Effect and mechanism of Huannao Yicong decoction extract on learning and memory ability of dementia model of amyloid precursor protein/presenilin 1 double transgenic mice

Chinese Journal of Pharmacology and Toxicology

Volumn 28, Issue 1, 2014, Pages 10-17

  Liu, Mei Xia ^a   Liu, Jian Gang ^b   Li, Hao ^a   Liu, Long Tao ^b   Liang, Lin ^a   Hu, Jia ^b   Wei, Yun ^b  

^a XIYUAN HOSPITAL   (China)

^b BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

Author keywords

Amyloid precursor protein; Huannao Yicong decoction; Mice, transgenic; Neurobehavioral manifestations; Nicastrin; Presenilin 1

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CARBOXYL TERMINUS OF HSC70 INTERACTING PROTEIN; DONEPEZIL; GUANINE NUCLEOTIDE BINDING PROTEIN; HEMATOXYLIN; HUANNAO YICONG DECOCTION EXTRACT; MESSENGER RNA; NICASTRIN; PLANT EXTRACT; PRESENILIN 1; PROTEIN; PS1 PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DEMENTIA; DIVING PLATFORM TEST; DRUG EFFECT; HIPPOCAMPAL CA1 REGION; LATENT PERIOD; LEARNING; LEARNING AND MEMORY TEST; MEMORY; MENTAL CAPACITY; MORRIS WATER MAZE TEST; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STAINING; TRANSGENIC MOUSE; TREATMENT DURATION;

EID: 84896760389     PISSN: 10003002     EISSN: None     Source Type: Journal    
DOI: 10.3867/j.issn.1000-3002.2014.01.002     Document Type: Article

References (22)

1. Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics[J]. Science, 2002, 297(5580):353-356. (Pubitemid 34790756)
2. Sheng B, Gong K, Niu Y, Liu L, Yan Y, Lu G, et al. Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: implications for the treatment of Alzheimer's disease[J]. Free Radic Biol Med, 2009, 46(10):1362-1375.
3. Cacquevel M, Aeschbach L, Houacine J, Fraering PC. Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes[J]. PLoS One, 2012, 7(4):e35133.
4. Li H, Liu JG, Liu LT, Liu MX, Wei Y, Guan J. A traditional Chinese drug and preparation method for the prevention and treatment of Alzheimer disease; China, 201110007105.6[P]. 2011-06-01.
5. Li H, Cai LL, Liu JG, Liu LT, Guan J, Liu MF, et al. Effect of early intervention with extract of Huannao Yicong Decoction on the pathologic picture of hippocampus and neurocyte apoptosis in APP transgenic mice model of dementia[J]. Chin J Integr Med, 2011, 17(6):430-435.
6. Li H, Liu MF, Liu JG, Liu LT, Guan J, Cai LL, et al. Effect of Huannao Yicong Prescription extract on β-amyloid precursor protein metabolic signal transduction-related protein in brain tissue of dementia model transgenic mouse[J]. Chin J Integr Med, 2012, 18(9):683-689.
7. Liu MX, Liu JG, Li H, Liu LT, Zhou WQ. Research thoughts and methods on concise prescriptions of Chinese medicine for prevention and treatment of Alzheimer's disease based on various kinds of animal models[J]. World Sci Technol-Mode Tradit Chin Med Mater Med, 2012, 14(2):1367-1375.
8. Weng XQ, Shen WC. Study for the key technology of hematoxylin-eosin staining and paraffin section[J]. J Med Forum, 2005, 26(21):80-83.
9. Wengenack TM, Whelan S, Curran GL, Duff KE, Poduslo JF. Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain[J]. Neuroscience, 2000, 101(4):939-944.
10. Zong YY, Wang XY, Wang HL, Liu YL, Huang L, Ma CM, et al. Continuous analysis of senile plaque and behaviour in APPswe/PPSΔE9 double-transgenic gene mouse model of Alzheimer disease[J]. Chin J Comp Med, 2008, 18(9):8-12.
11. Wirths O, Multhaup G, Czech C, Blanchard V, Tremp G, Pradier L, et al. Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice[J]. Neurosci Lett, 2001, 316(3):145-148. (Pubitemid 34020750)
12. 42 lowering by GSM-10h[J]. Neurodegener Dis, 2011, 8(1-2):15-24.
13. Song M, Tang J, Li DB, Xu HW, Ba Y. Genetype identification and histologic analysis of PS1/APP double transgenic Alzheimer disease mouse model[J]. Acta Acad Med Mil Tert, 2006, 28(14):1453-1456.
14. Wu Q, Li LS, Fan WH, Li HH, Cui M, Wu F, et al. Genetype identification and parxiological observation of APP/PS1 double transgenic Alzheimer disease mouse model[J]. Stroke Nerv Dis, 2009, 16(5):293-296.
15. Zhang JT. Neuron-synapse loss and dementias[J]. Acta Neuropharmacol, 2011, 1(1):1-15.
16. Yin XW, Liu HQ. Research progresses on the structure and function of γ-secretase[J]. Chin Bull Life Sci, 2010, 22(9):913-918.
17. Steiner H. The catalytic core of gamma-secretase: presenilin revisited[J]. Curr Alzheimer Res, 2008, 5(2):147-157. (Pubitemid 351536339)
18. Zohar O, Cavallaro S, D'Agata V, Alkon DL. Quantification and distribution of beta-secretase alternative splice variants in the rat and human brain[J]. Brain Res Mol Brain Res, 2003, 115(1):63-68. (Pubitemid 36725036)
19. Yan WQ, Wang JL, Tang BS. Functions of carboxyl-terminus of HseT0 interacting protein and its role in neurodegenerative disease[J]. Chin J Med Genet, 2012, 29(4):426-430.
20. Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, et al. Nicastrin functions as a gamma-secretase-substrate receptor[J]. Cell, 2005, 122(3):435-447.
21. Long ZM, He GQ. Progress in the research on Nicastrin, one of essential subunits of γ-secretase[J]. Chin Bull Life Sci, 2010, 22(9): 906-912.
22. Yang M, Cai F, Pan Q, Long ZG, Xia JH, Xia K, et al. Transcriptional regulation of the Alzheimer's disease-related gene, nicastrin[J]. Prog Biochem Biophys, 2009, 36(8):994-1002.