Inhibiting mitochondrial β-oxidation selectively reduces levels of nonenzymatic oxidative polyunsaturated fatty acid metabolites in the brain

Journal of Cerebral Blood Flow and Metabolism

Volumn 34, Issue 3, 2014, Pages 376-379

  Chen, Chuck T ^a   Trépanier, Marc Olivier ^a   Hopperton, Kathryn E ^a   Domenichiello, Anthony F ^a   Masoodi, Mojgan ^b   Bazinet, Richard P ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

oxidation; metabolites; oxidative stress; peroxidation; PUFA

Indexed keywords

PALMOXIRIC ACID METHYL ESTER; POLYUNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FATTY ACID OXIDATION; LIPID BRAIN LEVEL; LIPIDOMICS; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MICROWAVE RADIATION; MITOCHONDRIAL BETA OXIDATION; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; ASPHYXIA; BRAIN; EPOXY COMPOUNDS; FATTY ACIDS, UNSATURATED; MALE; MICROWAVES; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROPIONATES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84896719586     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2013.221     Document Type: Article

References (15)

1. Dickens F. Metabolism of normal and tumour tissue: the respiratory quotient of brain cortex. Biochem J 1936; 30: 661-664.
2. Sokoloff L. The metabolism of the central nervous system in vivo. In: J. Field HM, Hall V (eds). Handbook of Physiology Neurophysiology. American Physiology Society: Washington DC, 1960, pp 1843-1846.
3. Erecinska M, Silver IA. Tissue oxygen tension and brain sensitivity to hypoxia. Respir Physiol 2001; 128: 263-276.
4. Rodrigues JV, Gomes CM. Mechanism of superoxide and hydrogen peroxide generation by human electron-Transfer flavoprotein and pathological variants. Free Radic Biol Med 2012; 53: 12-19.
5. Seifert EL, Estey C, Xuan JY, Harper ME. Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation. J Biol Chem 2010; 285: 5748-5758.
6. Dumont M, Beal MF. Neuroprotective strategies involving ROS in Alzheimer disease. Free Radic Biol Med 2011; 51: 1014-1026.
7. Chen CT, Liu Z, Bazinet RP. Rapid de-esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study. J Neurochem 2011; 116: 363-373.
8. Igarashi M, Ma K, Gao F, Kim HW, Greenstein D, Rapoport SI et al. Brain lipid concentrations in bipolar disorder. J Psychiatr Res 2010; 44: 177-182.
9. Cand F, Verdetti J. Superoxide dismutase, glutathione peroxidase, catalase, and lipid peroxidation in the major organs of the aging rats. Free Radic Biol Med 1989; 7: 59-63.
10. Schonfeld P, Reiser G. Why does brain metabolism not favor burning of fatty acids to provide energy?-Reflections on disadvantages of the use of free fatty acids as fuel for brain. J Cereb Blood Flow Metab 2013; 33: 1493-1499.
11. Chen CT, Domenichiello AF, Trepanier MO, Liu Z, Masoodi M, Bazinet RP. The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms. J Lipid Res 2013; 54: 2410-2422.
12. Golovko MY, Murphy EJ. An improved LC-MS/MS procedure for brain prostanoid analysis using brain fixation with head-focused microwave irradiation and liquidliquid extraction. J Lipid Res 2008; 49: 893-902.
13. Vannucci S, Hawkins R. Substrates of energy metabolism of the pituitary and pineal glands. J Neurochem 1983; 41: 1718-1725.
14. Adibhatla RM, Hatcher JF. Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 2010; 12: 125-169.
15. Hall ED, Vaishnav RA, Mustafa AG. Antioxidant therapies for traumatic brain injury. Neurotherapeutics 2010; 7: 51-61.