The effect of bevacizumab and 5-Fluorouracil combination on epidural fibrosis in a rat laminectomy model

European Review for Medical and Pharmacological Sciences

Volumn 18, Issue 1, 2014, Pages 95-100

  Ozkan, U ^a   Osun, A ^a   Samancioglu, A ^a   Ercan, S ^b   Firat, U ^b   Kemaloglu, S ^b  

^a DUMLUPINAR UNIVERSITY   (Turkey)

^b DICLE UNIVERSITY   (Turkey)

Author keywords

5 Flu orouracil; Bevacizumab; Epidural fibrosis; Laminectomy

Indexed keywords

BEVACIZUMAB; FLUOROURACIL; MONOCLONAL ANTIBODY; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EPIDURAL FIBROSIS; FIBROBLAST; FIBROSIS; LAMINECTOMY; MONOTHERAPY; NONHUMAN; POSTOPERATIVE COMPLICATION; RAT; SCAR FORMATION; SPINE DISEASE; SPRAGUE DAWLEY RAT; TISSUE SECTION; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG COMBINATION; DRUG EFFECTS; EPIDURAL SPACE; LUMBAR VERTEBRA; MALE; PATHOLOGY; POSTOPERATIVE COMPLICATIONS; SURGERY;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; DRUG THERAPY, COMBINATION; EPIDURAL SPACE; FIBROSIS; FLUOROURACIL; LAMINECTOMY; LUMBAR VERTEBRAE; MALE; POSTOPERATIVE COMPLICATIONS; RATS, SPRAGUE-DAWLEY; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84896959999     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. CHAN C, PENG P. Review Article. Failed Back Surgery Syndrome: Pain Medicine 2011; 12: 577-606.
2. LAMA PJ, FECHTNER RD Antifibrotic and wound healing in glaucoma surgery. Surv Ophthalmol 2003; 48: 314-346.
3. YILDIZ KH, GEZEN F, IS M., CUKUR S, DOSOGLU M. Mito-mycin C, 5-fluorouracil, and cyclosporin A prevent epidural fibrosis in an experimental laminectomy model. Euro Spine 2007; 16: 1525-1530.
4. ZHONGIU L, BERGEN T V, VEIRE S V, VAN DE VEL I, MOREAU H, DEWERCHIN M. Inhibation of vascular en-dothelial growth factor reduces scar formation after glaucoma filtration surgery. Invest Ophthalmol Vis Sci 2009; 50: 5217-5225.
5. FARROKHI RM, VASEI M, FAREGHBAL S. The effect of methylene blue on peridural fibrosis formation after laminectomy in rats: an experimental novel study. Spine J 2011; 11: 147-152.
6. HOW A, CHUA JL, CHARLTON A, SU R., LIM M, KUMAR RS, CROWSTON J.G., WONG TT. Combined treatment with bevacizumab and 5-fluorouracil attenuates the postoperative scarring response after experimental glaucoma filtration surgery. Invest Oph-thalmol Vis Sci 2009; 51: 928-932.
7. KASIMCAN MO, BAKAR B, AKTA S S, ALHAN A, YILMAZ M. Effectiveness of the biophysical barriers on the peridural fibrosis of a postlaminectomy rat model: An experimental research. Injury 2011; 42: 778-781.
8. KEMALOGLU S, OZKAN U, YILMAZ F. Prevention of spinal epidural fibrozis by recombinant tissue plasminogen activator in rats Spinal Cord 2003; 41: 427-431.
9. KESKIN F, ESEN H. Comparison of the effects of an adhesion barrier and chitin on experimental epidural fi-brosis. Turk Neurosurg 2010; 20: 457-463.
10. KLINGER M, EIPELDAUER S, HACKER S., HERBERGER B, TAMANDL D, DORFMEISTER M., KOELBLINGER C, GRUEN-BERGER B, GRUENBERGER T. Bevacizumab protects against sinusoidal obstruction syndrome and does not increase response rate in neoadjuvant XELOX/FOLFOX therapy of colorectal cancer liver metastases. Eur J Surg Oncol 2009; 35: 515-520.
11. MEMARZADEB F, VARMA R, TIEN L., PARIKH JG, DUSTIN L, ALCARAZ A, ELIOTT D. Postoperative use of beva-cizumab as an antifibrotic agent in glaucoma filtration surgery in the rabbits. Invest Ophthalmol Vis Sci 2009; 50: 3233-3237.
12. PESSAUX P, PANARO F, CASNEDI S., ZECA I, MARZANO E, BACHELLIER P., JAECK D, CHENARD M P. Targeted molecular therapies (cetuximab and bevacizumab) do not induce additional hepatotoxicity: preliminary results of a case-control study. Eur J Surg Oncol 2010; 36: 575-582.
13. TEMIZ C, TEMIZ P, SAYIN M., UÇAR K. Effect of cepea extract-heparin and allantoin mixture on epidural fibrosis in a rat hemilaminectomy model. Turk Neurosurg 2009; 19: 387-392.
14. WILGUS TA, FERREIRA AM, OBERYSZYN T.M., BERGDALL VK, DIPIEDRO LA Regulation of scar formation by vascularendothelial growth factor Lab Invest 2008; 88: 579-590.
15. HOWDIESHELL TR, CALLAWAY D, WEBB W.L., GAINES MD, PROCTER CD, SATHYANARAYANA MD, POLLOCK J.S., BROCK TL, MCNEIL PL. Antibody neutralization of vascular endothelial growth factor inhibits wound granulation tissue formation. J Surg Res 2001; 96: 173-182.
16. KARATAY M, ERDEM Y, KÖKTEKIR E, ERKOÇ YS, ÇAYDERE M, BAYAR MA. Te effect of bevacizumab on spinal epidural fibrosis in a postlaminectomy rat model. Turk Neurosurg 2012; 22: 753-757.
17. FEINER L, BARR EE, SHUI Y.B., HOLEKAMP NM, BRANTLEY MA Safety of intravitreal injection of bevacizumab in rabbit eyes. Retina 2006; 26: 882-888.
18. KOWANETZ M, FERRARA N. Vascular endothelial grwth factor signaling pathways:therapeutic perspective. Clin Cancer Res 2006; 12: 5018-5022.
19. MARTY M, PIVOT X. The potential of anti-vascular endothelial growth factor theraphy in metastatic brest cancer; clinical experience with anti-angio-genic agents, focusing on bevacizumab. Eur J Cancer 2008; 44: 912-920.
20. WENDLING J, MARCHAND A, MAUVIEL A., VERRECCHIA F. 5-Fluorouracil blocks transforming growth factor-β induced α2 Type I collagen gene (COL1A2) expression in human fibroblasts via c-Jun NH2-Terminal Kinase/Activator Protein-1 activation. Mol Pharmacol 2003; 64: 707-713.
21. KHAW PT, SHERWOOD MB, MACKAY SLD. Five-minute treatments with fluorouracil, floxuridine, and mito-mycin have long-term effects on human Tenon's capsule fibroblasts. Arch Ophthalmol 1992; 110: 1150-1154.
22. OCCLESTON NL, ALEXANDER RA, MAZURE A, LARKIN G., KHAW PT Effects of single exposures to antiprolif-erative agents on ocular fibroblast-mediated collagen contraction. Invest Ophthalmol Vis Sci 1994; 35: 3681-3690.
23. JOU IM, TAI TW, TSAI C.L., TSAI TM, YUNG WS, JUNG YC Spinal somatosensory evoked potential to evaluate neurophysiologic changes associated with postlaminotomy fibrosis: an experimental study. Spine (Phila Pa 1976) 2007; 32: 2111-2118.
24. ALKALAY RN, KIM DH, URRY D.W., XU J., PARKER TM, GALAZER PA Prevention of postlaminectomy epidural fibrozis using bioelastic materials. Spine 2003; 28: 1659-1665.
25. COOPER RG, FREEMONT AJ, HOYLAND J.A., JENKINS J P, WEST CG, ILLINGWORTH K.J., JAYSON MI. Herniated intervertebral disc-associated periradicular fibrosis and vascular abnormalities occur without inflammatory cell infiltration. Spine (Phila Pa 1976). 1995; 20: 591-598.
26. SCHIMIZZI AL, MASSIE JB, MURPHY M, PERRY A., KIM CW, GARFIN SR, AKESON WH High-molecular-weight hyaluronan inhibits macrophage proliferation and cytokine release in the early wound of a preclini-cal postlaminectomy rat model. Spine J 2006; 6: 550-556.
27. BREVING K, ERIKSSON E, LIV P., MILLER DR Healing of partial thickness porcine skin wounds in a liquid environment. J Surg Res 1992; 52: 50.
28. HOWDIESHELL TR, RIEGNER C, GUPTA V., CALLAWAY D, SATHYANARAYANA MD, MCNEIL PL Normoxic wound fluid contains high levels of vascular endothelial growth factor. Ann Surg 1998; 228: 707.
29. BROWN L.F., YEO KT, BERSE B, SENGER D.R., DVORAK H F, VAN DE WATER L. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med 1992; 176: 1375.
30. ROBERTS AB, SPORN MB Transforming growth factor beta. In: Clark RAF, ed. The Molecular and Cellular Biology of Wound Repair. New York/London: Plenum, 1996; 275-310.
31. SHAH M, FOREMAN, DM, FERGUSON, MW. Control of scarring in adult wounds by neutralizing antibody to transforming growth factor beta. Lancet 1992; 339: 213.
32. UITTO J, KOUBA D. Cytokine modulation of extracellular matrix gene expression: relevance to fibrotic skin diseases. J Dermatol Sci 2000; 24: S60-S69.