Discovery of novel urea derivatives as dual-target hypoglycemic agents that activate glucokinase and PPARγ

European Journal of Medicinal Chemistry

Volumn 76, Issue , 2014, Pages 182-192

  Li, Yongqiang ^a   Tian, Kang ^b   Qin, Aifang ^b   Zhang, Lijian ^b   Huo, Lianchao ^a   Lei, Lei ^a   Shen, Zhufang ^a   Song, Hongrui ^b   Feng, Zhiqiang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Dual target; Glucokinase activator; PPAR ; Type 2 diabetes; Urea derivatives

Indexed keywords

2 (4 (ALLYL(BENZO[D]THIAZOL 2 YL)AMINO)PHENOXY) 2 METHYLPROPANOIC ACID; 2 (4 (BENZO[D]THIAZOL 2 YL(2 ETHOXYETHYL)AMINO)PHENOXY) 2 METHYLPROPANOIC ACID; 2 (4 (BENZO[D]THIAZOL 2 YL(3 METHYLBUT 2 ENYL)AMINO)PHENOXY) 2 METHYLPROPANOIC A; 2 (4 (BENZO[D]THIAZOL 2 YL(CYCLOHEXYLMETHYL)AMINO)PHENOXY) 2 METHYLPROPANOIC ACI; 2 (4 (BENZO[D]THIAZOL 2 YL(ETHYL)AMINO)PHENOXY) 2 METHYLPROPANOIC ACID; 2 (4 (BENZO[D]THIAZOL 2 YL(ISOPENTYL)AMINO)PHENOXY) 2 METHYLPROPANOIC ACID; ANTIDIABETIC AGENT; ETHYL 2 (4 ((2 ETHOXYETHYL)(THIAZOL 2 YL)AMINO)PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 (4 ((3 FLUOROBENZYL)(BENZO[D]THIAZOL 2 YL)AMINO) PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 (4 ((3 UOROBENZYL)(THIAZOL 2 YL)AMINO)PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 (4 ((CYCLOHEXYLMETHYL)(THIAZOL 2 YL)AMINO)PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 (4 ((CYCLOPENTYLMETHYL)(THIAZOL 2 YL)AMINO)PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 (4 ((FURAN 2 YLMETHYL)(THIAZOL 2 YL)AMINO)PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 (4 (ALLY(THIAZOL 2 YL)AMINO)PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 (4 (ALLYL(BENZO[D]THIAZOL 2 YL)AMINO)PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 (4 (BENZO[D]THIAZOL 2 YL(2 ETHOXYETHYL)AMINO)PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 (4 (BENZO[D]THIAZOL 2 YL(3 METHYLBUT 2 ENYL)AMINO) PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 (4 (BENZO[D]THIAZOL 2 YL(CYCLOHEXYLMETHYL)AMINO) PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 (4 (BENZO[D]THIAZOL 2 YL(CYCLOPENTYLMETHYL)AMINO) PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 (4 (BENZO[D]THIAZOL 2 YL(ETHYL)AMINO)PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 (4 (BENZO[D]THIAZOL 2 YL(FURAN 2 YLMETHYL)AMINO) PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 (4 (BENZO[D]THIAZOL 2 YL(ISOPENTYL)AMINO)PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 (4 (ISOPENTYL(THIAZOL 2 YL)AMINO)PHENOXY) 2 METHYLPROPANOATE; ETHYL 2 METHYL 2 (4 ((3 METHYLBUT 2 ENYL)(THIAZOL 2 YL) AMINO)PHENOXY)PROPANOATE; ETHYL 2 METHYL 2 (4 (PENTYL(THIAZOL 2 YL)AMINO)PHENOXY) PROPANOATE; GLUCOKINASE; GLUCOSE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE; UREA;

ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DEVELOPMENT; DRUG SYNTHESIS; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHARMACOLOGICAL PARAMETERS; AGONISTS; ANIMAL; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVATION; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANIMALS; DRUG DISCOVERY; ENZYME ACTIVATION; GLUCOKINASE; HYPOGLYCEMIC AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED ICR; PPAR GAMMA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; UREA;

EID: 84896863981     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.02.024     Document Type: Article

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