Nuclear physics meets medicine and biology: Boron neutron capture therapy

CERN-Proceedings

Volumn 2, Issue , 2010, Pages 561-571

  Ballarini, F ^a,b   Bakeine, J G ^a   Bortolussi, S ^a,b   Bruschi, P ^a   Clerici, A M ^a   De Bari, A ^a,b   Dionigi, P ^a   Ferrari, C ^a   Gadan, M A ^a   Protti, N ^a,b   Stella, S ^a,b   Zonta, C ^a   Zonta, A ^a   Altieri, S ^a,b  

^a UNIVERSITY OF PAVIA   (Italy)

^b INFN SEZIONE DI PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HISTOLOGY; MONTE CARLO METHODS; NATURAL RESOURCES MANAGEMENT; NEUTRON IRRADIATION; NUCLEAR REACTIONS; TUMORS;

BORON CONCENTRATIONS; BORON NEUTRON CAPTURE THERAPY; CELLULAR LEVELS; HIGH LINEAR ENERGY TRANSFERS; LUNG TUMOURS; MONTE CARLO CALCULATION; MONTE CARLO CODES; NORMAL TISSUE;

BORON;

EID: 84896926890     PISSN: 20788835     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (35)

1. J. Chadwick, Possible existence of a neutron, Nature 192 (1932) 312.
2. G.L. Locher, Biological Effects and therapeutical possibilities of neutrons, Am. J. Roentgenol. Radium. Ther. 36 (1936) 1-13.
3. L.E. Farr, W.H. Sweet, J.S. Robertson, G.S. Forster, H.B. Locksley, D.L. Sutherland, M.L. Mendelsohn and E.E. Stickey, Neutron Capture Therapy with Boron in the treatment of Glioblastoma Multiforme, Am. J. Roentgenol. 71 (1954) 279-291.
4. Y. Nakagawa and H. Hatanaka, Boron Neutron Capture Therapy: clinical brain tumour studies, J. Neuro-Oncol. 33 (1997) 105-115.
5. J.A. Coderre, E.E. Elowitz, M. Chadha, R. Bergland, J. Capala, D.D. Joel, H.B. Liu, D.N. Slatkin and D.A. Chanana, Boron neutron capture therapy of glioblastoma multiforme using the p-borophenylalanine-fructose complex and epithermal neutrons: trial design and early clinical results, J. Neuro - Oncol. 33 (1997) 141-152.
6. A.Z. Diaz, A.D. Chanana, J.A. Coderre and R. Ma, Retrospective review of the clinical BNCT trial at Brookhaven National laboratory, Proc. Ninth International Symposium on Neutron Capture Therapy for Cancer, Osaka, October 2-6, 2000, pp. 13-14.
7. H. Madoc-Jones, R. Zamenhof, G. Solares, O. Harling, C-S. Yam, K. Riley, S. Kiger, D. Wazer, G. Rogers and M. Atkins, A phase-I dose escalation trial of boron neutron capture therapy for subjects with subcutaneous melanoma of the extremities, in Cancer Neutron Capture Therapy, Ed. Y. Mishima (Plenum Press, New York, 1996), pp. 707-716.
8. P. Busse, O.K. Harling, M.R. Palmer, W.S. Kiger, J. Kaplan, I. Kaplan, C. Chuang, J.Y. Goorley, K. Riley, T.H. Newton, G.A. Santa Cruz, X-Q. Lu and R.G Zamenhof, A critical examination of the results from the Harward-MIT NCT program phase I clinical trial on neutron capture therapy for intracranial disease, J. Neuro-Oncol. 62 (2003) 111-121.
9. R.L. Moss, Progress towards boron capture therapy at the High Flux Reactor Petten, Basic Life Sci. 54 (1990) 169-183.
10. J. Capala, B.H. Stenstam, K. Skold, P.M Af Rosenschold, V. Giusti, C. Persson, E. Wallin, A. Brun, L. Franzen, J. Carlsson, J. Salford, C. Cerberg, B. Persson, L. Pellettieri, R. Henriksson, Boron neutron capture therapy for glioblastoma multiforme: clinical studies in Sweden, J. Neuro-Oncol. 62 (2003) 135-144.
11. H. Joensuu, L. Kankaanranta, T. Seppala, I. Auterinen, M. Kallio, M. Kulvik, J. Laakso, J. Vahatalo, M. Kortesniemi, P. Kotiluoto, T. Seren, J. Karila, A. Brander, E. Jarviluoma, P. Ryynanen, A. Paetau, I. Ruokonen, H. Minn, M. Tenhunen, J. Jaaskelainen, M. Farkkila and S. Savolainen, Boron neutron capture therapy of brain tumours: clinical trials at the Finnish facility using borophenylalanine, J. Neuro-Oncol. 62 (2003) 123-134.
12. A. Zonta, U. Prati, L. Roveda, C. Ferrari, S. Zonta, A.M. Clerici, C. Zonta, P. Bruschi, R. Nano, S. Barni, T. Pinelli, F. Fossati, S. Altieri, S. Bortolussi, P. Chiari and G. Mazzini, Clinical lessons from the first applications of BNCT on unresectable liver metastases, J. of Phys. Conf. Series 41 (2006) 484-495.
13. A. Zonta, T. Pinelli, U. Prati, L. Roveda, C. Ferrari, A.M. Clerici, C. Zonta, G. Mazzini, P. Dionigi, S. Altieri, S. Bortolussi, P. Bruschi and F. Fossati, Extra-corporeal liver BNCT for the treatment of diffuse metastases: What was learned and what is still to be learned, Appl. Radiat. Isot. (2009), doi:10.1016/j.apradiso.2009.03.087, in press
14. S.J. Gonzales, M.R. Bonomi, G.A. Santa Cruz, H.R. Blaumann, O.A. Calzetta Larrieu, P. Menendez, R. Jimenez Rebagliati, J. Longhino, D.B. Feld, M.A. Dagrosa, C. Angerich, S.G. Castiglia, D.A. Batistoni, S.J. Libermann and B.M. Roth, First BNCT treatment of a skin melanoma in Argentina: dosimetric analysis and clinical outcome, Appl. Radiat. Isot. 61 (2004) 1101-1105.
15. th ICNCT - A new option against cancer, Florence, November 2-7, 2008, Eds. A. Zonta, S. Altieri, L. Roveda and R. Barth (ENEA, Roma, 2008), p. 21.
16. A. Wittig, J. Michel, R.L. Moss, F. Stecher-Rasmussen, H.F. Arlinghaus, P. Bendel, P.L. Mauri, S. Altieri, R. Hilger, P.A. Salvadori, L. Menichetti, R. Zamenhof and W.A.G. Sauerwein, Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT), Crit. Rev. Oncol. Hematol. 68 (2008) 66-90.
17. S. Altieri, S. Bortolussi, P. Bruschi et al., Neutron autoradiography imaging of selective boron uptake in human metastatic tumours, Appl. Radiat. Isot. 66 (2008) 1850-1855.
18. D. Chiaraviglio, F. De Grazia, A. Zonta, S. Altieri, A. Braghieri, F. Fossati, P. Pedroni, T. Pinelli, A. Perotti, A. Specchiarello, G. Perlini and H. Rief, Evaluation of selective boron absorption in liver tumors, Strahlenther. Onkol. 165 (1989) 170-172.
19. S. Bortolussi, Boron Neutron Capture Therapy of disseminated tumours, Ph. D. thesis, University of Pavia, 2007.
20. S. Altieri, S. Bortolussi, P. Bruschi, P. Chiari, F. Fossati, A. Facoetti, R. Nano, A. Clerici, C. Ferrari, A. Zonta, C. Zonta, A. Marchetti, E. Solcia, J.J. Bakeine and O. Salvucci, Monte Carlo dose calculations for BNCT treatment of diffuse human lung tumours. Proc. ICNCT-12 - Advances in Neutron Capture Therapy, Takamatsu, Japan, October 9-14, 2006, Eds. Y. Nakagawa, T. Kobayashi and H. Fukuda, pp. 500-503.
21. N. Protti, S. Bortolussi, S. Stella, M.A. Gadan, A. De Bari, F. Ballarini, P. Bruschi, C. Ferrari, A.M. Clerici, C. Zonta, J.G. Bakeine, P. Dionigi, A. Zonta and S. Altieri, Calculations of dose distributions in the lungs of a rat model irradiated in the thermal column of the TRIGA reactor in Pavia, Appl. Radiat. Isotopes (2009), doi:10.1016/j.apradiso.2009.03.052, in press.
22. G.J. Bakeine, M. Di Salvo, S. Bortolussi, S. Stella, P. Bruschi, A. Bertolotti, R. Nano, A. Clerici, C. Ferrari, C. Zonta, A. Marchetti and S. Altieri, Feasibility study on the utilization of boron neutron capture therapy (BNCT) in a rat model of diffuse lung metastases, Appl. Radiat. Isotopes (2009), doi:10.1016/j.apradiso.2009.03.073, in press.
23. th ICNCT - A new option against cancer, Florence, November 2-7, 2008, Eds. A. Zonta, S. Altieri, L. Roveda and R. Barth (ENEA, Roma, 2008), pp. 331-336.
24. F. Ballarini, Meccanismi d'azione della radiazione ionizzante: modelli e simulazioni M.C. del processo d'induzione di aberrazioni cromosomiche, Laurea thesis, Università degli Studi di Milano, 1997.
25. F. Ballarini, M. Merzagora, F. Monforti, M. Durante, G. Gialanella, G.F. Grossi, M. Pugliese and A. Ottolenghi, Chromosome aberrations induced by light ions: Monte carlo simulations based on a mechanistic model, Int. J. Radiat. Biol. 75 (1999) 35-46.
26. F. Ballarini, M. Biaggi and A. Ottolenghi, Nuclear architecture and radiation-induced chromosome aberrations: models and simulations, Radiat. Prot. Dosim. 99 (2002) 175-182.
27. F. Ballarini and A. Ottolenghi, Chromosome aberrations as biomarkers of radiation exposure: modelling basic mechanisms, Adv. Space Res. 31/6 (2003) 1557.
28. F. Ballarini, D. Alloni, A. Facoetti, A. Mairani, R. Nano and A. Ottolenghi, Radiation risk estimation: modelling approaches for "targeted" and "non-targeted" effects, Adv. Space Res. 40 (2007) 1392-1400.
29. F. Ballarini, D. Alloni, A. Facoetti and A. Ottolenghi, Heavy-ion effects: from track structure to DNA and chromosome damage, New Journal of Physics 10 (2008) 075008, http://www.njp.org
30. F. Ballarini and A. Ottolenghi, A model of chromosome aberration induction and CML incidence at low doses, Radiat. Environ. Biophys. 43 (2004) 165-171.
31. F. Ballarini and A. Ottolenghi, A model of chromosome aberration induction: applications to space research, Radiat. Res. 164/4 (2005) 567-70.
32. F. Ballarini, Chromosome damage by ionizing radiation: a review, Il Nuovo Cimento B, in press.
33. M. Cornforth and J. Bedford, A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts, Radiat. Res. 111 (1987) 385-405.
34. M. Belli, F. Cera, R. Cherubini, M. Dalla Vecchia, A. Haque, F. Ianzini, G. Meschini, O. Sapora, G. Simone, M.A. Tabacchini and P. Tiveron, RBE-LET relationships for cell inactivation and mutation induced by low energy protons in V79 cells: further results at the LNL facility, Int. J. Radiat. Biol. 74 (1998), 501-509.
35. th ICNCT - A new option against cancer, Florence, November 2-7, 2008, Eds. A. Zonta, S. Altieri, L. Roveda and R. Barth (ENEA, Roma, 2008), pp. 307-310.