NGAL, L-FABP, and KIM-1 in comparison to established markers of renal dysfunction

Clinical Chemistry and Laboratory Medicine

Volumn 52, Issue 4, 2014, Pages 537-546

  Holzscheiter, Leon ^a   Beck, Claus ^b   Rutz, Sandra ^b   Manuilova, Ekaterina ^b   Domke, Ingrid ^b   Guder, Walter G ^c   Hofmann, Walter ^c  

^a StKM   (Germany)

^b ROCHE DIAGNOSTICS GMBH   (Germany)

^c Munich Municipal Hospital   (Germany)

Author keywords

acute kidney injury (AKI); kidney injury molecule 1 (KIM 1); liver type fatty acid binding protein (L FABP); neutrophil gelatinase associated lipocalin (NGAL); urine protein differentiation

Indexed keywords

ALBUMIN; ALPHA 1 MICROGLOBULIN; BIOLOGICAL MARKER; CREATININE; CYSTATIN C; FATTY ACID BINDING PROTEIN; GLUCOSE; IMMUNOGLOBULIN G; KIDNEY INJURY MOLECULE 1; LIVER TYPE FATTY ACID BINDING PROTEIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; NITRITE; UNCLASSIFIED DRUG; ACUTE PHASE PROTEIN; FABP1 PROTEIN, HUMAN; HAVCR1 PROTEIN, HUMAN; LCN2 PROTEIN, HUMAN; LIPOCALIN; MEMBRANE PROTEIN; ONCOPROTEIN; VIRUS RECEPTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE URINE LEVEL; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLOMERULOPATHY; GLUCOSE URINE LEVEL; HEMATURIA; HUMAN; INFLAMMATION; INTERMETHOD COMPARISON; KIDNEY DYSFUNCTION; KIDNEY INJURY; KIDNEY TUBULE DISORDER; LEUKOCYTE; LEUKOCYTURIA; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; PROTEINURIA; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; URINE PH; VERY ELDERLY; YOUNG ADULT; BLOOD; CHRONIC DISEASE; COMPARATIVE STUDY; COMPLICATION; KIDNEY; KIDNEY DISEASES; PATHOPHYSIOLOGY; URINE;

ACUTE-PHASE PROTEINS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; FATTY ACID-BINDING PROTEINS; FEMALE; HEMATURIA; HUMANS; KIDNEY; KIDNEY DISEASES; LIPOCALINS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PROTEINURIA; PROTO-ONCOGENE PROTEINS; RECEPTORS, VIRUS; YOUNG ADULT;

EID: 84896763421     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2013-0693     Document Type: Article

References (33)

1. Noiri E, Doi K, Negishi K, Tanaka T, Hamasaki Y, Fujita T, et al. Urinary fatty acid-binding protein 1: an early predictive biomarker of kidney injury [review]. Am J Physiol Renal Physiol 2009;296:F669-79.
2. Guder WG, Hofmann W. Clinical role of urinary low molecular weight proteins: their diagnostic and prognostic implications. Scand J Clin Lab Invest 2008;68:95-8. (Pubitemid 351883666)
3. Hofmann W, Ehrich JH, Guder WG, Keller F, Scherberich J. Diagnostic pathways for exclusion and diagnosis of kidney diseases. Clin Lab 2012;58:871-89.
4. Bonventre JV, Venkata S, Himmelfarb J, Sayegh MH, editors. Chronic kidney disease, dialysis, and transplantation, 3rd ed. (Expert Consult Series): a companion to Brenner and Rector's the kidney. Chapter 48. Acute kidney injury: biomarkers from bench to bedside. Philadelphia: Saunders, Elsevier Health Sciences, 2010.
5. Nielsen BS, Borregaard N, Bundgaard JR, Timshel S, Sehested M, Kjeldsen L. Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases. Gut 1996;38:414-20.
6. Kotyza J, Bunatova K, Pesek M, Puzman P. Pleural injury and pleurisy-induced progelatinase B/proMMP-9 is associated with markers of neutrophil degranulation. Scand J Clin Lab Invest 2006;66:487-96. (Pubitemid 44454445)
7. Anwaar I, Gottsater A, Ohlsson K, Mattiasson I, Lindgärde F. Increasing levels of leukocyte-derived inflammatory mediators in plasma and camp in platelets during follow-up after acute cerebral ischemia. Cerebrovasc Dis 1998;8:310-7. (Pubitemid 28491091)
8. Clerico A, Galli C, Fortunato A, Ronco C. Neutrophil gelatinase- associated lipocalin (NGAL) as biomarker of acute kidney injury: a review of the laboratory characteristics and clinical evidences. Clin Chem Lab Med 2012;50:1505-17.
9. Cruz DN, Goh CY, Palazzuoli A, Slavin L, Calabrò A, Ronco C, et al. Laboratory parameters of cardiac and kidney dysfunction in cardio-renal syndromes. Heart Fail Rev 2011;16:545-51.
10. Zhang Z, Humphreys BD, Bonventre JV. Shedding of the urinary biomarker kidney injury molecule-1 (KIM-1) is regulated by MAP kinases and juxtamembrane region. J Am Soc Nephrol 2007;18:2704-14. (Pubitemid 47531197)
11. Ichimura T, Bonventre JV, Bailly V, Wei H, Hession CA, Cate RL, et al. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem 1998;273:4135-42. (Pubitemid 28103282)
12. Doi K, Negishi K, Ishizu T, Katagiri D, Fujita T, Matsubara T, et al. Evaluation of new acute kidney injury biomarkers in a mixed intensive care unit. Crit Care Med 2011;39:2464-9.
13. Trof RJ, Di Maggio F, Leereis J, Groeneveld AB. Biomarkers of acute renal injury and renal failure. Shock 2006;26:245-53.
14. Tsukasa N, Sugaya T, Node K, Ueda Y, Koide H. Urinary excretion of liver-type fatty acid-binding protein in contrast medium-induced nephropathy AJKD 2006;47:439-44. (Pubitemid 43255177)
15. Portilla D, Dent C, Sugaya T, Nagothu KK, Kundi I, Moore P, et al. Liver fatty acid-binding protein as a biomarker of acute kidney injury after cardiac surgery. Kidney Int 2008;73:465-72. (Pubitemid 351186293)
16. Han WK, Waikar SS, Johnson A, Betensky RA, Dent CL, Devarajan P, et al. Urinary biomarkers in the early diagnosis of acute kidney injury. Kidney Int 2008;73:863-9. (Pubitemid 351398278)
17. Hofmann W, Ruth D, Guder WG. Urine protein differentiation and Protis, a new expert system for its interpretation. Riv Med Lab JLM 2003;4:67-8. (Pubitemid 37013939)
18. Hofmann W, Sedlmeir-Hofmann C, Ivandic M, Ruth D, Luppa P. PROTIS: use of combined biomarkers for providing diagnostic information on disease states. Methods Mol Biol 2010;641: 123-42.
19. Chaturvedi S, Farmer T, Kapke GF. Assay validation for KIM-1: human urinary renal dysfunction biomarker. Int J Biol Sci 2009;5:128-34.
20. Nickolas TL, O'Rourke MJ, Yang J, Sise ME, Canetta PA, Barasch N, et al. Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med 2008;148:810-9. (Pubitemid 351786928)
21. Bolignano D, Donato V, Coppolino G, Campo S, Buemi A, Lacquaniti A, et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage. Am J Kidney Dis 2008;52:595-605.
22. Barresi V, Ieni A, Bolignano D, Magno C, Buemi M, Barresi G. Neutrophil gelatinase-associated lipocalin immunoexpression in renal tumors: correlation with histotype and histological grade. Oncol Rep 2010;24:305-10.
23. Mishra J, Mori K, Ma Q, Kelly C, Barasch J, Devarajan P. Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol 2004;24:307-15. (Pubitemid 39070114)
24. Decavele AS, Dhondt L, De Buyzere ML, Delanghe JR. Increased urinary neutrophil gelatinase associated lipocalin in urinary tract infections and leukocyturia. Clin Chem Lab Med 2011;49:999-1003.
25. Bolignano D, Coppolino G, Donato V, Lacquaniti A, Bono C, Buemi M. Neutrophil gelatinase-associated lipocalin (NGAL): a new piece of the anemia puzzle? Med Sci Monit 2010;16:RA131-5.
26. Bolignano D, Coppolino G, Aloisi C, Romeo A, Nicocia G, Buemi M. Effect of a single intravenous immunoglobulin infusion on neutrophil gelatinase-associated lipocalin levels in proteinuric patients with normal renal function. J Investig Med 2008;56:997-1003.
27. Bolignano D, Della Torre A, Lacquaniti A, Costantino G, Fries W, Buemi M. Neutrophil gelatinase-associated lipocalin levels in patients with Crohn disease undergoing treatment with infliximab. J Investig Med 2010;58:569-71.
28. Lippi G, Plebani M. Neutrophil gelatinase-associated lipocalin (NGAL): the laboratory perspective. Clin Chem Lab Med 2012;50:1483-7.
29. Devarajan P. Emerging urinary biomarkers in the diagnosis of acute kidney injury. Expert Opin Med Diagn 2008;2:387-98. (Pubitemid 351659225)
30. Kamijo A, Sugaya T, Hikawa A, Okada M, Okumura F, Yamanouchi M, et al. Urinary excretion of fatty acid-binding protein reflects stress overload on the proximal tubules. Am J Pathol 2004;165:1243-55. (Pubitemid 39297730)
31. Bonventre JV. Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more. Nephrol Dial Transpl 2009;24:3265-8.
32. Han WK, Alinani A, Wu CL, Michaelson D, Loda M, McGovern FJ, et al. Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma. J Am Soc Nephrol 2005;16:1126-34. (Pubitemid 41710324)
33. Nickolas TL, Schmidt-Ott KM, Canetta P, Forster C, Singer E, Sise M, et al. Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage: a multicenter prospective cohort study. J Am Coll Cardiol 2012;59:246-55.