Regional grey matter structure differences between transsexuals and healthy controls - A voxel based morphometry study

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Simon, Lajos ^a   Kozák, Lajos R ^a   Simon, Viktória ^a   Czobor, Pál ^a,b   Unoka, Zsolt ^a   Szabó, Ádám ^a   Csukly, Gábor ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANGULAR GYRUS; ARTICLE; BIOLOGICAL GENDER; BRAIN SIZE; CALCARINUS; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; FEMALE TO MALE TRANSSEXUAL; GENDER; GENDER DYSPHORIA; GENDER IDENTITY; GRAY MATTER; HUMAN; INFERIOR OCCIPITAL GYRUS; LEFT ANGULAR GYRUS; LEFT INFERIOR PARIETAL LOBULE; LEFT POSTCENTRAL GYRUS; LEFT POSTERIOR CINGULATE; LEFT PRECENTRAL GYRUS; MALE; MALE TO FEMALE TRANSSEXUAL; MIDDLE OCCIPITAL GYRUS; NEUROANATOMY; PARIETAL LOBE; PRECUNEUS; PRIMARY MOTOR CORTEX; RIGHT CUNEUS; RIGHT FUSIFORM; RIGHT PRECENTRAL GYRUS; STRUCTURE ANALYSIS; TONGUE; VOXEL BASED MORPHOMETRY; YOUNG ADULT;

ADULT; BRAIN; CASE-CONTROL STUDIES; FEMALE; GENDER IDENTITY; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; NEUROIMAGING; TRANSSEXUALISM; YOUNG ADULT;

EID: 84896709028     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083947     Document Type: Article

References (36)

1. American Psychiatric Association (2000) Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. APA, Washington, DC.
2. Bao AM, Swaab DF (2011) Sexual differentiation of the human brain: Relation to gender identity, sexual orientation and neuropsychiatric disorders. Front Neuroendocrinol 32: 214-226.
3. Zhou JN, Hofman MA, Gooren LJ, Swaab DF (1995) A sex difference in the human brain and its relation to transsexuality. Nature 378: 68-70.
4. Garcia-Falgueras A, Swaab DF (2008) A sex difference in the hypothalamic uncinate nucleus: relationship to gender identity. Brain 131: 3132-3146.
5. Kruijver FP, Zhou JN, Pool CW, Hofman MA, Gooren LJ, et al. (2000) Male-to-female transsexuals have female neuron numbers in a limbic nucleus. J Clin Endocrinol Metab 85: 2034-2041. (Pubitemid 32269317)
6. Emory LE, Williams DH, Cole CM, Amparo EG, Meyer WJ (1991) Anatomic variation of the corpus callosum in persons with gender dysphoria. Arch Sex Behav 20: 409e17.
7. Yokota Y, Kawamura Y, Kameya Y (2005) Callosal shapes at the midsagittal plane: MRI differences of normal males, normal females, and GID. In: Proceedings of the 2005 IEEE, Engineering in Medicine and biology 27th Annual Conference; p.3055e8.
8. Rametti G, Carrillo B, Gomez-Gil E, Junque C, Segovia S, et al. (2011a) White matter microstructure in female to male transsexuals before cross-sex hormonal treatment. A diffusion tensor imaging study. J Psychiatr Res 45(2): 199-204.
9. Rametti G, Carrillo B, Gómez-Gil E, Junque C, Zubiaurre-Elorza L, et al. (2011b) The microstructure of white matter in male to female transsexuals before cross-sex hormonal treatment. A DTI study. J Psychiatr Res 45(7): 949-54.
10. Rametti G, Carillo B, Gómez-Gil E, Junque C, Zubiaurre-Elorza L, et al. (2012) Effects of androgenization on the white matter microstructure of female-to-male transsexuals. A diffusion tensor imaging study. Psychoneuroendocrinol 37:1261-1269.
11. Luders E, Sanchez FJ, Gaser C, Toga AW, Narr KL, et al. (2009) Regional gray matter variation in male-to-female transsexualism. Neuroimage 46(4): 904-907.
12. Savic I, Arver S (2011) Sex Dimorphism of the Brain in Male-to-Female Transsexuals. Cerebral Cortex 21: 2525-2533.
13. Luders E, Sánchez FJ, Tosun D, Shattuck DW, Gaser C, et al. (2012) Increased Cortical Thickness in Male-to-Female Transsexualism. J Behav Brain Sci 2: 357-362.
14. Zubiaurre-Elorza L, Junque C, Gómez-Gil E, Segovia S, Carillo B, et al. (2012) Cortical Thickness in Untreated Transsexuals. Cereb Cortex doi:10.1093/cercor/bhs267
15. Blanchard R, Clemmensen LH, Steiner BW (1987) Heterosexual and homosexual gender dysphoria. Arch Sex Behav 16: 139-152. (Pubitemid 17057964)
16. Blanchard R (1989) The classification and labeling of nonhomosexual gender dysphorias. Arch Sex Behav 18: 315-334.
17. Blanchard R, Dickey R, Jones CL (1995) Comparison of height and weight in homosexual versus nonhomosexual male gender dysphorics. Arch Sex Behav 24: 543-554.
18. Derogatis LR, Rickels K, Rock AF (1976) The SCL-90 and the MMPI: a step in the validation of a new self-report scale. Br J Psychiatry 128: 280-289
19. Ashburner J, Friston KJ (2000) Voxel-based morphometry-The methods. Neuroimage 11: 805-821.
20. Ashburner J (2007) A fast diffeomorphic image registration algorithm. Neuroimage 38(1): 95-113.
21. Evans AC, Collins DL, Mills SR, Brown ED, Kelly RL, et al. (1993) 3D statistical neuroanatomical models from 305 MRI volumes. Proc. IEEE Nucl. Sci. Symp. Med. Imaging Conf. 1813-1817.
22. Tohka J, Zijdenbos A, Evans A (2004) Fast and robust parameter estimation for statistical partial volume models in brain MRI. Neuroimage 23: 84-97. (Pubitemid 39119438)
23. Rajapakse JC, Giedd JN, Rapoport JL (1997) Statistical Approach to Segmentation of Single-Channel Cerebral MR Images. IEEE Trans. Med. Imag. 16: 176-186. (Pubitemid 127762929)
24. Manjon JV, Coupé P, Martí-Bonmatí L, Collins DL, Robles M (2010). Adaptive Non-Local Means Denoising of MR Images With Spatially Varying Noise Levels. J Magn Reson Imaging 31: 192-203.
25. Ridgway GR, Henley SM, Rohrer JD, Scahill RI, Warren JD, et al. (2008) Ten simple rules for reporting voxel-based morphometry studies.NeuroImage 40: 1429-1435.
26. th International Conference on Functional Mapping of the Human Brain. 2002 June 2-6, Sendai, Japan
27. Gallagher HL, Frith CD (2003) Functional imaging of "theory of mind". Trends Cogn Sci 7: 77-83.
28. Hodzic A, Kaas A, Muckli L, Stirn A, Singer W (2009) Distinct cortical networks for the detection and identification of human body. Neuroimage 45: 1264-1271.
29. Northoff G, Heinzel A, de Greck M, Bermpohl F, Dobrowolny H, et al. (2006) Self-referential processing in our brain-a meta-analysis of imaging studies on the self. Neuroimage 31: 440-457. (Pubitemid 44250876)
30. Rekkas PV, Constable RT (2005) Evidence that autobiographic memory retrieval does not become independent of the hippocampus: an fMRI study contrasting very recent with remote events. J Cogn Neurosci 17: 1950-1961.
31. Mechelli A, Price CJ, Friston KJ, Ashburner J (2005) Voxel-Based Morphometry of the Human Brain: Methods and Applications. Curr Med Imaging Rev 1: 2pp. 105-113.
32. Woermann FG, Free SL, Koepp MJ, Ashburner J, Duncan JD (1999) Voxel-byvoxel comparison of automatically segmented cerebral grey matter-A rater-independent comparison of structural MRI in patients with epilepsy. Neuro-Image 10:373-384. (Pubitemid 29472823)
33. Henley SM, Ridgway GR, Scahill RI, Klöppel S, Tabrizi SJ, et al. (2010) Pitfalls in the use of voxel-based morphometry as a biomarker: examples from huntington disease. Am J Neuroradiol. 31:711-719.
34. Ferreira LK, Diniz BS, Forlenza OV, Busatto GF, Zanetti MV (2011) Neurostructural predictors of Alzheimer's disease: a meta-analysis of VBM studies. Neurobiol Aging. 32:1733-1741.
35. Chen X, Sachdev PS, Wen W, Ansteyc KJ (2007) Sex differences in regional GM in healthy individuals aged 44-48 years: A voxel-based morphometric study. Neuroimage 36: 691-699. (Pubitemid 46907644)
36. Raz N, Gunning-Dixon F, Head D, Rodrigue KM, Williamson A, et al. (2004) Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volume. Neurobiol Aging 25: 377-396. (Pubitemid 38220973)