Determination of warfarin alcohols by ultra-high performance liquid chromatography-tandem mass spectrometry: Application to in vitro enzyme kinetic studies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 944, Issue , 2014, Pages 63-68

  Alshogran, Osama Y ^a   Ocque, Andrew J ^a   Zhao, Jielu ^a   Day, Billy W ^a   Leblond, François A ^b   Pichette, Vincent ^b,c   Nolin, Thomas D ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Enzyme kinetics; LC MS; Reduction; Warfarin; Warfarin alcohols

Indexed keywords

ELECTROSPRAY IONIZATION; ENZYME KINETICS; FORMIC ACID; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETIC THEORY; KINETICS; LIQUIDS; MASS SPECTROMETRY; METABOLITES; ORGANIC SOLVENTS; REDUCTION;

CHROMATOGRAPHIC SEPARATIONS; HEATED ELECTROSPRAY IONIZATION; LC-MS; LIQUID-LIQUID EXTRACTION; METHYL TERT BUTYL ETHER; SELECTED REACTION MONITORING; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES; WARFARIN;

DRUG PRODUCTS;

ALCOHOL; FORMIC ACID; TERT BUTYL METHYL ETHER; WARFARIN;

ACCURACY; ACIDIFICATION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOLIC FRACTION; DRUG DETERMINATION; DRUG TISSUE LEVEL; ELECTROSPRAY; ELUTION; ENZYME KINETICS; FLOW RATE; IN VITRO STUDY; INCUBATION TIME; LIQUID LIQUID EXTRACTION; LIVER; NONHUMAN; PH; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ENZYME KINETICS; LC-MS; REDUCTION; WARFARIN; WARFARIN ALCOHOLS;

ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; KINETICS; LIVER; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; WARFARIN;

EID: 84897006040     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.11.014     Document Type: Article

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