CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Peterson, Jonathan M ^a,b   Seldin, Marcus M ^a   Tan, Stefanie Y ^a   Wong, G William ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EAST TENNESSEE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; FATTY ACID; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; PLASMA PROTEIN; PROTEIN CTRP2; PYRUVATE SODIUM; RESISTIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; COMPLEMENT; CTRP2 PROTEIN, MOUSE; PRIMER DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENERGY BALANCE; ENERGY EXPENDITURE; FAT TOLERANCE TEST; FATTY ACID BLOOD LEVEL; FOOD INTAKE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HORMONE INHIBITION; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; INTRAABDOMINAL FAT; LIPID DIET; LIPID METABOLISM; LOW FAT DIET; MALE; METABOLIC RATE; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SUBCUTANEOUS FAT; TISSUE DISTRIBUTION; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; WEIGHT GAIN; WHITE ADIPOSE TISSUE; ANALYSIS OF VARIANCE; ANIMAL; BLOOD; C57BL MOUSE; DIET RESTRICTION; EATING; ENERGY METABOLISM; GENETICS; IMMUNOBLOTTING; INSULIN RESISTANCE; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ADIPOSITY; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; COMPLEMENT SYSTEM PROTEINS; DIET, HIGH-FAT; DNA PRIMERS; EATING; ENERGY METABOLISM; FASTING; IMMUNOBLOTTING; INSULIN; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84896740731     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0088535     Document Type: Article

References (22)

1. Wong GW, Wang J, Hug C, Tsao TS, Lodish HF (2004) A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci U S A 101: 10302-10307. (Pubitemid 38924920)
2. Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, Ge G, Spooner E, et al. (2009) Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. FASEB J 23: 241-258.
3. Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, Revett T, Gimeno R, et al. (2008) Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem J 416: 161-177.
4. Wei Z, Peterson JM, Lei X, Cebotaru L, Wolfgang MJ, et al. (2012) C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes. J Biol Chem 287: 10301-10315.
5. Wei Z, Peterson JM, Wong GW (2011) Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling. J Biol Chem 286: 15652-15665.
6. Wei Z, Seldin MM, Natarajan N, Djemal DC, Peterson JM, et al. (2013) C1q/Tumor Necrosis Factor-related Protein 11 (CTRP11), a Novel Adipose Stroma-derived Regulator of Adipogenesis. J Biol Chem 288: 10214-10229.
7. Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW (2012) Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem 287: 11968-11980.
8. Byerly MS, Petersen PS, Ramamurthy S, Seldin MM, Lei X, et al. (2013) C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight. J Biol Chem In press.
9. Seldin MM, Tan SY, Wong GW (2013) Metabolic function of the CTRP family of hormones. Rev Endocr Metab Disord in press.
10. Peterson JM, Aja S, Wei Z, Wong GW (2012) C1q/TNF-related protein-1 (CTRP1) enhances fatty acid oxidation via AMPK activation and ACC inhibition. J Biol Chem 287: 1576-1587.
11. Peterson JM, Seldin MM, Wei Z, Aja S, Wong GW (2013) CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism. Am J Physiol Gastrointest Liver Physiol 305: G214-224.
12. Peterson JM, Wei Z, Seldin MM, Byerly MS, Aja S, et al. (2013) CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction. Am J Physiol Regul Integr Comp Physiol 305: R522-533.
13. Peterson JM, Wei Z, Wong GW (2010) C1q/TNF-related Protein-3 (CTRP3), a Novel Adipokine That Regulates Hepatic Glucose Output. J Biol Chem 285: 39691-39701.
14. Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, et al. (2011) Adipolin/C1qdc2/CTRP12 functions as an adipokine that improves glucose metabolism. J Biol Chem 286: 34552-34558.
15. Byerly MS, Swanson R, Wei Z, Seldin MM, McCulloh PS, et al. (2013) A Central Role for C1q/TNF-Related Protein 13 (CTRP13) in Modulating Food Intake and Body Weight. PLoS One 8: e62862.
16. Su H, Yuan Y, Wang XM, Lau WB, Wang Y, et al. (2013) Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNFalpha-initiated oxidative signaling contributes to exacerbated cardiac injury in diabetic mice. Basic Res Cardiol 108: 315-326.
17. Uemura Y, Shibata R, Ohashi K, Enomoto T, Kambara T, et al. (2013) Adipose-derived factor CTRP9 attenuates vascular smooth muscle cell proliferation and neointimal formation. FASEB J 27: 25-33.
18. Kambara T, Ohashi K, Shibata R, Ogura Y, Maruyama S, et al. (2012) CTRP9 protein protects against myocardial injury following ischemia-reperfusion through AMP-activated protein kinase (AMPK)-dependent mechanism. J Biol Chem 287: 18965-18973.
19. Zheng Q, Yuan Y, Yi W, Lau WB, Wang Y, et al. (2011) C1q/TNF-Related Proteins, A Family of Novel Adipokines, Induce Vascular Relaxation Through the Adiponectin Receptor-1/AMPK/eNOS/Nitric Oxide Signaling Pathway. Arterioscler Thromb Vasc Biol 31: 2616-2623.
20. Lusk G (1928) The elements of the science of nutrition. Philadelphia London: W. B. Saunders company.
21. Cherrington AD (1999) Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo. Diabetes 48: 1198-1214.
22. Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME, et al. (2007) Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 117: 2621-2637. (Pubitemid 47494363)