Identification of small molecules that selectively inhibit diacylglycerol lipase-α activity

Journal of Biomolecular Screening

Volumn 19, Issue 4, 2014, Pages 595-605

  Appiah, Kingsley K ^a   Blat, Yuval ^a,c   Robertson, Barbara J ^a   Pearce, Bradley C ^a   Pedicord, Donna L ^a   Gentles, Robert G ^a   Yu, Xuan Chuan ^b,e   Mseeh, Faika ^b   Nguyen, Nghi ^b,f   Swaffield, Jonathan C ^b   Harden, David G ^a   Westphal, Ryan S ^a,d   Banks, Martyn N ^a   O'Connell, Jonathan C ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b LEXICON PHARMACEUTICALS INC   (United States)

^c ARMGO Pharma Inc   (United States)

^d EnVivo Pharmaceuticals   (United States)

^e Epoch Life Science Inc   (United States)

^f TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

2 arachidonoyl glycerol (2 AG); diacylglycerol lipase (DAGL ); enzyme; HTS; inhibitor

Indexed keywords

ACYLGLYCEROL LIPASE; ESTERASE INHIBITOR; LIPOPROTEIN LIPASE; LIPOPROTEIN LIPASE ALPHA; LIPOPROTEIN LIPASE ALPHA INHIBITOR; OLEIC ACID; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; PRIORITY JOURNAL;

2-ARACHIDONOYL-GLYCEROL (2-AG); DIACYLGLYCEROL LIPASE-Α (DAGL-Α); ENZYME; HTS; INHIBITOR;

CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; KINETICS; LIPOPROTEIN LIPASE; REPRODUCIBILITY OF RESULTS; SMALL MOLECULE LIBRARIES; SUBSTRATE SPECIFICITY;

EID: 84896786634     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113511111     Document Type: Article

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