Effects of ghrelin on gastric distension sensitive neurons and gastric motility in the lateral septum and arcuate nucleus regulation

Journal of Gastroenterology

Volumn 49, Issue 2, 2014, Pages 219-230

  Gong, Yanling ^a,b   Xu, Luo ^a   Guo, Feifei ^a   Pang, Mingjie ^c   Shi, Zhenyan ^a   Gao, Shengli ^a   Sun, Xiangrong ^a  

^a QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

^b QINGDAO UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c QINGDAO MUNICIPAL HOSPITAL   (China)

Author keywords

Arcuate nucleus; Gastric distension responsive neurons; Gastric motility; Ghrelin; Lateral septum

Indexed keywords

GHRELIN; GHRELIN RECEPTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ELECTROSTIMULATION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STOMACH CONTENT; STOMACH DISTENSION; STOMACH MOTILITY; STOMACH MUSCLE; WESTERN BLOTTING;

ANIMALS; ARCUATE NUCLEUS; ELECTRIC STIMULATION; GASTROINTESTINAL MOTILITY; GHRELIN; HUMANS; MALE; NEURONS; OLIGOPEPTIDES; RATS; RATS, WISTAR; RECEPTORS, GHRELIN; RNA, MESSENGER; SEPTAL NUCLEI; STOMACH; VISCERAL AFFERENTS;

EID: 84896738087     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-013-0789-y     Document Type: Article

References (46)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402:656-60.
2. Kojima M, Hosoda H, Matsuo H, Kangawa K. Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol Metab. 2001;12:118-22.
3. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab. 2002;87:2988-91.
4. Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 2003;37:649-61.
5. Morpurgo PS, Cappiello V, Verga U, Vicentini L, Vaghi I, Lauri E, et al. Ghrelin in human medullary thyroid carcinomas. Clin Endocrinol. 2005;63:437-41.
6. Van der Lely AJ, Tschöp M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev. 2004;25:426-57.
7. Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB. Ghrelin-a hormone with multiple functions. Front Neuroendocrinol. 2004;25:27-68.
8. Ghigo E, Broglio F, Arvat E, Maccario M, Papotti M, Muccioli G. Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor. Clin Endocrinol(Oxf). 2005;62:1-17.
9. Grove KL, Cowley MA. Is ghrelin a signal for the development of metabolic systems? J Clin Invest. 2005;115:3393-7.
10. Horvath TL, Diano S, Sotonyi P, Heiman M, Tschöp M. Minireview: ghrelin and the regulation of energy balance-a hypothalamic perspective. Endocrinology. 2001;142:4163-9.
11. Fujino K, Inui A, Asakawa A, Kihara N, Fujimura M, Fujimiya M. Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J Physiol. 2003;550:227-40.
12. Kitazawa T, De Smet B, Verbeke K, Depoortere I, Peeters TL. Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro. Gut. 2005;54:1078-84.
13. Perboni S, Inui A. Appetite and gastrointestinal motility: role of ghrelin-family peptides. Clin Nutr. 2010;29:227-34.
14. Fujimiya M, Asakawa A, Ataka K, Kato I, Inui A. Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motility in conscious rats. World J Gastroenterol. 2008;14:6318-26.
15. Trudel L, Tomasetto C, Rio MC, Bouin M, Plourde V, Eberling P, et al. Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postopera-tive ileus in rat. Am J Physiol Gastrointest Liver Physiol. 2002;282:G948-52.
16. Edholm T. Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons. Regul Pept. 2004;121:25-30.
17. Davenport AP, Bonner TI, Foord SM, Harmar AJ, Neubig RR, Pin JP, Spedding M, et al. International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function. Pharmacol Rev. 2005;57:541-6.
18. Diéguez C, da Boit K, Novelle MG, Martínez de Morentin PB, Nogueiras R, et al. New insights in ghrelin orexigenic effect. Front Horm Res. 2010;38:196-205.
19. Shioda S, Takenoya F, Yagi M, Wang L, Hori Y, Kageyama H. Neural networks of several novel neuropeptides involved in feeding regulation. Nutrition. 2008;24:848-53.
20. Hewson AK, Tung LY, Connell DW, Tookman L, Dickson SL. The rat arcuate nucleus integrates peripheral signals provided by leptin, insulin, and a ghrelin mimetic. Diabetes. 2002;51:3412-9.
21. Cone RD, Cowley MA, Butler AA, Fan W, Marks DL, Low MJ. The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. Int J Obes Relat Metab Disord. 2001;25(Suppl 5):S63-7.
22. Currie PJ, Mirza A, Fuld R, Park D, Vasselli JR. Ghrelin is an orexigenic and metabolic signaling peptide in the arcuate and paraventricular nuclei. Am J Physiol Regul Integr Comp Physiol. 2005;289:R353-8.
23. Scopinho AA, Resstel LB, Corrêa FM. alpha(1)-Adrenoceptors in the lateral septal area modulate food intake behavior in rats. Br J Pharmacol. 2008;155:752-6.
24. de Arruda Camargo GM, de Arruda Camargo LA, Saad WA. On a possible dual role for the lateral septal area 5-HT(1A) receptor system in the regulation of water intake and urinary excretion. Behav Brain Res. 2010;215:122-8.
25. Paxinos G, Watson C. The rat brain in steriotaxic coordinates. San Diego: Academic Press; 1998.
26. Xu L, Sun X, Depoortere I, Lu J, Guo F, Peeters TL. Effect of motilin on the discharge of rat hippocampal neurons responding to gastric distension and its potential mechanism. Peptides. 2008;29:585-92.
27. Jhamandas JH, Lind RW, Renau LP. Angiotensin II may mediate excitatory neurotransmission from the subfornical organ to the hypothalamic supraoptic nucleus: an anatomical and electrophysiological study in the rat. Brain Res. 1989;487:52-6.
28. Guan Y, Tang M, Jiang Z, Peeters TL. Excitatory effects of motilin in the hippocampus on gastric motility in rats. Brain Res. 2003;984:33-41.
29. Brisch R, Bernstein HG, Dobrowolny H, Krell D, Stauch R, Trübner K, et al. A morphometric analysis of the septal nuclei in schizophrenia and affective disorders: reduced neuronal density in the lateral septal nuclei in bipolar disorder. Eur Arch Psychiatry Clin Neurosci. 2011;261:47-58.
30. Jakab RL, Leranth C. "Septum." In: Paxinos G, editor. The rat nervous system. 3rd ed. San Diego: Academic Press; 2004.
31. Majeed NH, Przewłocka B, Wedzony K, Przewłocki R. Stimulation of food intake following opioid microinjection into the nucleus accumbens septi in rats. Peptides. 1986;7:711-6.
32. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 2001;86:5992.
33. Taniguchi H, Ariga H, Zheng J, Ludwig K, Takahashi T. Effects of ghrelin on interdigestive contractions of the rat gastrointestinal tract. World J Gastroenterol. 2008;14:6299-302.
34. Taniguchi H, Ariga H, Zheng J, Ludwig K, Mantyh C, Pappas TN, et al. Endogenous ghrelin and 5-HT regulate interdigestive gastrointestinal contractions in conscious rats. Am J Physiol Gastrointest Liver Physiol. 2008;295:G403-11.
35. Yakabi K, Kawashima J, Kato S. Ghrelin and gastric acid secretion. World J Gastroenterol. 2008;14:6334-8.
36. Levin F, Edholm T, Ehrström M, Wallin B, Schmidt PT, Kirchgessner AM, et al. Effect of peripherally administered ghrelin on gastric emptying and acid secretion in the rat. Regul Pept. 2005;131:59-65.
37. Ogawa A, Mochiki E, Yanai M, Morita H, Toyomasu Y, Ogata K, et al. Interdigestive migrating contractions are coregulated by ghrelin and motilin in conscious dogs. Am J Physiol Regul Integr Comp Physiol. 2012;302:233-41.
38. Fujimiya M, Ataka K, Asakawa A, Chen CY, Kato I, Inui A. Ghrelin, des-acyl ghrelin and obestatin on the gastrointestinal motility. Peptides. 2011;32:2348-51.
39. Ariga H, Nakade Y, Tsukamoto K, Imai K, Chen C, Mantyh C, et al. Ghrelin accelerates gastric emptying via early manifestation of antropyloric coordination in conscious rats. Regul Pept. 2008;146:112-6.
40. Peteers TL. Central and peripheral mechanisms by which ghrelin regulates gut motility. J Physiol Pharmacol. 2003;54:95-103.
41. Yang CG, Wang WG, Yan J, Fei J, Wang ZG, Zheng Q. Gastric motility in ghrelin receptor knockout mice. Mol Med Report. 2012 (Epub ahead of print).
42. Bülbül M, Babygirija R, Zheng J, Ludwig K, Xu H, Lazar J, et al. Food intake and interdigestive gastrointestinal motility in ghrelin receptor mutant rats. J Gastroenterol. 2011;46:469-78.
43. Stengel A, Taché Y. Ghrelin: new insight to mechanisms and treatment of postoperative gastric ileus. Curr Pharm Des. 2011;17:1587-93.
44. Fujitsuka N, Asakawa A, Amitani H, Fujimiya M, Inui A. Ghrelin and gastrointestinal movement. Methods Enzymol. 2012;514:289-301.
45. Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA, et al. Ghrelin causes hyperphagia and obesity in rats. Diabetes. 2001;50:2540-7.
46. Mondal MS, Date Y, Yamaguchi H, Toshinai K, Tsuruta T, Kangawa K, et al. Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus. Regul Pept. 2005;126:55-9.