Effects of a screening and treatment protocol with haloperidol on post-cardiotomy delirium: A prospective cohort study

Interactive Cardiovascular and Thoracic Surgery

Volumn 18, Issue 4, 2014, Pages 438-445

  Pedersen, Sofie Schrøder ^a   Kirkegaard, Thomas ^b   Jørgensen, Martin Balslev ^b   Jørgensen, Vibeke Lind ^a  

^a International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^b Psychiatric Centre Copenhagen   (Denmark)

Author keywords

Cardiac surgery; Complications; Delirium; Post cardiotomy; Postoperative care; Postoperative cognitive dysfunction

Indexed keywords

BENZODIAZEPINE; HALOPERIDOL; LORAZEPAM; PROMETHAZINE; NEUROLEPTIC AGENT;

ADULT; AGE; AGED; ANXIETY DISORDER; ARTICLE; COHORT ANALYSIS; COMA; CONFUSION ASSESSMENT METHOD FOR THE INTENSIVE CARE UNIT; DELIRIUM; DELIRIUM OBSERVATION SCREENING SCALE; DENMARK; DISEASE ASSOCIATION; DRUG SCREENING; EARLY DIAGNOSIS; FEMALE; HEART SURGERY; HUMAN; INCIDENCE; INSOMNIA; INTERVENTION STUDY; LENGTH OF STAY; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MORNING DOSAGE; MORTALITY; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; POST CARDIOTOMY DELIRIUM; POSTCARDIOTOMY SYNDROME; PRIORITY JOURNAL; PROSPECTIVE STUDY; TREATMENT DURATION; CHECKLIST; CHI SQUARE DISTRIBUTION; CLINICAL TRIAL; MIDDLE AGED; PREDICTIVE VALUE; PSYCHOLOGY; RISK ASSESSMENT; RISK FACTOR; STATISTICAL MODEL; TIME; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; AGED; ANTIPSYCHOTIC AGENTS; CARDIAC SURGICAL PROCEDURES; CHECKLIST; CHI-SQUARE DISTRIBUTION; DELIRIUM; DENMARK; EARLY DIAGNOSIS; FEMALE; HALOPERIDOL; HUMANS; LENGTH OF STAY; LOGISTIC MODELS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84896974729     PISSN: 15699293     EISSN: 15699285     Source Type: Journal    
DOI: 10.1093/icvts/ivt501     Document Type: Article

References (24)

1. Diagnostic and Statistical Manual of Mental Disorders. 4th edn. Washington, DC: American Psychiatric Association, 2000.
2. Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE Jr. et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 2004;291:1753-62.
3. Koster S, Hensens AG, van der Palen J. The long-term cognitive and functional outcomes of postoperative delirium after cardiac surgery. Ann Thorac Surg 2009;87:1469-74.
4. Bartels K, McDonagh DL, Newman MF, Mathew JP. Neurocognitive outcomes after cardiac surgery. Curr Opin Anaesthesiol 2013;26:91-7.
5. Ely EW, Gautam S, Margolin R, Francis J, May L, Speroff T et al. The impact of delirium in the intensive care unit on hospital length of stay. Intensive Care Med 2001;27:1892-900.
6. Svenningsen H, Tonnesen E. Delirium incidents in three Danish intensive care units. Nurs Crit Care 2011;16:186-92.
7. Jensen BO, Rasmussen LS, Steinbruchel DA. Cognitive outcomes in elderly high-risk patients 1 year after off-pump versus on-pump coronary artery bypass grafting. A Randomized Trial. Eur J Cardiothorac Surg 2008;34: 1016-21.
8. Koster S, Hensens AG, Schuurmans MJ, van der Palen J. Risk factors of delirium after cardiac surgery: a systematic review. Eur J Cardiovasc Nurs 2011;10:197-204.
9. Cerejeira J, Nogueira V, Luis P, Vaz-Serra A, Mukaetova-Ladinska EB. The cholinergic system and inflammation: common pathways in delirium pathophysiology. J Am Geriatr Soc 2012;60:669-75.
10. Zhang H, Lu Y, Liu M, Zou Z, Wang L, Xu FY et al. Strategies for prevention of postoperative delirium: a systematic review and meta-analysis of randomized trials. Crit Care 2013;17:R47.
11. Greer N, Rossom R, Anderson P, MacDonald R, Tacklind J, Rutks I, Wilt TJ. Delirium: Screening, Prevention, and Diagnosis - A Systematic Review of the Evidence. VA-ESP Project #09-009; 2011.
12. Koster S, Hensens AG, Oosterveld FG, Wijma A, van der Palen J. The delirium observation screening scale recognizes delirium early after cardiac surgery. Eur J Cardiovasc Nurs 2009;8:309-14.
13. Schuurmans MJ, Shortridge-Baggett LM, Duursma SA. The Delirium Observation Screening Scale: a screening instrument for delirium. Res Theory Nurs Pract 2003;17:31-50.
14. O'Regan NA, Fitzgerald J, Timmons S, O'Connell H, Meagher D. Delirium: a key challenge for perioperative care. Int J Surg 2013;11: 136-44.
15. van den Boogaard M. Delirium in intensive care patients: detection, impact, prediction, prevention and biomarkers. Dissertation. Radboud Universiteit Nijmegen, Nederlands Intensive Care Unit 2012.
16. Devlin JW, Skrobik Y. Antipsychotics for the prevention and treatment of delirium in the intensive care unit: what is their role? Harv Rev Psychiatry 2011;19:59-67.
17. Lonergan E, Britton AM, Luxenberg J, Wyller T. Antipsychotics for delirium. Cochrane Database Syst Rev 2007 Apr 18;(2):CD005594.
18. Girard TD, Pandharipande PP, Carson SS, Schmidt GA, Wright PE, Canonico AE et al. Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med 2010;38:428-37.
19. Page VJ, Ely EW, Gates S, Zhao XB, Alce T, Shintani A et al. Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial. Lancet Respir Med 2013;1:515-23.
20. Atalan N, Efe Sevim M, Akgun S, Fazliogullari O, Basaran C. Morphine is a reasonable alternative to haloperidol in the treatment of postoperative hyperactive-type delirium after cardiac surgery. J Cardiothorac Vasc Anesth 2013 Oct;27(5):933-8. doi: 10.1053/j.jvca.2013.01.017. Epub 2013 Jun 18.
21. Ely EW, Inouye SK, Bernard GR, Gordon S, Francis J, May L et al. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 2001; 286:2703-10.
22. Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH. Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med 2009;180:1092-7.
23. McPherson JA, Wagner CE, Boehm LM, Hall JD, Johnson DC, Miller LR et al. Delirium in the cardiovascular ICU: exploring modifiable risk factors. Crit Care Med 2013;41:405-13.
24. Koster S, Hensens AG, Schuurmans MJ, van der Palen J. Consequences of delirium after cardiac operations. Ann Thorac Surg 2012;93: 705-11.