Enzyme analysis of the polyketide synthase leads to the discovery of a novel analog of the antibiotic α-lipomycin

Journal of Antibiotics

Volumn 67, Issue 2, 2014, Pages 199-201

  Yuzawa, Satoshi ^a   Eng, Clara H ^a,b,c   Katz, Leonard ^a,c   Keasling, Jay D ^a,b,c,d,e  

^a JOINT BIOENERGY INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Synthetic Biology Engineering Research Center   (United States)

^d University of California at Berkeley   (United States)

^e LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

broad substrate specificity; isoleucine; lipomycin synthase

Indexed keywords

ACYL COENZYME A; ALPHA LIPOMYCIN DERIVATIVE; ISOLEUCINE; POLYENE ANTIBIOTIC AGENT; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; ELECTRON; ENZYME ANALYSIS; ENZYME SUBSTRATE; ESCHERICHIA COLI; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES AUREOFACIENS; ULTRAVIOLET SPECTROSCOPY;

BACILLUS SUBTILIS; DRUG DISCOVERY; ESCHERICHIA COLI; GLYCOSIDES; GRAM-POSITIVE BACTERIA; GRAM-POSITIVE BACTERIAL INFECTIONS; MAGNETIC RESONANCE IMAGING; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; POLYENES; POLYKETIDE SYNTHASES; STREPTOMYCES AUREOFACIENS;

EID: 84896821323     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2013.110     Document Type: Article

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