Phenotypic modulation of smooth muscle cells by chemical and mechanical cues of electrospun tecophilic/gelatin nanofibers

ACS Applied Materials and Interfaces

Volumn 6, Issue 6, 2014, Pages 4089-4101

  Vatankhah, Elham ^a,b   Prabhakaran, Molamma P ^b   Semnani, Dariush ^a   Razavi, Shahnaz ^c   Zamani, Maedeh ^b   Ramakrishna, Seeram ^b  

^a ISFAHAN UNIVERSITY OF TECHNOLOGY   (Iran)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

contractile phenotype; electrospun scaffold; ligand density; stiffness

Indexed keywords

CELL PROLIFERATION; CELLS; LIGANDS; NANOFIBERS; STIFFNESS; TISSUE;

CONTRACTILE BEHAVIOR; CONTRACTILE PHENOTYPE; ELECTROSPUN SCAFFOLDS; LIGAND DENSITY; PHENOTYPIC MODULATION; PHYSICAL ADSORPTION; SMOOTH MUSCLE CELLS; TISSUE ENGINEERED VASCULAR GRAFTS;

SCAFFOLDS (BIOLOGY);

GELATIN; NANOFIBER; TISSUE SCAFFOLD;

ARTICLE; BIOMECHANICS; CELL CULTURE; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; EQUIPMENT; PHENOTYPE; SMOOTH MUSCLE FIBER; TISSUE ENGINEERING;

BIOMECHANICAL PHENOMENA; CELL PROLIFERATION; CELLS, CULTURED; GELATIN; MYOCYTES, SMOOTH MUSCLE; NANOFIBERS; PHENOTYPE; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84896991473     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/am405673h     Document Type: Article

References (55)

1. Han, Y.; Deng, J.; Guo, L.; Yan, C.; Liang, M.; Kang, J.; Liu, H.; Graham, A. M.; Li, S. CREG Promotes a Mature Smooth Muscle Cell Phenotype and Reduces Neointimal Formation in Balloon-injured Rat Carotid Artery Cardiovasc. Res. 2008, 78, 597-604
2. Chan-Park, M. B.; Shen, J. Y.; Cao, Y.; Xiong, Y.; Liu, Y.; Rayatpisheh, S.; Kang, G. C.-W.; Greisler, H. P. Biomimetic Control of Vascular Smooth Muscle Cell Morphology and Phenotype for Functional Tissue-Engineered Small-Diameter Blood Vessels J. Biomed. Mater. Res., A 2009, 88A, 1104-1121
3. Thakar, R. G.; Cheng, Q.; Patel, S.; Chu, J.; Nasir, M.; Liepmann, D.; Komvopoulos, K.; Li, S. Cell-Shape Regulation of Smooth Muscle Cell Proliferation Biophys. J. 2009, 96, 3423-3432
4. Blit, P. H.; Battiston, K. G.; Yang, M.; Paul Santerre, J.; Woodhouse, K. A. Electrospun Elastin-Like Polypeptide Enriched Polyurethanes and Their Interactions with Vascular Smooth Muscle Cells Acta Biomater. 2012, 8, 2493-2503
5. Mason, B. N.; Califano, J. P.; Reinhart-King, C. A. Matrix Stiffness: A Regulator of Cellular Behavior and Tissue Formation. In Engineering Biomaterials for Regenerative Medicine; Bhatia, S. K., Ed.; Springer: New York, 2012; pp 19-37.
6. Greenwald, S. E.; Berry, C. L. Improving Vascular Grafts: The Importance of Mechanical and Haemodynamic Properties J. Pathol. 2000, 190, 292-299
7. Lee, S. J.; Yoo, J. J.; Lim, G. J.; Atala, A.; Stitzel, J. In Vitro Evaluation of Electrospun Nanofiber Scaffolds for Vascular Graft Application J. Biomed. Mater. Res., A 2007, 83A, 999-1008
8. Stegemann, J. P.; Hong, H.; Nerem, R. M. Mechanical, Biochemical, and Extracellular Matrix Effects on Vascular Smooth Muscle Cell Phenotype J. Appl. Physiol. 2005, 98, 2321-2327
9. Gunatillake, P. A.; Martin, D. J.; Meijs, G. F.; McCarthy, S. J.; Adhikari, R. Designing Biostable Polyurethane Elastomers for Biomedical Implants Aust. J. Chem. 2003, 56, 545-557
10. Kampeerapappun, P. The Design, Characterization, and Application of Polyurethane Dressing Using the Electrospinning Process. Ph.D. Dissertation, The University of Akron, Akron, Ohio, 2008.
11. Chong, E. J.; Phan, T. T.; Lim, I. J.; Zhang, Y. Z.; Bay, B. H.; Ramakrishna, S.; Lim, C. T. Evaluation of Electrospun PCL/Gelatin Nanofibrous Scaffold for Wound Healing and Layered Dermal Reconstitution Acta Biomater. 2007, 3, 321-330
12. Aubin, H.; Nichol, J. W.; Hutson, C. B.; Bae, H.; Sieminski, A. L.; Cropek, D. M.; Akhyari, P.; Khademhosseini, A. Directed 3D Cell Alignment and Elongation in Microengineered Hydrogels Biomaterials 2010, 31, 6941-6951
13. Srichatrapimuk, V. W.; Cooper, S. L. Infrared Thermal Analysis of Polyurethane Block Polymers J. Macromol. Sci. B 1978, 15, 267-311
14. McCarthy, S. J.; Meijs, G. F.; Mitchell, N.; Gunatillake, P. A.; Heath, G.; Brandwood, A.; Schindhelm, K. In-vivo Degradation of Polyurethanes: Transmission-FTIR Microscopic Characterization of Polyurethanes Sectioned by Cryomicrotomy Biomaterials 1997, 18, 1387-1409
15. Shanmugam, T.; Nasar, A. S. Novel Hyperbranched Poly(aryl ether urethane)s Using AB2-Type Blocked Isocyanate Monomers and Copolymerization with AB-Type Monomers Macromol. Chem. Phys. 2008, 209, 651-665
16. Kim, S. E.; Heo, D. N.; Lee, J. B.; Kim, J. R.; Park, S. H.; Jeon, S. H.; Kwon, I. K. Electrospun Gelatin/Polyurethane Blended Nanofibers for Wound Healing Biomed. Mater. 2009, 4, 044106
17. Meng, Z. X.; Wang, Y. S.; Ma, C.; Zheng, W.; Li, L.; Zheng, Y. F. Electrospinning of PLGA/Gelatin Randomly-Oriented and Aligned Nanofibers as Potential Scaffold in Tissue Engineering Mater. Sci. Eng., C 2010, 30, 1204-1210
18. Ki, C. S.; Baek, D. H.; Gang, K. D.; Lee, K. H.; Um, I. C.; Park, Y. H. Characterization of Gelatin Nanofiber Prepared from Gelatin-Formic Acid Solution Polymer 2005, 46, 5094-5102
19. Jia, L.; Prabhakaran, M.; Qin, X.; Kai, D.; Ramakrishna, S. Biocompatibility Evaluation of Protein-Incorporated Electrospun Polyurethane-Based Scaffolds with Smooth Muscle Cells for Vascular Tissue Engineering J. Mater. Sci. 2013, 48, 5113-5124
20. Ebersole, G. C.; Paranjape, H.; Anderson, P. M.; Powell, H. M. Influence of Hydration on Fiber Geometry in Electrospun Scaffolds Acta Biomater. 2012, 8, 4342-4348
21. Kao, P. H.; Lammers, S. R.; Hunter, K.; Stenmark, K. R.; Shandas, R.; Qi, H. J. Constitutive Modeling of Anisotropic Finite-Deformation Hyperelastic Behaviors of Soft Materials Reinforced by Tortuous Fibers Int. J. Struct. Changes Solid 2010, 2, 19-29
22. Ohmura, J. Effects of Elastic Modulus on Single Fiber Uniaxial Deformation. Undergraduate Honors Thesis, The Ohio State University, Columbus, OH, 2011.
23. Ping, Z. H.; Nguyen, Q. T.; Chen, S. M.; Zhou, J. Q.; Ding, Y. D. States of Water in Different Hydrophilic Polymers - DSC and FTIR Studies Polymer 2001, 42, 8461-8467
24. Vatankhah, E.; Prabhakaran, M. P.; Jin, G.; Mobarakeh, L. G.; Ramakrishna, S. Development of Nanofibrous Cellulose Acetate/Gelatin Skin Substitutes for Variety Wound Treatment Applications J. Biomater. Appl. 2014, 28, 909-921
25. Vatankhah, E.; Semnani, D.; Prabhakaran, M. P.; Tadayon, M.; Razavi, S.; Ramakrishna, S. Artificial Neural Network for Modeling the Elastic Modulus of Electrospun Polycaprolactone/Gelatin Scaffolds Acta Biomater. 2014, 10, 709-721
26. Rensen, S. S. M.; Doevendans, P. A. F. M.; Eys, G. J. J. M. Regulation and Characteristics of Vascular Smooth Muscle Cell Phenotypic Diversity Neth. Heart J. 2007, 15, 100-108
27. Wanjare, M.; Kuo, F.; Gerecht, S. Derivation and Maturation of Synthetic and Contractile Vascular Smooth Muscle Cells from Human Pluripotent Stem Cells Cardiovasc. Res. 2013, 97, 321-330
28. Brown, X. Q.; Bartolak-Suki, E.; Williams, C.; Walker, M. L.; Weaver, V. M.; Wong, J. Y. Effect of Substrate Stiffness and PDGF on the Behavior of Vascular Smooth Muscle Cells: Implications for Atherosclerosis J. Cell Physiol. 2010, 225, 115-122
29. Boettger, T.; Beetz, N.; Kostin, S.; Schneider, J.; Krüger M, M.; Hein, L.; Braun, T. Acquisition of the Contractile Phenotype by Murine Arterial Smooth Muscle Cells Depends on the Mir143/145 Gene Cluster J. Clin. Invest. 2009, 119, 2634-2647
30. Beamish, J. A.; He, P.; Kottke-Marchant, K.; Marchant, R. E. Molecular Regulation of Contractile Smooth Muscle Cell Phenotype: Implications for Vascular Tissue Engineering Tissue Eng., Part B 2010, 16, 467-491
31. Shinohara, S.; Shinohara, S.; Kihara, T.; Miyake, J. Regulation of Differentiated Phenotypes of Vascular Smooth Muscle Cells. In Current basic and pathological approaches to the function of muscle cells and tissues-from molecules to humans; Sugi, H., Ed.; InTech: Rijeka, Croatia, 2012; pp 331-344.
32. Owens, G. K. Regulation of Differentiation of Vascular Smooth Muscle Cells Physiol. Rev. 1995, 75, 487-517
33. Hayashi, K. i.; Saga, H.; Chimori, Y.; Kimura, K.; Yamanaka, Y.; Sobue, K. Differentiated Phenotype of Smooth Muscle Cells Depends on Signaling Pathways through Insulin-like Growth Factors and Phosphatidylinositol 3-Kinase J. Biol. Chem. 1998, 273, 28860-28867
34. Hayashi, K. i.; Takahashi, M.; Kimura, K.; Nishida, W.; Saga, H.; Sobue, K. Changes in the Balance of Phosphoinositide 3-Kinase/Protein Kinase B (Akt) and the Mitogen-activated Protein Kinases (ERK/p38MAPK) Determine a Phenotype of Visceral and Vascular Smooth Muscle Cells J. Cell Biol. 1999, 145, 727-740
35. Schauwienold, D.; Plum, C.; Helbing, T.; Voigt, P.; Bobbert, T.; Hoffmann, D.; Paul, M.; Reusch, H. P. ERK1/2-Dependent Contractile Protein Expression in Vascular Smooth Muscle Cells Hypertension 2003, 41, 546-552
36. Fisher, S. A. Vascular Smooth Muscle Phenotypic Diversity and Function Physiol. Genomics 2010, 42A, 169-187
37. Kim, B.-S.; Nikolovski, J.; Bonadio, J.; Smiley, E.; Mooney, D. J. Engineered Smooth Muscle Tissues: Regulating Cell Phenotype with the Scaffold Exp. Cell Res. 1999, 251, 318-328
38. Discher, D. E.; Janmey, P.; Wang, Y.-l. Tissue Cells Feel and Respond to the Stiffness of Their Substrate Science 2005, 310, 1139-1143
39. Wong, J. Y.; Velasco, A.; Rajagopalan, P.; Pham, Q. Directed Movement of Vascular Smooth Muscle Cells on Gradient-Compliant Hydrogels Langmuir 2003, 19, 1908-1913
40. Engler, A.; Bacakova, L.; Newman, C.; Hategan, A.; Griffin, M.; Discher, D. Substrate Compliance versus Ligand Density in Cell on Gel Responses Biophys. J. 2004, 86, 617-628
41. Peyton, S. R.; Putnam, A. J. Extracellular Matrix Rigidity Governs Smooth Muscle Cell Motility in a Biphasic Fashion J. Cell. Physiol. 2005, 204, 198-209
42. Isenberg, B. C.; DiMilla, P. A.; Walker, M.; Kim, S.; Wong, J. Y. Vascular Smooth Muscle Cell Durotaxis Depends on Substrate Stiffness Gradient Strength Biophys. J. 2009, 97, 1313-1322
43. Brown, X. Q.; Ookawa, K.; Wong, J. Y. Evaluation of Polydimethylsiloxane Scaffolds with Physiologically-Relevant Elastic Moduli: Interplay of Substrate Mechanics and Surface Chemistry Effects on Vascular Smooth Muscle Cell Response Biomaterials 2005, 26, 3123-3129
44. Peyton, S. R.; Raub, C. B.; Keschrumrus, V. P.; Putnam, A. J. The Use of Poly(ethylene glycol) Hydrogels to Investigate the Impact of ECM Chemistry and Mechanics on Smooth Muscle Cells Biomaterials 2006, 27, 4881-4893
45. Peyton, S. R.; Kim, P. D.; Ghajar, C. M.; Seliktar, D.; Putnam, A. J. The Effects of Matrix Stiffness and RhoA on the Phenotypic Plasticity of Smooth Muscle Cells in a 3-D Biosynthetic Hydrogel System Biomaterials 2008, 29, 2597-2607
46. McDaniel, D. P.; Shaw, G. A.; Elliott, J. T.; Bhadriraju, K.; Meuse, C.; Chung, K.-H.; Plant, A. L. The Stiffness of Collagen Fibrils Influences Vascular Smooth Muscle Cell Phenotype Biophys. J. 2007, 92, 1759-1769
47. Wingate, K.; Bonani, W.; Tan, Y.; Bryant, S. J.; Tan, W. Compressive Elasticity of Three-Dimensional Nanofiber Matrix Directs Mesenchymal Stem Cell Differentiation to Vascular Cells with Endothelial or Smooth Muscle Cell Markers Acta Biomater. 2012, 8, 1440-1449
48. Vaz, C. M.; van Tuijl, S.; Bouten, C. V. C.; Baaijens, F. P. T. Design of Scaffolds for Blood Vessel Tissue Engineering Using a Multi-Layering Electrospinning Technique Acta Biomater. 2005, 1, 575-582
49. Zhang, X.; Thomas, V.; Xu, Y.; Bellis, S. L.; Vohra, Y. K. An In Vitro Regenerated Functional Human Endothelium on a Nanofibrous Electrospun Scaffold Biomaterials 2010, 31, 4376-4381
50. Wang, H.; Feng, Y.; Fang, Z.; Yuan, W.; Khan, M. Co-electrospun Blends of PU and PEG as Potential Biocompatible Scaffolds for Small-Diameter Vascular Tissue Engineering Mater. Sci. Eng., C 2012, 32, 2306-2315
51. Wong, J. Y.; Leach, J. B.; Brown, X. Q. Balance of Chemistry, Topography, and Mechanics at the Cell-Biomaterial Interface: Issues and Challenges for Assessing the Role of Substrate Mechanics on Cell Response Surf. Sci. 2004, 570, 119-133
52. Hajiali, H.; Shahgasempour, S.; Naimi-Jamal, M. R.; Peirovi, H. Electrospun PGA/Gelatin Nanofibrous Scaffolds and Their Potential Application in Vascular Tissue Engineering Int. J. Nanomed. 2011, 6, 2133-2141
53. Huang, Z.-M.; Zhang, Y. Z.; Ramakrishna, S.; Lim, C. T. Electrospinning and Mechanical Characterization of Gelatin Nanofibers Polymer 2004, 45, 5361-5368
54. Hedin, U.; Bottger, B. A.; Luthman, J.; Johansson, S.; Thyberg, J. A Substrate of the Cell-Attachment Sequence of Fibronectin (Arg-Gly-Asp-Ser) Is Sufficient to Promote Transition of Arterial Smooth Muscle Cells from a Contractile to a Synthetic Phenotype Dev. Biol. 1989, 133, 489-501
55. Beamish, J. A.; Fu, A. Y.; Choi, A.-j.; Haq, N. A.; Kottke-Marchant, K.; Marchant, R. E. The Influence of RGD-Bearing Hydrogels on the Re-expression of Contractile Vascular Smooth Muscle Cell Phenotype Biomaterials 2009, 30, 4127-4135