Fascin expression predicts lymph node metastasis and worse survival in small intestinal carcinoma

Pathology

Volumn 46, Issue 1, 2014, Pages 21-24

  Gu, Mi Jin ^a   Kim, Jung Yeon ^b   Park, Jae Bok ^c  

^a Yeungnam University College of Medicine   (South Korea)

^b Inje University College of Medicine   (South Korea)

^c Catholic University of Daegu   (South Korea)

Author keywords

Carcinoma; Fascin; Immunohistochemistry; Small intestine

Indexed keywords

ACTIN BINDING PROTEIN; CARRIER PROTEIN; FASCIN; TUMOR MARKER;

ADULT; AGED; CARCINOMA; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; INTESTINE TUMOR; LYMPH NODE; LYMPH NODE METASTASIS; MALE; METABOLISM; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; PATHOLOGY; PROGNOSIS; SMALL INTESTINE; TISSUE MICROARRAY; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA; CARRIER PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL NEOPLASMS; INTESTINE, SMALL; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MICROFILAMENT PROTEINS; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84896765562     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1097/PAT.0000000000000024     Document Type: Article

References (25)

1. Cobrin GM, Pittman RH, Lewis BS Increased diagnostic yield of small bowel tumors with capsule endoscopy. Cancer 2006; 107: 22-7.
2. Chan OT, Chen ZM, Chung F, et al Lack of HER2 overexpression and amplification in small intestinal adenocarcinoma. Am J Clin Pathol 2010; 134: 880-5.
3. Chang HK, Yu E, Kim J., et al Adenocarcinoma of the small intestine: A multi-institutional study of 197 surgically resected cases. Hum Pathol 2010; 41: 1087-96.
4. Yamamoto H, Kohashi K, Fujita A., Oda Y. Fascin-1 overexpression and miR-133b downregulation in the progression of gastrointestinal stromal tumor. Mod Pathol 2013; 26: 563-71.
5. Chan C, Jankova L, Fung C.L., et al Fascin expression predicts survival after potentially curative resection of node-positive colon cancer. Am J Surg Pathol 2010; 34: 656-66.
6. Won KY, Kim GY, Lim S.J., et al Prognostic significance of fascin expression in extrahepatic bile duct carcinomas. Pathol Res Pract 2009; 205: 742-8.
7. Mosialos G, Birkenbach M, Ayehunie S., et al Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein. Am J Pathol 1996; 148: 593-600.
8. Tsai WC, Lin CK, Lee H.S., et al The correlation of cortactin and fascin-1 expression with clinicopathological parameters in pancreatic and ampulla of vater adenocarcinoma. APMIS 2013; 121: 171-81.
9. Hu W, McCrea PD, Deavers M, et al Increased expression of fascin, motility associated protein, in cell cultures derived from ovarian cancer and in borderline and carcinomatous ovarian tumors. Clin Exp Metastasis 2000; 18: 83-8.
10. Hanker LC, Karn T, Holtrich U., et al Prognostic impact of fascin-1 (FSCN1) in epithelial ovarian cancer. Anticancer Res 2013; 33: 371-7.
11. Kim SJ, Kim DC, Kim M.C., et al Fascin expression is related to poor survival in gastric cancer. Pathol Int 2012; 62: 777-84.
12. Zou J, Yang H, Chen F., et al Prognostic significance of fascin-1 and E-cadherin expression in laryngeal squamous cell carcinoma. Eur J Cancer Prev 2010; 19: 11-7.
13. Gao W, Zhang C, Feng Y., et al Fascin-1, ezrin and paxillin contribute to the malignant progression and are predictors of clinical prognosis in laryngeal squamous cell carcinoma. PLoS One 2012; 7: e50710.
14. Zhang Y, Tong X. Expression of the actin-binding proteins indicates that cofilin and fascin are related to breast tumour size. J Int Med Res 2010; 38: 1042-8.
15. Soukup V, Babjuk M, Duskova J., et al Does the expression of fascin-1 and tumor subclassification help to assess the risk of recurrence and progression in t1 urothelial urinary bladder carcinoma? Urol Int 2008; 80: 413-8.
16. Kulasingam V, Diamandis EP Fascin-1 is a novel biomarker of aggressiveness in some carcinomas. BMC Med 2013; 11: 53.
17. Tan VY, Lewis SJ, Adams J.C., et al Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: A systematic review and meta-analysis. BMC Med 2013; 11: 52.
18. Vignjevic D, Schoumacher M, Gavert N., et al Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. Cancer Res 2007; 67: 6844-53.
19. Oh SY, Kim YB, Suh K.W., et al Prognostic impact of fascin-1 expression is more significant in advanced colorectal cancer. J Surg Res 2012; 172: 102-8.
20. Onodera M, Zen Y, Harada K., et al Fascin is involved in tumor necrosis factor-alpha-dependent production of MMP9 in cholangiocarcinoma. Lab Invest 2009; 89: 1261-74.
21. Xu YF, Yu SN, Lu Z.H., et al Fascin promotes the motility and invasiveness of pancreatic cancer cells. World J Gastroenterol 2011; 17: 4470-8.
22. Roh YH, Kim YH, Choi H.J., et al Fascin overexpression correlates with positive thrombospondin-1 and syndecan-1 expressions and a more aggressive clinical course in patients with gallbladder cancer. J Hepatobiliary Pancreat Surg 2009; 16: 315-21.
23. Lin CK, Chao TK, Yu C.P., et al The expression of six biomarkers in the four most common ovarian cancers: correlation with clinicopathological parameters. APMIS 2009; 117: 162-75.
24. Stewart CJ, Crook M, Loi S. Fascin expression in endocervical neoplasia: Correlation with tumour morphology and growth pattern. J Clin Pathol 2012; 65: 213-7.
25. Hashimoto Y, Shimada Y, Kawamura J., et al The prognostic relevance of fascin expression inhuman gastric carcinoma. Oncology 2004; 67: 262-70.