Mechanisms of Hg species induced toxicity in cultured human astrocytes: Genotoxicity and DNA-damage response

Metallomics

Volumn 6, Issue 3, 2014, Pages 662-671

  Pieper, Imke ^a   Wehe, Christoph A ^a   Bornhorst, Julia ^b   Ebert, Franziska ^b   Leffers, Larissa ^a   Holtkamp, Michael ^a   Höseler, Pia ^a   Weber, Till ^b   Mangerich, Aswin ^c   Bürkle, Alexander ^c   Karst, Uwe ^a   Schwerdtle, Tanja ^a,b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF POTSDAM   (Germany)

^c UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR DNA DAMAGE; CELLULAR SYSTEM; CYTOTOXIC EFFECTS; DNA STRAND BREAK; LEARNING ABILITIES; MOLECULAR MECHANISM; NEURONAL FUNCTION; ORGANIC SPECIES;

BIOCHEMISTRY; CYTOTOXICITY; EXPERIMENTS; MERCURY (METAL); MERCURY COMPOUNDS; NEURONS; TOXICITY;

DNA;

MERCURY;

ARTICLE; ASTROCYTE; BIOAVAILABILITY; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA STRAND BREAKAGE; GENE EXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; NERVE CELL; PRIORITY JOURNAL; SPECTROFLUOROMETRY;

ASTROCYTES; CELL LINE; DNA BREAKS; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; METHYLMERCURY COMPOUNDS; MUTAGENS; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; THIMEROSAL;

EID: 84896877556     PISSN: 17565901     EISSN: 1756591X     Source Type: Journal    
DOI: 10.1039/c3mt00337j     Document Type: Article

References (51)

1. FAO/WHO, Safety evaluation of certain food additives and contaminants. Mercury. World Health Organization, JECFA, Geneva, 2011
2. EFSA Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food1 EFSA J. 2012 10 1 241
3. P. Li X. Feng G. Qiu Methylmercury exposure and health effects from rice and fish consumption: a review Int. J. Environ. Res. Public Health 2010 7 2666 2691 10.3390/ijerph7062666
4. USFDA, United States Food Drug Administration, Center for Biologics Evaluation and Research. Thimerosal in vaccines. Available from http://www.fda.gov/cber/vaccine/thimerosal.htm#1/. 2009
5. M. Aschner N. Onishchenko S. Ceccatelli Toxicology of alkylmercury compounds Met. Ions Life Sci. 2010 7 403 434 10.1039/BK9781847551771-00403
6. R. Janzen M. Schwarzer M. Sperling M. Vogel T. Schwerdtle U. Karst Adduct formation of Thimerosal with human and rat hemoglobin: a study using liquid chromatography coupled to electrospray time-of-flight mass spectrometry (LC/ESI-TOF-MS) Metallomics 2011 3 847 852 10.1039/c1mt00043h
7. S. Trümpler W. Lohmann B. Meermann W. Buscher M. Sperling U. Karst Interaction of thimerosal with proteins-ethylmercury adduct formation of human serum albumin and beta-lactoglobulin A Metallomics 2009 1 87 91 10.1039/B815978e
8. FAO/WHO, Safety evaluation of certain food additives and contaminants. Methylmercury, World Health Organization, JECFA, Geneva, 2004, pp. 565-623
9. FAO/WHO, Safety evaluation of certain food additives and contaminants. Methylmercury, World Health Organization, JECFA, Geneva, 2007, pp. 269-315
10. G. Guzzi P. D. Pigatto F. Spadari C. A. La Porta Effect of thimerosal, methylmercury, and mercuric chloride in Jurkat T Cell Line Interdiscip. Toxicol. 2012 5 159 161 10.2478/v10102-012-0026-1
11. J. G. Dorea Integrating experimental (in vitro and in vivo) neurotoxicity studies of low-dose thimerosal relevant to vaccines Neurochem. Res. 2011 36 927 938 10.1007/s11064-011-0427-0
12. J. G. Dorea M. Farina J. B. Rocha Toxicity of ethylmercury (and Thimerosal): a comparison with methylmercury J. Appl. Toxicol. 2013 33 700 711 10.1002/jat.2855
13. M. Duszczyk-Budhathoki M. Olczak M. Lehner M. D. Majewska Administration of thimerosal to infant rats increases overflow of glutamate and aspartate in the prefrontal cortex: protective role of dehydroepiandrosterone sulfate Neurochem. Res. 2012 37 436 447 10.1007/s11064-011-0630-z
14. M. Farina J. B. Rocha M. Aschner Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies Life sci. 2011 89 555 563 10.1016/j.lfs.2011.05.019
15. N. Mori A. Yasutake M. Marumoto K. Hirayama Methylmercury inhibits electron transport chain activity and induces cytochrome c release in cerebellum mitochondria J. Toxicol. Sci. 2011 36 253 259
16. C. F. Huang S. H. Liu C. J. Hsu S. Y. Lin-Shiau Neurotoxicological effects of low-dose methylmercury and mercuric chloride in developing offspring mice Toxicol. Lett. 2011 201 196 204 10.1016/j.toxlet.2010.12.016
17. M. Farina M. Aschner J. B. Rocha Oxidative stress in MeHg-induced neurotoxicity Toxicol. Appl. Pharmacol. 2011 256 405 417 10.1016/j.taap.2011.05. 001
18. T. W. Clarkson L. Magos The toxicology of mercury and its chemical compounds Crit. Rev. Toxicol. 2006 36 609 662 10.1080/10408440600845619
19. J. L. Rodrigues J. M. Serpeloni B. L. Batista S. S. Souza F. Barbosa, Jr. Identification and distribution of mercury species in rat tissues following administration of thimerosal or methylmercury Arch. Toxicol. 2010 84 891 896 10.1007/s00204-010-0538-4
20. G. M. Richardson R. Wilson D. Allard C. Purtill S. Douma J. Graviere Mercury exposure and risks from dental amalgam in the US population, post-2000 Sci. Total Environ. 2011 409 4257 4268 10.1016/j.scitotenv.2011.06.035
21. J. Bornhorst F. Ebert H. Lohren H. U. Humpf U. Karst T. Schwerdtle Effects of manganese and arsenic species on the level of energy related nucleotides in human cells Metallomics 2012 4 297 306 10.1039/c2mt00164k
22. J. Bornhorst C. A. Wehe S. Hüwel U. Karst H. J. Galla T. Schwerdtle Impact of manganese on and transfer across blood-brain and blood-cerebrospinal fluid barrier in vitro J. Biol. Chem. 2012 287 17140 17151 10.1074/jbc.M112. 344093
23. J. Bornhorst F. Ebert A. Hartwig B. Michalke T. Schwerdtle Manganese inhibits poly(ADP-ribosyl)ation in human cells: a possible mechanism behind manganese-induced toxicity? J. Environ. Monit. 2010 12 2062 2069 10.1039/c0em00252f
24. J. Bornhorst S. Meyer T. Weber C. Böker T. Marschall A. Mangerich S. Beneke A. Bürkle T. Schwerdtle Molecular mechanisms of Mn induced neurotoxicity: RONS generation, genotoxicity, and DNA-damage response Mol. Nutr. Food Res. 2013 57 1255 1269 10.1002/mnfr.201200758
25. H. Kawamitsu H. Hoshino H. Okada M. Miwa H. Momoi T. Sugimura Monoclonal antibodies to poly(adenosine diphosphate ribose) recognize different structures Biochemistry 1984 23 3771 3777
26. S. Beneke A. L. Scherr V. Ponath O. Popp A. Bürkle Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span Mech. Ageing Dev. 2010 131 366 369 10.1016/j.mad.2010.04.003
27. H. K. Kimelberg M. D. Norenberg Astrocytes Sci. Am. 1989 260 66 72
28. M. Ni X. Li Z. Yin M. Sidoryk-Wegrzynowicz H. Jiang M. Farina J. B. Rocha T. Syversen M. Aschner Comparative study on the response of rat primary astrocytes and microglia to methylmercury toxicity Glia 2011 59 810 820 10.1002/glia.21153
29. E. E. Benarroch Neuron-astrocyte interactions: partnership for normal function and disease in the central nervous system. Mayo Clinic proceedings Mayo Clin. Proc. 2005 80 1326 1338 10.4065/80.10.1326
30. M. Berlin, R. Zalups and B. A. Fowler, Mercury in Handbook on the Toxicology of Metals, 2007, pp. 675-729
31. T. W. Clarkson Molecular and ionic mimicry of toxic metals Annu. Rev. Pharmacol. Toxicol. 1993 33 545 571 10.1146/annurev.pa.33.040193.002553
32. J. C. Erie J. A. Butz J. A. Good E. A. Erie M. F. Burritt J. D. Cameron Heavy metal concentrations in human eyes Am. J. Ophthalmol. 2005 139 888 893 10.1016/j.ajo.2004.12.007
33. M. Xu C. Yan Y. Tian X. Yuan X. Shen Effects of low level of methylmercury on proliferation of cortical progenitor cells Brain Res. 2010 1359 272 280 10.1016/j.brainres.2010.08.069
34. M. Ni X. Li Z. Yin H. Jiang M. Sidoryk-Wegrzynowicz D. Milatovic J. Cai M. Aschner Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells Toxicol. Sci. 2010 116 590 603 10.1093/toxsci/kfq126
35. S. J. James W. Slikker, 3rd S. Melnyk E. New M. Pogribna S. Jernigan Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors Neurotoxicology 2005 26 1 8 10.1016/j.neuro.2004.07. 012
36. K. J. Woo T. J. Lee J. H. Bae B. C. Jang D. K. Song J. W. Cho S. I. Suh J. W. Park T. K. Kwon Thimerosal induces apoptosis and G2/M phase arrest in human leukemia cells Mol. Carcinog. 2006 45 657 666 10.1002/mc.20202
37. A. W. Tann I. Boldogh G. Meiss W. Qian B. Van Houten S. Mitra B. Szczesny Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5′-EXO/endonuclease) in their repair J. Biol. Chem. 2011 286 31975 31983 10.1074/jbc.M110.215715
38. X. Wu H. Liang K. A. O'Hara J. C. Yalowich B. B. Hasinoff Thiol-modulated mechanisms of the cytotoxicity of thimerosal and inhibition of DNA topoisomerase II alpha Chem. Res. Toxicol. 2008 21 483 493 10.1021/tx700341n
39. D. S. Baskin H. Ngo V. V. Didenko Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblasts Toxicol. Sci. 2003 74 361 368 10.1093/toxsci/kfg126
40. A. Mangerich A. Bürkle How to kill tumor cells with inhibitors of poly(ADP-ribosyl)ation Int. J. Cancer 2011 128 251 265 10.1002/ijc.25683
41. F. Dantzer J. C. Ame V. Schreiber J. Nakamura J. Menissier-de Murcia G. de Murcia Poly(ADP-ribose) polymerase-1 activation during DNA damage and repair Methods Enzymol. 2006 409 493 510 10.1016/S0076-6879(05)09029-4
42. I. D. Odell J. E. Barbour D. L. Murphy J. A. Della-Maria J. B. Sweasy A. E. Tomkinson S. S. Wallace D. S. Pederson Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair Mol. Cell. Biol. 2011 31 4623 4632 10.1128/MCB.05715-11
43. J. B. Leppard Z. Dong Z. B. Mackey A. E. Tomkinson Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair Mol. Cell. Biol. 2003 23 5919 5927
44. K. Erdelyi P. Bai I. Kovacs E. Szabo G. Mocsar A. Kakuk C. Szabo P. Gergely L. Virag Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells FASEB J. 2009 23 3553 3563 10.1096/fj.09-133264 fj.09-133264 [pii]
45. M. L. Meyer-Ficca R. G. Meyer E. L. Jacobson M. K. Jacobson Poly(ADP-ribose) polymerases: managing genome stability Int. J. Biochem. Cell Biol. 2005 37 920 926 10.1016/j.biocel.2004.09.011
46. P. M. Rappold K. Tieu Astrocytes and therapeutics for Parkinson's disease Neurotherapeutics 2010 7 413 423 10.1016/j.nurt.2010.07.001 S1933-7213(10)00087-5 [pii]
47. M. F. Mehler S. Gokhan Mechanisms underlying neural cell death in neurodegenerative diseases: alterations of a developmentally-mediated cellular rheostat Trends Neurosci. 2000 23 599 605
48. A. M. Gorman Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling J. Cell. Mol. Med. 2008 12 2263 2280 10.1111/j.1582-4934.2008.00402.x
49. T. M. Kauppinen Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease Neurochem. Int. 2007 50 954 958 10.1016/j.neuint.2006.11. 010
50. P. Grandjean P. Weihe R. F. White F. Debes S. Araki K. Yokoyama K. Murata N. Sorensen R. Dahl P. J. Jorgensen Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury Neurotoxicol. Teratol. 1997 19 417 428
51. R. A. Kohman J. S. Rhodes Neurogenesis inflammation and behavior Brain, Behav., Immun. 2013 27 22 32 10.1016/j.bbi.2012.09.003