Insulin-stimulated leptin secretion requires calcium and PI3K/Akt activation

Biochemical Journal

Volumn 458, Issue 3, 2014, Pages 491-498

  Wang, Yue ^a,b   Ali, Yusuf ^a   Lim, Chun Yan ^a,b   Hong, Wanjin ^b,c   Pang, Zhiping P ^d   Han, Weiping ^a,b,c  

^a AGENCY FOR SCIENCE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^d CHILD HEALTH INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Akt; Ca2+; Insulin; Leptin; Phosphoinositide 3 kinase (PI3K); Primary adipocyte; Secretion

Indexed keywords

BREFELDIN A; CALCIUM; CYCLOHEXIMIDE; INSULIN; LEPTIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENERGY BALANCE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXOCYTOSIS; GOLGI COMPLEX; HORMONAL REGULATION; HORMONE RELEASE; HORMONE SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; LEPTIN SECRETION; LEPTIN SYNTHESIS; MALE; MEMBRANE VESICLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SECRETORY GRANULE; SIGNAL TRANSDUCTION; SYNAPSE VESICLE; UPREGULATION;

3T3-L1 CELLS; ADIPOCYTES, WHITE; ANIMALS; CALCIUM; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GOLGI APPARATUS; INSULIN; LEPTIN; MALE; MICE; MICE, INBRED C57BL; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; SECRETORY VESICLES; SIGNAL TRANSDUCTION;

EID: 84896894616     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131176     Document Type: Article

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