F-box only protein 2 (Fbxo2) regulates amyloid precursor protein levels and processing

Journal of Biological Chemistry

Volumn 289, Issue 10, 2014, Pages 7038-7048

  Atkin, Graham ^a   Hunt, Jack ^a   Minakawa, Eiko ^a   Sharkey, Lisa ^a   Tipper, Nathan ^a   Tennant, William ^a   Paulson, Henry L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; GLYCOPROTEINS;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; UBIQUITIN LIGASES;

PROTEINS;

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; CASPASE 3; F BOX PROTEIN; PROTEIN FBXO2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN REGION; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SYNAPSE;

AMYLOID PRECURSOR PROTEIN; NEUROBIOLOGY; PROTEIN TARGETING; SYNAPSES; UBIQUITINATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELLS, CULTURED; F-BOX PROTEINS; HIPPOCAMPUS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEURONS;

EID: 84896789793     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.515056     Document Type: Article

References (38)

1. De Strooper, B., Vassar, R., and Golde, T. (2010) The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat. Rev. Neurol. 6, 99-107
2. Bertram, L., Lill, C. M., and Tanzi, R. E. (2010) The genetics of Alzheimer disease: back to the future. Neuron 68, 270-281
3. Thinakaran, G., and Koo, E. H. (2008) Amyloid precursor protein trafficking, processing, and function. J. Biol. Chem. 283, 29615-29619
4. Purro, S. A., Dickins, E. M., and Salinas, P. C. (2012) The secreted Wnt antagonist Dickkopf-1 is required for amyloid mediated synaptic loss. J. Neurosci. 32, 3492-3498
5. Palop, J. J., Chin, J., and Mucke, L. (2006) A network dysfunction perspective on neurodegenerative diseases. Nature 443, 768-773
6. Citron, M. (2010) Alzheimer's disease: strategies for disease modification. Nat. Rev. Drug Discov. 9, 387-398
7. Brouwers, N., Sleegers, K., Engelborghs, S., Bogaerts, V., Serneels, S., Kamali, K., Corsmit, E., De Leenheir, E., Martin, J. J., De Deyn, P. P., Van Broeckhoven, C., and Theuns, J. (2006) Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease. Brain 129, 2984-2991
8. Millan Sanchez, M., Heyn, S. N., Das, D., Moghadam, S., Martin, K. J., and Salehi, A. (2012) Neurobiological elements of cognitive dysfunction in down syndrome: exploring the role of APP. Biol. Psychiatry 71, 403-409
9. Rovelet-Lecrux, A., Hannequin, D., Raux, G., Le Meur, N., Laquerrière, A., Vital, A., Dumanchin, C., Feuillette, S., Brice, A., Vercelletto, M., Dubas, F., Frebourg, T., and Campion, D. (2006) APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat. Genet. 38, 24-26
10. Tyan, S. H., Shih, A. Y., Walsh, J. J., Maruyama, H., Sarsoza, F., Ku, L., Eggert, S., Hof, P. R., Koo, E. H., and Dickstein, D. L. (2012) Amyloid precursor protein (APP) regulates synaptic structure and function. Mol. Cell Neurosci. 51, 43-52
11. De Strooper, B., and Annaert, W. (2000) Proteolytic processing and cell biological functions of the amyloid precursor protein. J. Cell Sci. 113, 1857-1870
12. Mattson, M. P. (1997) Cellular actions ofamyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol. Rev. 77, 1081-1132
13. Cousins, S. L., Hoey, S. E., Anne Stephenson, F., and Perkinton, M. S. (2009) Amyloid precursor protein 695 associates with assembled NR2Aand NR2B-containing NMDA receptors to result in the enhancement of their cell surface delivery. J. Neurochem. 111, 1501-1513
14. Puzzo, D., Privitera, L., Fa', M., Staniszewski, A., Hashimoto, G., Aziz, F., Sakurai, M., Ribe, E. M., Troy, C. M., Mercken, M., Jung, S. S., Palmeri, A., and Arancio, O. (2011) Endogenous amyloid is necessary for hippocampal synaptic plasticity and memory. Ann. Neurol. 69, 819-830
15. Bero, A. W., Yan, P., Roh, J. H., Cirrito, J. R., Stewart, F. R., Raichle, M. E., Lee, J. M., and Holtzman, D. M. (2011) Neuronal activity regulates the regional vulnerability to amyloid deposition. Nat. Neurosci. 14, 750-756
16. Yoshida, Y., Chiba, T., Tokunaga, F., Kawasaki, H., Iwai, K., Suzuki, T., Ito, Y., Matsuoka, K., Yoshida, M., Tanaka, K., and Tai, T. (2002) E3 ubiquitin ligase that recognizes sugar chains. Nature 418, 438-442
17. Morales-Corraliza, J., Mazzella, M. J., Berger, J. D., Diaz, N. S., Choi, J. H., Levy, E., Matsuoka, Y., Planel, E., and Mathews, P. M. (2009) In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in theamyloid depositing mice. PLoS One 4, e7134
18. Kaneko, M., Koike, H., Saito, R., Kitamura, Y., Okuma, Y., and Nomura, Y. (2010) Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid generation. J. Neurosci. 30, 3924-3932
19. Nelson, R. F., Glenn, K. A., Miller, V. M., Wen, H., and Paulson, H. L. (2006) A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control. J. Biol. Chem. 281, 20242-20251
20. Gong, B., Chen, F., Pan, Y., Arrieta-Cruz, I., Yoshida, Y., Haroutunian, V., and Pasinetti, G. M. (2010) SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function. Aging Cell 9, 1018-1031
21. Nelson, R. F., Glenn, K. A., Zhang, Y., Wen, H., Knutson, T., Gouvion, C. M., Robinson, B. K., Zhou, Z., Yang, B., Smith, R. J., and Paulson, H. L. (2007) Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit. J. Neurosci. 27, 5163-5171
22. Miller, V. M., Nelson, R. F., Gouvion, C. M., Williams, A., Rodriguez-Lebron, E., Harper, S. Q., Davidson, B. L., Rebagliati, M. R., and Paulson, H. L. (2005) CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo. J. Neurosci. 25, 9152-9161
23. Thomas-Crusells, J., Vieira, A., Saarma, M., and Rivera, C. (2003) A novel method for monitoring surface membrane trafficking on hippocampal acute slice preparation. J. Neurosci. Methods 125, 159-166
24. Aakalu, G., Smith, W. B., Nguyen, N., Jiang, C., and Schuman, E. M. (2001) Dynamic visualization of local protein synthesis in hippocampal neurons. Neuron 30, 489-502
25. Iliff, A. J., Renoux, A. J., Krans, A., Usdin, K., Sutton, M. A., and Todd, P. K. (2013) Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice. Hum. Mol. Genet. 22, 1180-1192
26. Escrevente, C., Morais, V. A., Keller, S., Soares, C. M., Altevogt, P., and Costa, J. (2008) Functional role of N-glycosylation from ADAM10 in processing, localization and activity of the enzyme. Biochim. Biophys. Acta 1780, 905-913
27. Glenn, K. A., Nelson, R. F., Wen, H. M., Mallinger, A. J., and Paulson, H. L. (2008) Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. J. Biol. Chem. 283, 12717-12729
28. Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., and Malinow, R. (2003) APP processing and synaptic function. Neuron 37, 925-937
29. Wang, Y. J., Zhou, H. D., and Zhou, X. F. (2010) Modified immunotherapies against Alzheimer's disease: toward safer and effective amyloid clearance. J. Alzheimers Dis. 21, 1065-1075
30. Frisoni, G. B., Ganzola, R., Canu, E., Rüb, U., Pizzini, F. B., Alessandrini, F., Zoccatelli, G., Beltramello, A., Caltagirone, C., and Thompson, P. M. (2008) Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla. Brain 131, 3266-3276
31. Choy, R. W., Cheng, Z., and Schekman, R. (2012) Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid (A-) production in the trans-Golgi network. Proc. Natl. Acad. Sci. U.S.A. 109, E2077-E2082
32. Andersen, O. M., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., von Arnim, C. A., Breiderhoff, T., Jansen, P., Wu, X., Bales, K. R., Cappai, R., Masters, C. L., Gliemann, J., Mufson, E. J., Hyman, B. T., Paul, S. M., Nykjaer, A., and Willnow, T. E. (2005) Neuronal sorting proteinrelated receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc. Natl. Acad. Sci. U.S.A. 102, 13461-13466
33. Hoe, H. S., Fu, Z., Makarova, A., Lee, J. Y., Lu, C., Feng, L., Pajoohesh-Ganji, A., Matsuoka, Y., Hyman, B. T., Ehlers, M. D., Vicini, S., Pak, D. T., and Rebeck, G. W. (2009) The effects of amyloid precursor protein on postsynaptic composition and activity. J. Biol. Chem. 284, 8495-8506
34. Rushworth, J. V., and Hooper, N. M. (2010) Lipid Rafts: Linking Alzheimer's Amyloid production, aggregation, and toxicity at neuronal membranes. Int. J. Alzheimers Dis. 2011, 603052
35. Helenius, A., and Aebi, M. (2004) Roles of N-linked glycans in the endoplasmic reticulum. Annu. Rev. Biochem. 73, 1019-1049
36. Kato, A., Rouach, N., Nicoll, R. A., and Bredt, D. S. (2005) Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination. Proc. Natl. Acad. Sci. U.S.A. 102, 5600-5605
37. Huh, K. H., and Wenthold, R. J. (1999) Turnover analysis of glutamate receptors identifies a rapidly degraded pool of the N-methyl-D-aspartate receptor subunit, NR1, in cultured cerebellar granule cells. J. Biol. Chem. 274, 151-157
38. El Ayadi, A., Stieren, E. S., Barral, J. M., and Boehning, D. (2012) Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688. Proc. Natl. Acad. Sci. U.S.A. 109, 13416-13421