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Drug pipeline in neurodegeneration based on transgenic mice models of Alzheimer's disease
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Li C, Ebrahimi A, Schluesener H: Drug pipeline in neurodegeneration based on transgenic mice models of Alzheimer's disease. Ageing Res Rev 2013; 12: 116-140.
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Commentary to the recently published review 'Drug pipeline in neurodegeneration based on transgenic mice models of Alzheimer's disease' by Li
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Windisch M, Flunkert S, Havas D, Hutter-Paier B: Commentary to the recently published review 'Drug pipeline in neurodegeneration based on transgenic mice models of Alzheimer's disease' by Li, Evrahimi and Schluesener. Ageing Res Rev 2013; 12: 116-140.
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Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage
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Wilcock DM, Rojiani A, Rosenthal A, Subbarao S, Freeman MJ, Gordon MN, Morgan D: Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage, J Neuroinflamm 2004; 1: 24.
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Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2
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Wilcock DM, Lewis MR, Van Nostrand WE, Davis J, Previti ML, Gharkholonarehe N, Vitek MP, Colton CA: Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci 2008; 28: 1537-1545.
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11 C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: A phase 2, double-blind, placebo-controlled, ascendingdose study
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11 C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascendingdose study, Lancet Neurol 2010; 9: 363-372.
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In vitro and in vivo profiling of CHF5022 and CHF5074, two beta-amyloid 1-42 lowering agents
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Imbimbo BP, Del Giudice E, Cenacchi V, Volta R, Villetti G, Facchinetti F, Riccardi B, Puccini P, Moretto N, Grassi F, Ottonello S, Leon A: In vitro and in vivo profiling of CHF5022 and CHF5074, two beta-amyloid 1-42 lowering agents. Pharmacol Res 2007; 55: 318-328.
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Lack of specific amyloid-beta(1-42) suppression by nonsteroidal anti-inflammatory drugs in young, plaque-free Tg2576 mice and in guinea pig neuronal cultures
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Lanz TA, Fici GJ, Merchant KM: Lack of specific amyloid-beta(1-42) suppression by nonsteroidal anti-inflammatory drugs in young, plaque-free Tg2576 mice and in guinea pig neuronal cultures. J Pharmacol Exp Ther 2005; 312: 399-406.
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Differential effects between gamma-secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic mice
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Mitani Y, Yarimizu J, Saita K, Uchino H, Akashiba H, Shitaka Y, Ni K, Matsuoka N: Differential effects between gamma-secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic mice, J Neurosci 2012; 32: 2037-2050.
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Too much good news-are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?
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Zahs KR, Ashe KH: 'Too much good news'-are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease? Trends Neurosci 2010; 33: 381-389.
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Zahs, K.R.1
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A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric abeta, and frank neuronal loss
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Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, Vasilevko V, Glabe CG, Breunig JJ, Rakic P, Davtyan H, Agadjanyan MG, Kepe V, Barrio JR, Bannykh S, Szekely CA, Pechnick RN, Town T: A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric abeta, and frank neuronal loss. J Neurosci 2013; 33: 6245-6256.
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Barrio, J.R.15
Bannykh, S.16
Szekely, C.A.17
Pechnick, R.N.18
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Neuroprotection-STAIR-way to the future?
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Shuaib A: Neuroprotection-STAIR-way to the future? Cerebrovasc Dis 2006; 22: 10-17.
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Impact of ApoB-100 expression on cognition and brain pathology in wild-type and hAPPsl mice
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Loffler T, Flunkert S, Havas D, Santha M, Hutter-Paier B, Steyrer E, Windisch M: Impact of ApoB-100 expression on cognition and brain pathology in wild-type and hAPPsl mice. Neurobiol Aging 2013; 34: 2379-2388.
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Loffler, T.1
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