-
1
-
-
0023810994
-
Fascaplysin, an unusual antimicrobial pigment from the marine sponge Fascaplysinopsis sp
-
Roll, D.M.; Ireland, C.M.; Lu, H.S.M.; Clardy, J. Fascaplysin, an unusual antimicrobial pigment from the marine sponge Fascaplysinopsis sp. J. Org. Chem. 1988, 53, 3276-3278.
-
(1988)
J. Org. Chem.
, vol.53
, pp. 3276-3278
-
-
Roll, D.M.1
Ireland, C.M.2
Lu, H.S.M.3
Clardy, J.4
-
2
-
-
2542511641
-
Comparison of fascaplysin and related alkaloids: A study of structures, cytotoxicities, and sources
-
DOI 10.1021/np049935+
-
Segraves, N.L.; Robinson, S.J.; Garcia, D.; Said, S.A.; Fu, X.; Schmitz, F.J.; Pietraszkiewicz, H.; Valeriote, F.A.; Crews, P. Comparison of fascaplysin and related alkaloids: A study of structures, cytotoxicities, and sources. J. Nat. Prod. 2004, 67, 783-792. (Pubitemid 38702733)
-
(2004)
Journal of Natural Products
, vol.67
, Issue.5
, pp. 783-792
-
-
Segraves, N.L.1
Robinson, S.J.2
Garcia, D.3
Said, S.A.4
Fu, X.5
Schmitz, F.J.6
Pietraszkiewicz, H.7
Valeriote, F.A.8
Crews, P.9
-
3
-
-
0037459866
-
Structures and cytotoxicities of fascaplysin and related alkaloids from two marine phyla - Fascaplysinopsis sponges and Didemnum tunicates
-
DOI 10.1016/S0040-4039(03)00671-3
-
Segraves, N.L.; Lopez, S.; Johnson, T.A.; Said, S.A.; Fu, X.; Schmitz, F.J.; Pietraszkiewicz, H.; Valeriote, F.A.; Crews, P. Structures and cytotoxicities of fascaplysin and related alkaloids from two marine phyla - Fascaplysinopsis sponges and Didemnum tunicates. Tetrahedron Lett. 2003, 44, 3471-3475. (Pubitemid 36398314)
-
(2003)
Tetrahedron Letters
, vol.44
, Issue.17
, pp. 3471-3475
-
-
Segraves, N.L.1
Lopez, S.2
Johnson, T.A.3
Said, S.A.4
Fu, X.5
Schmitz, F.J.6
Pietraszkiewicz, H.7
Valeriote, F.A.8
Crews, P.9
-
4
-
-
84861754296
-
Chemistry and biology of fascaplysin, a potent marine-derived CDK-4 inhibitor
-
Bharate, S.B.; Manda, S.; Mupparapu, N.; Battini, N.; Vishwakarma, R.A. Chemistry and biology of fascaplysin, a potent marine-derived CDK-4 inhibitor. Mini Rev. Med. Chem. 2012, 12, 650-664.
-
(2012)
Mini Rev. Med. Chem.
, vol.12
, pp. 650-664
-
-
Bharate, S.B.1
Manda, S.2
Mupparapu, N.3
Battini, N.4
Vishwakarma, R.A.5
-
5
-
-
0035039381
-
DNA binding properties of the marine sponge pigment fascaplysin
-
DOI 10.1016/S0968-0896(00)00313-8, PII S0968089600003138
-
Hormann, A.; Chaudhari, B.; Fretz, H. DNA binding properties of marine sponge pigment fascaplysin. Bioorg. Med. Chem. 2001, 9, 917-921. (Pubitemid 32448111)
-
(2001)
Bioorganic and Medicinal Chemistry
, vol.9
, Issue.4
, pp. 917-921
-
-
Hormann, A.1
Chaudhuri, B.2
Fretz, H.3
-
6
-
-
0034618674
-
Inhibition of cyclindependent kinase 4 (Cdk4) by fascaplysin, a marine natural product
-
Soni, R.; Muller, L.; Furet, P.; Schoepfer, J.; Stephan, C.; Zumstein-Mecker, S.; Fretz, H.; Chaudhuri, B. Inhibition of cyclindependent kinase 4 (Cdk4) by fascaplysin, a marine natural product. Biochem. Biophys. Res. Commun. 2000, 275, 877-884.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.275
, pp. 877-884
-
-
Soni, R.1
Muller, L.2
Furet, P.3
Schoepfer, J.4
Stephan, C.5
Zumstein-Mecker, S.6
Fretz, H.7
Chaudhuri, B.8
-
7
-
-
0035925574
-
Selective in vivo and in vitro effects of a small molecule inhibitor of cyclindependent kinase-4
-
Soni, R.; O'Reilly, T.; Furet, P.; Muller, L.; Stephan, C.; Zumstein- Mecker, S.; Fretz, H.; Fabbro, D.; Chaudhuri, B. Selective in vivo and in vitro effects of a small molecule inhibitor of cyclindependent kinase-4. J. Natl. Cancer Inst. 2001, 93, 436-446.
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 436-446
-
-
Soni, R.1
O'Reilly, T.2
Furet, P.3
Muller, L.4
Stephan, C.5
Zumstein- Mecker, S.6
Fretz, H.7
Fabbro, D.8
Chaudhuri, B.9
-
8
-
-
84865057198
-
Fascaplysin as a specific inhibitor for CDK4: Insights from molecular modelling
-
Shafiq, M.I.; Steinbrecher, T.; Schmid, R. Fascaplysin as a specific inhibitor for CDK4: Insights from molecular modelling. PLoS One 2012, 7, e42612.
-
(2012)
PLoS One
, vol.7
-
-
Shafiq, M.I.1
Steinbrecher, T.2
Schmid, R.3
-
9
-
-
84875487955
-
Multidisciplinary management of small cell lung cancer
-
Goldberg, S.B.; Willers, H.; Heist, R.S. Multidisciplinary management of small cell lung cancer. Surg. Oncol. Clin. N. Am. 2013, 22, 329-343.
-
(2013)
Surg. Oncol. Clin. N. Am.
, vol.22
, pp. 329-343
-
-
Goldberg, S.B.1
Willers, H.2
Heist, R.S.3
-
10
-
-
71049132728
-
Anti-proliferation of human cervical cancer HeLa cell line by fascaplysin through apoptosis induction
-
Lu, X.L.; Zheng, Y.L.; Chen, H.M.; Yan, X.J.; Wang, F.; Xu, W.F. Anti-proliferation of human cervical cancer HeLa cell line by fascaplysin through apoptosis induction. Yao Xue Xue Bao 2009, 44, 980-986.
-
(2009)
Yao Xue Xue Bao
, vol.44
, pp. 980-986
-
-
Lu, X.L.1
Zheng, Y.L.2
Chen, H.M.3
Yan, X.J.4
Wang, F.5
Xu, W.F.6
-
11
-
-
77956878953
-
Direct effects of fascaplysin on human umbilical vein endothelial cells attributing the anti-angiogenesis activity
-
Zheng, Y.L.; Lu, X.L.; Lin, J.; Chen, H.M.; Yan, X.J.; Wang, F.; Xu, W.F. Direct effects of fascaplysin on human umbilical vein endothelial cells attributing the anti-angiogenesis activity. Biomed. Pharmacother. 2010, 64, 527-533.
-
(2010)
Biomed. Pharmacother.
, vol.64
, pp. 527-533
-
-
Zheng, Y.L.1
Lu, X.L.2
Lin, J.3
Chen, H.M.4
Yan, X.J.5
Wang, F.6
Xu, W.F.7
-
12
-
-
33846269340
-
Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo
-
Lin, J.; Yan, X.J.; Chen, H.M. Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo. Cancer Chemother. Pharmacol. 2007, 59, 439-445.
-
(2007)
Cancer Chemother. Pharmacol.
, vol.59
, pp. 439-445
-
-
Lin, J.1
Yan, X.J.2
Chen, H.M.3
-
13
-
-
84877320335
-
Fascaplysin sensitizes cells to TRAIL-induced apoptosis through upregulating DR5 expression
-
Wang, F.; Chen, H.; Yan, X.; Zhen, Y. Fascaplysin sensitizes cells to TRAIL-induced apoptosis through upregulating DR5 expression. Chin. J. Oceanol. Limnol. 2013, 31, 560-569.
-
(2013)
Chin. J. Oceanol. Limnol.
, vol.31
, pp. 560-569
-
-
Wang, F.1
Chen, H.2
Yan, X.3
Zhen, Y.4
-
14
-
-
79959619770
-
Fascaplysin exert anti-tumor effects through apoptotic and anti-angiogenesis pathways in sarcoma mice model
-
Yan, X.; Chen, H.; Lu, X.; Wang, F.; Xu, W.; Jin, H.; Zhu, P. Fascaplysin exert anti-tumor effects through apoptotic and anti-angiogenesis pathways in sarcoma mice model. Eur. J. Pharm. Sci. 2011, 43, 251-259.
-
(2011)
Eur. J. Pharm. Sci.
, vol.43
, pp. 251-259
-
-
Yan, X.1
Chen, H.2
Lu, X.3
Wang, F.4
Xu, W.5
Jin, H.6
Zhu, P.7
-
15
-
-
33646678195
-
A new paradigm for the development of anticancer agents from natural products
-
Subramanian, B.; Nakeff, A.; Tenney, K.; Crews, P.; Gunatilaka, L.; Valeriote, F. A new paradigm for the development of anticancer agents from natural products. J. Exp. Ther. Oncol. 2006, 5, 195-204. (Pubitemid 43843830)
-
(2006)
Journal of Experimental Therapeutics and Oncology
, vol.5
, Issue.3
, pp. 195-204
-
-
Subramanian, B.1
Nakeff, A.2
Tenney, K.3
Crews, P.4
Gunatilaka, L.5
Valeriote, F.6
-
16
-
-
84894617711
-
Synergistic anticancer activity of topotecan - cyclin-dependent kinase inhibitor combinations against drug-resistant small cell lung cancer (SCLC) cell lines
-
Hamilton, G.; Olszewski, U.; Klameth, L.; Ulsperger, E.; Geissler, K. Synergistic anticancer activity of topotecan - cyclin-dependent kinase inhibitor combinations against drug-resistant small cell lung cancer (SCLC) cell lines. J. Cancer Ther. 2013, 4, 47-53.
-
(2013)
J. Cancer Ther.
, vol.4
, pp. 47-53
-
-
Hamilton, G.1
Olszewski, U.2
Klameth, L.3
Ulsperger, E.4
Geissler, K.5
-
17
-
-
0024268963
-
Characterization of three small cell lung cancer cell lines established from one patient during longitudinal follow-up
-
Berendsen, H.H.; de Leij, L.; de Vries, E.G.; Mesander, G.; Mulder, N.H.; de Jong, B.; Buys, C.H.; Postmus, E.P.; Poppema, S.; Sluiter, H.S.; et al. Characterization of three small cell lung cancer cell lines established from one patient during longitudinal follow-up. Cancer Res. 1988, 48, 6891-6899.
-
(1988)
Cancer Res.
, vol.48
, pp. 6891-6899
-
-
Berendsen, H.H.1
De Leij, L.2
De Vries, E.G.3
Mesander, G.4
Mulder, N.H.5
De Jong, B.6
Buys, C.H.7
Postmus, E.P.8
Poppema, S.9
Sluiter, H.S.10
-
18
-
-
0026772144
-
Neuromedin B is present in lung cancer cell lines
-
Giaccone, G.; Battey, J.; Gazdar, A.F.; Oie, H.; Draoui, M.; Moody, T.W. Neuromedin B is present in lung cancer cell lines. Cancer Res. 1992, 52, 2732s-2736s.
-
(1992)
Cancer Res.
, vol.52
-
-
Giaccone, G.1
Battey, J.2
Gazdar, A.F.3
Oie, H.4
Draoui, M.5
Moody, T.W.6
-
19
-
-
0021053735
-
Amplification and expression of the c-myc oncogene in human lung cancer cell lines
-
Little, C.D.; Nau, M.M.; Carney, D.N.; Gazdar, A.F.; Minna, J.D. Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature 1983, 306, 194-196.
-
(1983)
Nature
, vol.306
, pp. 194-196
-
-
Little, C.D.1
Nau, M.M.2
Carney, D.N.3
Gazdar, A.F.4
Minna, J.D.5
-
20
-
-
59149099364
-
Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer
-
Jiang, T.; Collins, B.J.; Jin, N.; Watkins, D.N.; Brock, M.V.; Matsui, W.; Nelkin, B.D.; Ball, D.W. Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer. Cancer Res. 2009, 69, 845-854.
-
(2009)
Cancer Res.
, vol.69
, pp. 845-854
-
-
Jiang, T.1
Collins, B.J.2
Jin, N.3
Watkins, D.N.4
Brock, M.V.5
Matsui, W.6
Nelkin, B.D.7
Ball, D.W.8
-
21
-
-
0018889149
-
Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung
-
Pettengill, O.S.; Sorenson, G.D.; Wurster-Hill, D.H.; Curphey, T.J.; Noll, W.W.; Cate, C.C.; Maurer, L.H. Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung. Cancer 1980, 45, 906-918.
-
(1980)
Cancer
, vol.45
, pp. 906-918
-
-
Pettengill, O.S.1
Sorenson, G.D.2
Wurster-Hill, D.H.3
Curphey, T.J.4
Noll, W.W.5
Cate, C.C.6
Maurer, L.H.7
-
22
-
-
79960836823
-
Cyclin D as a therapeutic target in cancer
-
Musgrove, E.A.; Caldon, C.E.; Barraclough, J.; Stone, A.; Sutherland, R.L. Cyclin D as a therapeutic target in cancer. Nat. Rev. Cancer 2011, 11, 558-572.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 558-572
-
-
Musgrove, E.A.1
Caldon, C.E.2
Barraclough, J.3
Stone, A.4
Sutherland, R.L.5
-
23
-
-
0028172926
-
Absence of p16INK4 Protein Is Restricted to the Subset of Lung Cancer Lines that Retains Wildtype RB
-
Otterson, G.A.; Kratzke, R.A.; Coxon, A.; Kim, Y.W.; Kaye, F.J. Absence of p16INK4 Protein Is Restricted to the Subset of Lung Cancer Lines that Retains Wildtype RB. Oncogene 1994, 9, 3375-3378.
-
(1994)
Oncogene
, vol.9
, pp. 3375-3378
-
-
Otterson, G.A.1
Kratzke, R.A.2
Coxon, A.3
Kim, Y.W.4
Kaye, F.J.5
-
24
-
-
33746270787
-
1/S phase of the cell cycle and alterations in the RB pathway in human lung cancer
-
DOI 10.1586/14737140.6.4.515
-
Wikman, H.; Kettunen, E. Regulation of the G1/S Phase of the Cell Cycle and Alterations in the RB Pathway in Human Lung Cancer. Expert Rev. Anticancer Ther. 2006, 6, 515-530. (Pubitemid 44192902)
-
(2006)
Expert Review of Anticancer Therapy
, vol.6
, Issue.4
, pp. 515-530
-
-
Wikman, H.1
Kettunen, E.2
-
25
-
-
0025034079
-
Abnormalities in structure and expression of the retinoblastoma gene in small cell lung cancer cell lines and xenografts in nude mice
-
Rygaard, K.; Sorenson, G.D.; Pettengill, O.S.; Cate, C.C.; Spang-Thomsen, M. Abnormalities in structure and expression of the retinoblastoma gene in small cell lung cancer cell lines and xenografts in nude mice. Cancer Res. 1990, 50, 5312-5317. (Pubitemid 20302981)
-
(1990)
Cancer Research
, vol.50
, Issue.17
, pp. 5312-5317
-
-
Rygaard, K.1
Sorenson, G.D.2
Pettengill, O.S.3
Cate, C.C.4
Spang-Thomsen, M.5
-
26
-
-
0028987265
-
Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 Genes in Primary and Metastatic Lung Cancer
-
Okamoto, A.; Hussain, S.P.; Hagiwara, K.; Spillare, E.A.; Rusin, M.R.; Demetrick, D.J.; Serrano, M.; Hannon, G.J.; Shiseki, M.; Zariwala, M.; et al. Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 Genes in Primary and Metastatic Lung Cancer. Cancer Res. 1995, 55, 1448-1451.
-
(1995)
Cancer Res.
, vol.55
, pp. 1448-1451
-
-
Okamoto, A.1
Hussain, S.P.2
Hagiwara, K.3
Spillare, E.A.4
Rusin, M.R.5
Demetrick, D.J.6
Serrano, M.7
Hannon, G.J.8
Shiseki, M.9
Zariwala, M.10
-
27
-
-
79955495593
-
PRIMA-1Met/APR-246 Induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53
-
Zandi, R.; Selivanova, G.; Christensen, C.L. PRIMA-1Met/APR-246 Induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53. Clin. Cancer Res. 2011, 17, 2830-2841.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 2830-2841
-
-
Zandi, R.1
Selivanova, G.2
Christensen, C.L.3
-
28
-
-
79952079462
-
The cytoprotective effect of N-acetyl-L-cysteine against ROS-induced cytotoxicity is independent of its ability to enhance glutathione synthesis
-
Zhang, F.; Lau, S.S.; Monks, T.J. The cytoprotective effect of N-acetyl-L-cysteine against ROS-induced cytotoxicity is independent of its ability to enhance glutathione synthesis. Toxicol. Sci. 2011, 120, 87-97.
-
(2011)
Toxicol. Sci.
, vol.120
, pp. 87-97
-
-
Zhang, F.1
Lau, S.S.2
Monks, T.J.3
-
29
-
-
84867856740
-
Redox modulation of the DNA damage response
-
Caputo, F.; Vegliante, R.; Ghibelli, L. Redox modulation of the DNA damage response. Biochem. Pharmacol. 2012, 84, 1292-1306.
-
(2012)
Biochem. Pharmacol.
, vol.84
, pp. 1292-1306
-
-
Caputo, F.1
Vegliante, R.2
Ghibelli, L.3
-
30
-
-
57349119185
-
Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): A comparison with standard PARP inhibitors
-
Eltze, T.; Boer, R.; Wagner, T.; Weinbrenner, S.; McDonald, M.C.; Thiemermann, C.; Bürkle, A.; Klein, T. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): A comparison with standard PARP inhibitors. Mol. Pharmacol. 2008, 74, 1587-1598.
-
(2008)
Mol. Pharmacol.
, vol.74
, pp. 1587-1598
-
-
Eltze, T.1
Boer, R.2
Wagner, T.3
Weinbrenner, S.4
McDonald, M.C.5
Thiemermann, C.6
Bürkle, A.7
Klein, T.8
-
31
-
-
4344685333
-
The PARP superfamily
-
DOI 10.1002/bies.20085
-
Amé, J.C.; Spenlehauer, C.; de Murcia, G. The PARP superfamily. Bioessays 2004, 26, 882-893. (Pubitemid 39128102)
-
(2004)
BioEssays
, vol.26
, Issue.8
, pp. 882-893
-
-
Ame, J.-C.1
Spenlehauer, C.2
De Murcia, G.3
-
32
-
-
33745867638
-
Poly(ADP-ribose): Novel functions for an old molecule
-
Schreiber, V.; Dantzer, F.; Ame, J.C.; de Murcia, G. Poly(ADP-ribose): Novel functions for an old molecule. Nat. Rev. Mol. Cell Biol. 2006, 7, 517-528.
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 517-528
-
-
Schreiber, V.1
Dantzer, F.2
Ame, J.C.3
De Murcia, G.4
-
33
-
-
84891046100
-
Strategic combination of DNA-damaging agent and PARP inhibitor results in enhanced cytotoxicity
-
doi:10.3389/fonc.2013.00257
-
Horton, J.K.; Wilson, S.H. Strategic combination of DNA-damaging agent and PARP inhibitor results in enhanced cytotoxicity. Front. Oncol. 2013, 3, doi:10.3389/fonc.2013.00257.
-
(2013)
Front. Oncol.
, vol.3
-
-
Horton, J.K.1
Wilson, S.H.2
-
34
-
-
67649526000
-
Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos
-
Wang, Y.; Dawson, V.L.; Dawson, T.M. Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos. Exp. Neurol. 2009, 218, 193-202.
-
(2009)
Exp. Neurol.
, vol.218
, pp. 193-202
-
-
Wang, Y.1
Dawson, V.L.2
Dawson, T.M.3
-
35
-
-
33748794547
-
Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
-
Chou, T.C. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol. Rev. 2006, 58, 621-681.
-
(2006)
Pharmacol. Rev.
, vol.58
, pp. 621-681
-
-
Chou, T.C.1
|