A Central Role for C1q/TNF-Related Protein 13 (CTRP13) in Modulating Food Intake and Body Weight

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Byerly, Mardi S ^a   Swanson, Roy ^a   Wei, Zhikui ^a   Seldin, Marcus M ^a   McCulloh, Patrick S ^a   Wong, G William ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; C1Q TNF RELATED PROTEIN 13; NEUROPEPTIDE Y; RECOMBINANT PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; ADIPOCYTOKINE; CTRP13 PROTEIN, MOUSE; HORMONE; MESSENGER RNA; NEUROPEPTIDE;

AGOUTI RELATED PROTEIN GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DOWN REGULATION; FEEDBACK SYSTEM; FOOD INTAKE; GENE EXPRESSION; LIPID DIET; MALE; MOUSE; NERVE CELL NETWORK; NEUROPEPTIDE Y GENE; NONHUMAN; PHYSICAL ACTIVITY; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATOR GENE; UPREGULATION; WEIGHT CONTROL; WEIGHT REDUCTION; ANIMAL; ANOREXIA NERVOSA; BODY WEIGHT; C57BL MOUSE; DIET; DRUG EFFECTS; EATING; GENETICS; HEK293 CELL LINE; HUMAN; HYPOTHALAMUS; METABOLISM; OBESITY; PATHOPHYSIOLOGY; PHENOTYPE;

AGOUTI; MUS;

ADIPOKINES; AGOUTI-RELATED PROTEIN; ANIMALS; ANOREXIA; ANOREXIA NERVOSA; BODY WEIGHT; DIET; EATING; HEK293 CELLS; HORMONES; HUMANS; HYPOTHALAMUS; MALE; MICE; MICE, INBRED C57BL; NEUROPEPTIDES; OBESITY; PHENOTYPE; RECOMBINANT PROTEINS; RNA, MESSENGER;

EID: 84876719217     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062862     Document Type: Article

References (41)

1. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG, (2000) Central nervous system control of food intake. Nature 404: 661-671.
2. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432.
3. Moriya J, Takimoto Y, Yoshiuchi K, Shimosawa T, Akabayashi A, (2006) Plasma agouti-related protein levels in women with anorexia nervosa. Psychoneuroendocrinology 31: 1057-1061.
4. Merle JV, Haas V, Burghardt R, Dohler N, Schneider N, et al. (2011) Agouti-related protein in patients with acute and weight-restored anorexia nervosa. Psychol Med 41: 2183-2192.
5. Vink T, Hinney A, van Elburg AA, van Goozen SH, Sandkuijl LA, et al. (2001) Association between an agouti-related protein gene polymorphism and anorexia nervosa. Mol Psychiatry 6: 325-328.
6. Friedman JM, Halaas JL, (1998) Leptin and the regulation of body weight in mammals. Nature 395: 763-770.
7. Qi Y, Takahashi N, Hileman SM, Patel HR, Berg AH, et al. (2004) Adiponectin acts in the brain to decrease body weight. Nat Med 10: 524-529.
8. Kubota N, Yano W, Kubota T, Yamauchi T, Itoh S, et al. (2007) Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab 6: 55-68.
9. Hebebrand J, van der Heyden J, Devos R, Kopp W, Herpertz S, et al. (1995) Plasma concentrations of obese protein in anorexia nervosa. Lancet 346: 1624-1625.
10. Tagami T, Satoh N, Usui T, Yamada K, Shimatsu A, et al. (2004) Adiponectin in anorexia nervosa and bulimia nervosa. J Clin Endocrinol Metab 89: 1833-1837.
11. Housova J, Anderlova K, Krizova J, Haluzikova D, Kremen J, et al. (2005) Serum adiponectin and resistin concentrations in patients with restrictive and binge/purge form of anorexia nervosa and bulimia nervosa. J Clin Endocrinol Metab 90: 1366-1370.
12. Misra M, Miller KK, Cord J, Prabhakaran R, Herzog DB, et al. (2007) Relationships between serum adipokines, insulin levels, and bone density in girls with anorexia nervosa. J Clin Endocrinol Metab 92: 2046-2052.
13. Nogueira JP, Maraninchi M, Lorec AM, Corroller AB, Nicolay A, et al. (2010) Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa. Eur J Clin Nutr 64: 840-844.
14. Wong GW, Wang J, Hug C, Tsao TS, Lodish HF, (2004) A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci U S A 101: 10302-10307.
15. Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, Ge G, Spooner E, et al. (2009) Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. FASEB J 23: 241-258.
16. Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, Revett T, Gimeno R, et al. (2008) Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem J 416: 161-177.
17. Wei Z, Peterson JM, Lei X, Cebotaru L, Wolfgang MJ, et al. (2012) C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes. J Biol Chem 287: 10301-10315.
18. Wei Z, Peterson JM, Wong GW, (2011) Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling. J Biol Chem 286: 15652-15665.
19. Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW, (2012) Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem 287: 11968-11980.
20. Wei Z, Seldin MM, Natarajan N, Djemal DC, Peterson JM, et al. (2013) C1q/TNF-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis. J Biol Chem (in press).
21. Peterson JM, Wei Z, Wong GW, (2010) C1q/TNF-related Protein-3 (CTRP3), a Novel Adipokine That Regulates Hepatic Glucose Output. J Biol Chem 285: 39691-39701.
22. Peterson JM, Aja S, Wei Z, Wong GW, (2012) C1q/TNF-related protein-1 (CTRP1) enhances fatty acid oxidation via AMPK activation and ACC inhibition. J Biol Chem 287: 1576-1587.
23. de Rijke CE, Hillebrand JJ, Verhagen LA, Roeling TA, Adan RA, (2005) Hypothalamic neuropeptide expression following chronic food restriction in sedentary and wheel-running rats. J Mol Endocrinol 35: 381-390.
24. Hillebrand JJ, Kas MJ, Adan RA, (2005) alpha-MSH enhances activity-based anorexia. Peptides 26: 1690-1696.
25. Hillebrand JJ, Koeners MP, de Rijke CE, Kas MJ, Adan RA, (2005) Leptin treatment in activity-based anorexia. Biol Psychiatry 58: 165-171.
26. Aja S, Bi S, Knipp SB, McFadden JM, Ronnett GV, et al. (2006) Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats. Am J Physiol Regul Integr Comp Physiol 291: R148-154.
27. Lusk G (1928) The elements of the science of nutrition. Philadelphia London: W. B. Saunders company.
28. Hebebrand J, Exner C, Hebebrand K, Holtkamp C, Casper RC, et al. (2003) Hyperactivity in patients with anorexia nervosa and in semistarved rats: evidence for a pivotal role of hypoleptinemia. Physiol Behav 79: 25-37.
29. Davis C, Katzman DK, Kaptein S, Kirsh C, Brewer H, et al. (1997) The prevalence of high-level exercise in the eating disorders: etiological implications. Compr Psychiatry 38: 321-326.
30. Kim SF, (2012) Animal models of eating disorders. Neuroscience 211: 2-12.
31. Klenotich SJ, Dulawa SC, (2012) The activity-based anorexia mouse model. Methods Mol Biol 829: 377-393.
32. Pjetri E, de Haas R, de Jong S, Gelegen C, Oppelaar H, et al. (2012) Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations. PLoS One 7: e50453.
33. Gelegen C, Collier DA, Campbell IC, Oppelaar H, van den Heuvel J, et al. (2007) Difference in susceptibility to activity-based anorexia in two inbred strains of mice. Eur Neuropsychopharmacol 17: 199-205.
34. Gelegen C, van den Heuvel J, Collier DA, Campbell IC, Oppelaar H, et al. (2008) Dopaminergic and brain-derived neurotrophic factor signalling in inbred mice exposed to a restricted feeding schedule. Genes Brain Behav 7: 552-559.
35. Klenotich SJ, Seiglie MP, McMurray MS, Roitman JD, Le Grange D, et al. (2012) Olanzapine, but not fluoxetine, treatment increases survival in activity-based anorexia in mice. Neuropsychopharmacology 37: 1620-1631.
36. Lewis DY, Brett RR, (2010) Activity-based anorexia in C57/BL6 mice: effects of the phytocannabinoid, Delta9-tetrahydrocannabinol (THC) and the anandamide analogue, OMDM-2. Eur Neuropsychopharmacol 20: 622-631.
37. Attia E, (2010) Anorexia nervosa: current status and future directions. Annu Rev Med 61: 425-435.
38. Treasure J, Claudino AM, Zucker N, (2010) Eating disorders. Lancet 375: 583-593.
39. Bulik CM, Slof-Op't Landt MC, van Furth EF, Sullivan PF, (2007) The genetics of anorexia nervosa. Annu Rev Nutr 27: 263-275.
40. Javaras KN, Laird NM, Reichborn-Kjennerud T, Bulik CM, Pope HG Jr, et al. (2008) Familiality and heritability of binge eating disorder: results of a case-control family study and a twin study. Int J Eat Disord 41: 174-179.
41. Wade TD, Tiggemann M, Bulik CM, Fairburn CG, Wray NR, et al. (2008) Shared temperament risk factors for anorexia nervosa: a twin study. Psychosom Med 70: 239-244.