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Volumn 42, Issue 2, 2014, Pages 450-456

Methylglyoxal in diabetes: Link to treatment, glycaemic control and biomarkers of complications

Author keywords

Advanced glycation end product (AGE); Diabetic complication; Glycaemic fluctuation; Mass spectrometry; Metformin; Methylglyoxal

Indexed keywords

ADVANCED GLYCATION END PRODUCT; AMINOGUANIDINE; BIOLOGICAL MARKER; GLUCOSE; GLYOXAL; GLYOXALASE; HEMOGLOBIN A1C; METFORMIN; METHYLGLYOXAL;

EID: 84896979660     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20130275     Document Type: Review
Times cited : (45)

References (59)
  • 1
    • 58149269716 scopus 로고    scopus 로고
    • Projection of diabetic retinopathy and other major eye diseases among people with diabetes mellitus: United States, 2005-2050
    • Saaddine, J.B., Honeycutt, A.A., Narayan, K.M., Zhang, X., Klein, R. and Boyle, J.P. (2008) Projection of diabetic retinopathy and other major eye diseases among people with diabetes mellitus: United States, 2005-2050. Arch. Ophthalmol. 126, 1740-1747
    • (2008) Arch. Ophthalmol. , vol.126 , pp. 1740-1747
    • Saaddine, J.B.1    Honeycutt, A.A.2    Narayan, K.M.3    Zhang, X.4    Klein, R.5    Boyle, J.P.6
  • 3
    • 35348919453 scopus 로고    scopus 로고
    • The Metabolic Syndrome and the Impact of Diabetes on Coronary Heart Disease Mortality in Women and Men: The San Antonio Heart Study
    • DOI 10.1016/j.annepidem.2007.05.012, PII S1047279707002165
    • Hunt, K.J., Williams, K., Hazuda, H.P., Stern, M.P. and Haffner, S.M. (2007) The metabolic syndrome and the impact of diabetes on coronary heart disease mortality in women and men: the San Antonio Heart Study. Ann. Epidemiol. 17, 870-877 (Pubitemid 47588953)
    • (2007) Annals of Epidemiology , vol.17 , Issue.11 , pp. 870-877
    • Hunt, K.J.1    Williams, K.2    Hazuda, H.P.3    Stern, M.P.4    Haffner, S.M.5
  • 5
    • 0030725948 scopus 로고    scopus 로고
    • Clustering of long-term complications in families with diabetes in the Diabetes Control and Complications Trial
    • The Diabetes Control and Complications Trial Research Group
    • The Diabetes Control and Complications Trial Research Group (1997) Clustering of long-term complications in families with diabetes in the Diabetes Control and Complications Trial. Diabetes 46, 1829-1839
    • (1997) Diabetes , vol.46 , pp. 1829-1839
  • 6
    • 0033025091 scopus 로고    scopus 로고
    • Is diabetic nephropathy inherited? Studies of glomerular structure in type 1 diabetic sibling pairs
    • Fioretto, P., Steffes, M.W., Barbosa, J., Rich, S.S., Miller, M.E. and Mauer, M. (1999) Is diabetic nephropathy inherited? Studies of glomerular structure in type 1 diabetic sibling pairs. Diabetes 48, 865-869 (Pubitemid 29153088)
    • (1999) Diabetes , vol.48 , Issue.4 , pp. 865-869
    • Fioretto, P.1    Steffes, M.W.2    Barbosa, J.3    Rich, S.S.4    Miller, M.E.5    Mauer, M.6
  • 7
    • 0024559825 scopus 로고
    • Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy
    • Seaquist, E.R., Goetz, F.C., Rich, S. and Barbosa, J. (1989) Familial clustering of diabetic kidney disease: evidence for genetic susceptibility to diabetic nephropathy. N. Engl. J. Med. 320, 1161-1165 (Pubitemid 19124296)
    • (1989) New England Journal of Medicine , vol.320 , Issue.18 , pp. 1161-1165
    • Seaquist, E.R.1    Goetz, F.C.2    Rich, S.3    Barbosa, J.4
  • 8
    • 0021050961 scopus 로고
    • Diabetic nephropathy in type 1 (insulin-dependent) diabetes: An epidemiological study
    • Andersen, A.R., Christiansen, J.S., Andersen, J.K., Kreiner, S. and Deckert, T. (1983) Diabetic nephropathy in Type 1 (insulin-dependent) diabetes: an epidemiological study. Diabetologia 25, 496-501 (Pubitemid 14200886)
    • (1983) Diabetologia , vol.25 , Issue.6 , pp. 496-501
    • Andersen, A.R.1    Sandahl, C.J.2    Andersen, J.K.3
  • 9
    • 84862649086 scopus 로고
    • Epidemiologic approach to the etiology of Type I diabetes mellitus and its complications
    • Krolewski, A.J., Warram, J.H., Kahn, R., Kahn, L.I. and Kahn, C.R. (1987) Epidemiologic approach to the etiology of Type I diabetes mellitus and its complications. N. Engl. J. Med. 18, 267-273
    • (1987) N. Engl. J. Med. , vol.18 , pp. 267-273
    • Krolewski, A.J.1    Warram, J.H.2    Kahn, R.3    Kahn, L.I.4    Kahn, C.R.5
  • 10
    • 0029094533 scopus 로고
    • 1c) to the risk of development and progression of retinopathy in the diabetes control and complications trial
    • The Diabetes Control and Complications Trial Research Group
    • 1c) to the risk of development and progression of retinopathy in the diabetes control and complications trial. Diabetes 44, 968-983
    • (1995) Diabetes , vol.44 , pp. 968-983
  • 11
    • 0031665831 scopus 로고    scopus 로고
    • The importance of hyperglycemia in the nonfasting state to the development of cardiovascular disease
    • Haffner, S.M. (1998) The importance of hyperglycemia in the nonfasting state to the development of cardiovascular disease. Endocr. Rev. 19, 583-592
    • (1998) Endocr. Rev. , vol.19 , pp. 583-592
    • Haffner, S.M.1
  • 12
    • 0032515775 scopus 로고    scopus 로고
    • Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23)
    • Turner, R.C., Millns, H., Neil, H.A., Stratton, I.M., Manley, S.E., Matthews, D.R. and Holman, R.R. (1998) Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23). BMJ 316, 823-828 (Pubitemid 28112428)
    • (1998) British Medical Journal , vol.316 , Issue.7134 , pp. 823-828
    • Turner, R.C.1    Millns, H.2    Neil, H.A.W.3    Stratton, I.M.4    Manley, S.E.5    Matthews, D.R.6    Holman, R.R.7
  • 13
    • 39149145482 scopus 로고    scopus 로고
    • Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004
    • Ong, K.L., Cheung, B.M., Wong, L.Y., Wat, N.M., Tan, K.C. and Lam, K.S. (2008) Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004. Ann. Epidemiol. 18, 222-229
    • (2008) Ann. Epidemiol. , vol.18 , pp. 222-229
    • Ong, K.L.1    Cheung, B.M.2    Wong, L.Y.3    Wat, N.M.4    Tan, K.C.5    Lam, K.S.6
  • 14
    • 64849088474 scopus 로고    scopus 로고
    • Unchanged incidence of microalbuminuria in children with type 1 diabetes since 1986: A UK based inception cohort
    • Amin, R., Widmer, B., Dalton, R.N. and Dunger, D.B. (2009) Unchanged incidence of microalbuminuria in children with type 1 diabetes since 1986: a UK based inception cohort. Arch. Dis. Child. 94, 258-262
    • (2009) Arch. Dis. Child. , vol.94 , pp. 258-262
    • Amin, R.1    Widmer, B.2    Dalton, R.N.3    Dunger, D.B.4
  • 15
    • 34848815430 scopus 로고    scopus 로고
    • Changes in glycaemic control and risk of coronary artery disease in type 1 diabetes mellitus: Findings from the Pittsburgh Epidemiology of Diabetes Complications Study (EDC)
    • DOI 10.1007/s00125-007-0797-7
    • Prince, C.T., Becker, D.J., Costacou, T., Miller, R.G. and Orchard, T.J. (2007) Changes in glycaemic control and risk of coronary artery disease in type 1 diabetes mellitus: findings from the Pittsburgh Epidemiology of Diabetes Complications Study (EDC). Diabetologia 50, 2280-2288 (Pubitemid 47512402)
    • (2007) Diabetologia , vol.50 , Issue.11 , pp. 2280-2288
    • Prince, C.T.1    Becker, D.J.2    Costacou, T.3    Miller, R.G.4    Orchard, T.J.5
  • 16
    • 47249106993 scopus 로고    scopus 로고
    • Biomarker discovery for kidney diseases by mass spectrometry
    • Niwa, T. (2008) Biomarker discovery for kidney diseases by mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 870, 148-153
    • (2008) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , vol.870 , pp. 148-153
    • Niwa, T.1
  • 17
    • 42549126759 scopus 로고    scopus 로고
    • The role of the Amadori product in the complications of diabetes
    • DOI 10.1196/annals.1433.052, The Maillard Reaction Recent Advances in Food and Biomedical Sciences
    • Monnier, V.M., Sell, D.R., Dai, Z., Nemet, I., Collard, F. and Zhang, J. (2008) The role of the Amadori product in the complications of diabetes. Ann. N.Y. Acad. Sci. 1126, 81-88 (Pubitemid 351589314)
    • (2008) Annals of the New York Academy of Sciences , vol.1126 , pp. 81-88
    • Monnier, V.M.1    Sell, D.R.2    Dai, Z.3    Nemet, I.4    Collard, F.5    Zhang, J.6
  • 18
    • 23744467295 scopus 로고    scopus 로고
    • Glycation products as markers and predictors of the progression of diabetic complications
    • DOI 10.1196/annals.1333.065
    • Monnier, V.M., Sell, D.R. and Genuth, S. (2005) Glycation products as markers and predictors of the progression of diabetic complications. Ann. N.Y. Acad. Sci. 1043, 567-581 (Pubitemid 41123947)
    • (2005) Annals of the New York Academy of Sciences , vol.1043 , pp. 567-581
    • Monnier, V.M.1    Sell, D.R.2    Genuth, S.3
  • 19
    • 0034659178 scopus 로고    scopus 로고
    • Glycoxidation and lipoxidation in atherogenesis
    • DOI 10.1016/S0891-5849(00)00228-8, PII S0891584900002288
    • Baynes, J.W. and Thorpe, S.R. (2000) Glycoxidation and lipoxidation in atherogenesis. Free Radic. Biol. Med. 28, 1708-1716 (Pubitemid 30628657)
    • (2000) Free Radical Biology and Medicine , vol.28 , Issue.12 , pp. 1708-1716
    • Baynes, J.W.1    Thorpe, S.R.2
  • 22
    • 28244432123 scopus 로고    scopus 로고
    • Preparation of specific antibodies against CML, one of the major AGE structures
    • Nagai, R., Johno, T., Miyazaki, K. and Horiuchi, S. (2000) Preparation of specific antibodies against CML, one of the major AGE structures. Diabetes 49 (Suppl. 1), A144
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Nagai, R.1    Johno, T.2    Miyazaki, K.3    Horiuchi, S.4
  • 24
    • 33845477518 scopus 로고    scopus 로고
    • Skin autofluorescence as a noninvasive marker of vascular damage in patients with type 2 diabetes
    • DOI 10.2337/dc05-2173
    • Lutgers, H.L., Graaff, R., Links, T.P., Ubink-Veltmaat, L.J., Bilo, H.J., Gans, R.O. and Smit, A.J. (2006) Skin autofluorescence as a noninvasive marker of vascular damage in patients with type 2 diabetes. Diabetes Care 29, 2654-2659 (Pubitemid 44912194)
    • (2006) Diabetes Care , vol.29 , Issue.12 , pp. 2654-2659
    • Lutgers, H.L.1    Graaff, R.2    Links, T.P.3    Ubink-Veltmaat, L.J.4    Bilo, H.J.5    Gans, R.O.6    Smit, A.J.7
  • 25
    • 84858433338 scopus 로고    scopus 로고
    • 1c, vascular and tissue markers
    • 1c, vascular and tissue markers. Transl. Res. 159, 303-312
    • (2012) Transl. Res. , vol.159 , pp. 303-312
    • Lyons, T.1    Basu, A.2
  • 26
    • 0242468729 scopus 로고    scopus 로고
    • Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry
    • DOI 10.1042/BJ20030763
    • Thornalley, P.J., Battah, S., Ahmed, N., Karachalias, N., Agalou, S., Babaei-Jadidi, R. and Dawnay, A. (2003) Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry. Biochem. J. 375, 581-592 (Pubitemid 37433506)
    • (2003) Biochemical Journal , vol.375 , Issue.3 , pp. 581-592
    • Thornalley, P.J.1    Battah, S.2    Ahmed, N.3    Karachalias, N.4    Agalou, S.5    Babaei-Jadidi, R.6    Dawnay, A.7
  • 27
    • 0032913309 scopus 로고    scopus 로고
    • Role of oxidative stress in diabetic complications: A new perspective on an old paradigm
    • DOI 10.2337/diabetes.48.1.1
    • Baynes, J. and Thorpe, S. (1999) Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 48, 1-9 (Pubitemid 29019345)
    • (1999) Diabetes , vol.48 , Issue.1 , pp. 1-9
    • Baynes, J.W.1    Thorpe, S.R.2
  • 28
    • 33644667584 scopus 로고    scopus 로고
    • Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress
    • DOI 10.2337/diabetes.54.11.3274
    • Beisswenger, P., Drummond, K., Nelson, R., Howell, S., Szwergold, B. and Mauer, M. (2005) Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress. Diabetes 54, 3274-3281 (Pubitemid 43334385)
    • (2005) Diabetes , vol.54 , Issue.11 , pp. 3274-3281
    • Beisswenger, P.J.1    Drummond, K.S.2    Nelson, R.G.3    Howell, S.K.4    Szwergold, B.S.5    Mauer, M.6
  • 29
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications: A unifying mechanism
    • Brownlee, M. (2005) The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54, 1615-1625
    • (2005) Diabetes , vol.54 , pp. 1615-1625
    • Brownlee, M.1
  • 30
    • 22444447985 scopus 로고    scopus 로고
    • Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes
    • DOI 10.1007/s00125-005-1810-7
    • Ahmed, N., Babaei-Jadidi, R., Howell, S., Beisswenger, P. and Thornalley, P. (2005) Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes. Diabetologia 48, 1590-1603 (Pubitemid 41175513)
    • (2005) Diabetologia , vol.48 , Issue.8 , pp. 1590-1603
    • Ahmed, N.1    Babaei-Jadidi, R.2    Howell, S.K.3    Beisswenger, P.J.4    Thornalley, P.J.5
  • 31
    • 25644440026 scopus 로고    scopus 로고
    • Glycated and oxidized protein degradation products are indicators of fasting and postprandial hyperglycemia in diabetes
    • DOI 10.2337/diacare.28.10.2465
    • Ahmed, N., Babaei-Jadidi, R., Howell, S., Thornalley, P. and Beisswenger, P. (2005) Glycated and oxidised protein degradation products are indicators of fasting and postprandial hyperglycemia in diabetes. Diabetes Care 28, 2465-2471 (Pubitemid 41384295)
    • (2005) Diabetes Care , vol.28 , Issue.10 , pp. 2465-2471
    • Ahmed, N.1    Babaei-Jadidi, R.2    Howell, S.K.3    Thornalley, P.J.4    Beisswenger, P.J.5
  • 32
    • 84888108332 scopus 로고    scopus 로고
    • Early progression of diabetic nephropathy correlates with methylglyoxal derived advanced glycation end products (AGEs)
    • Beisswenger, P.J., Howell, S., Mauer, M., Russell, G., Miller, M. and Rich, S. (2013) Early progression of diabetic nephropathy correlates with methylglyoxal derived advanced glycation end products (AGEs). Diabetes Care 36, 3234-3239
    • (2013) Diabetes Care , vol.36 , pp. 3234-3239
    • Beisswenger, P.J.1    Howell, S.2    Mauer, M.3    Russell, G.4    Miller, M.5    Rich, S.6
  • 34
    • 0037097039 scopus 로고    scopus 로고
    • Acarbose for prevention of type 2 diabetes mellitus: The STOP-NIDDM randomised trial
    • DOI 10.1016/S0140-6736(02)08905-5
    • Chiasson, J.L., Josse, R.G., Gomis, R., Hanefeld, M., Karasik, A. and Laakso, M. (2002) Acarbose for prevention of Type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet 359, 2072-2077 (Pubitemid 34680970)
    • (2002) Lancet , vol.359 , Issue.9323 , pp. 2072-2077
    • Chiasson, J.-L.1    Josse, R.G.2    Gomis, R.3    Hanefeld, M.4    Karasik, A.5    Laakso, M.6
  • 35
    • 0033592101 scopus 로고    scopus 로고
    • Glucose tolerance and mortality: Comparison of WHO and American Diabetes Association diagnostic criteria
    • The DECODE study group on behalf of the Europe and Diabetes Epidemiology Group
    • The DECODE study group on behalf of the Europe and Diabetes Epidemiology Group (1999) Glucose tolerance and mortality: comparison of WHO and American Diabetes Association diagnostic criteria. Lancet 354, 617-621
    • (1999) Lancet , vol.354 , pp. 617-621
  • 36
    • 0036733143 scopus 로고    scopus 로고
    • In search of normoglycaemia in diabetes: Controlling postprandial glucose
    • Del Prato, S. (2002) In search of normoglycaemia in diabetes: controlling postprandial glucose. Int. J. Obes. Relat. Metab. Disord. 26 (Suppl. 3), S9-S17
    • (2002) Int. J. Obes. Relat. Metab. Disord. , vol.26 , Issue.SUPPL. 3
    • Del Prato, S.1
  • 37
    • 0029957413 scopus 로고    scopus 로고
    • Risk factors for myocardial infarction and death in newly detected NIDDM: The Diabetes Intervention Study, 11-year follow-up
    • DOI 10.1007/s001250050617
    • Hanefeld, M., Fischer, S., Julius, U., Schulze, J., Schwanebeck, U., Schmechel, H., Ziegelasch, H.J. and Lindner, J. (1996) Risk factors for myocardial infarction and death in newly detected NIDDM: the Diabetes Intervention Study, 11-year follow-up. Diabetologia 39, 1577-1583 (Pubitemid 26397370)
    • (1996) Diabetologia , vol.39 , Issue.12 , pp. 1577-1583
    • Hanefeld, M.1    Fischer, S.2    Julius, U.3    Schulze, J.4    Schwanebeck, U.5    Schmechel, H.6    Ziegelasch, H.J.7    Lindner, J.8
  • 38
    • 0030866140 scopus 로고    scopus 로고
    • Long-term instability of fasting plasma glucose, a novel predictor of cardiovascular mortality in elderly patients with non-insulin-dependent diabetes mellitus: The verona diabetes study
    • Muggeo, M., Verlato, G., Bonora, E., Zoppini, G., Corbellini, M. and de Marco, R. (1997) Long-term instability of fasting plasma glucose, a novel predictor of cardiovascular mortality in elderly patients with non-insulin-dependent diabetes mellitus: the Verona Diabetes Study. Circulation 96, 1750-1754 (Pubitemid 27400729)
    • (1997) Circulation , vol.96 , Issue.6 , pp. 1750-1754
    • Muggeo, M.1    Verlato, G.2    Bonora, E.3    Zoppini, G.4    Corbellini, M.5    De Marco, R.6
  • 39
    • 0034071036 scopus 로고    scopus 로고
    • Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients
    • Shichiri, M., Kishikawa, H., Ohkubo, Y. and Wake, N. (2000) Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients. Diabetes Care 23 (Suppl. 2), B21-B29 (Pubitemid 30185774)
    • (2000) Diabetes Care , vol.23 , Issue.SUPPL. 2
    • Shichiri, M.1    Kishikawa, H.2    Ohkubo, Y.3    Wake, N.4
  • 40
    • 0038455703 scopus 로고    scopus 로고
    • Acarbose Treatment and the Risk of Cardiovascular Disease and Hypertension in Patients with Impaired Glucose Tolerance: The STOP-NIDDM Trial
    • DOI 10.1001/jama.290.4.486
    • Chiasson, J.L., Josse, R.G., Gomis, R., Hanefeld, M., Karasik, A. and Laakso, M. (2003) Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA 290, 486-494 (Pubitemid 37430502)
    • (2003) Journal of the American Medical Association , vol.290 , Issue.4 , pp. 486-494
    • Chiasson, J.-L.1    Josse, R.G.2    Gomis, R.3    Hanefeld, M.4    Karasik, A.5    Laakso, M.6
  • 41
    • 0030176306 scopus 로고    scopus 로고
    • Pharmacology of methylglyoxal: Formation, modification of proteins and nucleic acids, and enzymatic detoxification: A role in pathogenesis and antiproliferative chemotherapy
    • Thornalley, P.J. (1996) Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification: a role in pathogenesis and antiproliferative chemotherapy. Gen. Pharmacol. 27, 565-573
    • (1996) Gen. Pharmacol. , vol.27 , pp. 565-573
    • Thornalley, P.J.1
  • 42
    • 0034820785 scopus 로고    scopus 로고
    • α-Dicarbonyls increase in the postprandial period and reflect the degree of hyperglycemia
    • Beisswenger, P., Howell, S., O'Dell, R., Wood, M., Touchette, A. and Szwergold, B. (2001) α-Dicarbonyls increase in the postprandial period and reflect the degree of hyperglycemia. Diabetes Care 24, 726-732 (Pubitemid 32888855)
    • (2001) Diabetes Care , vol.24 , Issue.4 , pp. 726-732
    • Beisswenger, P.J.1    Howell, S.K.2    O'Dell, R.M.3    Wood, M.E.4    Touchette, A.D.5    Szwergold, B.S.6
  • 43
    • 25644454324 scopus 로고    scopus 로고
    • Nateglinide reduces post-prandial glucose and methylglyoxal levels in Type 2 diabetes
    • Beisswenger, P., Tamber, M., LaPoint, N., Keshavarz, T., Howell, S. and Baron, M. (2004) Nateglinide reduces post-prandial glucose and methylglyoxal levels in Type 2 diabetes. Diabetes 53 (Suppl. 2), A471
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Beisswenger, P.1    Tamber, M.2    LaPoint, N.3    Keshavarz, T.4    Howell, S.5    Baron, M.6
  • 44
    • 12144251636 scopus 로고    scopus 로고
    • Postprandial hyperglycemia and diabetes complications: Is it time to treat?
    • Ceriello, A. (2005) Postprandial hyperglycemia and diabetes complications: is it time to treat? Diabetes 54, 1-7
    • (2005) Diabetes , vol.54 , pp. 1-7
    • Ceriello, A.1
  • 46
    • 33645745733 scopus 로고    scopus 로고
    • Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with Type 2 diabetes
    • Monnier, L., Mas, E., Ginet, C., Michel, F., Villon, L., Cristol, J.P. and Colette, C. (2006) Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with Type 2 diabetes. JAMA 295, 1681-1687
    • (2006) JAMA , vol.295 , pp. 1681-1687
    • Monnier, L.1    Mas, E.2    Ginet, C.3    Michel, F.4    Villon, L.5    Cristol, J.P.6    Colette, C.7
  • 47
    • 0032939905 scopus 로고    scopus 로고
    • Metformin reduces systemic methylglyoxal levels in type 2 diabetes
    • DOI 10.2337/diabetes.48.1.198
    • Beisswenger, P., Howell, S., Touchette, A., Lal, S. and Szwergold, B. (1999) Metformin reduces systemic methylglyoxal levels in Type 2 diabetes. Diabetes 48, 198-202 (Pubitemid 29019373)
    • (1999) Diabetes , vol.48 , Issue.1 , pp. 198-202
    • Beisswenger, P.J.1    Howell, S.K.2    Touchette, A.D.3    Lal, S.4    Szwergold, B.S.5
  • 48
  • 49
    • 11944272384 scopus 로고
    • Glycation products and the pathogenesis of diabetic complications
    • Brownlee, M. (1992) Glycation products and the pathogenesis of diabetic complications. Diabetes Care 15, 1835-1843
    • (1992) Diabetes Care , vol.15 , pp. 1835-1843
    • Brownlee, M.1
  • 52
    • 0000362052 scopus 로고    scopus 로고
    • Pimagedine (PG) lowers total urinary protein (TUP) and slows progression of overt diabetic nephropathy in patients with Type I diabetes mellitus (DM)
    • Appel, G., Bolton, K., Freedman, B., Wuerth, J.P. and Cartwright, K. (1999) Pimagedine (PG) lowers total urinary protein (TUP) and slows progression of overt diabetic nephropathy in patients with Type I diabetes mellitus (DM). J. Am. Soc. Nephrol. 10, 153 A
    • (1999) J. Am. Soc. Nephrol. , vol.10
    • Appel, G.1    Bolton, K.2    Freedman, B.3    Wuerth, J.P.4    Cartwright, K.5
  • 53
    • 0000212168 scopus 로고    scopus 로고
    • Pimagedine (PG) reduces progression of retinopathy and lowers lipid levels in patients with Type I diabetes mellitus
    • Raskin, P., Cattran, D., Williams, M., Wuerth, J.-P. and Cartwright, K. (1999) Pimagedine (PG) reduces progression of retinopathy and lowers lipid levels in patients with Type I diabetes mellitus. J. Am. Soc. Nephrol. 10, 179 A
    • (1999) J. Am. Soc. Nephrol. , vol.10
    • Raskin, P.1    Cattran, D.2    Williams, M.3    Wuerth, J.-P.4    Cartwright, K.5
  • 54
    • 0026682478 scopus 로고
    • Biguanides and NIDDM
    • Bailey, C.J. (1992) Biguanides and NIDDM. Diabetes Care 15, 755-772
    • (1992) Diabetes Care , vol.15 , pp. 755-772
    • Bailey, C.J.1
  • 55
    • 0034086934 scopus 로고    scopus 로고
    • Metformin: Intrinsic vasculoprotective properties
    • Wiernsperger, N.F. (2000) Metformin: intrinsic vasculoprotective properties. Diabetes Technol. Ther. 2, 259-272
    • (2000) Diabetes Technol. Ther. , vol.2 , pp. 259-272
    • Wiernsperger, N.F.1
  • 56
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group (1998) Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352, 854-865
    • (1998) Lancet , vol.352 , pp. 854-865
  • 57
    • 0032702642 scopus 로고    scopus 로고
    • Reaction of metformin with dicarbonyl compounds. Possible implication in the inhibition of advanced glycation end product formation
    • DOI 10.1016/S0006-2952(99)00263-4, PII S0006295299002634
    • Ruggiero-Lopez, D., Lecomte, M., Moinet, G., Patereau, G., Lagarde, M. and Wiernsperger, N. (1999) Reaction of metformin with dicarbonyl compounds: possible implication in the inhibition of advanced glycation end product formation. Biochem. Pharmacol. 58, 1765-1773 (Pubitemid 29505417)
    • (1999) Biochemical Pharmacology , vol.58 , Issue.11 , pp. 1765-1773
    • Ruggiero-Lopez, D.1    Lecomte, M.2    Moinet, G.3    Patereau, G.4    Lagarde, M.5    Wiernsperger, N.6
  • 58
    • 0033064519 scopus 로고    scopus 로고
    • Effect of metformin on advanced glycation endproduct formation and peripheral nerve function in streptozotocin-induced diabetic rats
    • DOI 10.1016/S0014-2999(99)00342-8, PII S0014299999003428
    • Tanaka, Y., Uchino, H., Shimizu, T., Yoshii, H., Niwa, M., Ohmura, C., Mitsuhashi, N., Onuma, T. and Kawamori, R. (1999) Effect of metformin on advanced glycation endproduct formation and peripheral nerve function in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 376, 17-22 (Pubitemid 29320165)
    • (1999) European Journal of Pharmacology , vol.376 , Issue.1-2 , pp. 17-22
    • Tanaka, Y.1    Uchino, H.2    Shimizu, T.3    Yoshii, H.4    Niwa, M.5    Ohmura, C.6    Mitsuhashi, N.7    Onuma, T.8    Kawamori, R.9
  • 59
    • 77951183729 scopus 로고    scopus 로고
    • Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin
    • Rabbani, N., Chittari, M.V., Bodmer, C.W., Zehnder, D., Ceriello, A. and Thornalley, P.J. (2010) Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin. Diabetes 59, 1038-1045
    • (2010) Diabetes , vol.59 , pp. 1038-1045
    • Rabbani, N.1    Chittari, M.V.2    Bodmer, C.W.3    Zehnder, D.4    Ceriello, A.5    Thornalley, P.J.6


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