Global and regional associations of smaller cerebral gray and white matter volumes with gait in older people

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Callisaya, Michele L ^a,b   Beare, Richard ^a   Phan, Thanh G ^a   Chen, Jian ^a   Srikanth, Velandai K ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF TASMANIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; AGED; ARTICLE; BODY HEIGHT; BRAIN CORTEX; BRAIN INFARCTION; BRAIN SIZE; CONTROLLED STUDY; COVARIANCE; FEMALE; GAIT DISORDER; GRAY MATTER; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MEMORY; MOTOR CONTROL; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PARKINSON DISEASE; PERCEPTION; PHYSICAL CAPACITY; POPULATION RESEARCH; SEX; VASCULAR DISEASE; VISION; VOXEL BASED MORPHOMETRY; WALKING SPEED; WHITE MATTER;

AGED; AGED, 80 AND OVER; BRAIN; FEMALE; GAIT; HUMANS; LINEAR MODELS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; ORGAN SIZE;

EID: 84897063405     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084909     Document Type: Article

References (45)

1. Cesari M (2011) Role of gait speed in the assessment of older patients. JAMA 305: 93-94.
2. Verghese J, Wang C, Holtzer R, Lipton R, Xue X (2007) Quantitative gait dysfunction and risk of cognitive decline and dementia. J Neurol Neurosurg Psychiatry 78: 929-935 (Pubitemid 47310826)
3. Montero-Odasso M, Schapira M, Soriano ER, Varela M, Kaplan R, et al. (2005) Gait velocity as a single predictor of adverse events in healthy seniors aged 75 years and older. J Gerontol A Biol Sci Med Sci 60: 1304-1309. (Pubitemid 41612425)
4. Callisaya ML, Blizzard L, Schmidt MD, McGinley JL, Srikanth VK (2008) Sex modifies the relationship between age and gait: a population-based study of older adults. J Gerontol A Biol Sci Med Sci 63: 165-170. (Pubitemid 351738447)
5. Lord SR, Lloyd DG, Li SK (1996) Sensori-motor function, gait patterns and falls in community-dwelling women. Age Ageing 25: 292-299. (Pubitemid 26245278)
6. Callisaya ML, Blizzard L, Schmidt MD, McGinley JL, Lord SR, et al. (2009) A population-based study of sensorimotor factors affecting gait in older people. Age Ageing 38: 290-295.
7. la Fougere C, Zwergal A, Rominger A, Forster S, Fesl G, et al. (2010) Real versus imagined locomotion: a [18F]-FDG PET-fMRI comparison. Neuroimage 50: 1589-1598.
8. Rosano C, Sigurdsson S, Siggeirsdottir K, Phillips CL, Garcia M, et al. (2010) Magnetization transfer imaging, white matter hyperintensities, brain atrophy and slower gait in older men and women. Neurobiol Aging 31: 1197-1204.
9. Rosano C, Brach J, Longstreth WT Jr, Newman AB (2006) Quantitative measures of gait characteristics indicate prevalence of underlying subclinical structural brain abnormalities in high-functioning older adults. Neuroepidemiology 26: 52-60. (Pubitemid 41797938)
10. Srikanth V, Beare R, Blizzard L, Phan T, Stapleton J, et al. (2009) Cerebral white matter lesions, gait, and the risk of incident falls: a prospective population-based study. Stroke 40: 175-180.
11. Baezner H, Blahak C, Poggesi A, Pantoni L, Inzitari D, et al. (2008) Association of gait and balance disorders with age-related white matter changes: the LADIS study. Neurology 70: 935-942. (Pubitemid 351430742)
12. de Laat KF, Tuladhar AM, van Norden AG, Norris DG, Zwiers MP, et al. (2011) Loss of white matter integrity is associated with gait disorders in cerebral small vessel disease. Brain 134: 73-83.
13. de Laat KF, van Norden AG, Gons RA, van Oudheusden LJ, van Uden IW, et al. (2010) Gait in elderly with cerebral small vessel disease. Stroke 41: 1652-1658.
14. Raji CA, Lopez OL, Kuller LH, Carmichael OT, Becker JT (2009) Age, Alzheimer disease, and brain structure. Neurology 73: 1899-1905.
15. Galluzzi S, Beltramello A, Filippi M, Frisoni GB (2008) Aging. Neurol Sci 29 Suppl 3: 296-300.
16. Rosano C, Aizenstein H, Brach J, Longenberger A, Studenski S, et al. (2008) Special article: gait measures indicate underlying focal gray matter atrophy in the brain of older adults. J Gerontol A Biol Sci Med Sci 63: 1380-1388.
17. Rosano C, Aizenstein HJ, Studenski S, Newman AB (2007) A regions-of-interest volumetric analysis of mobility limitations in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 62: 1048-1055. (Pubitemid 47531224)
18. Rosano C, Studenski SA, Aizenstein HJ, Boudreau RM, Longstreth WT, Jr., et al. (2012) Slower gait, slower information processing and smaller prefrontal area in older adults. Age Ageing 41: 58-64.
19. de Laat KF, Reid AT, Grim DC, Evans AC, Kotter R, et al. (2011) Cortical thickness is associated with gait disturbances in cerebral small vessel disease. Neuroimage 59:1478-1484
20. Australian Bureau of Statistics (2005) Population by age and sex, Tasmania [data cube: Super Table online]. In: Statistics ABo, editor. ABS publication.
21. Webster KE, Wittwer JE, Feller JA (2005) Validity of the GAITRite walkway system for the measurement of averaged and individual step parameters of gait. Gait Posture 22: 317-321. (Pubitemid 41586104)
22. Jenkinson M, Smith S (2001) A global optimisation method for robust affine registration of brain images. Med Image Anal 5: 143-156. (Pubitemid 35282800)
23. Otsu N (1979) A Threshold Selection Method from Gray-Level Histograms. EEE Transactions on Systems, Man and Cybernetics 9: 62-66.
24. Ashburner J, Friston KJ (2005) Unified segmentation. Neuroimage 26: 839-851. (Pubitemid 40825026)
25. Beare R, Srikanth V, Chen J, Phan TG, Stapleton J, et al. (2009) Development and validation of morphological segmentation of age-related cerebral white matter hyperintensities. Neuroimage 47: 199-203.
26. Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9: 179-186.
27. Maldonado G, Greenland S (1993) Simulation study of confounder-selection strategies. Am J Epidemiol 138: 923-936. (Pubitemid 24002359)
28. Wang C, Wai Y, Kuo B, Yeh YY, Wang J (2008) Cortical control of gait in healthy humans: an fMRI study. J Neural Transm 115: 1149-1158.
29. Margulies DS, Vincent JL, Kelly C, Lohmann G, Uddin LQ, et al. (2009) Precuneus shares intrinsic functional architecture in humans and monkeys. Proc Natl Acad Sci U S A 106: 20069-20074.
30. Paus T (2001) Primate anterior cingulate cortex: where motor control, drive and cognition interface. Nat Rev Neurosci 2: 417-424.
31. Srikanth V, Sanders L, Callisaya M, Martin K, Phan T (2010) Brain aging and gait. Aging Health 6: 123-131.
32. Martin KL, Blizzard L, Wood AG, Srikanth V, Thomson R, et al. (2012) Cognitive Function, Gait, and Gait Variability in Older People: A Population-Based Study. J Gerontol A Biol Sci Med Sci 68:726-732
33. Holtzer R, Verghese J, Xue X, Lipton RB (2006) Cognitive processes related to gait velocity: results from the Einstein Aging Study. Neuropsychology 20: 215-223.
34. Hollman JH, McDade EM, Petersen RC (2011) Normative spatiotemporal gait parameters in older adults. Gait Posture 34: 111-118.
35. Dietz V (2003) Spinal cord pattern generators for locomotion. Clin Neurophysiol 114: 1379-1389.
36. Al-Yahya E, Dawes H, Smith L, Dennis A, Howells K, et al. (2011) Cognitive motor interference while walking: a systematic review and meta-analysis. Neurosci Biobehav Rev 35: 715-728.
37. Ikram MA, Vrooman HA, Vernooij MW, van der Lijn F, Hofman A, et al. (2008) Brain tissue volumes in the general elderly population. The Rotterdam Scan Study. Neurobiol Aging 29: 882-890. (Pubitemid 351601893)
38. Leritz EC, Salat DH, Williams VJ, Schnyer DM, Rudolph JL, et al. (2011) Thickness of the human cerebral cortex is associated with metrics of cerebrovascular health in a normative sample of community dwelling older adults. Neuroimage 54: 2659-2671.
39. Meyer JS, Terayama Y, Konno S, Akiyama H, Margishvili GM, et al. (1998) Risk factors for cerebral degenerative changes and dementia. Eur Neurol 39 Suppl 1: 7-16. (Pubitemid 28075311)
40. Hampel H, Burger K, Teipel SJ, Bokde AL, Zetterberg H, et al. (2008) Core candidate neurochemical and imaging biomarkers of Alzheimer's disease. Alzheimers Dement 4: 38-48.
41. Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, et al. (2010) Brain atrophy in healthy aging is related to CSF levels of Abeta1-42. Cereb Cortex 20: 2069-2079.
42. Mitchell GF (2008) Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage. J Appl Physiol (1985) 105: 1652-1660.
43. Seidler RD, Bernard JA, Burutolu TB, Fling BW, Gordon MT, et al. (2010) Motor control and aging: links to age-related brain structural, functional, and biochemical effects. Neurosci Biobehav Rev 34: 721-733.
44. Colcombe SJ, Erickson KI, Scalf PE, Kim JS, Prakash R, et al. (2006) Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci 61: 1166-1170. (Pubitemid 46034467)
45. Hausdorff JM, Rios DA, Edelberg HK (2001) Gait variability and fall risk in community-living older adults: a 1-year prospective study. Arch Phys Med Rehabil 82: 1050-1056. (Pubitemid 32744331)