A meta-analysis of the risk of major affective disorder in relatives of individuals affected by major depressive disorder or bipolar disorder

Journal of Affective Disorders

Volumn 158, Issue , 2014, Pages 37-47

  Wilde, A ^a,b   Chan, H N ^a,b,c   Rahman, B ^d   Meiser, B ^d   Mitchell, P B ^a,b   Schofield, P R ^a,e   Green, M J ^a,b,e  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b BLACK DOG INSTITUTE   (Australia)

^c SINGAPORE GENERAL HOSPITAL   (Singapore)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

^e NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

Author keywords

Bipolar disorder; First degree relatives; Incidence; Major depressive disorder; Meta analysis

Indexed keywords

ARTICLE; BIPOLAR DISORDER; CASE CONTROL STUDY; COHORT ANALYSIS; ENVIRONMENTAL FACTOR; FAMILY HISTORY; FIRST DEGREE RELATIVE; HEREDITY; HUMAN; INFORMATION RETRIEVAL; MAJOR AFFECTIVE DISORDER; MAJOR DEPRESSION; META ANALYSIS (TOPIC); ONSET AGE; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; QUALITY CONTROL; RISK ASSESSMENT; RISK FACTOR; SAMPLE SIZE; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW; DEPRESSIVE DISORDER, MAJOR; FAMILY; GENETICS; INCIDENCE; META ANALYSIS; PSYCHOLOGY;

BIPOLAR DISORDER; DEPRESSIVE DISORDER, MAJOR; FAMILY; HUMANS; INCIDENCE; RISK ASSESSMENT;

EID: 84896736527     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2014.01.014     Document Type: Article

References (96)

1. N. Andreasen, J. Rice, J. Endicott, W. Coryell, M. Grove, and T. Reich Familial rates of affective disorder: a report from the National Institute of Mental Health Collaborative Study Arch. Gen. Psychiatry 44 1987 461 469
2. W. Beardslee, M. Keller, and R. Seifer Prediction of adolescent affective disorder: effects of prior parental affective disorders and child psychopathology J. Am. Acad. Child Adolesc. Psychiatry 35 1996 279 288
3. C. Begg, and M. Mazumdar Operating characteristics of a rank correlation test for publication bias Biometrics 50 1994 1088 1101
4. J. Biederman, S.V. Faraone, D.R. Hirshfeld-Becker, D. Friedman, J.A. Robin, and J.F. Rosenbaum Patterns of psychopathology and dysfunction in high-risk children of parents with panic disorder and major depression Am. J. Psychiatry 158 1 2001 49 57
5. B. Birmaher, D. Axelson, K. Monk, C. Kalas, B. Goldstein, M.B. Hickey, M. Obreja, M. Ehmann, S. Iyengar, W. Shamseddeen, D. Kupfer, and D. Brent Lifetime psychiatric disorders in school-aged offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring Study Arch. Gen. Psychiatry 66 3 2009 287 296
6. C. Bottomley, I. Nazareth, F. Torres-Gonzalez, I. Svab, H.-I. Maaroos, M.I. Geerlings, M. Xavier, S. Saldivia, and M. King Comparison of risk factors for the onset and maintenance of depression Br. J. Psychiatry 196 1 2010 13 17
7. D.A. Brent, M. Oquendo, B. Birmaher, L. Greenhill, D. Kolko, B. Stanley, J. Zelazny, B. Brodsky, N. Melhem, S.P. Ellis, and J.J. Mann Familial transmission of mood disorders: convergence and divergence with transmission of suicidal behavior J. Am. Acad. Child Adolesc. Psychiatry 43 10 2004 1259 1266
8. S. Brooks, S. Krulewicz, and S. Kutcher The Kutcher Adolescent Scale: assessment of its evaluative properties over the course of an 8-week pediatric pharmacotherpay trial J. Adolesc. Psychopharmacol. 13 2003 337 349
9. Centers for Disease Control and Prevention, 2000. Measuring Healthy Days. Atlanta, Georgia.
10. Cross-Disorder Group of the Psychiatric Genomics Consortium Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis Lancet 381 9875 2013 1371 1379
11. M.P. DelBello, and B. Geller Review of studies of child and adolescent offspring of bipolar parents Bipolar Disord. 3 6 2001 325 334
12. R. DerSimonian, and N. Laird Meta-analysis in clinical trials Control Clin. Trials 7 1986 177 188
13. T.C. Eley, H. Liang, R. Plomin, P. Sham, A. Sterne, R. Williamson, and S. Purcell Parental familial vulnerability, family environment, and their Interactions as predictors of depressive symptoms in adolescents J. Am. Acad. Child Adolesc. Psychiatry 43 3 2004 298 306
14. M. Egger, S. Davey, M. Schneider, and C. Minder Bias in meta-analysis detected by a simple, graphical test Br. Med. J. 315 1997 629 634
15. T. Ferro, H. Verdeli, F. Pierre, and M. Weissman Screening for depression in mothers bringing their offspring for evaluation or treatment of depression Am. J. Psychiatry 157 3 2000 375 379
16. C.T. Finn A brief overview of the genetics of bipolar disorder Focus 5 1 2007 14 17
17. M.A. Giovanni, M.R. Fickie, L.S. Lehmann, R.C. Green, L.M. Meckley, D. Veenstra, and M.F. Murray Health-care referrals from direct-to-consumer genetic testing Genet. Test. Mol. Biomark. 14 6 2010 817 819
18. W. Grove, N. Andreasen, G. Winokur, P. Clayton, J. Endicott, and W. Coryell Primary and secondary affective disorders: unipolar patients compared on familial aggregation Compr. Psychiatry 28 2 1987 113 126
19. C. Hammen, D. Burge, E. Burney, and C. Adrian Longitudinal study of diagnoses in children of women with unipolar and bipolar affective disorder Arch. Gen. Psychiatry 47 12 1990 1112 1117
20. C. Hammen, D. Gordon, D. Burge, C. Adrian, C. Jaenicke, and D. Hiroto Maternal affective disorders, illness, and stress: risk for children×s psychopathology Am. J. Psychiatry 144 6 1987 736 741
21. A. Henin, J. Biederman, E. Mick, G.S. Sachs, D.R. Hirshfeld-Becker, R.S. Siegel, S. McMurrich, L. Grandin, and A.A. Nierenberg Psychopathology in the offspring of parents with bipolar disorder: a controlled study Biol. Psychiatry 58 7 2005 554 561
22. J. Higgins, S. Thompson, J. Deeks, and D. Altman Measuring inconsistency in meta-analyses Br. Med. J. 327 2003 557 560
23. M.H.J. Hillegers, C.G. Reichart, M. Wals, F.C. Verhulst, J. Ormel, and W.A. Nolen Five-year prospective outcome of psychopathology in the adolescent offspring of bipolar parents Bipolar Disord. 7 4 2005 344 350
24. D.R. Hirshfeld-Becker, J. Biederman, A. Henin, S.V. Faraone, S.T. Dowd, L.A. De Petrillo, S.M. Markowitz, and J.F. Rosenbaum Psychopathology in the young offspring of parents with bipolar disorder: a controlled pilot study Psychiatry Res. 145 2-3 2006 155 167
25. J. Kaufman, B. Birmaher, D. Brent, R. Dahl, J. Bridge, and N.D. Ryan Psychopathology in the relatives of depressed-abused children Child Abuse Negl. 22 3 1998 171 181
26. K. Kendler, C. Davis, and R. Kessler The familial aggregation of common psychiatric and substance use disorders in the National Comorbidity Survey: a family history study Br. J. Psychiatry 170 6 1997 541 548
27. K. Kendler, A. Fiske, C. Gardner, and M. Gatz Delineation of two genetic pathways to major depression Biol. Psychiatry 65 9 2009 808 811
28. K. Kendler, and C. Prescott A population-based twin study of lifetime major depression in men and women Arch. Gen. Psychiatry 56 1 1999 39 44
29. K.S. Kendler, C.O. Gardner, M.C. Neale, and C.A. Prescott Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes? Psychol. Med. 31 4 2001 605 616
30. R.C. Kessler, G. Andrews, D. Mroczek, B. Ustun, and H.-U. Wittchen The World Health Organization Composite International Diagnostic Interview short-form (CIDI-SF) Int. J. Methods Psychiatr. Res. 7 4 1998 171 185
31. M.J. Khoury, J.F. Thrasher, W. Burke, E.A. Gettig, F. Fridinger, and R. Jackson Challenges in communicating genetics: a public health approach Genet. Med. 2 3 2000 198 202
32. T. Kieseppa, T. Partonen, J. Haukka, J. Kaprio, and J. Lönnqvist High concordance of bipolar I disorder in a nationwide sample of twins Am. J. Psychiatry 161 2004 1814 1821
33. D.N. Klein, R.A. Depue, and J.F. Slater Cyclothymia in the adolescent offspring of parents with bipolar affective disorder J. Abnorm. Psychol. 94 2 1985 115 127
34. D.N. Klein, P.M. Lewinsohn, P. Rohde, J.R. Seeley, and T.M. Olino Psychopathology in the adolescent and young adult offspring of a community sample of mothers and fathers with major depression Psychol. Med. 35 3 2005 353 365
35. M. Lapalme, S. Hodgins, and C. LaRoche Children of parents with bipolar disorder: a meta-analysis of risk for mental disorders Can. J. Psychiatry 42 6 1997 623 631
36. P. Lavori, G. Klerman, M. Keller, T. Reich, J. Rice, and J. Endicott Age-period cohort analysis of secular trends in onset of major depression: findings in siblings of patients with major affective disorder J. Psychiatr. Res. 21 1 1987 23 35
37. D.F. Levinson, G.S. Zubenko, R.R. Crowe, R.J. DePaulo, W.S. Scheftner, M.M. Weissman, P. Holmans, W.N. Zubenko, S. Boutelle, K. Murphy-Eberenz, D. MacKinnon, M.G. McInnis, D.H. Marta, P. Adams, S. Sassoon, J.A. Knowles, J. Thomas, and J. Chellis Genetics of recurrent early-onset depression (GenRED): design and preliminary clinical characteristics of a repository sample for genetic linkage studies Am. J. Med. Genet. B, Neuropsychiatr. Genet. 119B 1 2003 118 130
38. P. Lewinsohn, P. Rohde, J. Seeley, D. Klein, and I. Gotlib Natural course of adolescent major depressive disorder in a community sample: predictors of recurrence in young adults Am. J. Psychiatry 157 10 2000 1584 1591
39. X. Li, J. Sundquist, and K. Sundquist Age-specific familial risks of depression: a nation-wide epidemiological study from Sweden J. Psychiatr. Res. 42 10 2008 808 814
40. R. Lieb, B. Isensee, M. Hofler, and H. Pfister Parental major depression and the risk of depression and other mental disorders in offspring: a prospective-longitudinal community study Arch. Gen. Psychiatry 59 2002 365 374
41. W. Maier, D. Lichtermann, and J. Minges Continuity and discontinuity of affective disorders and schizophrenia: results of a controlled family study Arch. Gen. Psychiatry 50 11 1993 871 883
42. M. Marazita, K. Neiswanger, and M. Cooper Genetic segregation analysis of early-onset recurrent unipolar depression Am. J. Hum. Genet. 61 6 1997 1370 1378
43. N.R. Marmorstein Associations between subtypes of major depressive episodes and substance use disorders Psychiatry Res. 186 2-3 2011 248 253
44. N.R. Marmorstein, S.M. Malone, and W.G. Iacono Psychiatric disorders among offspring of depressed mothers: associations with paternal psychopathology Am. J. Psychiatry 161 2004 1588 1594
45. Martinez-Devesa, P., Perera, R., Theodoulou, M., Waddell, A., 2010. Cognitive behavioural therapy for tinnitus. Cochrane Database of Systematic Reviews, issue 9. Art. No.: CD005233. 10.1002/14651858.CD005233.pub3.
46. P. McGuffin, R. Katz, and P. Bebbington The Camberwell Collaborative Depression Study. III. Depression and adversity in the relatives of depressed probands Br. J. Psychiatry 152 6 1988 775 782
47. P. McGuffin, R. Katz, S. Watkins, and J. Rutherford A hospital-based twin register of the heritability of DSM-IV unipolar depression Arch. Gen. Psychiatry 53 2 1996 129 136
48. P. McGuffin, F. Rijsdijk, M. Andrew, P. Sham, R. Katz, and A. Cardno The heritability of bipolar disorder and the genetic relationship to unipolar despression Arch. Gen. Psychiatry 60 2003 497 502
49. F. McMahon, O. Stine, D. Meyers, S. Simpson, and J. DePaulo Patterns of maternal transmission in bipolar affective disorder Am. J. Hum. Genet. 56 6 1995 1277 1286
50. K. Merikangas, R. Jin, J. He, R. Kessler, S. Lee, N. Sampson, M. Viana, L. Andrade, C. Hu, E. Karam, M. Ladea, M. Medina-Mora, Y. Ono, J. Posada-Villa, R. Sagar, J. Wells, and Z. Zarkov Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative Arch. Gen. Psychiatry 68 3 2011 241 251
51. K.R. Merikangas, A. Chakravarti, S.O. Moldin, H. Araj, J. Blangero, M. Burmeister, J.C. Crabbe, J.R. Depaulo, E. Foulks, N.B. Freimer, D.S. Koretz, W. Lichtenstein, E. Mignot, A.L. Reiss, N.J. Risch, and J.S. Takahashi Future of genetics of mood disorders research Biol. Psychiatry 52 6 2002 457 477
52. K.R. Merikangas, B.A. Prusoff, and M.M. Weissman Parental concordance for affective disorders: psychopathology in offspring J. Affect. Disord. 15 3 1988 279 290
53. J. Mitchell, E. McCauley, P. Burke, R. Calderon, and K. Schloredt Psychopathology in parents of depressed children and adolescents J. Am. Acad. Child Adolesc. Psychiatry 28 3 1989 352 357
54. P. Mitchell, A. Johnston, and T. Slade Bipolar disorder in Australia: the 2007 National Survey of mental health and well-being Bipolar Disord. 11 2009 779
55. D. Moberg The adolescent drug involvement scale J. Adolesc. Chem. Depend. 2 1991 75 88
56. R. Mojtabai Parental psychopathology and childhood atopic disorders in the community Psychosom. Med. 67 3 2005 448 453
57. P.B. Mortensen, C.B. Pedersen, M. Melbye, O. Mors, and H. Ewald Individual and familial risk factors for bipolar affective disorders in Denmark Arch. Gen. Psychiatry 60 12 2003 1209 1215
58. L. Murray, A. Arteche, P. Fearon, S. Halligan, I. Goodyer, and P. Cooper Maternal postnatal depression and the development of depression in offspring up to 16 years of age J. Am. Acad. Child Adolesc. Psychiatry 50 5 2011 460 470
59. Y. Nomura, V. Warner, and P. Wickramaratne Parents concordant for major depressive disorder and the effect of psychopathology in offspring Psychol. Med. 31 7 2001 1211 1222
60. Y. Nomura, P.J. Wickramaratne, V. Warner, L. Mufson, and M.M. Weissman Family discord, parental depression, and psychopathology in offspring: ten-year follow-up J. Am. Acad. Child Adolesc. Psychiatry 41 4 2002 402 409
61. T.M. Olino, J.W. Pettit, D.N. Klein, N.B. Allen, J.R. Seeley, and P.M. Lewinsohn Influence of parental and grandparental major depressive disorder on behavior problems in early childhood: a three-generation study J. Am. Acad. Child Adolesc. Psychiatry 47 1 2008 53 60
62. H. Orvaschel Early onset psychiatric disorder in high risk children and increased familial morbidity J. Am. Acad. Child Adolesc. Psychiatry 29 2 1990 184 188
63. C. Peterson, A. Semmel, C. von Baeyer, L.Y. Abramson, G.I. Metalsky, and M.E.P. Seligman The attributional style questionnaire Cogn. Ther. Res. 6 3 1982 287 299
64. D.J. Pilowsky, P. Wickramaratne, Y. Nomura, and M.M. Weissman Family discord, parental depression, and psychopathology in offspring: 20-year follow-up J. Am. Acad. Child Adolesc. Psychiatry 45 4 2006 452 460
65. Psychiatric GWAS Consortium Coordinating Committee Genomewide association studies: history, rationale, and prospects for psychiatric disorders Am. Psychiatry 166 5 2009 540 556
66. H.Z. Reinherz, A.D. Paradis, R.M. Giaconia, C.K. Stashwick, and G. Fitzmaurice Childhood and adolescent predictors of major depression in the transition to adulthood Am. J. Psychiatry 160 12 2003 2141 2147
67. F. Rice, G. Harold, and A. Thapar The genetic aetiology of childhood depression: a review J. Child Psychol. Psychiatry 43 1 2002 65 79
68. N.D. Ryan, D.E. Williamson, S. Iyengar, H. Orvaschel, T. Reich, R.E. Dahl, and J. Puig Antich A secular increase in child and adolescent onset affective disorder J. Am. Acad. Child Adolesc. Psychiatry 31 4 1992 600 605
69. A. Schreier, M. Hofler, H.-U. Wittchen, and R. Lieb Clinical characteristics of major depressive disorder run in families - a community study of 933 mothers and their children J. Psychiatr. Res. 40 4 2006 283 292
70. M.K. Singh, M.P. DelBello, K.E. Stanford, C. Soutullo, P. McDonough-Ryan, S.L. McElroy, and S.M. Strakowski Psychopathology in children of bipolar parents J. Affect. Disord. 102 1-3 2007 131 136
71. T. Slade, A. Johnston, and M.O. Browne 2007 National Survey of Mental Health and Wellbeing: methods and key findings Aust. N. Z. J. Psychiatry 43 7 2009 594 605
72. D.J. Smith, and D.H.R. Blackwood Depression in young adults Adv. Psychiatr. Treat. 10 1 2004 4 12
73. M.D. Stevenson, A. Scope, P.A. Sutcliffe, A. Booth, P. Slade, G. Parry, D. Saxon, and E. Kalthenthaler Group cognitive behavioural therapy for postnatal depression: a systematic review of clinical effectiveness, cost-effectiveness and value of information analyses Health Technol. Assess. 14 44 2010 1 107 (iii-iv)
74. P.F. Sullivan, M.C. Neale, and K.S. Kendler Genetic epidemiology of major depression: review and meta-analysis Am. J. Psychiatry 157 10 2000 1552 1562
75. R.D. Todd, W. Reich, T.A. Petti, P. Joshi, J.R. DePaulo Jr., J. Nurnberger Jr., and T. Reich Psychiatric diagnoses in the child and adolescent members of extended families identified through adult bipolar affective disorder probands J. Am. Acad. Child Adolesc. Psychiatry 35 5 1996 664 671
76. R.D. Todd, W. Reich, and T. Reich Prevalence of affective disorder in the child and adolescent offspring of a single kindred: a pilot study J. Am. Acad. Child Adolesc. Psychiatry 33 2 1994 198 207
77. F. Tozzi, I. Prokopenko, and J. Perry Family history of depression is associated with younger age of onset in patients with recurrent depression Psychol. Med. 38 05 2008 641 649
78. M.T. Tsuang, and R. VanderMey Genes and the Mind: Inheritance of Mental Illness 1980 Oxford University Press Oxford; New York
79. M.T. Tsuang, G. Winokur, and R.R. Crowe Morbidity risks of schizophrenia and affective disorders among first degree relatives of patients with schizophrenia, mania, depression and surgical conditions Br. J. Psychiatry 137 6 1980 497 504
80. R. Valdez, P.W. Yoon, N. Qureshi, R.F. Green, and M.J. Khoury Family history in public health practice: a genomic tool for disease prevention and health promotion Annu. Rev. Public Health 31 1 2010 69 87
81. M. Wals, C.G. Reichart, M.H.J. Hillegers, J. Van Os, F.C. Verhulst, W.A. Nolen, and J. Ormel Impact of birth weight and genetic liability on psychopathology in children of bipolar parents J. Am. Acad. Child Adolesc. Psychiatry 42 9 2003 1116 1121
82. M. Wals, J. van Os, C. Reichart, M. Hillegers, J. Ormel, F. Verhulst, and W. Nolen Multiple dimensions of familial psychopathology affect risk of mood disorder in children of bipolar parents Am. J. Med. Genet. B, Neuropsychiatr. Genet. 127B 1 2004 35 41
83. V. Warner, L. Mufson, and M.M. Weissman Offspring at high and low risk for depression and anxiety: mechanisms of psychiatric disorder J. Am. Acad. Child Adolesc. Psychiatry 34 6 1995 786 797
84. V. Warner, M.M. Weissman, L. Mufson, and P.J. Wickramaratne Grandparents, parents, and grandchildren at high risk for depression: a three-generation study J. Am. Acad. Child Adolesc. Psychiatry 38 3 1999 289 296
85. M.M. Weissman, M. Fendrich, V. Warner, and P. Wickramaratne Incidence of psychiatric disorder in offspring at high and low risk for depression J. Am. Acad. Child Adolesc. Psychiatry 31 4 1992 640 648
86. M.M. Weissman, K.K. Kidd, and B.A. Prusoff Variability in rates of affective disorders in relatives of depressed and normal probands Arch. Gen. Psychiatry 39 12 1982 1397 1403
87. M.M. Weissman, B.A. Prusoff, G.D. Gammon, K.R. Merikangas, J.F. Leckman, and K.K. Kidd Psychopathology in the children (ages 6-18) of depressed and normal parents J. Am. Acad. Child Psychiatry 23 1 1984 78 84
88. M.M. Weissman, P. Wickramaratne, K.R. Merikangas, J.F. Leckman, B.A. Prusoff, K.A. Caruso, K.K. Kidd, and G.D. Gammon Onset of major depression in early adulthood: increased familial loading and specificity Arch. Gen. Psychiatry 41 12 1984 1136 1143
89. M.M. Weissman, P. Wickramaratne, Y. Nomura, V. Warner, D. Pilowsky, and H. Verdeli Offspring of depressed parents: 20 years later Am. J. Psychiatry 163 6 2006 1001 1008
90. P.J. Wickramaratne, V. Warner, and M.M. Weissman Selecting early onset MDD probands for genetic studies: results from a longitudinal high-risk study Am. J. Med. Genet. 96 1 2000 93 101
91. P.J. Wickramaratne, and M.M. Weissman Onset of psychopathology in offspring by developmental phase and parental depression J. Am. Acad. Child Adolesc. Psychiatry 37 9 1998 933 942
92. A. Wilde, B. Meiser, P.B. Mitchell, D. Hadzi-Pavlovic, and P.R. Schofield Community interest in predictive genetic testing for susceptibility to major depression in a large national sample Psychol. Med. 41 8 2011 1605 1614
93. A. Wilde, B. Meiser, P.B. Mitchell, and P.R. Schofield Public interest in predictive genetic testing, including direct-to-consumer testing, for susceptibility to major depression: preliminary findings Eur. J. Hum. Gen. 18 2010 47 51
94. A. Wilde, P.B. Mitchell, B. Meiser, and P.R. Schofield Implications of the use of genetic tests in psychiatry, with a focus on major depressive disorder: a review Depress. Anxiety 30 2013 267 275 10.1002/da.22000
95. G. Winokur, M.T. Tsuang, and R.R. Crowe The Iowa 500: affective disorder in relatives of manic and depressed patients Am. J. Psychiatry 139 2 1982 209 212
96. P.W. Yoon, M.T. Scheuner, K.L. Peterson-Oehlke, M. Gwinn, A. Faucett, and M.J. Khoury Can family history be used as a tool for public health and preventive medicine? Genet. Med. 4 4 2002 304 310