Elevated plasma free fatty acids are associated with sudden death: A prospective community-based evaluation at the time of cardiac arrest

Heart Rhythm

Volumn 11, Issue 4, 2014, Pages 691-696

  Havmoeller, Rasmus ^a,b   Reinier, Kyndaron ^a   Teodorescu, Carmen ^a   Ahmadi, Naser ^a   Kwok, Dorothy ^a   Uy Evanado, Audrey ^a   Chen, Yii Der I ^a   Rotter, Jerome I ^a   Gunson, Karen ^c   Jui, Jonathan ^c   Chugh, Sumeet S ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Biomarker; Cardiac arrest; Fatty acids; Risk prediction; Sudden cardiac death

Indexed keywords

FATTY ACID; BIOLOGICAL MARKER;

ADULT; ARTICLE; BLOOD SAMPLING; BODY MASS; CANINE MODEL; CARDIOVASCULAR RISK; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISEASE ASSOCIATION; FATTY ACID BLOOD LEVEL; FEMALE; HEART ARREST; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NONHUMAN; OUT OF HOSPITAL CARDIAC ARREST; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SMOKING; SUDDEN CARDIAC DEATH; WILCOXON SIGNED RANKS TEST; AGED; ANIMAL; BLOOD; DOG; SUDDEN DEATH; VERY ELDERLY; ANIMAL EXPERIMENT; ANIMAL MODEL; BIOCHEMICAL ANALYSIS; CASE CONTROL STUDY; COMMUNITY TRIAL; CONTROLLED STUDY; DYSLIPIDEMIA; EXPERIMENTAL DOG; HEART FAILURE; HYPERLIPIDEMIA; HYPERTENSION; RESUSCITATION;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; BIOLOGICAL MARKERS; DEATH, SUDDEN; DEATH, SUDDEN, CARDIAC; DOGS; FATTY ACIDS, NONESTERIFIED; FEMALE; HEART ARREST; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 84897064143     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2014.01.012     Document Type: Article

References (35)

1. Myerburg RJ, Kessler KM, Castellanos A. Sudden cardiac death: epidemiology, transient risk, and intervention assessment. Ann Intern Med 1993;119:1187-1197. (Pubitemid 23361449)
2. Zipes DP, Camm AJ, Borggrefe M, et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to develop guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death) developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Europace 2006;8:746-837.
3. Fishman GI, Chugh SS, Dimarco JP, et al. Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop. Circulation 2010;122:2335-2348.
4. Wang TJ, Gona P, Larson MG, et al. Multiple biomarkers for the prediction of first major cardiovascular events and death. New Engl J Med 2006;355:2631-2639. (Pubitemid 44969122)
5. Vasan RS. Biomarkers of cardiovascular disease: molecular basis and practical considerations. Circulation 2006;113:2335-2362. (Pubitemid 43947980)
6. Havmoller R, Chugh SS. Plasma biomarkers for prediction of sudden cardiac death: another piece of the risk stratification puzzle? Circ Arrhythm Electrophysiol 2012;5:237-243.
7. Oliver MF, Opie LH. Effects of glucose and fatty acids on myocardial ischaemia and arrhythmias. Lancet 1994;343:155-158.
8. Siddiqui RA, Harvey KA, Ruzmetov N, Miller SJ, Zaloga GP. n-3 fatty acids prevent whereas trans-fatty acids induce vascular inflammation and sudden cardiac death. Br J Nutr 2009;102:1811-1819.
9. Jouven X, Charles MA, Desnos M, Ducimetiere P. Circulating nonesterified fatty acid level as a predictive risk factor for sudden death in the population. Circulation 2001;104:756-761. (Pubitemid 32762671)
10. Pilz S, Scharnagl H, Tiran B, et al. Elevated plasma free fatty acids predict sudden cardiac death: a 6.85-year follow-up of 3315 patients after coronary angiography. Eur Heart J 2007;28:2763-2769. (Pubitemid 350135527)
11. Lemaitre RN, King IB, Mozaffarian D, et al. Plasma phospholipid trans fatty acids, fatal ischemic heart disease, and sudden cardiac death in older adults: the cardiovascular health study. Circulation 2006;114:209-215. (Pubitemid 44297114)
12. Djoussé L, Biggs ML, Ix JH, et al. Nonesterified fatty acids and risk of sudden cardiac death in older adults. Circ Arrhythm Electrophysiol 2012;5:273-278.
13. Chugh SS, Reinier K. Predicting sudden death in the general population: another step, N terminal B-type natriuretic factor levels. Circulation 2009;119:2863-2864.
14. Kannel WB, Gagnon DR, Cupples LA. Epidemiology of sudden coronary death: population at risk. Can J Cardiol 1990;6:439-444.
15. Kannel WB, Schatzkin A. Sudden death: lessons from subsets in population studies. J Am Coll Cardiol 1985;5:141B-149B. (Pubitemid 15063755)
16. Reinier K, Dervan C, Singh T, et al. Increased left ventricular mass and decreased left ventricular systolic function have independent pathways to ventricular arrhythmogenesis in coronary artery disease. Heart Rhythm 2011;8:1177-1182.
17. Oliver MF. Sudden cardiac death: the lost fatty acid hypothesis. QJM 2006;99:701-709. (Pubitemid 44542319)
18. Paolisso G, Gualdiero P, Manzella D, et al. Association of fasting plasma free fatty acid concentration and frequency of ventricular premature complexes in nonischemic non-insulin-dependent diabetic patients. Am J Cardiol 1997;80:932-937. (Pubitemid 27459171)
19. Willerbrands AF, ter Welle HF, Tasseron SJ. The effect of a high molar FFA-albumin ratio in the perfusion medium on rhythm and contractility of the isolated rat heart. J Mol Cell Cardiol 1973;5:259-273.
20. Makiguchi M, Kawaguchi H, Tamura M, Yasuda H. Effect of palmitic acid and fatty acid binding protein on ventricular fibrillation threshold in the perfused rat heart. Cardiovasc Drugs Ther 1991;5:753-761.
21. Soloff LA. Arrhythmias following infusions of fatty acids. Am Heart J 1970;80:671-674.
22. Kurien VA, Yates PA, Oliver MF. Free fatty acids, heparin, and arrhythmias during experimental myocardial infarction. Lancet 1969;2:185-187.
23. Chiu HC, Kovacs A, Blanton RM, et al. Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ Res 2005;96:225-233. (Pubitemid 40209370)
24. Yagyu H, Chen G, Yokoyama M, et al. Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy. J Clin Invest 2003;111:419-426. (Pubitemid 36182219)
25. Djoussé L, Benkeser D, Arnold A, et al. Plasma free fatty acids and risk of heart failure: the Cardiovascular Health Study. Circ Heart Fail 2013;6:964-969.
26. Kelly RA, O'Hara DS, Mitch WE, Smith TW. Identification of NaK-ATPase inhibitors in human plasma as nonesterified fatty acids and lysophospholipids. J Biol Chem 1986;261:11704-11711. (Pubitemid 17206094)
27. Huang JM, Xian H, Bacaner M. Long-chain fatty acids activate calcium channels in ventricular myocytes. Proc Natl Acad Sci U S A 1992;89:6452-6456.
28. + channels in cardiac myocytes by free fatty acids. Circ Res 1990;67:1040-1046.
29. Pilz S, Scharnagl H, Tiran B, et al. Free fatty acids are independently associated with all-cause and cardiovascular mortality in subjects with coronary artery disease. J Clin Endocrinol Metab 2006;91:2542-2547. (Pubitemid 44024615)
30. Lemaitre RN, King IB, Raghunathan TE, et al. Cell membrane trans-fatty acids and the risk of primary cardiac arrest. Circulation 2002;105:697-701. (Pubitemid 34157372)
31. Arab L. Biomarkers of fat and fatty acid intake. J Nutr 2003;133:925S-932S. (Pubitemid 36262800)
32. Rowe MJ, Neilson JM, Oliver MF. Control of ventricular arrhythmias during myocardial infarction by antilipolytic treatment using a nicotinic-acid analogue. Lancet 1975;1:295-300.
33. Siscovick DS, Raghunathan TE, King I, et al. Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. JAMA 1995;274:1363-1367.
34. Aarsetoey H, Aarsetoey R, Lindner T, Staines H, Harris WS, Nilsen DW. Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase. Lipids 2011;46:151-161.
35. Kark JD, Manor O, Goldman S, Berry EM. Stability of red blood cell membrane fatty acid composition after acute myocardial infarction. J Clin Epidemiol 1995;48:889-895.