Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration

Nephrology Dialysis Transplantation

Volumn 29, Issue 2, 2014, Pages 282-289

  Rodríguez Ortiz, Maria E ^a   Canalejo, Antonio ^b   Herencia, Carmen ^a   Martínez Moreno, Julio M ^a   Peralta Ramírez, Alan ^c   Perez Martinez, Pablo ^a   Navarro González, Juan F ^d   Rodríguez, Mariano ^a   Peter, Mirjam ^e   Gundlach, Kristina ^e   Steppan, Sonja ^e   Passlick Deetjen, Jutta ^f   Muñoz Castañeda, Juan R ^a   Almaden, Yolanda ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b UNIVERSITY OF HUELVA   (Spain)

^c Fundacion Carolina   (Spain)

^d HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

^e FRESENIUS MEDICAL CARE   (Germany)

^f HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

calcium sensing receptor; magnesium; parathyroid glands; PTH; vitamin D receptor

Indexed keywords

CALCIUM; CALCIUM SENSING RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; KLOTHO PROTEIN; MAGNESIUM; MESSENGER RNA; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; VITAMIN D RECEPTOR;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; IN VITRO STUDY; INCUBATION TIME; NONHUMAN; PARATHYROID GLAND; PARATHYROID HORMONE RELEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION;

CALCIUM-SENSING RECEPTOR; MAGNESIUM; PARATHYROID GLANDS; PTH; VITAMIN D RECEPTOR;

ANIMALS; CALCIUM; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MAGNESIUM COMPOUNDS; PARATHYROID GLANDS; PARATHYROID HORMONE; PHOSPHATES; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTOR, PARATHYROID HORMONE, TYPE 1; RECEPTORS, CALCITRIOL; RECEPTORS, CALCIUM-SENSING; RNA, MESSENGER; UP-REGULATION;

EID: 84896707943     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gft400     Document Type: Article

References (32)

1. Brown EM, Gamba G, Riccardi D et al. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature 1993; 366: 575-580
2. Brown EM, MacLeod RJ. Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 2001; 81: 239-297
3. Brown EM, Pollak M, Hebert SC. Sensing of extracellular Ca2+ by parathyroid and kidney cells: Cloning and characterization of an extracellular Ca(2+)-sensing receptor. Am J Kidney Dis 1995; 25: 506-513
4. Bourdeau A, Souberbielle JC, Bonnet P et al. Phospholipase-A2action and arachidonic acid metabolism in calcium-mediated parathyroid hormone secretion. Endocrinology 1992; 130: 1339-1344
5. Almadén Y, Canalejo A, Ballesteros E et al. Regulation of arachidonic acid production by intracellular calcium in parathyroid cells: Effect of extracellular phosphate. J Am Soc Nephrol 2002; 13: 693-698
6. Garfia B, Cañadillas S, Canalejo A et al. Regulation of parathyroid vitamin D receptor expression by extracellular calcium. J Am Soc Nephrol 2002; 13: 2945-2952
7. Mendoza FJ, Lopez I, Canalejo R et al. Direct upregulation of parathyroid calcium-sensing receptor and vitamin D receptor by calcimimetics in uremic rats. Am J Physiol Renal Physiol 2009; 296: F605-F613
8. Cañadillas S, Canalejo R, Rodriguez-Ortiz ME et al. Upregulation of parathyroid VDR expression by extracellular calcium is mediated by ERK1/2-MAPK signaling pathway. Am J Physiol Renal Physiol 2010; 298: F1197-F1204
9. Canalejo R, Canalejo A, Martinez-Moreno JM et al. FGF23 fails to inhibit uremic parathyroid glands. J Am Soc Nephrol 2010; 21: 1125-1135
10. Habener JF, Potts JT, Jr. Relative effectiveness of calcium and magnesium in the secretion and biosynthesis of parathyroid hormone in vitro. Endocrinology 1976; 98: 197-202
11. Brown EM. Relationship of 3, 50-Adenosine monophosphate accumulation to parathyroid hormone release in dispersed cells from pathological human parathyroid tissue. J Clin Endocrinol Metab 1981; 52: 961-968
12. Brown EM, Thatcher JG,Watson EJ et al. Extracellular calcium potentiates the inhibitory effects of magnesium on parathyroid function in dispersed bovine parathyroid cells. Metabolism 1984; 33: 171-176
13. Shoback DM, Thatcher JG, Brown EM. Interaction of extracellularcalcium and magnesium in the regulation of cytosolic calcium and PTH release in dispersed bovine parathyroid cells. Mol Cell Endocrinol 1984; 38: 179-186
14. McGonigle RJ, Weston MJ, Keenan J et al. Effect of hypermagnesemia on circulating plasma parathyroid hormone in patients on regular hemodialysis therapy. Magnesium 1984; 3: 1-7
15. Takahashi S, Okada K, Yanai M. Magnesium and parathyroid hormone changes to magnesium-free dialysate in continuous ambulatory peritoneal dialysis patients. Perit Dial Int 1994; 14: 75-78
16. Navarro JF, Mora C, Jiménez A et al. Relationship between serum magnesium and parathyroid hormone levels in hemodialysis patients. Am J Kidney Dis 1999; 34: 43-48
17. Navarro JF, Mora C, Macia M et al. Serum magnesium concentration is an independent predictor of parathyroid hormone levels in peritoneal dialysis patients. Perit Dial Int 1999; 19: 455-461
18. de Francisco AL, Leidig M, Covic AC et al. Evaluation of calcium acetate/ magnesium carbonate as a phosphate binder compared with sevelamer hydrochloride in haemodialysis patients: A controlled randomized study (CALMAG study) assessing efficacy and tolerability. Nephrol Dial Transplant 2010; 25: 3707-3717
19. Almadén Y, Canalejo A, Ballesteros E et al. Effect of high extracellular phosphate concentration on arachidonic acid production by parathyroid tissue in vitro. J Am Soc Nephrol 2000; 11: 1712-1718
20. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-cloroform extraction. Anal Biochem 1987; 162: 156-159
21. Massry SG, Coburn JW, Kleeman CR. Evidence for suppression of parathyroid gland activity by hypermagnesemia. J Clin Invest 1970; 49: 1619-1629
22. Cholst IN, Steinberg SF, Tropper PJ et al. The influence of hypermagnesemia on serum calcium and parathyroid hormone levels in human subjects. N Engl J Med 1984; 310: 1221-1225
23. Ferment O, Garnier PE, Touitou Y. Comparison of the feedback effect of magnesium and calcium on parathyroid hormone secretion in man. J Endocrinol 1987; 113: 117-122
24. Brown AJ, Zhong M, Ritter C et al. Loss of calcium responsiveness in cultured bovine parathyroid cells is associated with decreased calcium receptor expression. Biochem Biophys Res Commun 1995; 212: 861-867
25. Chattopadhyay N, Mithal A, Brown EM. The calcium-sensing receptor: A window into the physiology and pathophysiology of mineral ion metabolism. Endocr Rev 1996; 17: 289-307. Review. Erratum in: Endocr Rev 1996; 17: 517
26. Inaba M, Okuno S, Imanishi Y et al. Magnesium deficiency enhances secretion of parathyroid hormone in normal and 5/6-nephrectomized uremic rats. J Endocrinol Invest 1992; 15: 135-142
27. Mahaffee DD, Cooper CW, Ramp WK et al. Magnesium promotes both parathyroid hormone secretion and adenosine 30,50-monophosphate production in rat parathyroid tissues and reverses the inhibitory effects of calcium on adenylate cyclase. Endocrinology 1982; 110: 487-495
28. Duran MJ, Borst GC, III, Osburne RC et al. Concurrent renal hypomagnesemia and hypoparathyroidism with normal parathormone responsiveness. Am J Med 1984; 76: 151-154
29. Quitterer U, Hoffmann M, Freichel M et al. Paradoxical block of parathormone secretion is mediated by increased activity of G alpha subunits. J Biol Chem 2001; 276: 6763-6769
30. Miki H, Maercklein PB, Fitzpatrick LA. Effect of magnesium on parathyroid cells: Evidence for two sensing receptors or two intracellular pathways?. Am J Physiol 1997; 272: E1-E6
31. Rodriguez ME, Almaden Y, Cañadillas S et al. The calcimimetic R-568 increases vitamin D receptor expression in rat parathyroid glands. Am J Physiol Renal Physiol 2007; 292: F1390-F1395
32. Ben-Dov IZ, Galitzer H, Lavi-Moshayoff V et al. The parathyroid is a target organ for FGF23 in rats. J Clin Invest 2007; 117: 4003-4008