Ligand independence of the T618I mutation in the colony-stimulating factor 3 receptor (CSF3R) protein results from loss of O-linked glycosylation and increased receptor dimerization

Journal of Biological Chemistry

Volumn 289, Issue 9, 2014, Pages 5820-5827

  Maxson, Julia E ^a,b   Luty, Samuel B ^a,b   MacManiman, Jason D ^a,b   Abel, Melissa L ^a,c   Druker, Brian J ^a,b,c   Tyner, Jeffrey W ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR TRANSFORMATION; COLONY-STIMULATING FACTOR; CYTOKINE RECEPTOR; GRANULOCYTE-COLONY STIMULATING FACTOR; LIGAND-INDEPENDENT ACTIVATION; O-GLYCOSYLATION; OVER-EXPRESSION; SIGNALING PATHWAYS;

DIMERIZATION; DISEASES; ESTERIFICATION; GLYCOSYLATION; LIGANDS; MEMBRANES; MOLECULAR BIOLOGY;

BIOACTIVITY;

CYTOKINE RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; ISOLEUCINE; THREONINE;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; DIMERIZATION; FEMALE; GENE MUTATION; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR GENE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

CYTOKINE; GCSFR T595I; GLYCOPROTEIN; LEUKEMIA; MYELOPROLIFERATIVE NEOPLASM; NEUTROPHIL; RECEPTOR MODIFICATION;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; FEMALE; GLYCOSYLATION; HUMANS; LEUKEMIA, NEUTROPHILIC, CHRONIC; LIGANDS; MICE; MICE, INBRED BALB C; MUTATION, MISSENSE; NEOPLASM PROTEINS; PROTEIN MULTIMERIZATION; RECEPTORS, COLONY-STIMULATING FACTOR; SIGNAL TRANSDUCTION;

EID: 84896809170     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.508440     Document Type: Article

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