The effect of a diiodothyronine mimetic on insulin sensitivity in male cardiometabolic patients: A double-blind randomized controlled trial

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Van Der Valk, Fleur ^a   Hassing, Carlijne ^a   Visser, Maartje ^a   Thakkar, Purav ^b   Mohanan, Anookh ^b   Pathak, Kaushal ^b   Dutt, Chaitanya ^b   Chauthaiwale, Vijay ^b   Ackermans, Mariette ^a   Nederveen, Aart ^a   Serlie, Mireille ^a   Nieuwdorp, Max ^a   Stroes, Erik ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b Torrent Pharmaceuticals Ltd   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; DIIODOTHYRONINE; FATTY ACID; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; INSULIN; PLACEBO; THYROTROPIN; TRC 150094; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; THYRONINE DERIVATIVE; TRC150094;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; BODY TEMPERATURE; BODY WEIGHT; CARDIOMETABOLIC RISK; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FATTY ACID BLOOD LEVEL; GLUCONEOGENESIS; HEART RATE; HOMEOSTASIS; HUMAN; HYPERINSULINEMIA; INDIA; INSULIN SENSITIVITY; LIPOLYSIS; LIVER FUNCTION TEST; LIVER LEVEL; MALE; METABOLIC PARAMETERS; NETHERLANDS; OBESITY; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; UNSPECIFIED SIDE EFFECT; VITAL SIGN; GLUCOSE CLAMP TECHNIQUE; INSULIN RESISTANCE; METABOLIC SYNDROME X; METABOLISM; MIDDLE AGED; NONPARAMETRIC TEST; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY;

ADULT; DIIODOTHYRONINES; GLUCOSE CLAMP TECHNIQUE; HUMANS; INDIA; INSULIN RESISTANCE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NETHERLANDS; STATISTICS, NONPARAMETRIC; THYRONINES;

EID: 84896786828     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086890     Document Type: Article

References (28)

1. Ogden CL, Carroll MD, Kit BK, Flegal KM (2012) Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010. JAMA 307: 483-490. jama.2012.40 [pii];10.1001/jama.2012.40 [doi].
2. Cheng SY, Leonard JL, Davis PJ (2010) Molecular aspects of thyroid hormone actions. Endocr Rev 31: 139-170. er.2009-0007 [pii];10.1210/er.2009-0007 [doi].
3. Klieverik LP, Coomans CP, Endert E, Sauerwein HP, Havekes LM, et al. (2009) Thyroid hormone effects on whole-body energy homeostasis and tissue-specific fatty acid uptake in vivo. Endocrinology 150: 5639-5648. en.2009-0297 [pii];10.1210/en.2009-0297 [doi].
4. Klein I, Ojamaa K (2001) Thyroid hormone and the cardiovascular system. N Engl J Med 344: 501-509. 10.1056/NEJM200102153440707 [doi]. (Pubitemid 32164903)
5. Ladenson PW, Kristensen JD, Ridgway EC, Olsson AG, Carlsson B, et al. (2010) Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia. N Engl J Med 362: 906-916. 362/10/906 [pii];10.1056/NEJMoa0905633 [doi].
6. Per Bengtsson (2012) KARO BIO Terminsates the Eprotirome Program.
7. Moreno M, Lombardi A, Silvestri E, Lanni A, Goglia F (2008) Metabolic effects of thyroid hormone derivatives. Thyroid 18: 239-253. 10.1089/thy.2007.0248 [doi]. (Pubitemid 351271526)
8. Cioffi F, Zambad SP, Chhipa L, Senese R, Busiello RA, et al. (2010) TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet. FASEB J 24: 3451-3461. fj.10-157115 [pii];10.1096/fj.10-157115 [doi].
9. Silvestri E, Glinni D, Cioffi F, Moreno M, Lombardi A, et al. (2012) Metabolic effects of the iodothyronine functional analogue TRC150094 on the liver and skeletal muscle of high-fat diet fed overweight rats: an integrated proteomic study. Mol Biosyst 8: 1987-2000. 10.1039/c2mb25055a [doi].
10. Zambad SP, Munshi S, Dubey A, Gupta R, Busiello RA, et al. (2011) TRC150094 attenuates progression of nontraditional cardiovascular risk factors associated with obesity and type 2 diabetes in obese ZSF1 rats. Diabetes Metab Syndr Obes 4: 5-16. 10.2147/DMSOTT.S15323 [doi].
11. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, et al. (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120: 1640-1645. CIRCULATIONAHA. 109.192644 [pii];10.1161/CIRCULATIONAHA.109.192644 [doi].
12. Bryzgalova G, Effendic S, Khan A, Rehnmark S, Barbounis P, et al. (2008) Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor beta subtype selective agonist KB-141. J Steroid Biochem Mol Biol 111: 262-267. S0960-0760(08)00185-4 [pii];10.1016/j.jsbmb.2008.06.010 [doi].
13. Brenta G, Celi FS, Pisarev M, Schnitman M, Sinay I, et al. (2009) Acute thyroid hormone withdrawal in athyreotic patients results in a state of insulin resistance. Thyroid 19: 665-669. 10.1089/thy.2009.0108 [doi].
14. Rezzonico J, Niepomniszcze H, Rezzonico M, Pusiol E, Alberto M, et al. (2011) The association of insulin resistance with subclinical thyrotoxicosis. Thyroid 21: 945-949. 10.1089/thy.2010.0402 [doi].
15. Skarulis MC, Celi FS, Mueller E, Zemskova M, Malek R, et al. (2010) Thyroid hormone induced brown adipose tissue and amelioration of diabetes in a patient with extreme insulin resistance. J Clin Endocrinol Metab 95: 256-262. jc.2009-0543 [pii];10.1210/jc.2009-0543 [doi].
16. Soeters MR, Lammers NM, Dubbelhuis PF, Ackermans M, Jonkers-Schuitema CF, et al. (2009) Intermittent fasting does not affect whole-body glucose, lipid, or protein metabolism. Am J Clin Nutr 90: 1244-1251. ajcn.2008.27327 [pii];10.3945/ajcn.2008.27327 [doi].
17. van Raalte DH, Brands M, van der Zijl NJ, Muskiet MH, Pouwels PJ, et al. (2011) Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial. Diabetologia 54: 2103-2112. 10.1007/s00125-011-2174-9 [doi].
18. Pasarica M, Rood J, Ravussin E, Schwarz JM, Smith SR, et al. (2010) Reduced oxygenation in human obese adipose tissue is associated with impaired insulin suppression of lipolysis. J Clin Endocrinol Metab 95: 4052-4055. jc.2009-2377 [pii];10.1210/jc.2009-2377 [doi].
19. Hickner RC, Racette SB, Binder EF, Fisher JS, Kohrt WM (1999) Suppression of whole body and regional lipolysis by insulin: effects of obesity and exercise. J Clin Endocrinol Metab 84: 3886-3895. (Pubitemid 30644170)
20. Moreno M, Silvestri E, Lombardi A, Glinni D, Senese R, et al. (2011) 3,5-Diiodo-L-thyronine prevents high-fat-diet-induced insulin resistance in rat skeletal muscle through metabolic and structural adaptations. FASEB J 25: 3312-3324. fj.11-181982 [pii];10.1096/fj.11-181982 [doi].
21. Cioffi F, Senese R, Moreno M, Lombardi A, Silvestri E et al. (2011) Nonthyrotoxic prevention of diet-induced insulin resistance by 3,5-diiodo-Lthyronine in rats. Diabetes 60: 2730-2739. db11-0207 [pii];10.2337/db11-0207 [doi].
22. Ball SG, Sokolov J, Chin WW (1997) 3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitro. J Mol Endocrinol 19: 137-147. (Pubitemid 27431842)
23. Horst C, Rokos H, Seitz HJ (1989) Rapid stimulation of hepatic oxygen consumption by 3,5-di-iodo-L-thyronine. Biochem J 261: 945-950. (Pubitemid 19209537)
24. Pinna G, Hiedra L, Meinhold H, Eravci M, Prengel H, et al. (1998) 3,3'-Diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors and of healthy subjects during acute stress. J Clin Endocrinol Metab 83: 3071-3077. (Pubitemid 28500936)
25. Reagan-Shaw S, Nihal M, Ahmad N (2008) Dose translation from animal to human studies revisited. FASEB J 22: 659-661. fj.07-9574LSF [pii];10.1096/fj.07- 9574LSF [doi].
26. Vrieze A, Van NE, Holleman F, Salojarvi J, Kootte RS, et al. (2012) Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 143: 913-916. S0016-5085(12)00892-X [pii];10.1053/j.gastro.2012.06.031 [doi].
27. Eckel RH (2011) The complex metabolic mechanisms relating obesity to hypertriglyceridemia. Arterioscler Thromb Vasc Biol 31: 1946-1948. 31/9/1946 [pii];10.1161/ATVBAHA.111.233049 [doi].
28. Ribeiro MO (2008) Effects of thyroid hormone analogs on lipid metabolism and thermogenesis. Thyroid 18: 197-203. 10.1089/thy.2007.0288 [doi].