Determination of unbound warfarin enantiomers in human plasma and 7- hydroxywarfarin in human urine by chiral stationary-phase liquid chromatography with ultraviolet or fluorescence and on-line circular dichroism detection

Journal of Chromatography B: Biomedical Applications

Volumn 701, Issue 1, 1997, Pages 71-80

  Takahashi, Harumi ^a   Kashima, Toshitaka ^b   Kimura, Sosuke ^b   Muramoto, Nagisa ^a   Nakahata, Hiromi ^a   Kubo, Suzuko ^c   Shimoyama, Yoshiaki ^c   Kajiwara, Masahiro ^a   Echizen, Hirotoshi ^a  

^a MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^c Institute of Clinical Research   (Japan)

Author keywords

7 Hydroxywarfarin; Enantiomer separation; Warfarin

Indexed keywords

BETA GLUCURONIDASE; DICLOFENAC; DRUG METABOLITE; NAPROXEN; SULFATASE; WARFARIN;

ARTICLE; CHIRAL CHROMATOGRAPHY; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HYDROXYLATION; DRUG URINE LEVEL; ENANTIOMER; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ONLINE SYSTEM; PRIORITY JOURNAL; ULTRAFILTRATION; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTICOAGULANTS; BLOOD PROTEINS; CHROMATOGRAPHY, LIQUID; CIRCULAR DICHROISM; HUMANS; PROTEIN BINDING; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM; WARFARIN;

EID: 0030826062     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(97)00346-0     Document Type: Article

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