Cold atmospheric plasma (CAP) changes gene expression of key molecules of the wound healing machinery and improves wound healing in vitro and in vivo

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Arndt, Stephanie ^a   Unger, Petra ^b   Wacker, Eva ^a   Shimizu, Tetsuji ^c   Heinlin, Julia ^b   Li, Yang Fang ^c   Thomas, Hubertus M ^c   Morfill, Gregor E ^c   Zimmermann, Julia L ^c   Bosserhoff, Anja Katrin ^a   Karrer, Sigrid ^b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^c MAX PLANCK INSTITUT FÜR EXTRATERRESTRISCHE PHYSIK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; CYTOKINE; GROWTH FACTOR; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; ACTIN; ALPHA-SMOOTH MUSCLE ACTIN, MOUSE; COLLAGEN; PLASMA GAS; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASSAY; CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; COLD ATMOSPHERIC PLASMA; COLD ATMOSPHERIC PLASMA DEVICE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; IONIZED GAS; MEDICAL DEVICE; MOUSE; NONHUMAN; PHYSICAL PHASE; PROTEIN MICROARRAY; SCRATCH WOUND HEALING ASSAY; SKIN FIBROBLAST; SKIN INJURY; TISSUE INJURY; TISSUE REGENERATION; TISSUE REPAIR; WOUND HEALING; XTT ASSAY; ANIMAL; ATMOSPHERIC PRESSURE; BIOSYNTHESIS; CELL MOTION; COLD; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHARMACOLOGY; PLASMA GAS;

ADULT; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; FEMALE; HUMANS; MESENCHYMAL STROMAL CELLS; MICROSCOPY, FLUORESCENCE; NEOPLASM METASTASIS; PLASMA GASES; TIME FACTORS; ACTINS; ANIMALS; APOPTOSIS; ATMOSPHERIC PRESSURE; COLD TEMPERATURE; COLLAGEN; CYTOKINES; FIBROBLASTS; GENE EXPRESSION REGULATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; WOUND HEALING;

EID: 84896723565     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079325     Document Type: Article

References (32)

1. Heinlin J, Zimmermann JL, Zeman F, Bunk W, Isbary G, et al. (2013) Randomized placebo-controlled human pilot study of cold atmospheric argon plasma on skin graft donor sites. Wound Repair and Regeneration (accepted for publication).
2. Isbary G, Heinlin J, Shimizu T, Zimmermann JL, Morfill G, et al. (2012) Successful and safe use of 2 min cold atmospheric argon plasma in chronic wounds: results of a randomized controlled trial. Br J Dermatol 167: 404-410.
3. Isbary G, Morfill G, Schmidt HU, Georgi M, Ramrath K, et al. (2010) A first prospective randomized controlled trial to decrease bacterial load using cold atmospheric argon plasma on chronic wounds in patients. Br J Dermatol 163: 78-82.
4. Heinlin J, Morfill G, Landthaler M, Stolz W, Isbary G, et al. (2010) Plasma medicine: possible applications in dermatology. J Dtsch Dermatol Ges 8: 968-976.
5. Shimizu T, Steffes B, Pompl R, Jamitzky F, Bunk W, et al. (2008) Characterization of Microwave Plasma Torch for Decontamination. Plasma Process Polym: 5, 577-582.
6. Canady J, Arndt S, Karrer S, Bosserhoff AK (2013) Increased KGF expression promotes fibroblast activation in a double paracrine manner resulting in cutaneous fibrosis. J Invest Dermatol 133: 647-657.
7. Arndt S, Maegdefrau U, Dorn C, Schardt K, Hellerbrand C, et al. (2010) Iron-induced expression of bone morphogenic protein 6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo. Gastroenterology 138: 372-382.
8. Kappelmann M, Kuphal S, Meister G, Vardimon L, Bosserhoff AK (2012) MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expression. Oncogene.
9. Arndt S, Schmidt J, Wacker E, Karrer S, Bosserhoff AK (2011) Fussel-15, a new player in wound healing, is deregulated in keloid and localized scleroderma. Am J Pathol 178: 2622-2631.
10. Gabele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, et al. (2009) TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. Biochem Biophys Res Commun 378: 348-353.
11. Werner S, Grose R (2003) Regulation of wound healing by growth factors and cytokines. Physiol Rev 83: 835-870. (Pubitemid 36828927)
12. Penn JW, Grobbelaar AO, Rolfe KJ (2012) The role of the TGF-beta family in wound healing, burns and scarring: a review. Int J Burns Trauma 2: 18-28.
13. Amento EP, Beck LS (1991) TGF-beta and wound healing. Ciba Found Symp 157: 115-123; discussion 123-119.
14. Ahn HJ, Kim KI, Kim G, Moon E, Yang SS, et al. (2011) Atmospheric-pressure plasma jet induces apoptosis involving mitochondria via generation of free radicals. PLoS One 6: e28154.
15. Lupu AR, Georgescu N (2010) Cold atmospheric plasma jet effects on V79-4 cells. Roum Arch Microbiol Immunol 69: 67-74.
16. Lupu AR, Georgescu N, Calugaru A, Cremer L, Szegli G, et al. (2009) The effects of cold atmospheric plasma jets on B16 and COLO320 tumoral cells. Roum Arch Microbiol Immunol 68: 136-144.
17. Sensenig R, Kalghatgi S, Cerchar E, Fridman G, Shereshevsky A, et al. (2011) Non-thermal plasma induces apoptosis in melanoma cells via production of intracellular reactive oxygen species. Ann Biomed Eng 39: 674-687.
18. Reinke JM, Sorg H (2012) Wound repair and regeneration. Eur Surg Res 49: 35-43.
19. Gurtner GC, Werner S, Barrandon Y, Longaker MT (2008) Wound repair and regeneration. Nature 453: 314-321. (Pubitemid 351693137)
20. Paquet P, Pierard GE (1996) Interleukin-6 and the skin. Int Arch Allergy Immunol 109: 308-317. (Pubitemid 26082837)
21. Profyris C, Tziotzios C, Do Vale I (2012) Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics Part I. The molecular basis of scar formation. J Am Acad Dermatol 66: 1-10; quiz 11-12.
22. Gillitzer R, Goebeler M (2001) Chemokines in cutaneous wound healing. J Leukoc Biol 69: 513-521. (Pubitemid 32294835)
23. Kolar M, Szabo P, Dvorankova B, Lacina L, Gabius HJ, et al. (2012) Upregulation of IL-6, IL-8 and CXCL-1 production in dermal fibroblasts by normal/malignant epithelial cells in vitro: Immunohistochemical and transcriptomic analyses. Biol Cell 104: 738-751.
24. Qi L, Higgins SP, Lu Q, Samarakoon R, Wilkins-Port CE, et al. (2008) SERPINE1 (PAI-1) is a prominent member of the early G0-. G1 transition "wound repair" transcriptome in p53 mutant human keratinocytes. J Invest Dermatol 128: 749-753. (Pubitemid 351252668)
25. Chatzigeorgiou A, Lyberi M, Chatzilymperis G, Nezos A, Kamper E (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors 35: 474-483.
26. Yu Y, Tan M, Chen H, Wu Z, Xu L, et al. (2011) Non-thermal plasma suppresses bacterial colonization on skin wound and promotes wound healing in mice. J Huazhong Univ Sci Technolog Med Sci 31: 390-394.
27. Gharaee-Kermani M, Denholm EM, Phan SH (1996) Costimulation of fibroblast collagen and transforming growth factor beta1 gene expression by monocyte chemoattractant protein-1 via specific receptors. J Biol Chem 271: 17779-17784. (Pubitemid 26250752)
28. Kalghatgi S, Kelly CM, Cerchar E, Torabi B, Alekseev O, et al. (2011) Effects of non-thermal plasma on mammalian cells. PLoS One 6: e16270.
29. Tipa RS, Kroesen GMW (2011) Plasma-Stimulated Wound Healing Plasma Science IEEE Transactions on 39: 2978-2979.
30. Nosenko T, Shimizu T, Morfill G (2009) Designing plasmas for chronic wound disinfection. New J Phys 115013.
31. Metelmann H-R, von Woedtke T, Bussiahn R, Weltmann K-D, Rieck M, et al. (2012) Experimental Recovery of CO2-Laser Skin Lesions by Plasma Stimulation. American Journal of Cosmetic Surgery Vol. 29, No. 1, 52-56.
32. Witte MB, Barbul A (2002) Role of nitric oxide in wound repair. Am J Surg 183: 406-412. (Pubitemid 34442505)