Uremic toxins impair human bone marrow-derived mesenchymal stem cells functionality in vitro

Experimental and Toxicologic Pathology

Volumn 66, Issue 4, 2014, Pages 187-194

  Idziak, Marta ^a   Pedzisz, Piotr ^a   Burdzińska, Anna ^a   Gala, Kamila ^a   Paczek, Leszek ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

Author keywords

Indoxyl sulfate; Kidney regeneration; Mesenchymal stem cells; P Cresol; Uremic toxicity

Indexed keywords

INDICAN; INTERLEUKIN 8; LACTATE DEHYDROGENASE; PARA CRESOL; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

APOPTOSIS; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL DAMAGE; CELL FUNCTION; CELL ISOLATION; CELL MEMBRANE; CELL PROLIFERATION; CELL VIABILITY; CHRONIC KIDNEY DISEASE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IN VITRO STUDY; MESENCHYMAL STEM CELL; METABOLISM; PARACRINE SIGNALING;

INDOXYL SULFATE; KIDNEY REGENERATION; MESENCHYMAL STEM CELLS; P-CRESOL; UREMIC TOXICITY;

APOPTOSIS; CELL ADHESION; CELL MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CRESOLS; HUMANS; INDICAN; MESENCHYMAL STROMAL CELLS; UREMIA;

EID: 84896731511     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2014.01.003     Document Type: Article

References (33)

1. Baer P.C., Geiger H. Mesenchymal stem cell interactions with growth factors on kidney repair. Curr Opin Nephrol Hypertens 2010, 19:1-6.
2. Bolati D., Shimizu H., Higashiyama Y., Nishijima F., Niwa T. Indoxyl sulfate induces epithelial-to-mesenchymal transition in rat kidneys and human proximal tubular cells. Am J Nephrol 2011, 34:318-323.
3. Burst V.R., Gillis M., Putsch F., Herzog R., Fischer J.H., Heid P., et al. Poor cell survival limits the beneficial impact of mesenchymal stem cell transplantation on acute kidney injury. Nephron Exp Nephrol 2010, 114:e107-e116.
4. Bussolati B., Tetta C., Camussi G. Contribution of stem cells to kidney repair. Am J Nephrol 2008, 28:813-822.
5. Choi S., Park M., Kim J., Hwang S., Park S., Lee Y. The role of mesenchymal stem cells in the functional improvement of chronic renal failure. Stem Cells Dev 2009, 18:521-529.
6. Dou L., Bertrand E., Cerini C., Faure V., Sampol J., Vanholder R., et al. The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair. Kidney Int 2004, 65:442-451.
7. Feld S.M., Hirschberg R., Artishevsky A., Nast C., Adler S.G. Insulin-like growth factor I induces mesangial proliferation and increases mRNA and secretion of collagen. Kidney Int 1995, 48:45-51.
8. Gelasco A.K., Raymond J.R. Indoxyl sulfate induces complex redox alterations in mesangial cells. Am J Physiol Renal Physiol 2006, 290:F1551-F1558.
9. Hirschberg R., Kopple J., Lipsett P., Benjamin E., Minei J., Albertson T., et al. Multicenter clinical trial of recombinant human insulin-like growth factor I in patients with acute renal failure. Kidney Int 1999, 55:2423-2432.
10. Huang S.T., Shu K.H., Cheng C.H., Wu M.J., Yu T.M., Chuang Y.W., et al. Serum total p-cresol and indoxyl sulfate correlated with stage of chronic kidney disease in renal transplant recipients. Transplant Proc 2012, 44:621-624.
11. Imasawa T., Utsunomiya Y., Kawamura T., Zhong Y., Nagasawa R., Okabe M., et al. The potential of bone marrow-derived cells to differentiate to glomerular mesangial cells. J Am Soc Nephrol 2001, 12:1401-1409.
12. Imberti B., Morigi M., Tomasoni S., Rota C., Corna D., Longaretti L., et al. Insulin-like growth factor-1 sustains stem cell mediated renal repair. J Am Soc Nephrol 2007, 18:2921-2928.
13. Le Blanc K., Ringden O. Immunomodulation by mesenchymal stem cells and clinical experience. J Intern Med 2007, 262:509-525.
14. Lin C.J., Chen H.H., Pan C.F., Chuang C.K., Wang T.J., Sun F.J., et al. p-Cresylsulfate and indoxyl sulfate level at different stages of chronic kidney disease. J Clin Lab Anal 2011, 25:191-197.
15. Masuda Y., Shimizu A., Mori T., Ishiwata T., Kitamura H., Ohashi R., et al. Vascular endothelial growth factor enhances glomerular capillary repair and accelerates resolution of experimentally induced glomerulonephritis. Am J Pathol 2001, 159:599-608.
16. Moghadasali R., Mutsaers H.A., Azarnia M., Aghdami N., Baharvand H., Torensma R., et al. Mesenchymal stem cell-conditioned medium accelerates regeneration of human renal proximal tubule epithelial cells after gentamicin toxicity. Exp Toxicol Pathol: Official J Gesellschaft fur Toxikologische Pathologie 2013, 65:595-600.
17. Morigi M., Imberti B., Zoja C., Corna D., Tomasoni S., Abbate M., et al. Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol 2004, 15:1794-1804.
18. Morigi M., Introna M., Imberti B., Corna D., Abbate M., Rota C., et al. Human bone marrow mesenchymal stem cells accelerate recovery of acute renal injury and prolong survival in mice. Stem Cells 2008, 26:2075-2082.
19. Niwa T. Uremic toxicity of indoxyl sulfate. Nagoya J Med Sci 2010, 72:1-11.
20. Noh H., Yu M.R., Kim H.J., Jeon J.S., Kwon S.H., Jin S.Y., et al. Uremia induces functional incompetence of bone marrow-derived stromal cells. Nephrol Dial Transplant 2012, 27:218-225.
21. Prodromidi E.I., Poulsom R., Jeffery R., Roufosse C.A., Pollard P.J., Pusey C.D., et al. Bone marrow-derived cells contribute to podocyte regeneration and amelioration of renal disease in a mouse model of Alport syndrome. Stem Cells 2006, 24:2448-2455.
22. Qian H., Yang H., Xu W., Yan Y., Chen Q., Zhu W., et al. Bone marrow mesenchymal stem cells ameliorate rat acute renal failure by differentiation into renal tubular epithelial-like cells. Int J Mol Med 2008, 22:325-332.
23. Sun C.Y., Hsu H.H., Wu M.S. p-Cresol sulfate and indoxyl sulfate induce similar cellular inflammatory gene expressions in cultured proximal renal tubular cells. Nephrol Dial Transplant 2013, 28:70-78.
24. Tang N., Zhao Y., Feng R., Liu Y., Wang S., Wei W., et al. Lysophosphatidic acid accelerates lung fibrosis by inducing differentiation of mesenchymal stem cells into myofibroblasts. J Cell Mol Med 2014, 18:156-169.
25. Togel F., Cohen A., Zhang P., Yang Y., Hu Z., Westenfelder C. Autologous and allogeneic marrow stromal cells are safe and effective for the treatment of acute kidney injury. Stem Cells Dev 2009, 18:475-485.
26. Togel F., Hu Z., Weiss K., Isaac J., Lange C., Westenfelder C. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol 2005, 289:F31-F42.
27. Togel F., Weiss K., Yang Y., Hu Z., Zhang P., Westenfelder C. Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. Am J Physiol Renal Physiol 2007, 292:F1626-F1635.
28. Togel F., Zhang P., Hu Z., Westenfelder C. VEGF is a mediator of the renoprotective effects of multipotent marrow stromal cells in acute kidney injury. J Cell Mol Med 2009, 13:2109-2114.
29. Tsang M. Mesenchymal cells emerge as primary contributors to fibrosis in multiple tissues. J Cell Commun Signal 2013, [Epub ahead of print].
30. Vanholder R., De Smet R., Glorieux G., Argiles A., Baurmeister U., Brunet P., et al. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int 2003, 63:1934-1943.
31. Wu I.W., Hsu K.H., Lee C.C., Sun C.Y., Hsu H.J., Tsai C.J., et al. p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease. Nephrol Dial Transplant 2011, 26:938-947.
32. Ying Y., Yang K., Liu Y., Chen Q.J., Shen W.F., Lu L., et al. A uremic solute P-cresol, inhibits the proliferation of endothelial progenitor cells via the p38 pathway. Circ J 2011, 75:2252-2259.
33. Zhang Q.L., Rothenbacher D. Prevalence of chronic kidney disease in population-based studies: systematic review. BMC Public Health 2008, 8:117.