Disturbing miR-182 and -381 inhibits BRD7 transcription and Glioma growth by directly targeting LRRC4

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Tang, Hailin ^a,b   Wang, Zeyou ^a   Liu, Qing ^c   Liu, Xiaoping ^a,b   Wu, Minghua ^a,c   Li, Guiyuan ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^c The Center for Skull Base Surgery and Neurooncology   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 182; MICRORNA 381; PROTEIN BRD7; PROTEIN P53; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRD7 GENE; CANCER GROWTH; CARCINOGENICITY; CELL GROWTH; CELL PROLIFERATION; CELL PROLIFERATION ASSAY; CONTROLLED STUDY; DOWN REGULATION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCHEMISTRY; IMMUNOFLUORESCENCE; IN SITU HYBRIDIZATION; IN VITRO STUDY; LRRC4 GENE; MAJOR CLINICAL STUDY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; TUMOR GENE; WESTERN BLOTTING;

ANIMALS; BASE PAIRING; BASE SEQUENCE; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMAL PROTEINS, NON-HISTONE; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GLIOMA; HETEROGRAFTS; HUMANS; MICRORNAS; NERVE TISSUE PROTEINS; RATS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TUMOR BURDEN;

EID: 84896764687     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084146     Document Type: Article

References (27)

1. Hulleman E, Helin K (2005) Molecular mechanisms in gliomagenesis. Adv Cancer Res 94: 1-27. (Pubitemid 41202363)
2. Zhang Q, Wang J, Fan S, Wang L, Cao L, et al. (2005) Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily. FEBS Lett 579: 3674-3682. (Pubitemid 40897708)
3. Wang JR, Li XL, Fan SQ, Tan C, Xiang JJ, et al. (2003) Expression of LRRC4 has the potential to decrease the growth rate and tumorigenesis of glioblastoma cell line U251. Ai Zheng 22: 897-902.
4. Wu M, Huang C, Gan K, Huang H, Chen Q, et al. (2006) LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway. Mol Biol Cell 17: 3534-3542. (Pubitemid 44156446)
5. Zhang Z, Li D, Wu M, Xiang B, Wang L, et al. (2008) Promoter hypermethylation-mediated inactivation of LRRC4 in gliomas. BMC Mol Biol 9: 99.
6. Wu M, Huang C, Li X, Li X, Gan K, et al. (2008) LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses. J Cell Physiol 214: 65-74. (Pubitemid 350220060)
7. Wu M, Chen Q, Li D, Li X, Li X, et al. (2008) LRRC4 inhibits human glioblastoma cells proliferation, invasion, and proMMP-2 activation by reducing SDF-1 alpha/CXCR4-mediated ERK1/2 and Akt signaling pathways. J Cell Biochem 103: 245-255.
8. Wu M, Huang H, Chen Q, Li D, Zheng Z, et al. (2007) Leucine-rich repeat C4 protein is involved in nervous tissue development and neurite outgrowth, and induction of glioma cell differentiation. Acta Biochim Biophys Sin (Shanghai) 39: 731-738. (Pubitemid 47631035)
9. Tang H, Deng M, Tang Y, Xie X, Guo J, et al. (2013) miR-200b and miR-200c as prognostic factors and mediators of gastric cancer cell progression. Clin Cancer Res.
10. Tang H, Kong Y, Guo J, Tang Y, Xie X, et al. (2013) Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22. Cancer Lett.
11. Weeraratne SD, Amani V, Teider N, Pierre-Francois J, Winter D, et al. (2012) Pleiotropic effects of miR-183,96,182 converge to regulate cell survival, proliferation and migration in medulloblastoma. Acta Neuropathol 123: 539-552.
12. Mihelich BL, Khramtsova EA, Arva N, Vaishnav A, Johnson DN, et al. (2011) miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells. J Biol Chem 286: 44503-44511.
13. Tang H, Bian Y, Tu C, Wang Z, Yu Z, et al. (2013) The miR-183/96/182 cluster regulates oxidative apoptosis and sensitizes cells to chemotherapy in gliomas. Curr Cancer Drug Targets 13: 221-231.
14. Nagadia R, Pandit P, Coman WB, Cooper-White J, Punyadeera C (2013) miRNAs in head and neck cancer revisited. Cell Oncol (Dordr) 36: 1-7.
15. Harquail J, Benzina S, Robichaud GA (2012) MicroRNAs and breast cancer malignancy: an overview of miRNA-regulated cancer processes leading to metastasis. Cancer Biomark 11: 269-280.
16. Gao J, Li L, Wu M, Liu M, Xie X, et al. (2013) MiR-26a inhibits proliferation and migration of breast cancer through repression of MCL-1. PLoS One 8: e65138.
17. Tang H, Liu X, Wang Z, She X, Zeng X, et al. (2011) Interaction of hsa-miR-381 and glioma suppressor LRRC4 is involved in glioma growth. Brain Res 1390: 21-32.
18. Zhou J, Ma J, Zhang BC, Li XL, Shen SR, et al. (2004) BRD7, a novel bromodomain gene, inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways. J Cell Physiol 200: 89-98. (Pubitemid 38724156)
19. Liu H, Zhou M, Luo X, Zhang L, Niu Z, et al. (2008) Transcriptional regulation of BRD7 expression by Sp1 and c-Myc. BMC Mol Biol 9: 111.
20. Mantovani F, Drost J, Voorhoeve PM, Del Sal G, Agami R (2010) Gene regulation and tumor suppression by the bromodomain-containing protein BRD7. Cell Cycle 9: 2777-2781.
21. Drost J, Mantovani F, Tocco F, Elkon R, Comel A, et al. (2010) BRD7 is a candidate tumour suppressor gene required for p53 function. Nat Cell Biol 12: 380-389.
22. Tae S, Karkhanis V, Velasco K, Yaneva M, Erdjument-Bromage H, et al. (2011) Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes. Nucleic Acids Res 39: 5424-5438.
23. Zhang L, Liu T, Huang Y, Liu J (2011) microRNA-182 inhibits the proliferation and invasion of human lung adenocarcinoma cells through its effect on human cortical actin-associated protein. Int J Mol Med 28: 381-388.
24. Rossi S, Calin GA (2013) Bioinformatics, non-coding RNAs and its possible application in personalized medicine. Adv Exp Med Biol 774: 21-37.
25. Titolo D, Mayer CM, Dhillon SS, Cai F, Belsham DD (2008) Estrogen facilitates both phosphatidylinositol 3-kinase/Akt and ERK1/2 mitogen-activated protein kinase membrane signaling required for long-term neuropeptide Y transcriptional regulation in clonal, immortalized neurons. J Neurosci 28: 6473-6482.
26. Wu M, Li X, Li X, Li G (2009) Signaling Transduction Network Mediated by Tumor Suppressor/Susceptibility Genes in NPC. Curr Genomics 10: 216-222.
27. Zhou M, Xu XJ, Zhou HD, Liu HY, He JJ, et al. (2006) BRD2 is one of BRD7-interacting proteins and its over-expression could initiate apoptosis. Mol Cell Biochem 292: 205-212. (Pubitemid 44697415)