Regulation of autophagy by LRRK2 in caenorhabditis elegans

Neurodegenerative Diseases

Volumn 13, Issue 2-3, 2014, Pages 110-113

  Saha, Shamol ^a   Liu Yesucevitz, Liqun ^a   Wolozin, Benjamin ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autophagy; Endoplasmic reticulum; Heat shock protein; Mitochondria; Parkinson's disease; Stress

Indexed keywords

LEUCINE RICH REPEAT KINASE 2;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CAENORHABDITIS ELEGANS; CELL FUNCTION; CELL ORGANELLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE MUTATION; INTRACELLULAR SPACE; MITOCHONDRION; NEMATODE; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CYTOPLASM; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AUTOPHAGY; CAENORHABDITIS ELEGANS; PROTEINS;

EID: 84896724297     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000355654     Document Type: Article

References (19)

1. Plowey ED, et al: Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem 2008; 105: 1048-1056.
2. Tong Y, et al: Loss of leucine-rich repeat kinase causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci USA 2010; 107: 9879-9884.
3. Orenstein SJ, et al: Interplay of LRRK2 with chaperone-mediated autophagy. Nat Neurosci 2013; 16: 394-406.
4. Biskup S, et al: Genes associated with Parkinson syndrome. J Neurol 2008; 255(suppl 5):8-17.
5. Shin N, et al: LRRK2 regulates synaptic vesicle endocytosis. Exp Cell Res 2008; 314: 2055-2065.
6. Matta S, et al: LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron 2012; 75: 1008-1021.
7. Chan D, et al: Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2). J Biol Chem 2011; 286: 16140-16149.
8. MacLeod DA, et al: RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. Neuron 2013; 77: 425-439.
9. Dodson MW, et al: Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning. Hum Mol Genet 2012; 21: 1350-1363.
10. Saha S, et al: LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J Neurosci 2009; 29: 9210-9218.
11. Di Domenico F, et al: Redox proteomics analyses of the influence of co-expression of wildtype or mutated LRRK2 and tau on C. elegans protein expression and oxidative modification: relevance to Parkinson disease. Antioxid Redox Signal 2012; 17: 1490-1506.
12. Ferree A, et al: Regulation of physiologic actions of LRRK2: focus on autophagy. Neurodegener Dis 2012; 10: 238-241.
13. Samann J, et al: Caenorhabditis elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth. J Biol Chem 2009; 284: 16482-16491.
14. Yuan Y, et al: Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans. PLoS One 2011; 6:e22354.
15. Yao C, et al: LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease. Neurobiol Dis 2010; 40: 73-81.
16. Yoneda T, et al: Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J Cell Sci 2004; 117: 4055-4066.
17. Alegre-Abarrategui J, et al: LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum Mol Genet 2009; 18: 4022-4034.
18. Niu J, et al: Leucine-rich repeat kinase 2 (LRRK2) disturbs mitochondrial dynamics via dynamin-like protein (DLP1). J Neurochem 2012; 122: 650-658.
19. Cherra SJ 3rd, et al: Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons. Am J Pathol 2012; 182: 474-484.