RP, Judge DP, Dietz HC (2004) TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome. J Clin Invest 114:1586-1592
15. Ono RN, Sengle G, Charbonneau NL, Carlberg V, Bachinger HP, Sasaki T, Lee-Arteaga S, Zilberberg L, Rifkin DB, Ramirez F, Chu ML, Sakai LY (2009) Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites. J Biol Chem 284:16872-16881
16. Robertson I, Jensen S, Handford P (2011) TB domain proteins: Evolutionary insights into the multifaceted roles of fibrillins and LTBPs. Biochem J 433:263-276
17. Saharinen J, Keski-Oja J (2000) Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta. Mol Biol Cell 11:2691-2704
18. Shen Y, Bax A (2012) Identification of helix capping and b-turn motifs from NMR chemical shifts. J Biomol NMR 52:211-232
19. Smallridge RS, Whiteman P, Werner JM, Campbell ID, Handford PA, Downing AK (2003) Solution structure and dynamics of a calcium binding epidermal growth factor-like domain pair from the neonatal region of human fibrillin-1. J Biol Chem 278:12199-12206
20. Vranken WF, Boucher W, Stevens TJ, Fogh RH, Pajon A, Llinas M, Ulrich EL, Markley JL, Ionides J, Laue ED (2005) The CCPN data model for NMR spectroscopy: Development of a software pipeline. Proteins 59:687-696