Mechanisms underlying the development of the electrocardiographic and arrhythmic manifestations of early repolarization syndrome

Journal of Molecular and Cellular Cardiology

Volumn 68, Issue , 2014, Pages 20-28

  Koncz, István ^a,b   Gurabi, Zsolt ^a,b   Patocskai, Bence ^a,b   Panama, Brian K ^a   Szél, Tamás ^a,b   Hu, Dan ^a   Barajas Martínez, Hector ^a   Antzelevitch, Charles ^a  

^a MASONIC MEDICAL RESEARCH LABORATORY   (United States)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Electrophysiology; J wave syndrome; Parasympathetic tone; Transient outward potassium current; Ventricular fibrillation

Indexed keywords

ISOPRENALINE; QUINIDINE;

ADULT; ANIMAL CELL; ARTICLE; CELL DENSITY; CLINICAL EFFECTIVENESS; CLINICAL FEATURE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DOG; DRUG EFFICACY; DRUG MECHANISM; EARLY REPOLARIZATION SYNDROME; ELECTROCARDIOGRAM; ELECTROCARDIOGRAPHY; FEMALE; HEART ARRHYTHMIA; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART REPOLARIZATION; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HIGH RISK PATIENT; MALE; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NONHUMAN; PRIORITY JOURNAL; REENTRY ARRHYTHMIA; RISK ASSESSMENT; RISK FACTOR; SENSITIVITY ANALYSIS; SYNDROME;

ELECTROPHYSIOLOGY; J WAVE SYNDROME; PARASYMPATHETIC TONE; TRANSIENT OUTWARD POTASSIUM CURRENT; VENTRICULAR FIBRILLATION;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIAS, CARDIAC; DOGS; FEMALE; HEART CONDUCTION SYSTEM; HEART VENTRICLES; MALE; MYOCARDIAL CONTRACTION; PATCH-CLAMP TECHNIQUES; PERICARDIUM; PHENYLUREA COMPOUNDS; SYNDROME; TETRAZOLES; VERAPAMIL;

EID: 84896729820     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2013.12.012     Document Type: Article

References (46)

1. Yan G.X., Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST segment elevation. Circulation 1999, 100:1660-1666.
2. Gussak I., Antzelevitch C. Early repolarization syndrome: clinical characteristics and possible cellular and ionic mechanisms. J Electrocardiol 2000, 33:299-309.
3. Haissaguerre M., Derval N., Sacher F., Jesel L., Deisenhofer I., De Roy L., et al. Sudden cardiac arrest associated with early repolarization. N Engl J Med 2008, 358:2016-2023.
4. Nam G.B., Kim Y.H., Antzelevitch C. Augmentation of J waves and electrical storms in patients with early repolarization. N Engl J Med 2008, 358:2078-2079.
5. Rosso R., Kogan E., Belhassen B., Rozovski U., Scheinman M.M., Zeltser D., et al. J-point elevation in survivors of primary ventricular fibrillation and matched control subjects: incidence and clinical significance. J Am Coll Cardiol 2008, 52:1231-1238.
6. Nam G.B., Ko K.H., Kim J., Park K.M., Rhee K.S., Choi K.J., et al. Mode of onset of ventricular fibrillation in patients with early repolarization pattern vs. Brugada syndrome. Eur Heart J 2010, 31:330-339.
7. ATP channel. J Cardiovasc Electrophysiol 2009, 20:93-98.
8. Medeiros-Domingo A., Tan B.H., Crotti L., Tester D.J., Eckhardt L., Cuoretti A., et al. Gain-of-function mutation S422L in the KCNJ8-encoded cardiac K(ATP) channel Kir6.1 as a pathogenic substrate for J-wave syndromes. Heart Rhythm 2010, 7:1466-1471.
9. Barajas-Martinez H., Hu D., Ferrer T., Onetti C.G., Wu Y., Burashnikov E., et al. Molecular genetic and functional association of Brugada and early repolarization syndromes with S422L missense mutation in KCNJ8. Heart Rhythm 2012, 9:548-555.
10. Burashnikov E., Pfeiffer R., Barajas-Martinez H., Delpon E., Hu D., Desai M., et al. Mutations in the cardiac L-type calcium channel associated J wave syndrome and sudden cardiac death. Heart Rhythm 2010, 7:1872-1882.
11. Watanabe H., Nogami A., Ohkubo K., Kawata H., Hayashi Y., Ishikawa T., et al. Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization. Circ Arrhythm Electrophysiol 2011, 4:874-881.
12. Wilhelm M., Brem M.H., Rost C., Klinghammer L., Hennig F.F., Daniel W.G., et al. Early repolarization, left ventricular diastolic function, and left atrial size in professional soccer players. Am J Cardiol 2010, 106:569-574.
13. Marcus R.R., Kalisetti D., Raxwal V., Kiratli B.J., Myers J., Perkash I., et al. Early repolarization in patients with spinal cord injury: prevalence and clinical significance. J Spinal Cord Med 2002, 25:33-38.
14. Mizumaki K., Nishida K., Iwamoto J., Nakatani Y., Yamaguchi Y., Sakamoto T., et al. Vagal activity modulates spontaneous augmentation of J-wave elevation in patients with idiopathic ventricular fibrillation. Heart Rhythm 2012, 9:249-255.
15. Koutbi L., Roussel M., Haissaguerre M., Deharo J.C. Hyperpnea test triggering malignant ventricular arrhythmia in a child with early repolarization. Heart Rhythm 2012, 9:1153-1156.
16. Kawata H., Noda T., Yamada Y., Okamura H., Satomi K., Aiba T., et al. Effect of sodium-channel blockade on early repolarization in inferior/lateral leads in patients with idiopathic ventricular fibrillation and Brugada syndrome. Heart Rhythm 2012, 9:77-83.
17. Kasanuki H., Ohnishi S., Ohtuka M., Matsuda N., Nirei T., Isogai R., et al. Idiopathic ventricular fibrillation induced with vagal activity in patients without obvious heart disease. Circulation 1997, 95:2277-2285.
18. Tikkanen J.T., Anttonen O., Junttila M.J., Aro A.L., Kerola T., Rissanen H.A., et al. Long-term outcome associated with early repolarization on electrocardiography. N Engl J Med 2009, 361:2529-2537.
19. Junttila M.J., Sager S.J., Tikkanen J.T., Anttonen O., Huikuri H.V., Myerburg R.J. Clinical significance of variants of J-points and J-waves: early repolarization patterns and risk. Eur Heart J 2012, 33:2639-2643.
20. Fish J.M., Welchons D.R., Kim Y.S., Lee S.H., Ho W.K., Antzelevitch C. Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome. Circulation 2006, 113:1393-1400.
21. Di Diego J.M., Sicouri S., Myles R.C., Burton F.L., Smith G.L., Antzelevitch C. Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. J Mol Cell Cardiol 2013, 54:53-64.
22. Zygmunt A.C., Goodrow R.J., Antzelevitch C. Sodium effects on 4-aminopyridine-sensitive transient outward current in canine ventricular cells. Am J Physiol 1997, 272:H1-H11.
23. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981, 391:85-100.
24. Yan G.X., Antzelevitch C. Cellular basis for the electrocardiographic J wave. Circulation 1996, 93:372-379.
25. Antzelevitch C., Pollevick G.D., Cordeiro J.M., Casis O., Sanguinetti M.C., Aizawa Y., et al. Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Circulation 2007, 115:442-449.
26. Gross G.J. Early repolarization and ventricular fibrillation: vagally familiar?. Heart Rhythm 2010, 7:653-654.
27. Litovsky S.H., Antzelevitch C. Differences in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol. A direct effect of acetylcholine in ventricular myocardium. Circ Res 1990, 67:615-627.
28. Ulphani J.S., Cain J.H., Inderyas F., Gordon D., Gikas P.V., Shade G., et al. Quantitative analysis of parasympathetic innervation of the porcine heart. Heart Rhythm 2010, 7:1113-1119.
29. Takahashi N., Barber M.J., Zipes D.P. Efferent vagal innervation of canine ventricle. Am J Physiol 1985, 248:H89-H97.
30. DeGeest H., Levy M.N., Zieske H., Lipman R.I. Depression of ventricular contractility by stimulation of the vagus nerves. Circ Res 1965, 17:222-235.
31. Yang Z.K., Boyett M.R., Janvier N.C., McMorn S.O., Shui Z., Karim F. Regional differences in the negative inotropic effect of acetylcholine within the canine ventricle. J Physiol (Lond) 1996, 492(Pt 3):789-806.
32. Levy M.N. Sympathetic-parasympathetic interactions in the heart. Circ Res 1971, 29:437-445.
33. Kakinuma Y., Akiyama T., Sato T. Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium. FEBS J 2009, 276:5111-5125.
34. Rocha-Resende C., Roy A., Resende R., Ladeira M.S., Lara A., de Morais Gomes E.R., et al. Non-neuronal cholinergic machinery present in cardiomyocytes offsets hypertrophic signals. J Mol Cell Cardiol 2012, 53:206-216.
35. Junttila M.J., Sager S.J., Tikkanen J.T., Anttonen O., Huikuri H.V., Myerburg R.J. Use {15361}. Eur Heart J 2012, 33:2639-2643.
36. Noseworthy P.A., Tikkanen J.T., Porthan K., Oikarinen L., Pietila A., Harald K., et al. The early repolarization pattern in the general population clinical correlates and heritability. J Am Coll Cardiol 2011, 57:2284-2289.
37. Tikkanen J.T., Junttila M.J., Anttonen O., Aro A.L., Luttinen S., Kerola T., et al. Early repolarization: electrocardiographic phenotypes associated with favorable long-term outcome. Circulation 2011, 123:2666-2673.
38. Rosso R., Adler A., Halkin A., Viskin S. Risk of sudden death among young individuals with J waves and early repolarization: putting the evidence into perspective. Heart Rhythm 2011, 8:923-929.
39. Rosso R., Glikson E., Belhassen B., Katz A., Halkin A., Steinvil A., et al. Distinguishing "benign" from "malignant early repolarization": the value of the ST-segment morphology. Heart Rhythm 2012, 9:225-229.
40. Rosso R., Halkin A., Viskin S. J waves and early repolarization: do not confuse me with the facts!. Heart Rhythm 2012, 9:1603-1604.
41. Viskin S., Rosso R., Halkin A. Making sense of early repolarization. Heart Rhythm 2012, 9:566-569.
42. Szentandrassy N., Banyasz T., Biro T., Szabo G., Toth B.I., Magyar J., et al. Apico-basal inhomogeneity in distribution of ion channels in canine and human ventricular myocardium. Cardiovasc Res 2005, 65:851-860.
43. to and action potential notch are smaller in left vs. right canine ventricular epicardium. Am J Physiol 1996, 271:H548-H561.
44. Pierpont G.L., DeMaster E.G., Cohn J.N. Regional differences in adrenergic function within the left ventricle. Am J Physiol 1984, 246:H824-H829.
45. Haissaguerre M., Sacher F., Nogami A., Komiya N., Bernard A., Probst V., et al. Characteristics of recurrent ventricular fibrillation associated with inferolateral early repolarization role of drug therapy. J Am Coll Cardiol 2009, 53:612-619.
46. Roten L., Derval N., Sacher F., Pascale P., Scherr D., Komatsu Y., et al. Heterogeneous response of J wave syndromes to beta-adrenergic stimulation. Heart Rhythm 2012, 9:1970-1976.