Smoking and male reproduction: A review

International Journal of Andrology

Volumn 19, Issue 6, 1996, Pages 323-337

  Vine, M F ^a  

^a University of North Carolina at Chapel Hill   (United States)

Author keywords

Cancer; Congenital anomalies; Fertility; Hormones; Male reproduction; Mutation; Smoking; Spermatozoa; Spontaneous abortion

Indexed keywords

CARCINOGEN; CIGARETTE SMOKE; ESTRADIOL; ESTRONE; MUTAGENIC AGENT;

AGE; CELL STRUCTURE; CHILDHOOD CANCER; CIGARETTE SMOKING; CONCEPTION; CONGENITAL MALFORMATION; EPIDEMIOLOGICAL DATA; HUMAN; LABORATORY TEST; MALE; MALE FERTILITY; MALE INFERTILITY; METHODOLOGY; PREGNANCY; PRIORITY JOURNAL; REPRODUCTION; REVIEW; SEMEN ANALYSIS; SMOKING CESSATION; SMOKING HABIT; SPERMATOZOON MOTILITY;

EID: 0030485052     PISSN: 01056263     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2605.1996.tb00523.x     Document Type: Review

References (110)

1. Anersen, A. N., Semczuk, M. & Tabor, A. (1984) Prolactin and pituitary-gonadal function in cigarette smoking infertile patients. Andrologia, 16, 391-396.
2. Baird, D. D. & Wilcox, A. J. (1985) Cigarette smoking associated with delayed conception. Journal of American Medical Association, 253, 2979-2983.
3. Baird, D. D. & Wilcox, A. J. (1986) Future fertility after prenatal exposure to cigarette smoke. Fertility and Sterility, 46, 368-372.
4. Banerjee, A., Pakrashi, A., Chatterjee, S., Ghosh, S. & Dutta, S. K. (1993) Semen characteristics of tobacco users in India. Archives of Andrology, 30, 35-40.
5. Barrett-Connor, E. & Khaw, K. T. (1987) Cigarette smoking and increased endogenous estrogen levels in men. American Journal of Epidemiology, 126, 187-192.
6. Birch, J. M., Hartley, A. L., Teare, M. D., Blaire, V., McKinney, P A., Mann, J. R., Stiller, C. A., Drapper, G. J., Johnston, H. E., Cartwright, R. A. & Waterhouse, J. A. H. (1990) The interregional epidemiological study of childhood cancer (IRESCC): A case-control study of children with central nervous system tumours. British Journal of Neurosurgery, 4, 17-26.
7. Bolumar, F., Olsen, J., Boldsen, J. & the European Group on Infertility and Suhfecundity (1996) Smoking reduces fecudity: a European multicenter study on infertility and subfecundity. American Journal of Epidemiology, 143, 578-587.
8. Bracken, M. B., Eskenazi, B., Sachse, K., McSharry, J-E., Hellenbrand, K., Leo-Summers, L. (1990) Association of cocaine use with sperm concentration, motility, and morphology. Fertility and Sterility, 53, 315-322.
9. Briggs, M. H. (1973) (Correspondence) Cigarette smoking and infertility in men. The Medical Journal of Australia, 1, 616-617.
10. Buckley, J. D., Sather, H., Ruccione, K, Rogers, P. C. J., Haas, J. E., Henderson, B. E. & Hammond, G. D. (1989) A case-control study of risk factors for hepatoblastoma. A report from the Childrens Cancer Study Group. Cancer, 64, 1169-1176.
11. Bunin, G. R., Meadows, A. T., Emanuel, B. S., Buckley, J. D., Woods, W. G. & Hammond, G. D. (1989) Pre- and post-conception factors associated with sporadic heritable and nonheritable retionoblastoma. Cancer Research, 49, 5730-5735.
12. Bunin, G. R., Buckley, J. D., Boesel, C. P., Rorke, L. B., Meadows, A. T. (1994) Risk factors for astrocytic glioma and primitive neuroectodermal tumor of the brain in young children: a report from the Children's Cancer Group. Cancer Epidemiology, Biomarkers and Prevention, 3, 197-204.
13. Chandley, A. C. (1991) On the parental origin of de novo mutation in man. Journal of Medical Genetics, 28, 217-223.
14. Chia, S. E., Ong, C. N. & Tsakok, F. M. H. (1994) Effects of cigarette smoking on human semen quality. Archives of Andrology, 33, 163-168.
15. Close, C. E., Robert, P. L. & Berger, R. E. (1990) Cigarettes, alcohol and marijuana are related to pyospermia in infertile men. Journal of Urology, 144, 900-903.
16. Connolly, G. N. (1992) Worldwide expansion of transnational tobacco industry. Journal of the National Cancer Institute Monographs, 12, 29-35.
17. Cooper, T. G., Neuwinger, J., Bahrs, S., Nieschlag, E. (1992) Internal quality control of semen analysis. Fertility and Sterility, 58, 172-178.
18. Council on Scientific Affairs (1990) The worldwide smoking epidemic - tobacco, trade, use, and control. Journal of the American Medical Association, 263, 3312-3318.
19. Dai, W. S., Gutai, J. P., Kuller, L. H. & Cauley, J. A. (1988) Cigarette smoking and serum sex hormones in men. American Journal of Epidemiology, 128, 796-805.
20. de Mouzon, J., Spira, A. & Schwartz, D. (1988) A prospective study of the relation between smoking and fertility. International Journal of Epidemiology, 17, 378-384.
21. Dikshit, R. K., Buch, J. G. & Mansuri, S. M. (1987) Effect of tobacco consumption on semen quality of a population of hypofertile males. Fertility and Sterility, 48, 334-336.
22. Dunphy, B. C., Kay, R., Barrat, C. L., Cooke, I. D. (1989) Quality control in the conventional analysis of semen, an essential exercise. Journal of Andrology, 10, 378-385.
23. Dunphy, B. C., Barratt, C. L. R., von Tongelen, B. P. & Cooke, I. D. (1990) Male cigarette smoking and fecundity in couples attending an infertility clinic. Andrologia, 23, 223-225.
24. Epstein, S. S., Arnold, E., Andrea, J., Bass, W. & Bishop, Y. (1972) Detection of chemical mutagens by the dominant lethal assay in the mouse. Toxicology and Applied Pharmacology, 23, 288-325.
25. Essenberg, J. M., Fagan, L., Mallerstein, A. J. (1951) Chronic poisoning of the ovaries and testis of albino rats and mice by nicotine and cigarette smoke. Western Journal of Surgery Obstettrics and Gynecolology, 59, 27-32.
26. Evans, H. J., Fletcher, J., Torrance, M. & Hargreave, T. B. (1981) Sperm abnormalities and cigarette smoking. Lancet, i, 627-629.
27. Evenson, D. & Jost, L. (1994) Sperm chromatin structure assay: DNA denaturabihty. Chapter In: Methods In Cell Biology, Vol. 42 (eds Z. Darzynkiewicz, J. P. Robinson, H. A. Chrissman), pp. 160-175. Academic Press, New York.
28. Everson, R. B., Randerath, E., Santella, R. M., Avitts, T. A., Weinsten, I. B., Randerath, K. (1986) Quantitative association between DNA damage in human placenta and maternal smoking and birth weight. Journal of the National Cancer Institute, 80, 567-575.
29. Field, A. E., Colditz, G. A., Willett, W. C., Longcope, C. & McKinlay, J. B. (1994) The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men. Journal of Clinical Endocrinology and Metabolism, 79, 1310-1316.
30. Fillipini, G., Farinotti, M., Lovicu, G., Maisonneuve, P., Boyle, P. (1994) Mothers' active and passive smoking during pregnancy and risk of brain tumours in children. International Journal of Cancer, 57, 769-774.
31. 32P-Postlabellmg analysis of DNA adducts in human sperm cells from smokers and non-smokers. Cancer Epidemiology, Biomarkers and Prevention, 2, 581-585.
32. Godfrey, B. (1981) Sperm morphology in smokers. Lancet, i, 948.
33. Gold, E. B., Leviton, A., Lopez, R., Gilles, F. H., Hedley-Whyte, E. T., Kolonel, L. N., Lyon, J. L., Swanson, G. M., Weiss, N. S., West, D., Aschenbrener, C. & Austin, D. F. (1993) Parental smoking and risk of childhood brain tumors. American Journal of Epidemiology, 137, 620-628.
34. Grufferman, S., Wang, H. H., DeLong, E. R., Kimm, S. Y. S., Delzell, E. S. & Falletta, J. M. (1982) Environmental factors in the etiology of rhabdomyosarcoma in childhood. Journal of National Cancer Institute, 68, 107-113.
35. Grufferman, S., Gula, M. J., Olshan, A. E, Falletta, J. M., Buckley, J., Pendergrass, T. W. & Maurer, H. M. (1991) Absence of an association between parents' cigarette smoking and risk of rhabdomyosarcoma in their children. Pediatric Perinatal Epidemiology, 5, A17.
36. Handelsman, D. J., Conway, A. J., Boylan, L. M. & Turtle, J. R. (1984) Testicular function in potential sperm donors: Normal ranges and the effects of smoking and varicocele. International Journal of Andrology, 7, 369-382.
37. Hassold, T., Abruzzo, M., Adkins, K., Griffin, D., Merrill, M., Millie, E., Saker, D., Shen, J., Zaragoza, M. (1996) Human aneuploidy: Incidence, origin and etiology. Environmental and Molecular Mutagenesis, 28, 167-175.
38. Hearey, C. D., Harris, J. A., Usatin, M. S., Epstein, D. M., Ury, H. K. & Neutra, R. R. (1984) Investigation of a cluster of anencephaly and spina bifida. American Journal of Epidemiology, 120, 559-564.
39. Holly, E. A., Aston, D. A., Ahn, D. K. & Kristiansen, J. J. (1992) Ewing's bone sarcoma, paternal occupational exposure, and other factors. American Journal of Epidemiology, 135, 122-129.
40. Holmberg, P. C. & Nurminen, M. (1980) Congenital defects of the central nervous system and occupational factors during pregnancy: A case-referent study. American Journal of Industrial Medicine, 1, 167-176.
41. Holzki, G., Gall, H. & Hermann, J. (1991) Cigarette smoking and sperm quality. Andrologia, 23, 141-144.
42. Howe, G. R., Burch, J. D., Chiarelli, A. M., Risch, H. A. & Choi, B. C. K. (1989) An exploratory case-control study of brain tumors in children. Cancer Research, 49, 4349-4352.
43. Hughes, E. G., Yeo, J., Claman, P., YoungLai, E. V., Sagle, M. A., Daya, S. & Collins, J. A. (1994) Cigarette smoking and the outcomes of in vitro fertilization: Measurement of effect size and levels of action. Fertility and Sterility, 62, 807-814.
44. International Agency for Research on Cancer (1985) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans: Tobacco smoking. IARC Mongraphs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, 38, 65-74.
45. Istvan, J., Matarzzo, J. D. (1984) Tobacco, alcohol and caffeine use. A review of their relationships. Psychology Bulletin, 95, 301-326.
46. John, E. M., Savitz, D. A. & Sandler, D. P. (1991) Prenatal exposure to parents' smoking and childhood cancer. American Journal of Epidemiology, 133, 123-132.
47. Jouannet P, Ducot B, Feneux D, Spira, A. (1988) Male factors and the likelihood of pregnancy in infertile couples. I. Study of sperm characteristics. International Journal of Andrology, 11, 379-394.
48. Kelsey, K. T., Christiani, D. C., Little, J. B. (1986) Enhancement of benzo (a)pyrene sister chromatid exchanges in lymphocytes from cigarette smokers occupationally exposed to asbestos. Journal of the National Cancer Institute, 77, 321-327.
49. Klaiber, E. L., Broverman, D. M. & Dalen, J. E. (1984) Serum estradiol levels in male cigarette smokers. American Journal of Medicine, 77, 858-892.
50. Klaiber, E. L., Broverman, D. M., Pokoly, T. B., Albert, A. J., Howard, P. J. & Sherer, J. F. (1987) Interrelationships of cigarette smoking, testicular varicoceles, and seminal fluid indexes. Fertility and Sterility, 47, 481-486.
51. Kramer, S., Ward, E., Meadows, A. T. & Malone, K. E. (1987) Medical and drug risk factors associated with neuroblastoma: A case-control study. Journal of National Cancer Institute, 78, 797-804.
52. Kucheria, K., Saxena, R., Mohan, D. (1985) Semen analysis in alcohol dependence syndrome. Andrologia, 17, 558-563.
53. Kulikauskas, V., Blaustein, D. & Ablin, R. J. (1985) Cigarette smoking and its possible effects on sperm. Fertility and Sterility, 44, 526-528.
54. Lähdetie, J. (1986) Micronucleated spermatids in the seminal fluid of smokers and non-smokers. Mutation Research, 172, 255-263.
55. Lewin, A., Gonen, O., Orvieto, R. & Schenker, J. G. (1991) Effect of smoking on concentration, motility and zona-free hamster test on human sperm. Archives of Andrology, 27, 51-54.
56. Lichtenstein, M. J., Yarnell, J. W., Elwood, P. C., Beswick, A. D., Sweetnam, P. M., Marks, V., Teale, D. & Riad-Fahmy, D. (1987) Sex hormones, insulin, lipids, and prevalent ischemic heart disease. American Journal of Epidemiology, 126, 647-657.
57. Lindbohm, M.-L., Sallmen, M., Anttila, A., Taskinen, H. & Hemminki, K. (1991) Paternal occupational lead exposure and spontaneous abortion. Scandinavian Journal of Work, Environment and Health, 17, 95-103.
58. Lindholm, J., Winkel, P., Brodthagen, U & Gyntelberg, F. (1982) Coronary risk factors and plasma sex hormones. American Journal of Medicine, 73, 648-651.
59. Little, J. & Vainio, H. (1994) Mutagenic lifestyles? A review of evidence of associations between germ-cell mutations in humans and smoking, alcohol consumption and use of 'recreational' drugs. Mutation Research, 313, 131-151.
60. McCredie, M., Maisonneuve, P. & Boyle, P. (1994) Antenatal risk factors for malignant brain tumours in new South Wales children. International Journal of Cancer, 56, 6-10.
61. MacKenzie, K. M. & Angevine, D. M. (1981) Infertility in mice exposed in utero to benzo (a)pyrene. Biology of Reproduction, 24, 183-191.
62. Magnani, C., Pastore, G., Luzzatto, L., Carli, M., Lubrano, P. & Terracini, B. (1989) Risk factors for soft tissue sarcomas in childhood: A case-control study. Tumori, 75, 396-100.
63. Magnani, C., Pastore, G., Luzatto, L. & Terracini, B. (1990) Parental occupation and other environmental factors in the etiology of leukemias and non-Hodgkin's lymphomas in childhood: A case-control study. Tumori, 76, 413-419.
64. Marshburn, P. B. & Sloan, C. S. (1989) Semen quality and association with coffee drinking, cigarette smoking, and ethanol consumption. Fertility and Sterility, 52, 162-165.
65. Mattison, D. R. (1982) The effects of smoking on fertility from gametogenesis to implantation. Environmental Research, 28, 410-433.
66. Mau, G. & Netter, P. (1974) Effects of paternal cigarette smoking on perinatal mortality and incidence of malformations. Deutsche Medizinische Wochenschrift, 99, 1113-1118.
67. Moruzzi, J. F., Wyrobek, A. J., Mayall, B. H., Gledhill, B. L. (1988) Quantification and classification of human sperm morphology by computer-assisted image analysis. Fertility Sterility, 50, 142-152.
68. National Research Council Subcommittee on Reproductive and Neurodevelopmental Toxicology (1989) Chapter 7: Biologic markers of human male reproductive health and physiologic damage. In: Biological Markers in Reproductive Toxicology (eds N. Grossblatt & L. R. Paulson), pp. 83-105. National Academy Press, Washington, DC.
69. Nomura, T. (1988) X-ray and chemically induced germ-line mutation causing phenotypical abnormalities in mice. Mutation Research, 198, 309-320.
70. Nomura, T. (1989) Role of radiation induced mutations in multigenerational carcinogenesis. In: Perinatal and multigenerational carcinogenesis (eds N. P. Napalov, J. M. Rice, L. Tomatis, H. Yamasaki), pp. 375-387. International Agency for Research on Cancer, Lyon.
71. Oldereid, N. B., Rui, H., Clausen, O. P. F. & Purvis, K. (1989) Cigarette smoking and human sperm quality assessed by laser-Doppler spectroscopy and DNA flow cytometry. Journal of Reproduction and Fertility, 86, 731-736.
72. Olshan, A. F., Breslow, N. E., Falletta, J. M., Grufferman, S., Pendergrass, T., Robison, L. L., Waskerwitz, M., Woods, W. G., Vietti, T. J. & Hammond, G. D. (1993) Risk factors for Wilms tumor. Cancer, 72, 938-944.
73. Osser, S., Beckman-Ramirez, A. & Liedholm, P. (1992) Semen quality of smoking and nonsmoking men in infertile couples in a Swedish population. Acta Obstetricia et Gynecologica Scandinavica, 71, 215-218.
74. Pacifici, R., Altieri, I., Gandini, L., Lenzi, A., Pichini, Rosa, M., Zuccaro, P. & Dondero, F. (1993) Nicotine, cotinine, and trans-3-hydroxycotinine levels in seminal plasma of smokers: Effects on sperm parameters. Therapeutic Drug Monitoring, 15, 358-363.
75. Perera, F. P., Santella, R. M., Brenner, D., Poirier, M. C., Munshi, A. A., Fischman, H. K. & Van Ryzin, J. (1987) DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and non-smokers. Journal of the National Cancer Institute, 79, 449-456.
76. Preston-Martin, S., Yu, M. C., Benton, B. & Henderson, B. E. (1982) N-Nitroso compounds and childhood brain tumors: A case-control study. Cancer Research, 42, 5240-5245.
77. Rantala, M. L. & Koskimies, A. I. (1986) Semen quality of infertile couples-comparison between smokers and non-smokers. Andrologia, 19, 42-46.
78. Ratcliffe, J. M., Gladen, B. C., Wilcox, A. J. & Herbst, A. L. (1992) Does early exposure to maternal smoking affect future fertility in adult males? Reproductive Toxicology, 6, 297-307.
79. Remington, R. D. & Schork M. A. (1985) Statistics with Applications to the Biological and Health Sciences, p. 16. Prentice Hall, Inc., Englewood Cliffs.
80. Rivrud, G. N. (1988) Mutagenicity testing of seminal fluid: Seminal fluid increases the mutagenicity of the precursor mutagen benzo[a]pyrene in the presence of S9 mix. Mutation Research, 208, 195-200.
81. Robaire, B. & Hales, B. F. (1994) Post-testicular mechanisms of male-mediated developmental toxicity. In: Male-Mediated Developmental Toxicity (eds A. F. Olshan & D. R. Mattison), pp. 93-103. Plenum Press, New York.
82. Rodrique-Rigau, L. J., Smith, K. D. & Steinberger, E. (1982) Cigarette smoking and semen quality. Fertility and Sterility, 38, 115-116.
83. Robbins, W. A., Segraves, R., Pinkel, D. & Wyrobek, A. J. (1993) Detection of aneuploid human sperm by fluorescence in situ hybridization: Evidence for a donor difference in frequency of sperm disomic for chromosomes 1 and Y. American Journal of Human Genetics, 52, 799-807.
84. Rubes, J., Lowe, X., Cassel, M., Moore, D., Perreault, S., Slott, V., Evenson, D., Zudova, Z. Borkovec, L., Selevan, S. & Wyrobek, A. (1995) Sperm aneuploidy in smokers and non-smokers living in the Teplice district of the Czech Republic. Presented at the Second International Conference on Environmental Mutagens in Human Populations, August 20-25, Prague, Czech Republic.
85. Rupa, D. S., Reddy, P. P. & Reddi, O. S. (1991) Reproductive performance in population exposed to pesticides in cotton fields in India. Environmental Research, 55, 123-128.
86. Saaranen, M., Suonio, S., Kauhanen, O. & Saarikoski, S. (1987) Cigarette smoking and semen quality in men of reproductive age. Andrologia, 19, 670-676.
87. Savitz, D. A. (1994) Paternal exposures and pregnancy outcome: Miscarriage, stillbirth, low birth weight, preterm delivery. In: Male-Mediated Developmental Toxicity (eds A. F. Olshan & D. R. Mattison), pp. 177-184. Plenum Press, New York.
88. Savitz, D. A., Schwingl, P. J. & Keels, M. A. (1991) Influence of paternal age, smoking, and alcohol consumption on congenital anomalies. Teratology, 44, 429-440.
89. Schirren, C. & Gey, G. (1969) Der Einfluss des Rauchens auf die Fortpflanzungsfähigheit bei Mann und Frau. Zeitschrift Haut Geschlechtskrankheiten, 44, 175-182.
90. Sega, G. A. & Owens, J. G. (1983) Methylation of DNA and protamine by methyl methanesulfonate in the germ cells of male mice. Mutation Research, 111, 227-244.
91. Seidman, D. S., Ever-Hadani, P. & Gale, R. (1990) Effect of maternal smoking and age on congenital anomalies. Obstetrics and Gynecology, 76, 1046-1053.
92. Severson, R. K., Buckley, J. D., Woods, W. G., Benjamin, D. & Robison, L. L. (1993) Cigarette smoking and alcohol consumption by parents of children with acute myeloid leukemia: An analysis within morphological subgroups -a report from the Children Cancer group. Cancer Epidemiology, Biomarkers and Prevention, 2, 433-439.
93. Shaarawy, M. & Mahmoud, K. Z. (1982) Endocrine profile and semen characteristics in male smokers. Fertility and Sterility, 38, 255-257.
94. Shu, X. O., Gao, Y. T., Brinton, L. A., Linet M. S. Tu J. T. Zheng, W, Fraumeni, J. F., Jr (1988) A population-based case-control study of childhood leukemia in Shanghai. Cancer, 62, 635-644.
95. Simon, D., Preziosi, P., Barrett-Connor, E., Roger, M., Saint-Paul, M., Nahoul, K. & Papoz, L. (1992) The influence of aging on plasma sex hormones in men: The Telecom Study. American Journal of Epidemiology, 135, 783-791.
96. Sofikitis, N., Miyagawa, I., Dimitriadis, D., Zavos, P., Sikka, S. & Hellstrom, W. (1995) Effects of smoking on testicular function, semen quality and sperm fertilizing capacity. The Journal of Urology, 154, 1030-1034.
97. Sorahan, T., Lancashire, R., Prior, P., Peck, I. & Stewart, A. (1995) Childhood cancer and parental use of alcohol and tobacco. Annals of Epidemiology, 5, 354-359.
98. Spira, A., Ducot, B., Jouannet, P., Soumah, A., Feneux, D. & Albert, M. (1981) Consommation de tabac, d'alcool, et fertilite masculine. In: Human Fertility Factors (eds P. Jouannet & A. Spira), pp. 363-373. Institut National de la Sante et de la Recherche Medicale, Paris.
99. Stillman, R. J., Rosenberg, M. J., Sachs, B. P. (1986) Smoking and reproduction. Fertility and Sterility, 46, 545-566.
100. Tokuhata, G. M. (1968) Smoking in relation to infertility and fetal loss. Archives of Environmental Health, 17, 353-359.
101. Viczián, M. (1969) Ergebnisse von Sperniauntersuchungen bei Zigarettenrauchern. Zeitschrift Haut Geschlechtskrankheiten, 44, 183-187.
102. Vine, M. F., Margolin, B. H., Morrison, H. I. & Hulka, B. S. (1994) Cigarette smoking and sperm concentration: A metaanalysis. Fertility and Sterility, 61, 35-13.
103. Vine, M. F., Tse, C. K. J., Hu, P. C. & Truong, K. Y. (1996) Cigarette smoking and semen quality. Fertility and Sterility, 65, 835-842.
104. Vogel, W., Broverman, D. M. & Klaiber, E. L. (1979) Gonadal, behavioral and electroencephalographic correlates of smoking. In: Electrophysiological Effects of Nicotine (eds A. Redmond, C. Izard), pp. 201-215. Elsevier/North Holland Biomedical Press, Amsterdam.
105. Vogt, H. J., Heller, W. D., Obe, G. (1984) Spermatogenesis in smokers and non-smokers: an andrological and genetic study. In: Mutations in Man. (ed. G. Obe), pp. 247-291. Springer-Verlag, Berlin.
106. Vogt, H.-J., Heller, W.-D. & Borelli, S. (1986) Sperm quality of healthy smokers, ex-smokers, and never smokers. Fertility and Sterility, 45, 106-110.
107. Windham, G. C., Swan, S. H., Fenster, L. (1992) Paternal cigarette smoking and the risk of spontaneous abortion. American Journal of Epidemiology, 135, 1394-1403.
108. Wyrobek, A. J. & Bruce, W. R. (1975) Chemical induction of sperm abnormalities in mice. Proceedings of the National Academy of Science USA, 72, 4425-4429.
109. Yamasaki, E. & Ames, B. N. (1977) Concentrations of mutagens from urine by adsorption with the nonpolar resin XAD-2: Cigarette smokers have mutagenic urine. Proceedings of the National Academy of Science, USA, 74, 3555-3559.
110. Zhang, J., Savitz, D. A., Schwingl, P. J. & Cai, W W. (1992) A case-control study of paternal smoking and birth defects. International Journal of Epidemiology, 21, 273-278.