Subject-specific increases in serum S-100B distinguish sports-related concussion from sports-related exertion

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Kiechle, Karin ^a   Bazarian, Jeffrey J ^b   Merchant Borna, Kian ^b   Stoecklein, Veit ^a   Rozen, Eric ^c   Blyth, Brian ^b   Huang, Jason H ^b   Dayawansa, Samantha ^b   Kanz, Karl ^a   Biberthaler, Peter ^d  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c UNIVERSITY OF ROCHESTER   (United States)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN S100B;

ADULT; ARTICLE; ATHLETE; CHEMOLUMINESCENCE; CLINICAL ARTICLE; COHORT ANALYSIS; CONCUSSION; EXERCISE; FEMALE; GERMANY; HUMAN; LONGITUDINAL STUDY; MALE; MEASUREMENT ACCURACY; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SPORT INJURY; UNITED STATES;

ADULT; ATHLETES; BIOLOGICAL MARKERS; BRAIN CONCUSSION; FEMALE; GENE EXPRESSION; HUMANS; LONGITUDINAL STUDIES; MALE; PHYSICAL EXERTION; S100 CALCIUM BINDING PROTEIN BETA SUBUNIT; SPORTS; TIME FACTORS;

EID: 84897064749     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084977     Document Type: Article

References (29)

1. Prevention CCfDC (2007) Nonfatal traumatic brain injuries from sports and recreation activities-United States, 2001-2005. MMWR - Morbidity & Mortality Weekly Report 56: 733-737.
2. Marar MN, Fields SK, Comstock DR (2012) Epidemiology of Concussions Among United States High School Athletes in 20 Sports. The American Journal of Sports Medicine 40: 747-755.
3. Rickels E vWK, Wenzlaff P (2011) Treatment of traumatic brain injury in Germany. Unfallchirurg 114: 417-423.
4. Rickels E, von Wild K, Wenzlaff P (2010) Head injury in Germany: A population-based prospective study on epidemiology, causes, treatment and outcome of all degrees of head-injury severity in two distinct areas. Brain Injury 24: 1491-1504.
5. McCrory P, Meeuwisse W, Johnston K, Dvorak J, Aubry M, et al. (2009) Consensus statement on concussion in sport: the 3rd International Conference on Concussion in Sport held in Zurich, November 2008. Journal of Athletic Training 44: 434-448.
6. Echemendia RJ, Putukian M, Mackin RS, Julian L, Shoss N (2001) Neuropsychological test performance prior to and following sports-related mild traumatic brain injury. Clinical Journal of Sport Medicine 11: 23-31. (Pubitemid 32062197)
7. McCrea M, Randolph C, Barr WB, Hammeke TA, Marshall SW, et al. (2013) Incidence, Clinical Course, and Predictors of Prolonged Recovery Time Following Sport-Related Concussion in High School and College Athletes. Journal of the International Neuropsychological Society 19: 22-33.
8. McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, et al. (2009) Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. Journal of Neuropathology & Experimental Neurology 68: 709-735.
9. McCrea M, Kelly JP, Randolph C, Kluge J, Bartolic E, et al. (1998) Standardized assessment of concussion (SAC): on-site mental status evaluation of the athlete. The Journal of head trauma rehabilitation 13(2): 27-35. (Pubitemid 28176857)
10. McCrory P, Meeuwisse WH, Aubry M, Cantu RC, Dvorak J, et al. (2013) Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport, Zurich, November 2012. Journal of Athletic Training 48: 554-575.
11. McCrea M, Hammeke T, Olsen G, Leo P, Guskiewicz K (2004) Unreported Concussion in High School Football Players Implications for Prevention. Clin J Sport Med 14: 13-17. (Pubitemid 38057637)
12. Zimmer DB, Cornwall EH, Landar A, Song W (1995) The S100 protein family: history, function, and expression. Brain Research Bulletin 37: 417-429.
13. Donato R (2003) Intracellular and extracellular roles of S100 proteins. Microscopy Research & Technique 60: 540-551.
14. Marenholz I, Heizmann CW, Fritz G (2004) S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature). Biochemical & Biophysical Research Communications 322: 1111-1122. (Pubitemid 39164640)
15. Unden J, Romner B (2010) Can low serum levels of S100B predict normal CT findings after minor head injury in adults?: an evidence-based review and meta-analysis. Journal of Head Trauma Rehabilitation 25: 228-240.
16. Biberthaler P, Linsenmeier U, Pfeifer KJ, Kroetz M, Mussack T, et al. (2006) Serum S-100B concentration provides additional information fot the indication of computed tomography in patients after minor head injury: a prospective multicenter study. Shock 25: 446-453.
17. Bazarian JJ, Blyth BJ, He H, Mookerjee S, Jones C, et al. (2013) Classification Accuracy of Serum Apo A-I and S100B for the Diagnosis of Mild Traumatic Brain Injury and Prediction of Abnormal Initial Head Computed Tomography Scan. Journal of Neurotrauma 30: 1747-1754.
18. Otto M, Holthusen S, Bahn E, Sohnchen N, Wiltfang J, et al. (2000) Boxing and running lead to a rise in serum levels of S-100B protein. International Journal of Sports Medicine 21: 551-555. (Pubitemid 32002965)
19. Hasselblatt M, Mooren FC, Von Ahsen N, Keyvani K, Fromme A, et al. (2004) Serum S100beta increases in marathon runners reflect extracranial release rather than glial damage. Neurology 62: 1634-1636. (Pubitemid 38608215)
20. Stalnacke BM, Tegner Y, Sojka P (2003) Playing Ice Hockey and Basketball Increases Serum Levels of S-100B in Elite Players; A Pilot Study. Clinical Journal of Sport Medicine 13: 292-302. (Pubitemid 37210524)
21. Stalnacke BM, Tegner Y, Sojka P (2004) Playing soccer increases serum concentration of the biochemical markers of brain damage S-100B and neuron-specific enolase in elite players: a pilot study. Brain Injury 18: 899-909. (Pubitemid 38996823)
22. Corrigan JD, Bogner J (2007) Initial reliability and validity of the Ohio State University TBI Identification Method. Journal of Head Trauma Rehabilitation 22: 318-329. (Pubitemid 350145100)
23. Ben Abdesselam O, Vally J, Adem C, Foglietti M-J, Beaudeux J-L (2003) Reference values for serum S-100B protein depend on the race of individuals. Clinical Chemistry 49: 836-837. (Pubitemid 36513275)
24. Tang W, Hua H, Tu XM (2012) Applied Categorical and Count Data Analysis. Boca Raton, FL: CRC Press, Taylor & Francis Group.
25. Stalnacke BM, Ohlsson A, Tegner Y, Sojka P (2006) Serum concentrations of two biochemical markers of brain tissue damage S-100B and neurone specific enolase are increased in elite female soccer players after a competitive game. British Journal of Sports Medicine 40: 313-316.
26. Towend W (2006) Rapid Elimination of protein S-100B from Serum after Minor Head Trauma. Journal of Neuotrauma 23: 149-155.
27. FierceBiomarkers (2012) A*STAR's Institute of Microelectronics and SFC Fluidics Collaborate To Develop Point-of-Need Traumatic Brain Injury Diagnostic Device. FierceBiotech Research Channel.
28. Bonham VL, Dover GJ, Brody LC (2010) Screening student athletes for sickle cell trait-a social and clinical experiment. New England Journal of Medicine 363: 997-999.
29. Pham N, Fazio V, Cucullo L, Teng Q, Biberthaler P, et al. (2010) Extracranial sources of S100B do not affect serum levels.[Erratum appears in PLoS One. 2010;5(10). doi: 10.1371/annotation/bdcb41f2-a320-4401-a6ab- 86e71738597e]. PLoS ONE [Electronic Resource] 5.